公开(公告)号：US10725275B2

公开(公告)日：2020-07-28

申请号：US13522038

申请日：2011-01-13

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gert 'T Hooft ,  Jeroen Jan Lambertus Horikx

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gert 'T Hooft ,  Jeroen Jan Lambertus Horikx

IPC分类号： G02B21/00 ,  G01N21/64

摘要： The invention discloses an optical microscopy system (10) for stimulated emission depletion (STED) of an object (O). An optical element (6) is applied for focusing a first excitation (1) and a second depletion (2) beam on the object thereby defining a common optical path (OP) for both the first and the second beam. A phase modifying member (5) is inserted in the common optical path (OP), and the phase modifying member is optically arranged for leaving the wavefront of the first beam substantially unchanged, and for changing the wavefront of the second beam (2′) so as to create an undepleted region of interest (ROI) in the object. The first beam and the second beam have a common optical path because the phase modifying member adapts the wavefront or phase in such a way that it has no effect on the first beam, while on the second beam it gives rise to a wavefront, or phase change, resulting in a depleted region in the object (e.g. to the donut shaped spot) at the focal plane. The invention facilitates smaller and/or improved optical designs for STED microscopy; this is particularly relevant for medical in-vivo imaging, e.g. endoscopes and catheters.

公开(公告)号：US09733466B2

公开(公告)日：2017-08-15

申请号：US12593298

申请日：2008-03-31

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

IPC分类号： G02B23/24 ,  G02B26/10 ,  A61B5/00 ,  A61B10/00 ,  A61B17/00 ,  G02B3/00 ,  A61B90/20 ,  G02B3/10 ,  G02B3/02 ,  A61B90/00

CPC分类号： G02B23/243 ,  A61B5/0068 ,  A61B5/0084 ,  A61B10/00 ,  A61B90/20 ,  A61B90/361 ,  A61B2017/00061 ,  A61B2090/3616 ,  G02B3/0081 ,  G02B3/02 ,  G02B3/10 ,  G02B26/10 ,  G02B26/103

摘要： An objective lens system for an optical biopsy device has a lens that comprises a first part configured for viewing at a first magnification, and a second part configured for viewing at a second magnification. The second magnification is substantially different from the first magnification. The first magnification enables viewing a larger area of a target and the second magnification enables viewing the target at a cellular level with high sensitivity and specificity. Combining viewing at two different magnifications in a single objective lens results in a compact optical biopsy device.

公开(公告)号：US09498136B2

公开(公告)日：2016-11-22

申请号：US14112555

申请日：2012-04-10

申请人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

发明人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

IPC分类号： A61B5/00 ,  A61B1/00 ,  G01N21/64

CPC分类号： A61B5/0075 ,  A61B1/00 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4887 ,  A61B5/6848 ,  A61B5/6852 ,  G01N21/64 ,  G01N2021/6421

摘要： The present invention deals with discrimination of malignant tissue from normal and benign tissue in a single patient on the basis of optical spectroscopic measurements. Starting from spectroscopic measurements in normal tissue, reference values are obtained for the normal class. With spectroscopic measurements in other tissues data points can be assigned to new class(es) when the spectral characteristics fall outside a threshold defining the reference class. Thresholds between different classes can also be defined. Finding (the transition to) malignant tissue is based on comparing the spectroscopic values to the classification threshold discriminating normal and benign versus malignant tissue. Thus, the basis of normal spectroscopic measurements is tuned to the individual patient characteristic. Discriminating the normal plus benign and malignant from that reference is more efficient compared to the reference of the all patient database.

