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    Disposable cartridge for microfluidics system
    91.
    发明授权
    Disposable cartridge for microfluidics system 有权

    公开(公告)号：US09915631B2

    公开(公告)日：2018-03-13

    申请号：US14361556

    申请日：2014-01-06

    Applicant: TECAN TRADING AG

    Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee

    IPC: G01N27/447 ,  B01L3/00 ,  B81B1/00

    CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

    Abstract: A digital microfluidics system for manipulating samples in liquid droplets within a gap between a first hydrophobic surface of a bottom layer and a second hydrophobic surface of at least one disposable cartridge. Disposable cartridges comprise a body and/or a rigid cover plate. The bottom layer of each disposable cartridge is a flexible film that is sealingly attached to the body or plate. The cartridge has no spacer between the first and second hydrophobic surfaces. When using these cartridges, the bottom layers configured as a working film for manipulating samples in liquid droplets thereon, is placed on an electrode array of a digital microfluidics system. The array has individual electrodes. The digital microfluidics system also comprises a central control unit for controlling the selection of the individual electrodes of the electrode array and for providing these electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting.

    STR genotyping by differential hybridization
    92.
    发明授权
    STR genotyping by differential hybridization 有权

    公开(公告)号：US09783842B2

    公开(公告)日：2017-10-10

    申请号：US14372796

    申请日：2013-01-18

    Applicant: TECAN TRADING AG

    Inventor： Joseph Mamone ,  Marc N. Feiglin ,  Howard Gamper

    IPC: C12Q1/68

    CPC classification number: C12Q1/6813 ,  C12Q1/6827 ,  C12Q2525/151 ,  C12Q2525/186

    Abstract: In a method of deducing the number of repeat units in a selected short tandem repeat (STR) in a genomic sample, at least a single stranded target DNA generated from a genomic sample comprising a selected STR, an STR probe (P1,P1′), a reference probe (P2), and two blockers (B1,B2) are provided, and at least three differential hybridization experiments are carried out, based on which the number of STR probe oligonucleotides (P1,P1′) bound per target DNA strand in each differential hybridization experiment is determined. The method further comprises the step of comparing these numbers of STR probe oligonucleotides (P1,P1′) bound per target DNA strand in the differential hybridization experiments for deducing the number of repeat units in the selected STR on the single stranded target DNA strand. Also disclosed are kits for carrying out STR genotyping by differential hybridization.

    Pipetting apparatus
    94.
    发明授权
    Pipetting apparatus 有权
    移液器

    公开(公告)号：US09333499B2

    公开(公告)日：2016-05-10

    申请号：US13974582

    申请日：2013-08-23

    Applicant: Tecan Trading AG

    Inventor： Roland Bolliger

    IPC: B01L3/02

    CPC classification number: B01L3/021 ,  B01L3/0279 ,  B01L2200/021 ,  B01L2200/026

    Abstract: Pipetting apparatus has a block for holding pipette tips and connecting to pipette cones of a multiple-pipette head of a liquid handling apparatus. The block has cavities in an array and pipette tips inserted therein as well as conical plug-in openings for pipette cones of a multiple-pipette head. The block additionally has devices for connecting the block and the head. The block has receptacles with a shoulder and inserts for inserting into the receptacles, insert having a cavity, a cylindrical insertion opening with inserted pipette tip and a conical plug-in opening for sealing introduction of a pipette cone. Each insert has a support with which it rests on the shoulder of a corresponding receptacle when inserted into the block. Preferably each insert lies in the corresponding receptacle of the block with horizontal play on all sides.

    Abstract translation: 移液装置具有用于保持移液管尖端并连接到液体处理装置的多吸头的移液管锥的块。 该块具有阵列中的腔和插入其中的移液管尖端以及用于多吸头头的移液管锥的锥形插入开口。 该块还具有用于连接块和头的装置。 该块具有带有肩部的插座和用于插入容器的插入件，具有空腔的插入件，具有插入的吸头的圆柱形插入开口和用于密封移液管锥体的引入的锥形插入开口。 每个插入件具有支撑件，当插入到该块体中时，该支架搁置在相应插座的肩部上。 每个插入件优选地在所有侧面上具有水平游隙的块的相应的容器中。

    MAGNETIC COUPLING AND MIXING DEVICE
    95.
    发明申请
    MAGNETIC COUPLING AND MIXING DEVICE 审中-公开
    磁耦合和混合装置

    公开(公告)号：US20160121281A1

    公开(公告)日：2016-05-05

    申请号：US14895522

    申请日：2013-06-06

    Applicant: TECAN TRADING AG

    Inventor： Thomas GEIGES

    IPC: B01F13/08 ,  B01F3/08

    CPC classification number: B01F13/08 ,  B01F3/0853 ,  B01F11/0082 ,  B01F13/0818 ,  B01F13/1022

