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    Polymeric cannulae proteins, nucleic acids encoding them and methods for making and using them
    3.
    发明申请
    Polymeric cannulae proteins, nucleic acids encoding them and methods for making and using them 审中-公开
    聚合插管蛋白，编码它们的核酸以及制备和使用它们的方法

    公开(公告)号：US20050208121A1

    公开(公告)日：2005-09-22

    申请号：US11046203

    申请日：2005-01-28

    申请人： Nelson Barton ,  Eileen O'Donoghue ,  Gerhard Frey ,  Jay Short ,  W. Lafferty ,  Kevin Chow

    发明人： Nelson Barton ,  Eileen O'Donoghue ,  Gerhard Frey ,  Jay Short ,  W. Lafferty ,  Kevin Chow

    IPC分类号： A01K67/00 ,  A61K33/44 ,  A61K38/17 ,  C07B57/00 ,  C07H21/04 ,  C07K14/195 ,  C07K14/705 ,  C12P21/04 ,  G01N33/573 ,  G01N33/68

    CPC分类号： B82Y5/00 ,  A01K2217/05 ,  A61K9/127 ,  A61K9/1274 ,  B82Y30/00 ,  C07K14/195 ,  C07K2319/00 ,  G01N33/573 ,  G01N33/68 ,  G01N2333/195

    摘要： The invention provides chimeric cannulae polypeptides and methods for making and using them. In one aspect, the invention provides compositions and methods for the identification, separation or synthesis of proteins or ligands. In one aspect, the invention provides compositions and methods for making and using nanotubules. In one aspect, the invention provides compositions and methods for the selection and purification of chiral compositions from racemic mixtures. The invention provides compositions comprising polymers prepared by self-assembly of a plurality of monomeric polypeptide units, including nanorobots, biochips, drug delivery systems. In one aspect, the polymer can form a nanotube, and the polymer (nanotubule) can encapsulate a drug molecule—a drug delivery systems of the invention. A drug delivery system of the invention may be delivered to a particular location of human body to effectively cure a disease or treat a symptom. In one aspect, a targeting vector can be attached to a monomeric polypeptide unit or a polymer to facilitate the targeting of the drug delivery system of the invention.

    摘要翻译： 本发明提供了嵌合插管多肽及其制备和使用方法。 一方面，本发明提供用于鉴定，分离或合成蛋白质或配体的组合物和方法。 一方面，本发明提供了制备和使用纳米管的组合物和方法。 一方面，本发明提供了用于从外消旋混合物中选择和纯化手性组合物的组合物和方法。 本发明提供了包含通过自组装多个单体多肽单元制备的聚合物的组合物，包括纳米机器人，生物芯片，药物递送系统。 在一个方面，聚合物可以形成纳米管，并且聚合物（纳米管）可以包封药物分子 - 本发明的药物递送系统。 本发明的药物递送系统可以被递送到人体的特定位置以有效地治愈疾病或治疗症状。 在一个方面，靶向载体可以连接到单体多肽单元或聚合物以促进本发明的药物递送系统的靶向。

    Method of making a protein polymer and uses of the polymer
    6.
    发明授权
    Method of making a protein polymer and uses of the polymer 失效
    制备蛋白质聚合物的方法和聚合物的用途

    公开(公告)号：US07459172B2

    公开(公告)日：2008-12-02

    申请号：US09997807

    申请日：2001-11-30

    申请人： Jay Short ,  Eric J. Mathur ,  W. Michael Lafferty ,  Nelson Barton ,  Kevin Chow

    发明人： Jay Short ,  Eric J. Mathur ,  W. Michael Lafferty ,  Nelson Barton ,  Kevin Chow

    IPC分类号： A61K31/74 ,  A61K38/16

    CPC分类号： B82Y30/00 ,  A61K9/0092 ,  A61K9/1274 ,  C07K14/195

    摘要： A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once encapsulated in the polymer of the present invention, the drug molecule may be delivered to a particular location of human body to effectively cure a disease or treat a symptom.Generally, the monomeric polypeptide unit of the present invention has a sequence found in Pyrodictium abyssi, a microorganism that produces an extracellular network having hollow protein tubes, or a sequence substantially identical thereto. The monomeric polypeptide may be mass produced using recombinant biotechnologies and be polymerized into the polymer of the present invention. One or more additional targeting vector may be attached to the monomeric polypeptide unit or the polymer to facilitate the targeting of the drug molecule that may be held there within. The sequence contained in the monomeric polypeptide unit may be further optimized using one or more technique selected from Gene Site Saturation Mutagenesis and GeneReasembly™.