摘要翻译： 本发明基于光学光谱测量法处理单个患者中恶性组织与正常和良性组织的鉴别。 从正常组织中的光谱测量开始，获得正常类的参考值。 通过在其他组织中的光谱测量，当光谱特性落在定义参考类的阈值之外时，可以将数据点分配给新类。 也可以定义不同类之间的阈值。 寻找（过渡到）恶性组织是基于将光谱值与鉴别正常和良性与恶性组织的分类阈值进行比较。 因此，正常光谱测量的基础被调整到个体患者的特征。 与所有患者数据库的参考相比，从该参考文献中区分正常和良性和恶性的效果更高。

公开(公告)号：US09072475B2

公开(公告)日：2015-07-07

申请号：US13881379

申请日：2011-10-17

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Theodoor Jacques Marie Ruers

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Theodoor Jacques Marie Ruers

IPC分类号： A61B5/1459 ,  A61B5/00 ,  A61M25/06

CPC分类号： A61B5/1459 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6848 ,  A61B5/6882 ,  A61M25/065

摘要： A needle comprises an elongated first shaft element with a C-shaped cross section and an elongated second shaft element with a C-shaped cross section. The first shaft element and the second shaft element are adapted to be detachably connected to each other. This is achieved by an overlap of respective end sections of the first and second shaft elements. Within the channel formed by the shaft elements, an optical probe may be accommodated from which the shaft elements may be removed by separating the two shaft elements from each other.

摘要翻译： 针包括具有C形横截面的细长的第一轴元件和具有C形横截面的细长的第二轴元件。 第一轴元件和第二轴元件适于彼此可拆卸地连接。 这通过第一和第二轴元件的相应端部部分的重叠来实现。 在由轴元件形成的通道内，可以容纳光学探针，通过将两个轴元件彼此分离，可以从中移除轴元件。

公开(公告)号：US20140213911A1

公开(公告)日：2014-07-31

申请号：US14342442

申请日：2012-09-07

申请人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Franciscus Marinus Antonius Maria Van Gaal

发明人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Franciscus Marinus Antonius Maria Van Gaal

IPC分类号： A61B5/00

CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/6844 ,  A61B5/6848

摘要： A needle device according to the invention comprises a hollow shaft, an elongated insert and an operating means. The hollow shaft has a first distal end portion with a bevel, the elongated insert has a second distal end portion and is movably arranged within the hollow shaft, and the operating means is shiftable between a first condition and a second condition. Furthermore, the operating means is interconnected with the elongated insert, so that the second distal end portion is located within the hollow shaft and proximally to the bevel, when the operating means is in the first condition, and that the second distal end portion is located outside the hollow shaft and distally to the bevel, when the operating means is in the second condition.

摘要翻译： 根据本发明的针装置包括中空轴，细长插入件和操作装置。 空心轴具有带斜面的第一远端部分，细长插入件具有第二远端部分，并且可移动地布置在中空轴内，并且操作装置可在第一状态和第二状态之间移动。 此外，操作装置与细长插入件互连，使得当操作装置处于第一状态时，第二远端部分位于空心轴内并且向近侧位于斜面，并且第二远端部分位于 当操作装置处于第二状态时，在空心轴之外并且远离斜面。

公开(公告)号：US08771176B2

公开(公告)日：2014-07-08

申请号：US12374506

申请日：2007-04-12

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Michael Harald Kuhn ,  Thomas Zaengel ,  Nijs Cornelis Van Der Vaart

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Michael Harald Kuhn ,  Thomas Zaengel ,  Nijs Cornelis Van Der Vaart

IPC分类号： A61B1/06

CPC分类号： A61B1/00087 ,  A61B1/00165 ,  A61B1/00188 ,  A61B1/0019 ,  A61B1/041 ,  A61B1/042 ,  A61B1/043 ,  A61B1/06 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0084 ,  A61B18/20 ,  A61B2018/00482 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00642 ,  A61B2018/00904 ,  A61N5/0601 ,  A61N5/0603 ,  A61N5/062 ,  A61N2005/0609 ,  G03B15/02

摘要： The application relates to an ingestible capsule and method for in vivo imaging and/or treatment of one or more diseased areas of interest within the gastrointestinal tract of an animal or human being. The capsule comprises an image sensor; a lens system for focusing images onto the image sensor; at least one light source for illumination of the tissue area of interest, the at least one light source optionally being capable of providing optical therapeutic treatment to the diseased areas; a variable lens system located in front of the at least one light source, wherein the variable lens system comprises beam steering means and focusing means for directing and focusing the light beams from the at least one light source onto the diseased tissue areas, —a control unit in communication with the image sensor, the at least one light source, and variable lens system, a power source for powering the image sensor, the at least one light source and the control unit; and a non-digestible, transparent outer protective shell configured to pass through the gastrointestinal tract, housing within the image sensor, the lens system, the at least one light source, the variable lens system, the control unit and the power source.