    Abstract: A device for mixing liquids in a container having an inner chamber with an enclosing wall and a bottom, an external encasement, an interspace and a transfer opening on top of the inner chamber. A mixing body located in the inner chamber comprises magnetizable material or a permanent magnet spaced from the wall. A coupling body movable in the interspace along a longitudinal axis and wall has magnetic working connection with the mixing body. The wall and the external encasement are transparent to magnetic fields. An acting permanent magnet or magnetizable material outside the external encasement, is in magnetic working connection with the coupling body. Moving the acting magnet or magnetizable material parallel to the longitudinal axis induces movement of the coupling body inside the interspace and moving the mixing body in the inner chamber, mixes liquids present in the inner chamber.

    Abstract translation: 一种用于将液体混合在容器中的装置，该容器具有内室和封闭壁和底部，外部外壳，间隙和内腔顶部的传送开口。 位于内室中的混合体包括可磁化材料或与壁间隔开的永磁体。 沿着纵向轴线和壁在间隙中移动的连接体与混合体具有磁力加工连接。 墙壁和外部外壳对磁场是透明的。 外部外壳外部的作用永磁体或可磁化材料与联接体处于磁力加工连接。 使作用磁体或可磁化材料平行于纵向轴线移动，引起联接体在空隙内的移动，并使混合体在内腔中移动，从而混合内腔中存在的液体。

    Monochromator Comprising Vibration Resistant Moveable Optical Elements
    97.
    发明申请
    Monochromator Comprising Vibration Resistant Moveable Optical Elements 有权
    包含抗振动移动光学元件的单色器

    公开(公告)号：US20160018261A1

    公开(公告)日：2016-01-21

    申请号：US14732170

    申请日：2015-06-05

    Applicant: TECAN Trading AG

    Inventor： Lutz NIGGL ,  Andreas STEINBACHER

    IPC: G01J3/18 ,  G01N21/64 ,  G01N21/25 ,  G01J3/06

    CPC classification number: G01J3/18 ,  G01J3/06 ,  G01J2003/062 ,  G01N21/255 ,  G01N21/64 ,  G01N2201/0635

    Abstract: A monochromator has at least one optical grating which is rotatable in relation to incident light of a source of light, a drive unit to rotate the optical grating by a connected drive rod around a longitudinal axis, and a control unit to control the drive unit and thereby the rotation of the optical grating. The drive unit further has a first damping element with at least one electrical conductive surface, and a second damping element which provides at least one magnetic field having a magnetic axis which penetrates the electrical conductive surface. One of the first and second damping elements is fixed to the drive rod and is rotatable along with the drive rod around the longitudinal axis thereof in relation to the other one of the second or first damping element.

    Abstract translation: 单色仪具有至少一个相对于光源的入射光可旋转的光栅;驱动单元，用于通过连接的驱动杆围绕纵轴旋转光栅;以及控制单元，用于控制驱动单元和 从而光栅的旋转。 驱动单元还具有带有至少一个导电表面的第一阻尼元件和提供至少一个具有穿过导电表面的磁轴的磁场的第二阻尼元件。 第一和第二阻尼元件中的一个被固定到驱动杆，并且可以与驱动杆一起围绕其纵向轴线相对于第二或第一阻尼元件中的另一个旋转。

    Spectrometer with Monochromator and Order Sorting Filter
    98.
    发明申请
    Spectrometer with Monochromator and Order Sorting Filter 有权
    光谱仪与单色器和订单分选过滤器

    公开(公告)号：US20160011048A1

    公开(公告)日：2016-01-14

    申请号：US14794316

    申请日：2015-07-08

    Applicant: TECAN Trading AG

    Inventor： Lutz NIGGL ,  Andreas ERLBACHER ,  Frank MÜNCHOW

    IPC: G01J3/18 ,  G01J3/42 ,  G01J3/06

    CPC classification number: G01J3/18 ,  G01J3/06 ,  G01J3/42 ,  G01J2003/1204 ,  G01J2003/1213 ,  G01J2003/1217 ,  G01N21/253 ,  G01N21/31 ,  G01N35/028 ,  G01N2021/3174 ,  G01N2201/084

    Abstract: A spectrometer (1) comprises a light source (2), a monochromator (3) with at least one diffraction grating (4), a monochromator housing (5), an order sorting filter (7), a microplate receptacle (12) and a controller (6). The order sorting filter (7) of the spectrometer (1) comprises a substrate (23), a first optical thin film (24) and a second optical thin film (25), wherein, in a spatially partly overlapping and interference-free manner, the first optical thin film (24) is arranged on a first surface (26) and the second optical thin film (25) is arranged on a second surface (27) of the substrate (23). A spectrometer (1) equipped with a respective order sorting filter is used in a scanning method for detecting the absorption spectrum of samples examined in wells (14) of microplates (13).

