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    Insertable neural probe with flexible structure
    91.
    发明授权
    Insertable neural probe with flexible structure 有权
    可插入神经探针，结构灵活

    公开(公告)号：US09427164B2

    公开(公告)日：2016-08-30

    申请号：US14096879

    申请日：2012-06-04

    申请人： Euisik Yoon ,  Fan Wu

    发明人： Euisik Yoon ,  Fan Wu

    IPC分类号： A61B5/04 ,  A61N1/05 ,  A61B5/0478 ,  A61B5/00 ,  A61L29/14 ,  A61N5/06 ,  A61N1/36

    CPC分类号： A61B5/04001 ,  A61B5/0478 ,  A61B5/40 ,  A61L29/148 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/3605 ,  A61N5/0622

    摘要： A neural probe (10) is provided for in vivo communication with biological tissue, including stimulating neurons and/or recording neural electrical activity. The probe (10) may be constructed so that the immune response by the biological tissue in which the device is implanted is reduced over known implantable probes. The probe (10) can be constructed with a tip (16) that has a branched configuration, with electrodes (24) located along each of the branches (20). A biodegradable coating (18) is disposed over at least the tip (16) of the probe (10) to provide the probe (10) with sufficient integrity for insertion into the biological tissue and to degrade after insertion. The biodegradable coating (18) can have an anti-inflammatory drug or other bioagent distributed therein for localized release of the bioagent to further reduce the immune response.

    摘要翻译： 提供神经探针（10）用于与生物组织的体内通信，包括刺激神经元和/或记录神经电活动。 可以构造探针（10），使得通过已知的可植入探针减少其中植入装置的生物组织的免疫应答。 探针（10）可以由具有分支构造的尖端（16）构成，电极（24）沿着每个分支（20）定位。 至少在探针（10）的尖端（16）上设置可生物降解的涂层（18），从而为探针（10）提供足够的完整性以插入生物组织中并在插入后降解。 可生物降解的涂层（18）可以具有分布在其中的抗炎药物或其它生物剂，用于生物制剂的局部释放以进一步降低免疫应答。

    BIOSENSOR
    93.
    发明申请
    BIOSENSOR 审中-公开
    生物传感器

    公开(公告)号：US20160235310A1

    公开(公告)日：2016-08-18

    申请号：US15141058

    申请日：2016-04-28

    申请人： Murata Manufacturing Co., Ltd.

    发明人： TORU SHIMUTA

    IPC分类号： A61B5/0205 ,  A61B5/0408 ,  A61B5/1455 ,  A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/0205 ,  A61B5/0245 ,  A61B5/0408 ,  A61B5/0478 ,  A61B5/0492 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/6826

    摘要： A biosensor includes light emitting elements and a light receiving element disposed on a principal surface of a wiring board; a light shielding portion disposed between a light-emitting-element sealing portion and a light-receiving-element sealing portion; a base medium having light transmitting properties, disposed in parallel with the wiring board with the light shielding portion therebetween; an adhesion layer having light transmitting properties, configured to bond the base medium with the light-emitting-element sealing portion, the light-receiving-element sealing portion, and the light shielding portion; and a first electrocardiograph electrode attached to a principal surface of the base medium. The refractive index of the base medium is set to be higher than that of the adhesion layer, and a surface of the first electrocardiograph electrode which is adjacent to the base medium is roughened so that stray light passing through the base medium will be scattered.

    摘要翻译： 生物传感器包括配置在布线基板的主面上的发光元件和受光元件， 遮光部，设置在发光元件密封部和受光元件密封部之间; 具有透光性的基底介质，与布线板平行设置，其间具有遮光部分; 具有透光性的粘合层，被配置为将基底介质与发光元件密封部分接合，光接收元件密封部分和遮光部分; 以及附接到基础介质的主表面的第一心电图仪电极。 将基础介质的折射率设定为高于粘合层的折射率，并且与基底介质相邻的第一心电图仪电极的表面被粗糙化，使得穿过基底介质的杂散光将被散射。

    METHOD AND SYSTEM FOR DETERMINING A PARAMETER WHICH IS INDICATIVE FOR WHETHER A PATIENT IS DELIRIOUS
    94.
    发明申请
    METHOD AND SYSTEM FOR DETERMINING A PARAMETER WHICH IS INDICATIVE FOR WHETHER A PATIENT IS DELIRIOUS 审中-公开
    用于确定参与者的方法和系统，无论患者是否出现，都是指示性的

    公开(公告)号：US20160228028A1

    公开(公告)日：2016-08-11

    申请号：US15023074

    申请日：2013-09-19

    申请人： UMC UTRECHT HOLDING B.V.