摘要翻译： 本申请涉及用于体内成像和/或治疗在动物或人的胃肠道内的一个或多个感兴趣的感兴趣区域的可摄取胶囊和方法。 胶囊包括图像传感器; 用于将图像聚焦到图像传感器上的透镜系统; 用于照射所述组织区域的至少一个光源，所述至少一个光源任选地能够向所述患病区域提供光学治疗性治疗; 位于所述至少一个光源前面的可变透镜系统，其中所述可变透镜系统包括光束转向装置和用于将来自所述至少一个光源的光束引导和聚焦到所述病变组织区域上的聚焦装置， - 控制 与图像传感器，至少一个光源和可变透镜系统连通的单元，用于为图像传感器供电的电源，至少一个光源和控制单元; 以及构造成穿过胃肠道，容纳在图像传感器，透镜系统，至少一个光源，可变透镜系统，控制单元和电源中的不可消化，透明的外保护壳。

公开(公告)号：US20140142563A1

公开(公告)日：2014-05-22

申请号：US14131518

申请日：2012-07-05

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabé ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabé ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

IPC分类号： A61B19/00 ,  A61B18/14

CPC分类号： A61B34/10 ,  A61B18/14 ,  A61B2018/00577 ,  A61B2034/101

摘要： The invention relates to an energy application planning apparatus for planning an application of energy to an object (3) like a tumor. An energy application element representation represents an energy application element (5) like an ablation needle including an energy application part for applying energy and a sensing part (7). An arrangement of the energy application element (5) with respect to the object (3) is determined depending on the positions of the energy application part and the sensing part (7) with respect to the energy application element (5) as defined by the energy application element representation and depending on the object representation. The application of energy can therefore not only be planned such that the application of energy is performed as desired, but also such that the object and/or a surrounding of the object are sensible as desired. In this way, the planning procedure can be improved.

摘要翻译： 本发明涉及一种能量应用计划装置，用于规划能量到诸如肿瘤的物体（3）的应用。 能量应用元件表示代表诸如包括用于施加能量的能量施加部分和感测部分（7）的消融针的能量施加元件（5）。 能量施加元件（5）相对于物体（3）的布置根据能量施加部分和感测部分（7）相对于能量施加元件（5）的位置来确定，如由 能量应用元素表示，并取决于对象表示。 因此，能量的施加不仅可以被规划，使得能量的应用按照需要执行，而且还使得物体和/或物体的周围是期望的。 这样可以提高规划程序。

公开(公告)号：US20140121538A1

公开(公告)日：2014-05-01

申请号：US14127692

申请日：2012-06-13

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horiks ,  Susanne Dorien Van Den Bergdams ,  Christian Reich ,  Stephan Voss ,  Axel Winkel ,  Rami Nachabe ,  Manfred Muller ,  Marjolein Van Der Voort

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horiks ,  Susanne Dorien Van Den Bergdams ,  Christian Reich ,  Stephan Voss ,  Axel Winkel ,  Rami Nachabe ,  Manfred Muller ,  Marjolein Van Der Voort

IPC分类号： A61B5/00 ,  A61B10/02 ,  A61B1/00 ,  A61B1/06 ,  A61B1/07

CPC分类号： A61B1/00009 ,  A61B1/0646 ,  A61B1/0684 ,  A61B1/07 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6848 ,  A61B10/0233 ,  F04C2270/0421 ,  Y10T29/49826

摘要： A needle is proposed including a cannula or hollow shaft with a multilumen insert inside. The insert comprises at least two lumen. Both the insert as well as the cannula have bevelled ends. In the insert substantially straight cleaved fibers are present that may be connected at the proximal end to a console. At least one of the distal fiber ends in the insert may protrude more than half the fiber diameter out of the insert. Furthermore, the bevel angle of the insert is different from the bevel angle of the cannula such that combination cannula and insert is such that the fiber ends do not protrude the bevel surface of the cannula.

