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公开(公告)号：US20200223866A1
公开(公告)日：2020-07-16
申请号：US16686912
申请日：2019-11-18
Applicant: Gilead Sciences, Inc.
Inventor： Anna Chiu , John Enquist, JR. , Nolan Griggs , Christopher Hale , Norihiro Ikemoto , Katie Ann Keaton , Matt Kraft , Scott E. Lazerwith , Michel Leeman , Zhihui Peng , Kate Schrier , Jonathan Trinidad , Jochem Van Herpt , Andrew W. Waltman
IPC: C07D498/14 , C07D319/06 , C07C237/20 , C07D213/82 , C07D309/40 , C07C235/80 , C07D498/22 , C07C231/02 , C07C231/12
Abstract: Methods of making compounds of Formula I are disclosed:
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2.发明授权公开(公告)号：US10988498B2
公开(公告)日：2021-04-27
申请号：US16011055
申请日：2018-06-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
IPC: C07H1/00 , C07H19/23 , A61K31/7056 , A61K31/706 , A61K31/7052
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号：US10975096B2
公开(公告)日：2021-04-13
申请号：US16686912
申请日：2019-11-18
Applicant: Gilead Sciences, Inc.
Inventor： Anna Chiu , John Enquist, Jr. , Nolan Griggs , Christopher Hale , Norihiro Ikemoto , Katie Ann Keaton , Matt Kraft , Scott E. Lazerwith , Michel Leeman , Zhihui Peng , Kate Schrier , Jonathan Trinidad , Jochem Van Herpt , Andrew W. Waltman
IPC: C07D498/14 , C07D498/22 , C07D319/06 , C07D309/40 , C07C237/20 , C07D213/82 , C07C235/80 , C07C231/02 , C07C231/12
Abstract: Methods of making compounds of Formula I are disclosed:
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公开(公告)号：US09440991B2
公开(公告)日：2016-09-13
申请号：US14576143
申请日：2014-12-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondapally , Chris Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC: C07D403/12 , C07D413/14 , C07D498/16 , C07C227/02 , C07D453/02 , C07C209/00 , C07C51/09 , C07K5/083
CPC classification number: C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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5.发明申请公开(公告)号：US20180327437A1
公开(公告)日：2018-11-15
申请号：US16011055
申请日：2018-06-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
CPC classification number: C07H1/00 , A61K31/7052 , A61K31/7056 , A61K31/706 , C07H19/23
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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Patent Agency Ranking
公开(公告)号：US20180022757A1
公开(公告)日：2018-01-25
申请号：US15639833
申请日：2017-06-30
Applicant: Gilead Sciences, Inc.
Inventor： Anna Chiu , John Enquist, JR. , Nolan Griggs , Christopher Hale , Norihiro Ikemoto , Katie Ann Keaton , Matt Kraft , Scott E. Lazerwith , Michel Leeman , Zhihui Peng , Kate Schrier , Jonathan Trinidad , Jochem Van Herpt , Andrew W. Waltman
IPC: C07D498/14 , C07D213/82 , C07C237/20 , C07D319/06 , C07C237/16 , C07D309/40 , C07C235/80 , C07C231/02 , C07D498/22 , C07C231/12
Abstract: Methods of making compounds of Formula I are disclosed:
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公开(公告)号：US20170210756A1
公开(公告)日：2017-07-27
申请号：US15227527
申请日：2016-08-03
Applicant: Gilead Sciences, Inc.
Inventor： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondapally , Christopher Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC: C07D498/18 , C07C271/34 , C07C255/61 , C07C205/57 , C07C233/09 , C07C251/12 , C07D403/12 , C07D241/44
CPC classification number: C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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公开(公告)号：US20160122356A1
公开(公告)日：2016-05-05
申请号：US14926063
申请日：2015-10-29
Applicant: Gilead Sciences, Inc.
Inventor： Steven Donald Axt , Pavel Robertovich Badalov , Katrien Brak , Silvio Campagna , Andrei Chtchemelinine , Edward Doerffler , Morin Mae Frick , Detian Gao , Lars V. Heumann , Brittanie Hoang , Willard Lew , Robert Ronald Milburn , Sean Timothy Neville , Bruce Ross , Erik Rueden , Robert William Scott , Dustin Siegel , Andrew C. Stevens , Clarissa Tadeus , Tiago Vieira , Andrew W. Waltman , Xianghong Wang , Mark Charles Whitcomb , Lydia Wolfe , Chia-Yun Yu
IPC: C07D487/04 , C07F9/6561 , C07D519/00 , C07F9/24
CPC classification number: A61K31/685 , A61K31/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/675 , A61K31/683 , A61K31/7056 , A61K31/706 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/2429 , C07F9/65616 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K2300/00
Abstract: Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
Abstract translation: 提供制备用于治疗丝状病毒科病毒感染的化合物和药物组合物的方法所提供的化合物，组合物和方法特别可用于治疗马尔堡病毒，埃博拉病毒和Cueva病毒感染。
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9.发明申请公开(公告)号：US20210403497A1
公开(公告)日：2021-12-30
申请号：US17209639
申请日：2021-03-23
Applicant: Gilead Sciences, Inc.
Inventor： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号：US10519168B2
公开(公告)日：2019-12-31
申请号：US15639833
申请日：2017-06-30
Applicant: Gilead Sciences, Inc.
Inventor： John Enquist, Jr. , Nolan Griggs , Christopher Hale , Norihiro Ikemoto , Andrew W. Waltman
IPC: C07D317/26 , C07C235/80 , C07C231/02 , C07C237/16 , C07D498/14 , C07D319/06 , C07C237/20 , C07D213/82 , C07D309/40 , C07D498/22 , C07C231/12
Abstract: Methods of making compounds of Formula I are disclosed:
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