公开(公告)号：US20050146039A1

公开(公告)日：2005-07-07

申请号：US11030235

申请日：2005-01-06

申请人： Rajiv Shah ,  Shaun Pendo

发明人： Rajiv Shah ,  Shaun Pendo

IPC分类号： H01L21/48 ,  H05K1/16 ,  H05K3/04 ,  H05K3/40 ,  H05K3/46 ,  H01L21/44 ,  H01L23/48

CPC分类号： H05K3/467 ,  H01L21/4857 ,  H01L21/4867 ,  H01L2924/0002 ,  H01L2924/19107 ,  H05K1/162 ,  H05K3/048 ,  H05K3/4053 ,  H05K3/4061 ,  H05K3/4664 ,  H05K2201/0179 ,  H05K2203/0278 ,  H05K2203/085 ,  H05K2203/1476 ,  H05K2203/308 ,  H01L2924/00

摘要： A multilayer circuit substrate for multi-chip modules or hybrid circuits includes a dielectric base substrate, conductors formed on the base substrate and a vacuum deposited dielectric thin film formed over the conductors and the base substrate. The vacuum deposited dielectric thin film is patterned using sacrificial structures formed by shadow mask techniques. Substrates formed in this manner enable significant increases in interconnect density and significant reduction of over-all substrate thickness.

摘要翻译： 用于多芯片模块或混合电路的多层电路衬底包括电介质基底，形成在基底衬底上的导体和形成在导体和基底衬底上的真空沉积的电介质薄膜。 使用由荫罩技术形成的牺牲结构对真空沉积的电介质薄膜进行图案化。 以这种方式形成的基板能够显着增加互连密度并显着降低总体衬底厚度。

公开(公告)号：US20050106366A1

公开(公告)日：2005-05-19

申请号：US10969758

申请日：2004-10-20

申请人： Joseph Schulman ,  Joseph Lucisano ,  Rajiv Shah ,  Charles Byers ,  Shaun Pendo

发明人： Joseph Schulman ,  Joseph Lucisano ,  Rajiv Shah ,  Charles Byers ,  Shaun Pendo

IPC分类号： A61L2/00 ,  A61N1/02 ,  B05D3/00 ,  B32B9/00 ,  C23C14/00 ,  C23C14/04 ,  G03F1/00 ,  G03F7/20 ,  H01L21/308 ,  H01L23/29 ,  H05K3/28 ,  B32B15/04 ,  C23C14/32

CPC分类号： G03F7/70641 ,  A61N1/02 ,  A61N1/375 ,  C23C14/042 ,  H01L21/308 ,  H01L23/291 ,  H01L2924/0002 ,  H05K3/284 ,  Y10T29/49144 ,  Y10T428/24802 ,  Y10T428/24917 ,  Y10T428/24926 ,  Y10T428/265 ,  H01L2924/00

摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.

公开(公告)号：US20050090866A1

公开(公告)日：2005-04-28

申请号：US10996026

申请日：2004-11-22

申请人： Michael Miller ,  Rajiv Shah

发明人： Michael Miller ,  Rajiv Shah

IPC分类号： A61B5/00 ,  A61B17/34 ,  A61M1/16 ,  A61M5/142 ,  H05K1/03 ,  H05K3/40 ,  A61N1/00

CPC分类号： A61B5/145 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/6882 ,  A61B17/3468 ,  A61M1/1698 ,  A61M5/14276 ,  A61M2230/20 ,  A61M2230/201 ,  H05K1/0306 ,  H05K3/4061 ,  H05K2201/0179 ,  H05K2201/0317 ,  H05K2203/082 ,  H05K2203/085 ,  H05K2203/1147 ,  H05K2203/1476 ,  H05K2203/1572 ,  H05K2203/308

摘要： A method and system for non-vascular sensor implantation. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the area of the implant unit. The sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area of the body. A subcutaneous area of the body may be tunneled to place the sensor. The system may include an implant unit such as, for example, for delivering drug to a human body and a sensor for detecting a physiological parameter. The sensor may be separate from and connectable to the implant unit and may be placed in a non-vascular area of the human body.

