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    System and method for inducing turbulence in fluid for dissipating thermal energy of electronic circuitry
    8.
    发明授权
    System and method for inducing turbulence in fluid for dissipating thermal energy of electronic circuitry 失效
    用于在流体中引起湍流以耗散电子电路的热能的系统和方法

    公开(公告)号：US07359198B2

    公开(公告)日：2008-04-15

    申请号：US11238418

    申请日：2005-09-29

    申请人： Michael G. Kelly ,  Mark D. Johnson ,  William H. Sisson ,  Jeffrey P. Tobin

    发明人： Michael G. Kelly ,  Mark D. Johnson ,  William H. Sisson ,  Jeffrey P. Tobin

    IPC分类号： H05K7/20 ,  F28F7/00 ,  H01L23/34

    CPC分类号： H01L23/473 ,  H01L2924/0002 ,  H01L2924/00

    摘要： A method for cooling a circuit comprises generating movement of fluid along a path through a closed-loop system. The method further comprises inducing turbulence in the fluid by movement of at least a portion of a turbulence-inducing device arranged in the path, and dissipating thermal energy from the circuit by the fluid. A system comprises a circuit, and a closed-loop cooling system comprising fluid for cooling the circuit and at least one active turbulence-inducing device. In one embodiment, the turbulence-inducing device is a microelectromechanical system (MEMS) device. In one embodiment, the MEMS device is solely responsible for bulk fluid movement through the closed-loop cooling system.

    摘要翻译： 用于冷却回路的方法包括沿着通过闭环系统的路径产生流体的运动。 该方法还包括通过移动位于路径中的紊流诱导装置的至少一部分，并且通过流体从该回路消散热能来在流体中引起湍流。 一种系统包括电路和闭环冷却系统，其包括用于冷却电路的流体和至少一个主动湍流诱导装置。 在一个实施例中，湍流诱导装置是微机电系统（MEMS）装置。 在一个实施例中，MEMS装置单独负责通过闭环冷却系统的大量流体运动。

    Antipsychotic indolyl derivatives
    10.
    发明授权
    Antipsychotic indolyl derivatives 失效
    抗精神病药物吲哚衍生物

    公开(公告)号：US06689792B2

    公开(公告)日：2004-02-10

    申请号：US09976321

    申请日：2001-10-12

    申请人： Michael G. Kelly ,  Young H. Kang

    发明人： Michael G. Kelly ,  Young H. Kang

    IPC分类号： A61K31454

    CPC分类号： C07D209/42 ,  C07D209/08 ,  C07D209/34 ,  C07D403/12

    摘要： Compounds of formula (1) are provided: wherein R1 and R2 are H, OH, F, Cl, Br, I, 1 to 6 carbon alkyl or alkenyl, 1 to 6 carbon alkoxy, aryl, OR5, nitro, amino, CF3 or R1 and R2 are taken together to form a fused ring at the 2,3- or 3,4-positions providing a fused phenyl group or a benzodioxane group, or a 4- or 7-substituted indole group, or a 5- or 8-substituted quinoline group; R3 represents a group selected from hydrogen, a 1 to 6 carbon alkyl, a 1 to 4 carbon alkoxy or a halogen; R4 represents a group selected from hydrogen, 1 to 6 carbon alkyl or R5; R5 is CH2Ph in which the phenyl ring can be optionally substituted by a group selected from OMe, halogen, CF3; X is selected from a group represented by C, CR4, [[CHR4]] and CHCH2; A is selected from a group represented by N, NH, CH and CH2; B is selected from a group represented by ═O, ═S, H and H2; or A and B may be concatenated together to form indole, benzimidazole, indolone or indoline moieties; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods of treating central nervous system disorders utilizing these compounds.

    摘要翻译： 提供式（1）化合物：其中R 1和R 2是H，OH，F，Cl，Br，I，1至6碳烷基或烯基，1至6个碳烷氧基，芳基，OR 5，硝基，氨基，CF 3或R 1 并且R 2一起在2,3或3,4位上形成稠环，提供稠合苯基或苯并二恶烷基，或4-或7-取代的吲哚基，或5-或8-取代的吲哚基， 取代的喹啉基; R 3表示选自氢，1至6个碳烷基，1至4个碳烷氧基或卤素的基团; R 4表示选自氢，1至6个碳烷基或R 5的基团; R 5是CH 2 Ph，其中 苯环可任选被选自OMe，卤素，CF 3的基团取代; X选自C，CR 4，[[CHR]]和CHCH 2表示的基团; A选自N，NH， CH和CH 2; B选自由= O，= S，H和H 2表示的基团;或者A和B可以连接在一起形成吲哚，苯并咪唑，吲哚酮或二氢吲哚部分; 或其药学上可接受的盐，以及利用这些化合物治疗中枢神经系统疾病的药物组合物和方法。