    Abstract translation: 光谱仪（1）包括光源（2），具有至少一个衍射光栅（4）的单色仪（3），单色仪外壳（5），订单分类过滤器（7），微板容器（12）和 控制器（6）。 光谱仪（1）的顺序分选滤光器（7）包括基板（23），第一光学薄膜（24）和第二光学薄膜（25），其中在空间上部分重叠和无干扰的方式 第一光学薄膜（24）布置在第一表面（26）上，第二光学薄膜（25）被布置在基板（23）的第二表面（27）上。 在用于检测在微孔板（13）的孔（14）中检测的样品的吸收光谱的扫描方法中，使用装备有相应的顺序分选过滤器的光谱仪（1）。

    MICROPLATE READER WITH INCUBATION DEVICE
    99.
    发明申请
    MICROPLATE READER WITH INCUBATION DEVICE 有权
    微波炉读取器

    公开(公告)号：US20160003859A1

    公开(公告)日：2016-01-07

    申请号：US14654382

    申请日：2014-10-30

    Applicant: TECAN TRADING AG

    Inventor： Gyoergy WENCZEL ,  Harald GEBETSROITHER ,  Friedrich MENGES

    IPC: G01N35/02 ,  G01N35/04

    CPC classification number: G01N35/028 ,  B01L9/523 ,  B01L2200/142 ,  B01L2300/041 ,  B01L2300/0829 ,  C12M23/12 ,  C12M23/38 ,  G01N35/04 ,  G01N2035/00356 ,  G01N2035/0403 ,  G01N2035/0477

    Abstract: Microplate reader has measuring space, action source, measuring device for biological structure signals of microplate wells, transport support for positioning wells in relation to an optical axis of the device and controller for the action source, the measuring device and the transport support. An incubation apparatus with a frame accommodates a microplate with wells having bottoms for reducing liquid evaporation. The frame has a first opening surrounded by an inner wall for the microplate and an outer wall parallel to the inner wall and connected thereto by an intermediate bottom so that a channel is formed and the intermediate bottom for accommodating a liquid adjusted to the content of the microplate wells. The incubation apparatus has a support surface with a second opening for a microplate and, as a result, at least a portion of the well bottoms is freely accessible by the second opening.

    Abstract translation: 微孔板读数器具有测量空间，作用源，微孔板生物结构信号测量装置，相对于装置的光轴定位井的运输支撑和用于动作源的控制器，测量装置和运输支架。 具有框架的培养装置容纳具有用于减少液体蒸发的底部的孔的微孔板。 框架具有由微孔板的内壁包围的第一开口和平行于内壁的外壁，并通过中间底部与其连接，从而形成通道，并且中间底部用于容纳调节至 微板孔。 培养装置具有支撑表面，其具有用于微板的第二开口，因此，至少一部分井底可由第二开口自由地接近。

    Sorptive extraction layer for immobilized liquid extraction
    100.
    发明授权
    Sorptive extraction layer for immobilized liquid extraction 有权
    吸附萃取层用于固定液体萃取

    公开(公告)号：US09200991B2

    公开(公告)日：2015-12-01

    申请号：US13909447

    申请日：2013-06-04

    Applicant: Tecan Trading AG

    Inventor： Robert Wohleb

    IPC: B01L3/00 ,  G01N1/34 ,  C09D135/02 ,  G01N1/40 ,  G01N30/00

    CPC classification number: G01N1/34 ,  B01J20/261 ,  B01J20/3276 ,  B01L3/50255 ,  C09D135/02 ,  G01N1/405 ,  Y10T436/255

    Abstract: A sorptive extraction layer for immobilized liquid extraction of target molecules preferably from biological samples is disclosed. The sorptive extraction layer is mainly composed of ethylene-acrylate-copolymer. Preferably, microplate wells are at least partially coated with such a sorptive extraction layer. There is also disclosed a method of extracting target molecules preferably from biological samples. According to this method, immobilized liquid extraction is carried out with a sorptive extraction layer which is mainly composed of ethylene-acrylate-copolymer.

    Abstract translation: 公开了用于固定化液体提取靶分子的吸附提取层，优选来自生物样品。 吸附提取层主要由乙烯 - 丙烯酸酯共聚物组成。 优选地，微板孔至少部分地涂覆有这样的吸附提取层。 还公开了优选从生物样品中提取目标分子的方法。 根据该方法，用主要由乙烯 - 丙烯酸酯共聚物组成的吸附萃取层进行固定化液体萃取。

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