    发明人： Arendina Wilhelmina VAN DER KOOI ,  Arjen Jacob Cornelis SLOOTER

    IPC分类号： A61B5/0478 ,  A61B5/04 ,  A61B5/00 ,  A61B5/048 ,  A61B5/16

    CPC分类号： A61B5/0478 ,  A61B5/04012 ,  A61B5/0476 ,  A61B5/048 ,  A61B5/165 ,  A61B5/6814 ,  A61B5/7257

    摘要： Method for determining a parameter which is indicative for whether a patient is delirious or not, or is at risk of becoming delirious or not, wherein the method comprises the steps of: —providing electroencephalography (EEG) data comprising recording signals from at least two electrodes located on different locations on the patient's scalp during a predetermined time period, for instance at least 10 seconds, wherein at least one of the signals is recorded from the frontal half on the scalp; —processing said EEG data for obtaining a deviation signal from the two recording signals from the electrodes; —analyzing said deviation signal in the frequency spectrum for establishing slowing of said deviation signal and defining the parameter as the degree of slowing of said deviation signal which in combination with the locations of the recordings on the patient's scalp is indicative whether said patient is delirious or not, or is at risk of becoming delirious or not.

    摘要翻译： 用于确定指示患者是否患有妄想或者是否有妄想的参数的方法，其中所述方法包括以下步骤： - 提供脑电图（EEG）数据，其包括从至少两个电极记录信号 位于患者头皮上的不同位置，例如至少10秒，其中至少一个信号是从头皮上的正面一半记录的; 处理所述EEG数据，以获得来自电极的两个记录信号的偏差信号; - 在所述频谱中分析所述偏差信号以建立所述偏差信号的减慢并将所述参数定义为所述偏差信号的减慢程度，所述偏差信号与患者头皮上的记录的位置相结合是指示所述患者是否妄想，或者 不是，还是有变得妄想的风险。

    VARIABLY CONFIGURABLE, ADAPTABLE ELECTRODE ARRAYS AND EFFECTUATING SOFTWARE, METHODS, AND SYSTEMS
    96.
    发明申请
    VARIABLY CONFIGURABLE, ADAPTABLE ELECTRODE ARRAYS AND EFFECTUATING SOFTWARE, METHODS, AND SYSTEMS 审中-公开
    可变配置，适配电极阵列和效能软件，方法和系统

    公开(公告)号：US20160206871A1

    公开(公告)日：2016-07-21

    申请号：US14083379

    申请日：2013-11-18

    申请人： Rio Grande Neurosciences, Inc.

    发明人： Michael Weisend

    IPC分类号： A61N1/04 ,  A61N1/36

    CPC分类号： A61N1/0476 ,  A61B5/0075 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4094 ,  A61B5/4812 ,  A61B5/4836 ,  A61N1/0456 ,  A61N1/0526 ,  A61N1/36025

    摘要： Electrical non-invasive brain stimulation (NIBS) delivers weak electrical currents to the brain via electrodes that are affixed to the scalp. NIBS can excite or inhibit the brain in areas that are impacted by that electrical current during and for a short time following stimulation. Electrical NIBS can be used to change brain structure in terms of increasing white matter integrity as measured by diffusion tensor imaging. Together the electrical NIBS can induce changes in brain structure and function. The present methods and devices are adaptable to and configurable for facilitating the enhancement of brain performance, and the treatment of neurological diseases and tissues. The present methods and devices are advantageously designed to utilize modern electrodes deployed with, inter alia, various spatial arrangements, polarities, and current strengths to target brain areas or networks to thereby enhance performance or deliver therapeutic interventions.

    摘要翻译： 电子非侵入性脑刺激（NIBS）通过固定在头皮上的电极向脑传递弱电流。 刺激后，短时间内，NIBS可以激发或抑制受到电流影响的区域的大脑。 根据扩散张量成像测量，电气NIBS可用于改变大脑结构，增加白质完整性。 电气NIBS一起可以引起大脑结构和功能的变化。 本发明的方法和装置适用于和配置以便于增强脑部的表现，以及神经系统疾病和组织的治疗。 本发明的方法和装置有利地被设计为利用部署了特别是各种空间布置，极性和电流强度的现代电极来靶向脑区域或网络，从而增强性能或递送治疗干预。

    Dry sensor EEG/EMG and motion sensing system for seizure detection and monitoring
    97.
    发明授权
    Dry sensor EEG/EMG and motion sensing system for seizure detection and monitoring 有权
    干式传感器EEG / EMG和运动感应系统，用于检测和监测

