公开(公告)号：US12094738B2

公开(公告)日：2024-09-17

申请号：US18320748

申请日：2023-05-19

Applicant: Elemental Scientific, Inc.

Inventor： Tyler Yost ,  Daniel R. Wiederin ,  Beau A. Marth ,  Jared Kaser ,  Jonathan Hein ,  Jae Seok Lee ,  Jae Min Kim ,  Stephen H. Sudyka

IPC: H01L21/67 ,  G01N21/73 ,  G01N33/00 ,  H01J49/00 ,  H01J49/10 ,  H01L21/66 ,  H01L21/677

CPC classification number: H01L21/6719 ,  G01N21/73 ,  H01J49/105 ,  H01L21/67051 ,  H01L21/6708 ,  H01L21/67126 ,  H01L21/6715 ,  H01L21/67259 ,  H01L21/67748 ,  H01L21/67772 ,  H01L22/14 ,  H01L22/34 ,  G01N33/0095 ,  H01J49/00 ,  H01L22/12

Abstract: Systems and methods are described for integrated decomposition and scanning of a semiconducting wafer, where a single chamber is utilized for decomposition and scanning of the wafer of interest.

公开(公告)号：US11835505B2

公开(公告)日：2023-12-05

申请号：US17893950

申请日：2022-08-23

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Nigel Clarke

IPC: G01N33/94 ,  G01N33/15 ,  G01N33/49 ,  G01N33/48 ,  G01N30/72 ,  H01J49/00 ,  H01J49/10

CPC classification number: G01N33/15 ,  G01N30/7233 ,  G01N33/49 ,  G01N33/94 ,  H01J49/004 ,  H01J49/0031 ,  H01J49/0045 ,  H01J49/10 ,  G01N33/48 ,  H01J49/00 ,  Y10T436/17 ,  Y10T436/24 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, N-Desmethyl Tamoxifen, and other tamoxifen metabolites.

公开(公告)号：US11802856B2

公开(公告)日：2023-10-31

申请号：US17747373

申请日：2022-05-18

Applicant: Thermo Finnigan LLC

Inventor： Joshua T. Maze ,  Scott T. Quarmby

IPC: G01N30/86 ,  H01J49/00 ,  G01N30/72 ,  H01J49/16

CPC classification number: G01N30/8658 ,  G01N30/7266 ,  H01J49/00 ,  H01J49/0036 ,  H01J49/167

Abstract: A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.

公开(公告)号：US11761968B2

公开(公告)日：2023-09-19

申请号：US17208564

申请日：2021-03-22

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  G01N33/68 ,  H01J49/00

CPC classification number: G01N33/82 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/0027 ,  G01N2560/00 ,  H01J49/00 ,  Y10T436/212

Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

公开(公告)号：US11705351B2

公开(公告)日：2023-07-18

申请号：US16200010

申请日：2018-11-26

Applicant: Elemental Scientific, Inc.

Inventor： Tyler Yost ,  Daniel R. Wiederin ,  Beau Marth ,  Jared Kaser ,  Jonathan Hein ,  Jae Seok Lee ,  Jae Min Kim ,  Stephen H. Sudyka

IPC: H01L21/67 ,  H01L21/677 ,  H01L21/66 ,  H01J49/10 ,  G01N21/73 ,  H01J49/00 ,  G01N33/00

CPC classification number: H01L21/6719 ,  G01N21/73 ,  H01J49/105 ,  H01L21/6708 ,  H01L21/6715 ,  H01L21/67051 ,  H01L21/67126 ,  H01L21/67259 ,  H01L21/67748 ,  H01L21/67772 ,  H01L22/14 ,  H01L22/34 ,  G01N2033/0095 ,  H01J49/00 ,  H01L22/12

Abstract: Systems and methods are described for integrated decomposition and scanning of a semiconducting wafer, where a single chamber is utilized for decomposition and scanning of the wafer of interest.

公开(公告)号：US20190250175A1

公开(公告)日：2019-08-15

申请号：US16390989

申请日：2019-04-22

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel J. Clarke ,  Brett Holmquist ,  Gloria Kwang-Ja Lee ,  Richard E. Reitz

IPC: G01N33/82 ,  G01N30/72

CPC classification number: G01N33/82 ,  G01N30/72 ,  G01N30/7233 ,  G01N2030/8813 ,  G01N2030/8822 ,  G01N2458/15 ,  G01N2560/00 ,  H01J49/00 ,  H01J49/004 ,  Y10T436/20 ,  Y10T436/203332 ,  Y10T436/24

Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.

公开(公告)号：US20190019660A1

公开(公告)日：2019-01-17

申请号：US16133149

申请日：2018-09-17

Applicant: Quest Diagnostics Investments Incorporated

Inventor： J. Fred BANKS ,  Peter P. CHOU ,  Noriya M. MATT

IPC: H01J49/04 ,  H01J49/10 ,  H01J49/00 ,  G01N30/72 ,  G01N33/68 ,  G01N33/78

CPC classification number: H01J49/04 ,  G01N30/7233 ,  G01N33/6848 ,  G01N33/78 ,  G01N2560/00 ,  H01J49/00 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0081 ,  H01J49/0431 ,  H01J49/10

Abstract: Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.

公开(公告)号：US20180247748A1

公开(公告)日：2018-08-30

申请号：US15964819

申请日：2018-04-27

Applicant: International Business Machines Corporation

Inventor： Oki Gunawan

IPC: H01F7/02 ,  H02N15/00 ,  H01J49/00

CPC classification number: H01F7/0236 ,  H01J49/00 ,  H02N15/00

Abstract: Techniques for tuning magnetic potential using a variable gap in a parallel dipole line (PDL) trap are provided. In one aspect, a PDL trap is provided. The PDL trap includes: a pair of dipole line magnets separated from one another by a variable gap g; and a diamagnetic object levitating above the dipole line magnets. The dipole line magnets can be separated from one another by at least one spacer, or a variable gap fixture can be used in which the dipole line magnets are affixed to separate mounts for varying the gap g between the dipole line magnets. A bigger trap or track can be built with multiple segments of PDL trap. A method of operating a PDL trap is also provided.

公开(公告)号：US20180156828A1

公开(公告)日：2018-06-07

申请号：US15848325

申请日：2017-12-20

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel J. Clarke ,  Brett Holmquist ,  Gloria Kwang-Ja Lee ,  Richard E. Reitz

IPC: G01N33/82 ,  G01N30/72 ,  H01J49/00 ,  G01N30/88

CPC classification number: G01N33/82 ,  G01N30/72 ,  G01N30/7233 ,  G01N2030/8813 ,  G01N2030/8822 ,  G01N2458/15 ,  G01N2560/00 ,  H01J49/00 ,  H01J49/004 ,  Y10T436/20 ,  Y10T436/203332 ,  Y10T436/24

Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.

公开(公告)号：US20170328885A1

公开(公告)日：2017-11-16

申请号：US15388954

申请日：2016-12-22

Applicant: John T. Stults ,  Alfred Greenquist ,  Alexander Sassi

Inventor： John T. Stults ,  Alfred Greenquist ,  Alexander Sassi

IPC: G01N33/50 ,  H01J49/00 ,  A61B5/15 ,  G01N27/26 ,  H01J49/16 ,  G06F19/24 ,  G06F19/18

CPC classification number: G01N33/50 ,  A61B5/150755 ,  G01N27/26 ,  G16B20/00 ,  G16B40/00 ,  H01J49/00 ,  H01J49/0027 ,  H01J49/165 ,  Y02A90/22 ,  Y02A90/26 ,  Y10T436/117497

Abstract: A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.