利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

424 条记录 (耗时 0.025 秒)

    Precursors and synthesis of methyl-9-oxo-11.alpha., 16-dihydroxy-16-vinyl-5-cis-13-trans-prostadienoates
    103.
    发明授权
    Precursors and synthesis of methyl-9-oxo-11.alpha., 16-dihydroxy-16-vinyl-5-cis-13-trans-prostadienoates 失效
    甲基-9-氧代-11α，16-二羟基-16-乙烯基-5-顺式-13-反 - 前列腺素的前体和合成

    公开(公告)号：US4958037A

    公开(公告)日：1990-09-18

    申请号：US185621

    申请日：1988-04-25

    申请人： Middleton B. Floyd, Jr.

    发明人： Middleton B. Floyd, Jr.

    IPC分类号： C07C405/00 ,  C07D307/32 ,  C07D307/42 ,  C07D307/54

    CPC分类号： C07D307/32 ,  C07C405/00 ,  C07D307/42 ,  C07D307/54 ,  Y02P20/55

    摘要： Novel precursors for the synthesis of methyl-9-oxo-11.alpha.,16-dihydroxy-16-vinyl-5-cis-13-trans prostadienoates having the formulae ##STR1## wherein R.sub.1 is H or C.sub.1 -C.sub.4 alkyl; R.sub.2 is C.sub.1 -C.sub.4 alkyl, R.sub.3 is H, C.sub.1 -C.sub.4 trialkylsilyl or C.sub.1 -C.sub.6 alkyl; X.sub.1 is halogen, cyano, C.sub.1 -C.sub.4 alkoxycarbonyl, carboxy or tri (C.sub.1 -C.sub.4 alkoxy)methyl; n is 2-4 inclusive; and P.sub.1 is H or a blocking or protective group; congeners and racemic mixture of these compounds and processes of synthesizing them.

    摘要翻译： 用于合成具有下式的甲基-9-氧代-11α，16-二羟基-16-乙烯基-5-顺式-13-反式前列腺素的新型前体（IMAGE）（2）（3）（ （4b）其中R1是H或C1-C4烷基; R2是C1-C4烷基，R3是H，C1-C4三烷基甲硅烷基或C1-C6烷基; X 1为卤素，氰基，C 1 -C 4烷氧基羰基，羧基或三（C 1 -C 4烷氧基）甲基; n为2-4; P1为H或封端或保护基团; 这些化合物的同源物和外消旋混合物以及它们的合成方法。

    3-phenyl-2-propeneamine derivatives, their preparation and composition containing them
    110.
    发明授权
    3-phenyl-2-propeneamine derivatives, their preparation and composition containing them 失效
    3-苯基-2-丙烯胺衍生物，它们的制备方法和含有它们的组合物

    公开(公告)号：US4755599A

    公开(公告)日：1988-07-05

    申请号：US10558

    申请日：1987-02-03

    申请人： Jean-Claude Barriere ,  Jean-Pierre Corbet ,  Claude Cotrel ,  Daniel Farge ,  Jean-Marc Paris

    发明人： Jean-Claude Barriere ,  Jean-Pierre Corbet ,  Claude Cotrel ,  Daniel Farge ,  Jean-Marc Paris

    IPC分类号： A61K31/135 ,  A61K31/10 ,  A61K31/137 ,  A61K31/21 ,  A61K31/22 ,  A61P25/24 ,  A61P25/26 ,  C07C67/00 ,  C07C213/00 ,  C07C213/02 ,  C07C215/28 ,  C07C215/30 ,  C07C215/42 ,  C07C219/22 ,  C07C219/32 ,  C07C239/00 ,  C07C271/20 ,  C07C313/00 ,  C07C317/28 ,  C07C317/36 ,  C07C319/20 ,  C07C323/27 ,  C07C323/32 ,  C07C323/65 ,  C07D207/08 ,  C07D213/38 ,  C07D213/70 ,  C07D295/084 ,  C07D295/092 ,  C07D307/32 ,  C07F9/40 ,  C07D279/04 ,  C07C149/24 ,  C07D205/04 ,  C07D223/04 ,  C07D275/02 ,  C07D277/04 ,  C07D401/06

    CPC分类号： C07D207/08 ,  C07D213/38 ,  C07D213/70 ,  C07D295/092 ,  C07D307/32 ,  C07F9/4006

    摘要： The invention provides compounds of formula: ##STR1## in which R=H, halogen, alkyl, alkyloxy, alkythio, NH.sub.2, alkylamino, dialkylamino or CF.sub.3, R.sub.3 =H or alkyl,either R.sub.4 and R.sub.5 =H and R.sub.1 and R.sub.2 =H or alkyl, optionally substituted by alkenyl (2 to 4 C) or alternatively R.sub.1 and R.sub.2 form together a saturated heterocyclic ring containing 4 to 7 ring members and optionally containing another heteroatom such as O, S or N optionally substituted by alkyl,or R.sub.4 =H, R.sub.1 =H or alkyl and R.sub.2 and R.sub.5 together form an alkylene (3 to 4 C) radical and(i) either A=alkyl or phenyl which is unsubstituted or substituted by one or two substituents chosen from halogen, alkyl, alkyloxy, alkylthio, NH.sub.2, alkylamino, dialkylamino, NO.sub.2 or CF.sub.3 or alternatively A=pyridyl, benzyl or cycloalkyl (3 to 6 C), Y=S, SO or SO.sub.2 or a radical: ##STR2## in which R.sub.6 =H or alkyl and R.sub.7 =H or alkylcarbonyl, alkyloxycarbonyl, alkylaminocarbonyl or benzoyl, optionally substituted by one or two halogen, alkyl, alkyloxy, alkylthio, NH.sub.2, alkylamino, dialkylamino, NO.sub.2 or CF.sub.3 groups,(ii) or Y and A together form a 1-hydroxycycloalkyl radical, the ring of which contains 5 or 6 C, optionally joined to a benzene ring,it being understood that the alkyl radicals and alkyl parts contains 1 to 4 C as a straight or branched chain, and that the invention relates to all the possible geometric and optical isomers as well as their mixtures.These compounds are useful as antidepressants.

    摘要翻译： 本发明提供下式的化合物：其中R = H，卤素，烷基，烷氧基，链烯基，NH 2，烷基氨基，二烷基氨基或CF 3，R 3 = H或烷基，R 4和R 5 = H，R 1和 R 2 = H或烷基，任选被烯基（2至4 C）取代，或者R 1和R 2一起形成含有4至7个环成员的饱和杂环，并任选地含有另外的杂原子，例如任选被烷基取代的O，S或N， 或R4 = H，R1 = H或烷基，R2和R5一起形成亚烷基（3至4 C）基团，和（i）A =烷基或苯基，其未被取代或被一个或两个选自卤素，烷基 ，烷氧基，烷硫基，NH 2，烷基氨基，二烷基氨基，NO 2或CF 3，或者A =吡啶基，苄基或环烷基（3至6 C），Y = S，SO或SO 2或基团：其中R 6 = H或烷基，且R7 = H或烷基羰基，烷氧基羰基，烷基氨基羰基或苯甲酰基，任选被一个或两个卤素，烷基，烷氧基，烷硫基，NH 2， 烷基氨基，二烷基氨基，NO 2或CF 3基团，（ii）或Y和A一起形成1-羟基环烷基，其环包含5或6个C，任选地连接到苯环，应理解烷基和烷基 部分包含1至4 C作为直链或支链，本发明涉及所有可能的几何和光学异构体及其混合物。 这些化合物可用作抗抑郁药。