摘要翻译： 一种用于非血管传感器植入的方法和系统。 植入单元被植入身体的一个区域，允许在植入单元的区域周围形成异物胶囊。 传感器可以被引导到体腔，例如腹膜空间，皮下组织，异物胶囊或身体的其它区域中。 身体的皮下区域可以被隧道以放置传感器。 该系统可以包括例如用于将药物输送到人体的植入单元和用于检测生理参数的传感器。 传感器可以与植入单元分离并且可连接到植入单元，并且可以放置在人体的非血管区域中。

公开(公告)号：US06671554B2

公开(公告)日：2003-12-30

申请号：US10033720

申请日：2001-12-27

申请人： Scott R. Gibson ,  Rajiv Shah ,  Edward Chernoff ,  Charles Byers

发明人： Scott R. Gibson ,  Rajiv Shah ,  Edward Chernoff ,  Charles Byers

IPC分类号： A61N1375

CPC分类号： A61N1/3752 ,  A61N1/05 ,  Y10S439/909

摘要： An implantable coaxial lead includes a cable with male and female connectors. The cable includes inner and outer helical coils separated by an inner insulator tube, with an outer insulator tube surrounding the outer helical coil. The male connector includes an outer conductive cylinder, a conductive pin and an insulator molded in between. For increased strength, a braided cylinder, infused with rubber, is included at the juncture of the male connector and the cable. The female connector includes a cylinder formed by two conducting body elements and an intervening insulating body element. The female connector includes respective conductive tension elements configured to engage the male connector. A first seal is provided between the conductive tension members for electrical isolation and tactile feedback. An insertion tool includes a cylinder with a hollow bore and detachable head, and a rod for pulling the lead through the cylinder.

公开(公告)号：US09642568B2

公开(公告)日：2017-05-09

申请号：US13478420

申请日：2012-05-23

申请人： Rajiv Shah ,  Jesper Svenning Kristensen ,  Katherine T. Wolfe ,  Soren Aasmul ,  Anubhuti Bansal

发明人： Rajiv Shah ,  Jesper Svenning Kristensen ,  Katherine T. Wolfe ,  Soren Aasmul ,  Anubhuti Bansal

IPC分类号： A61B5/1455 ,  A61B5/1459 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  G01N21/64 ,  G01N21/77 ,  G01N33/66

CPC分类号： A61B5/14532 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61B5/6848 ,  A61B5/6849 ,  A61B5/742 ,  A61M5/1723 ,  A61M2230/201 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/7703 ,  G01N33/66 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2021/772 ,  G01N2021/7733 ,  G01N2021/775 ,  G01N2021/7759 ,  G01N2021/7786 ,  G01N2333/4724

摘要： A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.

公开(公告)号：US09549698B2

公开(公告)日：2017-01-24

申请号：US13004646

申请日：2011-01-11

申请人： Rajiv Shah ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz

发明人： Rajiv Shah ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

IPC分类号： A61B5/05 ,  A61B5/1486 ,  G01N27/327 ,  A61B5/145 ,  A61B5/00 ,  A61M5/172

CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0223 ,  A61M5/1723 ,  A61M2230/201 ,  G01N27/327 ,  G01N27/3274

摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

摘要翻译： 血糖感测系统包括传感器和传感器电子设备。 传感器包括多个电极。 传感器电子设备包括稳定电路。 稳定电路使得第一电压被施加到第一时间帧中的一个电极，并且使得第二电压被施加到第二时间范围中的一个电极。 稳定电路重复施加第一电压和第二电压以继续阳极 - 阴极循环。 传感器电子设备可以包括电源，调节器和电压施加装置，其中电压施加装置从调节器接收调节电压，在第一时间帧向电极施加第一电压，并施加第二电压 第二时间段的电极。

