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公开(公告)号：USRE50171E1
公开(公告)日：2024-10-15
申请号：US17682960
申请日：2022-02-28
发明人： Byron Kieser
IPC分类号： B01D59/44
CPC分类号： B01D59/44
摘要： Improved systems, apparatus, methods, and programming useful for the automated analysis of complex compounds using mass spectrometers. Systems, apparatus, methods, and programming according to the invention provide for the automatic determination by a controller 54 of a mass spectrometer 14, 214 of an analysis operation to be implemented using the mass spectrometer, the analysis operation adapted specifically for analysis of one or more substances based contained within a compound based on identification of the compound and/or substances provided by a user of the spectrometer, and a database 66 or other library of information concerning suitable processes or process steps for analyzing substances.
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公开(公告)号：US10755905B2
公开(公告)日：2020-08-25
申请号：US11718235
申请日：2005-10-28
申请人： Yongdong Wang , Ming Gu
发明人： Yongdong Wang , Ming Gu
摘要： A method for analyzing data from a mass spectrometer comprising acquiring raw profile mode data containing one or more ions and their isotopes in a mass spectral range; calculating theoretical isotope distributions for all ions of interest including native or labeled ions based on their molecular composition; convoluting the theoretical isotope distributions with target peak shape function specified during instrument calibration, actual peak shape functions, or approximated peak shape functions, to obtain theoretical isotope profiles for all ions; constructing a peak component matrix of relevant theoretical isotope profiles included as peak components; performing a weighted multiple linear regression between the profile mode data and the peak component matrix; and reporting regression coefficients as relative concentrations for each of the ions, or ranking these ions based on fitting statistics as search results. A mass spectrometer system (FIG. 1) operating in accordance with the method. Medium having computer code for operating the spectrometer.
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3.发明申请公开(公告)号：US20190049460A1
公开(公告)日：2019-02-14
申请号：US16158931
申请日：2018-10-12
发明人： Uwe Kobold , Roland Thiele , Noah Weiss , Benjamin Tiemann
摘要： A method and an apparatus for determining a concentration of a target analyte in a sample of bodily fluid are disclosed. The method involves providing a sample of bodily fluid including the target analyte, providing an internal standard solution including a mixture of components having a plurality of isotopes of the target analyte, wherein a concentration of each isotope is unknown, adding the internal standard solution to the sample, analyzing the sample including the internal standard solution using a mass spectrometer, creating a sample function curve based on signal intensities, wherein the signal intensities define arbitrary units, transferring an analyte signal into a corresponding arbitrary analyte unit by means of the sample function curve, and transferring the arbitrary analyte unit into the concentration of a target analyte by means of a standardization function representing a curve of concentrations depending on the arbitrary units.
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公开(公告)号：US09865444B2
公开(公告)日：2018-01-09
申请号：US15504877
申请日：2015-08-19
申请人： SHIMADZU CORPORATION
发明人： Daisuke Okumura
CPC分类号： H01J49/401 , H01J49/0045 , H01J49/062 , H01J49/24 , H01J49/40
摘要： Ions ejected substantially simultaneously from a collision cell after being temporarily held inside the collision cell arrive at an orthogonal acceleration unit through an ion transport optical system. When the ions enter the orthogonal acceleration unit, voltages having a predetermined potential difference are applied to an entrance-side electrode and an exit-side auxiliary electrode, and as a result an electric field having a rising potential gradient along an axis is created in the orthogonal acceleration unit. As ions having low an m/z values and entering the orthogonal acceleration unit first is significantly decelerate, the packet of ions spread in the X-axis direction in accordance with the m/z values are compressed in the X-axis direction after entering the orthogonal acceleration unit. Thus, a mass-to-charge ratio range of ions that are accelerated in the orthogonal acceleration unit is broadened, and a mass spectrum of a broad range of mass-to-charge ratios can be obtained.
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公开(公告)号：US09793477B2
公开(公告)日：2017-10-17
申请号：US14137840
申请日：2013-12-20
发明人： Daojing Wang , Pan Mao , Hung-Ta Wang , Peidong Yang
CPC分类号： H01L49/00 , B01D59/44 , B01L3/5027 , G01N30/72 , G01N30/7206 , H01J49/0018 , H01J49/04 , H01J49/167
摘要： The present invention provides for a structure comprising a plurality of emitters, wherein a first nozzle of a first emitter and a second nozzle of a second emitter emit in two directions that are not or essentially not in the same direction; wherein the walls of the nozzles and the emitters form a monolithic whole. The present invention also provides for a structure comprising an emitter with a sharpened end from which the emitter emits; wherein the emitters forms a monolithic whole. The present invention also provides for a fully integrated separation of proteins and small molecules on a silicon chip before the electrospray mass spectrometry analysis.
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公开(公告)号：US09638178B1
公开(公告)日：2017-05-02
申请号：US15098954
申请日：2016-04-14
申请人： Busek Co., Inc.
