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    COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS
    5.
    发明申请
    COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS 审中-公开
    化合物和治疗眼病的方法

    公开(公告)号：WO2011071995A2

    公开(公告)日：2011-06-16

    申请号：PCT/US2010/059426

    申请日：2010-12-08

    申请人： CASE WESTERN RESERVE UNIVERSITY ,  PALCZEWSKI, Krzysztof ,  MAEDA, Akiko ,  GOLCZAK, Marcin

    发明人： PALCZEWSKI, Krzysztof ,  MAEDA, Akiko ,  GOLCZAK, Marcin

    IPC分类号： A61K31/428 ,  A61K31/4162 ,  A61K31/4184 ,  A61K31/56 ,  A61K9/22 ,  A61K9/20 ,  A61P27/02

    CPC分类号： C07D487/04 ,  A61K9/0048 ,  A61K31/4162 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/56 ,  C07C211/01 ,  C07C229/12 ,  C07C229/60 ,  C07C229/64 ,  C07C237/48 ,  C07C251/58 ,  C07C317/36 ,  C07D261/04

    摘要： A method of treating an ocular disorder in a subject associated with aberrant all- trans -retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R 1 is an aliphatic and/or aromatic compound; the primary amine compound upon administration to the subject forming a reversible Schiff-base with theall- trans -retinal or its metabolite including A2E and retinal dimer without adversely affecting normal retinoid cycle performance; the primary amine compound when administered to a Rdh8 -1- Abca4 -1- mouse increasing the optical coherence tomography score of the mouse to at least about 2.5 and increasing 11-ds-retinal amount at least about 30% in comparison to untreated control animal, wherein the primary amine compound is not a local anesthetic, which includes an aromatic amine, that demonstrates sodium channel blockade when administered to the subject.

    摘要翻译： 一种治疗与视网膜异常全反式视网膜清除相关的受试者的眼部疾病的方法，所述方法包括向受试者施用治疗有效量的下式的伯胺化合物：其中R 1是脂族和/或 芳香族化合物; 给予受试者形成伯胺化合物，其形成具有全反式视黄醛或其代谢物的可逆希夫碱，包括A2E和视黄醛二聚体，而不会不利地影响正常的类视黄醇循环性能; 当向Rdh8-1-Abca4-1小鼠施用时，将伯胺化合物与未处理的对照动物相比，将小鼠的光学相干断层摄影得分提高至至少约2.5并增加11-ds-视网膜量至少约30％ 其中伯胺化合物不是局部麻醉剂，其包括芳族胺，其在施用于受试者时显示出钠通道阻断。

    PHENYL-METHOXYIMINO-GLYOXYLIC ACID DERIVATIVES AS PESTICIDES
    8.
    发明申请
    PHENYL-METHOXYIMINO-GLYOXYLIC ACID DERIVATIVES AS PESTICIDES 审中-公开
    作为杀虫剂的苯甲酰甲氧基 - 羧甲酸衍生物

    公开(公告)号：WO99050232A1

    公开(公告)日：1999-10-07

    申请号：PCT/EP1999/002037

    申请日：1999-03-25

    IPC分类号： A01N37/50 ,  C07C249/04 ,  C07C249/16 ,  C07C251/48 ,  C07C251/58 ,  C07C251/86 ,  C07C251/88

    CPC分类号： C07C251/58 ,  A01N37/50 ,  C07C251/48 ,  C07C251/86 ,  C07C251/88 ,  C07C2601/02

    摘要： Compounds of formula (I), wherein: A is a group OCHR4 or N=CR4; Y is O or NH; R1 is C1-C6-alkyl; R2 is C1-C6-alkyl or C1-C6-alkyl substituted by 1 to 5 fluorine atoms; R3 is C1-C6-alkyl, C1-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkoxy, C2-C6-alkenyl, C2-C6-alkenyloxy, C2-C6-alkinyl, C2-C6-alkinyloxy, C1-C6-alkoxycarbonyl, CN or halogen, aryl, hetaryl, heterocyclyl, aryloxy, hetaryloxy or heterocyclyloxy, whereby the above-mentioned groups, with the exception of CN and halogen, may be substituted by the same or different substituents; R4 is methyl, ethyl or cyclopropyl; R6 is hydrogen or methyl; have microbicidal, insecticidal and acaricidal activity, and may be used to control plant-pathogenic fungi, acarids and insects in agriculture and in the field of hygiene.