公开(公告)号：US09364177B2

公开(公告)日：2016-06-14

申请号：US12757796

申请日：2010-04-09

申请人： Rajiv Shah ,  Rebecca K. Gottlieb

发明人： Rajiv Shah ,  Rebecca K. Gottlieb

IPC分类号： A61B5/05 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  C12Q1/00 ,  C23C14/20 ,  C23C14/34

CPC分类号： A61B5/14865 ,  A61B5/0004 ,  A61B5/0017 ,  A61B5/14532 ,  A61B5/6848 ,  A61B5/6849 ,  C12Q1/006 ,  C23C14/20 ,  C23C14/3414 ,  G01N27/307 ,  G01N27/3273 ,  G01N27/4166 ,  Y10T29/49002 ,  Y10T29/49005 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49155

摘要： A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.

摘要翻译： 提供薄膜传感器，例如葡萄糖传感器，用于经皮放置在患者体内的选定部位。 传感器包括几个传感器层，其包括导电层，并且包括限定适于与合适的监视器电连接的导电触点的近端段，以及具有用于经皮放置的传感器电极的远端段。 传感器电极层大致彼此上下设置，例如，在工作电极上方的参考电极和对置电极上方的工作电极。 电极层由电介质层分离。

公开(公告)号：US09237865B2

公开(公告)日：2016-01-19

申请号：US11492273

申请日：2006-07-25

申请人： Yunbing Wang ,  Rajiv Shah ,  Jenn-Hann Larry Wang ,  William P. Van Antwerp ,  Brooks B. Cochran

发明人： Yunbing Wang ,  Udo Hoss ,  Rajiv Shah ,  Jenn-Hann Larry Wang ,  William P. Van Antwerp ,  Brooks B. Cochran

IPC分类号： G01N33/48 ,  A61B5/05 ,  A61B5/1486 ,  A61B5/145 ,  C12Q1/00

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/14546 ,  C12Q1/006 ,  Y10T29/49002

摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.

摘要翻译： 本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。 在本发明的某些实施方案中，传感器包括具有中心链和耦合到中心链的多个侧链的亲水梳状共聚物，其中至少一个侧链包含硅氧烷部分。

公开(公告)号：US09125607B2

公开(公告)日：2015-09-08

申请号：US13340562

申请日：2011-12-29

申请人： Lu Wang ,  Rajiv Shah ,  Wayne A. Morgan ,  Barry Keenan

发明人： Lu Wang ,  Rajiv Shah ,  Wayne A. Morgan ,  Barry Keenan

IPC分类号： A61B5/1473 ,  A61B5/1468 ,  A61B5/1495 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/145 ,  A61M5/172

CPC分类号： A61B5/1495 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14865 ,  A61B2560/0223 ,  A61M2005/1726

摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.

摘要翻译： 用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。 使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计 电极（Vmeasured）随着时间的推移。 然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。 可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。 然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

公开(公告)号：US08919180B2

公开(公告)日：2014-12-30

申请号：US13282128

申请日：2011-10-26

申请人： Rebecca K. Gottlieb ,  Ying Luo ,  Raghavendhar Gautham ,  Bradley Liang ,  Anirban Roy ,  Kenneth W. Cooper ,  Rajiv Shah ,  Barry Keenan

发明人： Rebecca K. Gottlieb ,  Ying Luo ,  Raghavendhar Gautham ,  Bradley Liang ,  Anirban Roy ,  Kenneth W. Cooper ,  Rajiv Shah ,  Barry Keenan

IPC分类号： G01N35/00 ,  A61B5/145 ,  A61B5/00 ,  A61M5/172

CPC分类号： A61B5/7221 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/7275 ,  A61B5/743 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3303 ,  A61M2230/201

摘要： Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.

摘要翻译： 公开了一种用于在提供葡萄糖测量中确定血糖传感器的可靠性的度量和/或指标的系统和方法。 在一个方面，可以至少部分地基于与由血糖传感器产生的信号相关联的观察趋势来计算度量和/或指示符。