摘要翻译： 提出了一种针头，其中包括插入件或空心轴，其中具有多孔插入件。 插入件包括至少两个内腔。 插入件以及套管均具有倾斜端部。 在插入件中，存在基本上直的切割的纤维，其可以在近端连接到控制台。 插入件中的远端纤维端部中的至少一个可以突出超过插入件的纤维直径的一半以上。 此外，插入件的斜角与插管的斜角不同，使得组合插管和插入件使得纤维端部不突出套管的斜面。

公开(公告)号：US08655184B2

公开(公告)日：2014-02-18

申请号：US12993264

申请日：2009-05-20

申请人： Gert Het Hooft ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Mischa Megens

发明人： Gert Het Hooft ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Mischa Megens

IPC分类号： H04B10/12

CPC分类号： G02B5/00 ,  G02B5/04 ,  G02B27/095 ,  G02B2207/117 ,  H01S3/0057

摘要： The present invention relates to a higher-order dispersion compensation device (210), the device being adapted to cooperate with a pair of optical components (P1, P2), e.g. a pair of prisms, being arranged to compensate first-order dispersion by separating different wavelengths spatially. The compensation device (210) has the form of a phase plate, wherein the phase change for each wavelength is adjusted by designing the height (h) at the corresponding position (x) of the plate so as to substantially compensate for higher-order dispersion. The invention is advantageous for obtaining a higher-order dispersion compensation device which is relatively simple to construct and use making it a quite cost-effective device. The invention also relates to a corresponding optical system and method for compensating dispersion where this is important, e.g. in a multiple-photon imaging system.

摘要翻译： 本发明涉及一种高阶色散补偿装置（210），该装置适于与一对光学部件（P1，P2）配合，例如， 一对棱镜被布置成通过在空间上分离不同波长来补偿一阶色散。 补偿装置（210）具有相位板的形式，其中通过设计板的对应位置（x）处的高度（h）来调整每个波长的相位变化，以便基本上补偿高阶色散 。 本发明有利于获得相对简单的构造和使用的高阶色散补偿装置，使其成为一种相当具有成本效益的装置。 本发明还涉及一种相应的光学系统和方法，用于补偿这一点很重要的色散。 在多光子成像系统中。

公开(公告)号：US20120316558A1

公开(公告)日：2012-12-13

申请号：US13578883

申请日：2011-02-22

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gerhrdus Wilhelmus Lucassen ,  Rami Nachabe ,  Waltherus Cornelis Jozef Bierhoff ,  Adrien Emmanuel Desjardins

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gerhrdus Wilhelmus Lucassen ,  Rami Nachabe ,  Waltherus Cornelis Jozef Bierhoff ,  Adrien Emmanuel Desjardins

IPC分类号： A61B18/14

CPC分类号： A61B18/1477 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B8/0841 ,  A61B18/02 ,  A61B2017/00057 ,  A61B2017/00061 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2018/00577 ,  A61B2034/2063 ,  A61B2090/378

摘要： An interventional ablation device (1) is proposed to comprise an ablation needle (3) with an elongated body (5) and a handle (7). Adjacent to an ablation element (9) provided on the body (5), at least one or preferably two or more sensors (11-21) are provided, preferably at both of opposing sides of the ablation element (9). The ablation device (1) is adapted for detecting physiological information of tissue (27, 29, 31) surrounding an ablation site (33) based on measurement values provided by the sensors. E.g., optical sensors may be used to measure a reflectance spectrum indicating whether the adjacent tissue is healthy tissue (31), tumorous tissue (27) or ablated tissue (29). Using such information, an ablation process may be controlled.

摘要翻译： 提出介入消融装置（1）包括具有细长主体（5）和手柄（7）的消融针（3）。 设置在主体（5）上的消融元件（9）附近，优选地在消融元件（9）的相对两侧提供至少一个或优选两个或更多个传感器（11-21）。 消融装置（1）适于基于由传感器提供的测量值来检测围绕消融部位（33）的组织（27,29,31）的生理信息。 例如，光学传感器可用于测量反映光谱，其指示相邻组织是健康组织（31），肿瘤组织（27）还是消融组织（29）。 使用这种信息，可以控制消融过程。