专利检索 ap:("Lisa A. Hasvold" OR "Laura Hexamer" OR "Gaoquan Li" OR "Nan-Horng Lin" OR "Hing Sham" OR "Thomas J. Sowin" OR "Gerard M. Sullivan" OR "Le Wang" OR "Ping Xia") AND inv:"Thomas J. Sowin" 第 1 页

1.

发明授权
Heterocyclic kinase inhibitors 有权
标题翻译：杂环激酶抑制剂

公开(公告)号：US07456169B2

公开(公告)日：2008-11-25

申请号：US11466638

申请日：2006-08-23

申请人： Lisa A. Hasvold , Laura Hexamer , Gaoquan Li , Nan-Horng Lin , Hing Sham , Thomas J. Sowin , Gerard M. Sullivan , Le Wang , Ping Xia

发明人： Lisa A. Hasvold , Laura Hexamer , Gaoquan Li , Nan-Horng Lin , Hing Sham , Thomas J. Sowin , Gerard M. Sullivan , Le Wang , Ping Xia

IPC分类号： C07D413/00 , A61K31/5513

CPC分类号： C07D243/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/10

摘要： Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

摘要翻译： 具有该式的化合物可用于抑制蛋白激酶。还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。

2.

发明授权
Macrocyclic kinase inhibitors 有权
标题翻译：大环激酶抑制剂

公开(公告)号：US07163939B2

公开(公告)日：2007-01-16

申请号：US10980740

申请日：2004-11-03

申请人： Nan-Horng Lin , Gaoquan Li , Magdalena K. Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Le Wang

发明人： Nan-Horng Lin , Gaoquan Li , Magdalena K. Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Le Wang

IPC分类号： C07D513/08 , A61K31/529

CPC分类号： C07D487/08

摘要： Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

摘要翻译： 具有下式的化合物可用于抑制蛋白激酶。还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。

3.

发明授权
Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases 有权
标题翻译：马球状激酶的环丁-3-烯-1,2， - 二酮抑制剂

公开(公告)号：US07956185B2

公开(公告)日：2011-06-07

申请号：US11753279

申请日：2007-05-24

申请人： Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang

发明人： Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang

IPC分类号： C07D239/02

CPC分类号： C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20

摘要： Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.

摘要翻译： 其中X1，C1和D1在本文中定义的式（I）化合物是polo样激酶的抑制剂。式（I）化合物可用于治疗细胞增殖疾病，例如癌症。

4.

发明授权
Fused tri and tetra-cyclic pyrazole kinase inhibitors 有权
标题翻译：融合的三和四环吡唑激酶抑制剂

公开(公告)号：US07320986B2

公开(公告)日：2008-01-22

申请号：US10792564

申请日：2004-03-03

申请人： Yunsong Tong , Akiyo K. Claiborne , Gaoquan Li , Nan-Horng Lin , Hing L. Sham , Thomas J. Sowin , Zhi-Fu Tao

发明人： Yunsong Tong , Akiyo K. Claiborne , Gaoquan Li , Nan-Horng Lin , Hing L. Sham , Thomas J. Sowin , Zhi-Fu Tao

IPC分类号： A61K31/4745 , A61K31/4162 , C07D487/14

CPC分类号： C07D249/08 , C07D231/12 , C07D231/54 , C07D233/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14

摘要： Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

摘要翻译： 具有式（I）的化合物可用于抑制蛋白激酶。还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。

5.

发明授权
Coding combinatorial libraries with fluorine tags 失效
标题翻译：用氟标签编码组合库

公开(公告)号：US06168913A

公开(公告)日：2001-01-02

申请号：US08949987

申请日：1997-10-14

申请人： Jill Edie Hochlowski , Thomas J. Sowin , Daniel W. Norbeck , Warren S. Wade , David N. Whittern

发明人： Jill Edie Hochlowski , Thomas J. Sowin , Daniel W. Norbeck , Warren S. Wade , David N. Whittern

IPC分类号： C12Q100

CPC分类号： C40B50/16 , B01J2219/00576 , C07K1/047 , C40B99/00

摘要： The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching “tags” that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to the solid support by fluorine nuclear magnetic resonance spectroscopy to follow the reaction history of individual beads, and to determine the particular member of the library that is attached on the bead.

摘要翻译： 本发明涉及通过以组合和/或比率附着包含含氟化合物的“标签”，在多个固体支持物上合成的组合化学文库编码。可以通过氟核磁共振光谱法附着到固体支持物上来对标签进行解码，以跟踪单个珠粒的反应历程，并确定附着在珠粒上的文库的特定成员。

6.

发明授权
Retroviral protease inhibiting compounds 有权

公开(公告)号：US6150530A

公开(公告)日：2000-11-21

申请号：US207881

申请日：1998-12-08

申请人： Dale J. Kempf , Daniel W. Norbeck , Hing Leung Sham , Chen Zhao , Thomas J. Sowin , Daniel S. Reno , Anthony R. Haight

发明人： Dale J. Kempf , Daniel W. Norbeck , Hing Leung Sham , Chen Zhao , Thomas J. Sowin , Daniel S. Reno , Anthony R. Haight

IPC分类号： C07D275/02 , A61K31/395 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K45/06 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/10 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/06 , C07D261/08 , C07D263/24 , C07D263/30 , C07D263/32 , C07D263/48 , C07D265/30 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07F5/02 , C07F5/04 , C07K5/06 , C07K5/065

CPC分类号： C07D413/12 , A61K31/425 , A61K31/427 , A61K45/06 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C33/46 , C07C381/00 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K38/00

摘要： A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.

7.

发明授权
Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane 失效
标题翻译：制备取代的2,5-二氨基-3-羟基己烷的方法

公开(公告)号：US5541328A

公开(公告)日：1996-07-30

申请号：US415385

申请日：1995-04-03

申请人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , Hing L. Sham , Thomas J. Sowin , Jien-Heh J. Tien , Chen Zhao , David Scarpetti

发明人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , Hing L. Sham , Thomas J. Sowin , Jien-Heh J. Tien , Chen Zhao , David Scarpetti

IPC分类号： C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14 , C07C251/78 , C07C209/44 , C07C221/14

CPC分类号： C07D221/14 , C07C213/00 , C07C215/28 , C07C225/16 , C07C251/40 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07B2200/07

摘要： A substantially pure compound of formula: ##STR1## wherein R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.l are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; andR.sub.g is hydrogen, loweralkyl or benzyl; or an acid addition salt thereof.

摘要翻译： （I）其中R a和R b独立地选自氢，低级烷基和苯基，R c，R d和R 10独立地选自氢，低级烷基，三氟甲基，烷氧基，卤素和苯基; （ii）其中萘基环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或R 6如上所定义，且R 7为R 7aa（O） - ，其中R 7a为低级烷基; 或者R 6和R 7与它们所键合的氮原子一起是其中R f，R g，R h和R 1独立地选自氢，低级烷基，烷氧基，卤素和三氟甲基; R g为氢，低级烷基或苄基; 或其酸加成盐。