    摘要翻译： 式（I）化合物，其中：A为基团OCHR4或N = CR4; Y为O或NH; R1是C1-C6-烷基; R2是C1-C6-烷基或被1〜5个氟原子取代的C1-C6-烷基; R3是C1-C6-烷基，C1-C6-烷氧基，C3-C6-环烷基，C3-C6-环烷氧基，C2-C6-烯基，C2-C6-烯氧基，C2-C6-炔基，C2-C6-烷氧基， C 1 -C 6烷氧基羰基，CN或卤素，芳基，杂芳基，杂环基，芳氧基，杂芳氧基或杂环氧基，其中除了CN和卤素之外，上述基团可以被相同或不同的取代基取代; R4是甲基，乙基或环丙基; R6是氢或甲基; 具有杀菌，杀虫和杀螨活性，可用于控制农业和卫生领域的植物致病真菌，螨虫和昆虫。

    'alpha'-ALKOXYIMINOBENZYL DERIVATIVES AND AGRICULTURAL CHEMICALS CONTAINING THEM AS ACTIVE INGREDIENTS
    9.
    发明申请
    'alpha'-ALKOXYIMINOBENZYL DERIVATIVES AND AGRICULTURAL CHEMICALS CONTAINING THEM AS ACTIVE INGREDIENTS 审中-公开
    α-ALKOXYIMINBENZYL衍生物和含有它们作为活性成分的农业化学品

    公开(公告)号：WO1997037968A1

    公开(公告)日：1997-10-16

    申请号：PCT/JP1997001163

    申请日：1997-04-04

    申请人： SHIONOGI & CO., LTD. ,  KAI, Hiroyuki ,  MASUI, Moriyasu

    发明人： SHIONOGI & CO., LTD.

    IPC分类号： C07C251/50

    CPC分类号： C07D271/10 ,  A01N35/10 ,  A01N37/50 ,  A01N43/08 ,  A01N43/50 ,  A01N43/653 ,  A01N43/74 ,  A01N43/80 ,  A01N43/82 ,  C07C251/58 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D261/04 ,  C07D261/08 ,  C07D263/32 ,  C07D277/04 ,  C07D307/52

    摘要： Compounds of general formula (I) are excellent bacteriocides exhibiting wide bacteriocidal spectra, wherein R is a heterocyclic group, CHO or CH2OR ; R is alkyl; R is hydrogen, alkyl, alkoxy, halogeno, nitro, cyano or haloalkyl; R is hydrogen, alkyl, cycloalkyl, alkoxyalkyl, alkoxycarbonyl, cyano, haloalkyl, aryl or a heterocyclic group; R is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, alkanoyl, aroyl, alkoxycarbonyl, aryl or a heterocyclic group; A is (1) -CH2ON=C(R )-, (2) -CH2N(R )-N=C(R ), (3) -CH=NOC(R )(R )- or (4) -CH=NN=C(R )-; B is oxygen or NR ; each wavy line refers to the configuration of an E- or Z-isomer or a mixture of both.

    摘要翻译： 通式（I）的化合物是显示出宽的杀菌光谱的优良杀菌剂，其中R 1是杂环基，CHO或CH2OR 6; R 2是烷基; R 3是氢，烷基，烷氧基，卤代，硝基，氰基或卤代烷基; R 4是氢，烷基，环烷基，烷氧基烷基，烷氧基羰基，氰基，卤代烷基，芳基或杂环基; R 5是氢，烷基，环烷基，烯基，炔基，烷酰基，芳酰基，烷氧基羰基，芳基或杂环基; A是（1）-CH 2 ON = C（R 7） - ，（2）-CH 2 N（R 8）-N = C（R 7），（3）-CH = NOC（R 9） >）（R 10） - 或（4）-CH = NN = C（R 7） - ; B是氧或NR 11; 每个波浪线是指E-或Z-异构体或两者的混合物的构型。