发明人： Daniel Courtney , Nathaniel Demmons , Peter Wright
CPC分类号： F03H1/0012 , B64G1/402 , B64G1/405
摘要： An ion electrospray device with a porous reservoir and at least one porous emitter includes a porous compliant interface sandwiched between the porous reservoir and the porous emitter for transferring fluid from the porous reservoir to the porous emitter. The interface has a characteristic capillary pressure stronger than the characteristic capillary pressure of the porous reservoir to fill the porous emitter with fluid via a fluid injection section of the interface and before the porous reservoir is then partially filled with fluid. Emitter leakage and propellant bridging problems are addressed.
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公开(公告)号：US09366649B2
公开(公告)日：2016-06-14
申请号：US13852675
申请日：2013-03-28
申请人： Ashley Wilks , Matthew Hart , Stephen Hartwell , Alison Hart , Lara Jamieson , Max Allsworth , John Somerville
发明人： Ashley Wilks , Matthew Hart , Stephen Hartwell , Alison Hart , Lara Jamieson , Max Allsworth , John Somerville
CPC分类号： G01N27/624 , G01N27/622
摘要： An apparatus, system and method for detecting, identifying, classifying and/or quantifying chemical species in a gas flow using a micro-fabricated ion filter coupled to a system adapted to apply drive signals to the ion filter. Coupled to the ion filter is a system adapted to measure the output of the ion filter, which in turn is coupled to a system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow.
摘要翻译： 一种用于使用耦合到适于将驱动信号施加到离子过滤器的系统的微制造离子过滤器来检测，识别，分类和/或定量气流中的化学物质的装置，系统和方法。 耦合到离子过滤器的系统是适于测量离子过滤器的输出的系统，该系统又耦合到适于从离子过滤器的测量输出提取数值参数的系统，以促进化学检测，识别，分类和/或 气流量化。
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8.发明授权公开(公告)号：US09330892B2
公开(公告)日：2016-05-03
申请号：US14323275
申请日：2014-07-03
发明人： Dirk Ardelt , Ulrich Heynen , Adi A. Scheidemann
CPC分类号： H01J49/025 , B01D59/44 , H01J49/322
摘要： An inorganic mass spectrometer capable of measuring a relevant and large or the full mass spectral range simultaneously may include a suitable ion source (e.g., an ICP mass spectrometer with an ICP ion source), an ion transfer region, ion optics to separate ions out of a plasma beam, a Mattauch-Herzog type mass spectrometer with a set of charged particle beam optics to condition the ion beam before an entrance slit, and a solid state multi-channel detector substantially separated from ground potential and separated from the potential of the magnet.
摘要翻译： 能够同时测量相关的和大的或全质谱范围的无机质谱仪可以包括合适的离子源（例如，具有ICP离子源的ICP质谱仪），离子转移区域，离子光学器件，用于将离子从 等离子体束，具有一组带电粒子束光学器件的Mattauch-Herzog型质谱仪，用于在入射狭缝之前调节离子束，以及基本上与地电位分离并与磁体的电位分离的固态多通道检测器 。
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公开(公告)号：US09293315B2
公开(公告)日：2016-03-22
申请号：US14746753
申请日：2015-06-22
IPC分类号： B01D59/44 , H01J49/00 , H01J49/26 , H01J3/00 , H01J49/10 , H01J49/06 , H01J49/42 , H01J49/04 , H01J49/40 , G01N27/62
CPC分类号： H01J49/10 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0481 , H01J49/06 , H01J49/063 , H01J49/401 , H01J49/4215 , H01J49/423 , H01J49/425 , H01J49/426 , H01J49/427 , H01J49/4295
摘要： An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap. Additionally or alternatively, ion optics receive ions ejected from the ion trap and cool the ions without substantial fragmentation. An ion analyzer receives ions ejected from the ion trap or ion optics and separates the ions in accordance with at least one characteristic of the ions.
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公开(公告)号：US09240310B2
公开(公告)日：2016-01-19
申请号：US14698364
申请日：2015-04-28
CPC分类号： H01J49/062 , H01J49/0031 , H01J49/4225
摘要： An ion transfer device for transferring ions emerging from an electrospray ion source at atmosphere to a vacuum chamber includes an inner surface in the shape of a diverging conical duct. The ion transfer device has an entrance aperture for positioning proximate the exit port of the electrospray ion source emitter, the entrance aperture receiving the electrosprayed ions from the exit port of the electrospray ion source emitter at atmosphere, the diverging conical duct being an electrode toward which the ions migrate and having an exit aperture with an inner diameter larger than an inner diameter of its entrance aperture, the exit aperture enclosed in the vacuum chamber, the diverging conical duct transporting the ions from atmosphere to vacuum. The vacuum chamber can be a chamber of a vacuum housing enclosing a mass analyzer.
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