    公开(公告)号：US09392956B2

    公开(公告)日：2016-07-19

    申请号：US13354148

    申请日：2012-01-19

    申请人： An Luo ,  Cheng-I Chuang ,  Stanley Yang

    发明人： An Luo ,  Cheng-I Chuang ,  Stanley Yang

    IPC分类号： A61B5/04 ,  A61B5/0492 ,  A61B5/0478 ,  A61B5/11 ,  A61B5/00

    CPC分类号： A61B5/0492 ,  A61B5/0478 ,  A61B5/11 ,  A61B5/4094 ,  A61B5/6803

    摘要： A dry sensor EEG/EMG and motion sensing system for seizure detection and monitoring is disclosed. In some embodiments, a system for seizure detection/monitoring is provided that can measure a user's EEG/EMG and motor activity, automatically detect an epileptic seizure and perform actions, such as triggering an alarm and/or turning off the provoking stimulation. In some embodiments, a system for seizure detection/monitoring is provided that can be used to continuously monitor and store a user's EEG/EMG and motor activity for doctor evaluation. In some embodiments, a system for seizure detection/monitoring is provided that can be mounted directly on a user's head using active dry EEG sensors. In some embodiments, a system for seizure detection/monitoring is provided that can be mounted into/onto a pair of glasses (e.g., 3D glasses), and the user's eyes can be automatically covered by the glasses if a seizure is detected.

    摘要翻译： 公开了用于检测和监测的干式传感器EEG / EMG和运动感测系统。 在一些实施例中，提供了用于检测/监测的系统，其可以测量用户的EEG / EMG和运动活动，自动检测癫痫发作并执行诸如触发警报和/或关闭激发刺激的动作。 在一些实施例中，提供了用于检测/监测的系统，其可以用于连续监视和存储用于医生评估的用户的EEG / EMG和运动活动。 在一些实施例中，提供了用于检测/监测的系统，其可以使用主动干式EEG传感器直接安装在使用者的头上。 在一些实施例中，提供了可以安装到一对眼镜（例如，3D眼镜）中的用于检测/监视的系统，并且如果检测到发作，则用户的眼睛可以被眼镜自动覆盖。

    DETERMINATION SYSTEM, CONTROL SIGNAL OUTPUT SYSTEM, REHABILITATION SYSTEM, DETERMINATION METHOD, CONTROL SIGNAL OUTPUT METHOD, RECORDING MEDIUM, AND ELECTROENCEPHALOGRAM SIGNAL ACQUISITION SYSTEM
    98.
    发明申请
    DETERMINATION SYSTEM, CONTROL SIGNAL OUTPUT SYSTEM, REHABILITATION SYSTEM, DETERMINATION METHOD, CONTROL SIGNAL OUTPUT METHOD, RECORDING MEDIUM, AND ELECTROENCEPHALOGRAM SIGNAL ACQUISITION SYSTEM 审中-公开
    决定系统，控制信号输出系统，康复系统，确定方法，控制信号输出方法，记录介质和电感信号采集系统

    公开(公告)号：US20160199203A1

    公开(公告)日：2016-07-14

    申请号：US14965902

    申请日：2015-12-11

    申请人： Panasonic Intellectual Property Management Co., Ltd.

    发明人： SHINOBU ADACHI ,  JUN OZAWA

    IPC分类号： A61F2/72 ,  A61B5/0478

    CPC分类号： A61F2/72 ,  A61B5/0478 ,  A61B5/048 ,  A61B5/6817 ,  A61B5/7275 ,  A61B2505/09 ,  A61F4/00 ,  A61F2002/704

    摘要： A determination system includes a mastoid electrode that is located on a left mastoid of a user when an intention of the user to move a portion on a right side of a body of the user is detected and that is located on a right mastoid of the user when an intention of the user to move a portion on a left side of the body of the user is detected; an ear hole electrode that is located in an ear hole of the user; an electroencephalogram signal measurer that obtains a voltage between the mastoid electrode and the ear hole electrode; and a determiner that determines whether or not a change in the voltage includes the intention to move the portion on the right side of the body or the intention to move the portion on the left side of the body.

    摘要翻译： 确定系统包括当用户移动用户的身体的右侧的部分的意图并且位于用户的右乳突时位于用户的左乳突时的乳突电极 当用户想要移动用户身体的左侧的部分时; 耳孔电极，其位于使用者的耳孔中; 获取乳突电极和耳孔电极之间的电压的脑波信号测量器; 以及决定器，其确定电压的变化是否包括使身体右侧的部分移动的意图或移动身体左侧的部分的意图。