    摘要翻译： 通过多个单体多肽单元的自组装制备聚合物。 聚合物倾向于形成纳米管并且能够封装特定的药物分子。 一旦包封在本发明的聚合物中，药物分子可以被递送到人体的特定位置以有效治愈疾病或治疗症状。 通常，本发明的单体多肽单元具有在黑腹果蝇（Pyrodictium abyssi）中发现的序列，该菌株产生具有中空蛋白管的细胞外网络或与其基本相同的序列。 单体多肽可以使用重组生物技术大规模生产并聚合成本发明的聚合物。 一个或多个另外的靶向载体可以连接到单体多肽单元或聚合物，以促进可能在其中保持的药物分子的靶向。 可以使用选自Gene Site Saturation Mutagenesis和GeneReasembly TM的一种或多种技术进一步优化单体多肽单元中所含的序列。

    CHIMERIC CANNULAE PROTEINS AND METHODS FOR MAKING AND USING THEM
    7.
    发明申请
    CHIMERIC CANNULAE PROTEINS AND METHODS FOR MAKING AND USING THEM 审中-公开
    CHIMERIC CANNULAE蛋白质及其制备和使用方法

    公开(公告)号：US20100172968A1

    公开(公告)日：2010-07-08

    申请号：US11929781

    申请日：2007-10-30

    申请人： Jay Short ,  Eric J. Mathur ,  W. Michael Lafferty ,  Nelson Barton ,  Kevin Chow

    发明人： Jay Short ,  Eric J. Mathur ,  W. Michael Lafferty ,  Nelson Barton ,  Kevin Chow

    IPC分类号： A61K9/48 ,  A61K9/10 ,  C12N15/63 ,  C07K14/00 ,  C07K16/00

    CPC分类号： B82Y30/00 ,  A61K9/0092 ,  A61K9/1274 ,  C07K14/195

    摘要： A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once encapsulated in the polymer of the present invention, the drug molecule may be delivered to a particular location of human body to effectively cure a disease or treat a symptom.Generally, the monomeric polypeptide unit of the present invention has a sequence found in Pyrodictium abyssi, a microorganism that produces an extracellular network having hollow protein tubes, or a sequence substantially identical thereto. The monomeric polypeptide may be mass produced using recombinant biotechnologies and be polymerized into the polymer of the present invention. One or more additional targeting vector may be attached to the monomeric polypeptide unit or the polymer to facilitate the targeting of the drug molecule that may be held there within. The sequence contained in the monomeric polypeptide unit may be further optimized using one or more technique selected from Gene Site Saturation Mutagenesis and GeneReasembly.

    摘要翻译： 通过多个单体多肽单元的自组装制备聚合物。 聚合物倾向于形成纳米管并且能够封装特定的药物分子。 一旦包封在本发明的聚合物中，药物分子可以被递送到人体的特定位置以有效治愈疾病或治疗症状。 通常，本发明的单体多肽单元具有在黑腹果蝇（Pyrodictium abyssi）中发现的序列，该菌株产生具有中空蛋白管的细胞外网络或与其基本相同的序列。 单体多肽可以使用重组生物技术大规模生产并聚合成本发明的聚合物。 一个或多个另外的靶向载体可以连接到单体多肽单元或聚合物，以促进可能在其中保持的药物分子的靶向。 可以使用选自基因位点饱和诱变和基因重组的一种或多种技术进一步优化单体多肽单元中所含的序列。