公开(公告)号：US06749626B1

公开(公告)日：2004-06-15

申请号：US09715510

申请日：2000-11-17

申请人： Vinayak D. Bhat ,  Daryush Mirzaee ,  Evgenia Mandrusov ,  Syed F. A. Hossainy ,  Deborra Sanders-Millare

发明人： Vinayak D. Bhat ,  Daryush Mirzaee ,  Evgenia Mandrusov ,  Syed F. A. Hossainy ,  Deborra Sanders-Millare

IPC分类号： A61F206

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/416 ,  C08L29/04

摘要： A composition, comprising actinomycin D, is locally or systemically administered for the treatment of a blood vessel, such as caused by recurring stenosis or restenosis following vascular trauma or disease.

摘要翻译： 包含放线菌素D的组合物局部或全身施用于治疗血管，例如由血管创伤或疾病引起的复发性狭窄或再狭窄引起的。

公开(公告)号：US06709514B1

公开(公告)日：2004-03-23

申请号：US10040574

申请日：2001-12-28

申请人： Syed F. A. Hossainy

发明人： Syed F. A. Hossainy

IPC分类号： B05C1108

CPC分类号： B05B3/1014 ,  A61F2/82 ,  B05B3/001 ,  B05B13/0228 ,  Y10S118/16

摘要： A rotary coating apparatus and a method of coating medical devices, such as stents, is disclosed.

摘要翻译： 公开了一种旋转涂覆装置和涂覆诸如支架的医疗装置的方法。

公开(公告)号：US06635082B1

公开(公告)日：2003-10-21

申请号：US09753206

申请日：2000-12-29

申请人： Syed F. A. Hossainy ,  Steven Wu

发明人： Syed F. A. Hossainy ,  Steven Wu

IPC分类号： A61F206

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0095 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2250/0068 ,  A61F2250/0098

摘要： A stent or intraductal medical device is provided having radiopaque marker material deposited on the surface of the stent or medical device to assist visualization of the device during implantation. A method for depositing a radiopaque material on an implantable medical device such as a stent is also described. The radiopaque material may be deposited on the medical device by dipping or immersion, or the radiopaque material may be applied to the device using micro-injection or electrodeposition. The radiopaque material may coat the entire surface of the stent, or only a portion of the stent, or it may be applied to cavities or microdepots formed in the outer surface of the medical device. Excess radiopaque material may be removed from the device by centrifugation or shaking, and the radiopaque material may be heated to bond the material to the surface of the device.

摘要翻译： 提供支架或导管内医疗装置，其具有沉积在支架或医疗装置的表面上的不透射线的标记材料，以辅助植入期间装置的可视化。 还描述了在诸如支架的可植入医疗装置上沉积不透射线材料的方法。 不透射线材料可以通过浸渍或浸渍沉积在医疗装置上，或者可以使用微注射或电沉积将不透射线材料施加到装置上。 不透射线的材料可以涂覆支架的整个表面，或仅涂覆支架的一部分，或者可以将其施加到形成在医疗装置的外表面中的腔或微口。 可以通过离心或摇动从设备中除去过量的不透射线的材料，并且可以加热不透射线的材料以将材料粘合到装置的表面。

公开(公告)号：US06616765B1

公开(公告)日：2003-09-09

申请号：US10043500

申请日：2002-01-10

申请人： Daniel Castro ,  Steven Wu ,  Kevin L. Woolbright ,  Kurt W. Scheinpflug ,  Syed F. A. Hossainy ,  Li Chen

发明人： Daniel Castro ,  Steven Wu ,  Kevin L. Woolbright ,  Kurt W. Scheinpflug ,  Syed F. A. Hossainy ,  Li Chen

IPC分类号： B05C1100

CPC分类号： A61L31/16 ,  A61F2/91 ,  A61F2250/0068 ,  A61L31/10 ,  A61L2300/606 ,  B05D1/002 ,  B05D1/26 ,  B05D1/40 ,  B05D3/107

摘要： A patterned coating on a prosthesis, for example a stent, and a method for forming the coating are disclosed. Additionally, an apparatus for forming the patterned coating is disclosed.

公开(公告)号：US06585765B1

公开(公告)日：2003-07-01

申请号：US09608444

申请日：2000-06-29

申请人： Syed F. A. Hossainy ,  Jacqueline Ghio ,  Li Chen

发明人： Syed F. A. Hossainy ,  Jacqueline Ghio ,  Li Chen

IPC分类号： A61F206

CPC分类号： A61L31/146 ,  A61F2/06 ,  A61F2/82 ,  A61F2250/0068 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00

摘要： The present invention provides a method of impregnating an implantable device, such as a vascular graft or a covering adapted to be disposed over a prosthesis. The substances may be impregnated within the implantable device as a passive coating or as a delivery matrix for a therapeutic substance. Also provided is an implantable device having such substances impregnated therein.

公开(公告)号：US06451373B1

公开(公告)日：2002-09-17

申请号：US09633081

申请日：2000-08-04

申请人： Syed F. A. Hossainy ,  Debbie Sanders-Millare ,  Steven Z. Wu

发明人： Syed F. A. Hossainy ,  Debbie Sanders-Millare ,  Steven Z. Wu

IPC分类号： A61L1700

CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  A61L2300/622 ,  A61L2420/02 ,  A61L2420/08 ,  Y10T428/2964 ,  Y10T428/2967

摘要： A method of coating an implantable prosthesis by applying a composition including a therapeutic substance and a fluid to the prosthesis and removing the fluid is disclosed. The fluid is not capable of significantly dissolving the therapeutic substance. A second fluid in which the therapeutic substance is soluble may be further included in the composition. Methods of providing the composition and a roughened polymeric primer layer are also disclosed.

摘要翻译： 公开了一种通过将包括治疗物质和流体的组合物应用于假体并去除流体来涂覆可植入假体的方法。 流体不能显着溶解治疗物质。 治疗物质可溶解的第二种液体可以进一步包括在组合物中。 还公开了提供组合物和粗糙化的聚合物底漆层的方法。

公开(公告)号：US6153252A

公开(公告)日：2000-11-28

申请号：US294164

申请日：1999-04-19

申请人： Syed F. A. Hossainy ,  Mark B. Roller ,  Gerard H. Llanos ,  Gregory A. Kopia

发明人： Syed F. A. Hossainy ,  Mark B. Roller ,  Gerard H. Llanos ,  Gregory A. Kopia

IPC分类号： A61F2/00 ,  A61F2/82 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61L33/10 ,  A61L33/14 ,  A61L33/16 ,  A61L27/00 ,  B05D7/22

CPC分类号： A61F2/82 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/0047 ,  A61F2250/0067 ,  A61L2300/606 ,  A61L2420/02

摘要： A process is provided for coating stents having a first and second surface with passages there between to avoid blockage and bridging of the passages. The process comprises contacting the stent with a liquid coating solution containing a film forming biocompatible polymer under conditions suitable to allow the film forming biocompatible polymer to coat at least one surface of the stent while maintaining a fluid flow through said passages sufficient prevent the film forming biocompatible polymer from substantially blocking said passages. Also described are stents coated by this process.

摘要翻译： 提供了一种用于涂覆具有第一和第二表面的支架的过程，其间具有通道，以避免通道的阻塞和桥接。 该方法包括使支架与含有成膜生物相容性聚合物的液体涂布溶液接触，所述液体涂覆溶液在适于允许成膜生物相容性聚合物涂覆支架的至少一个表面的条件下同时保持流经所述通道的流体足以防止膜形成生物相容性 聚合物基本上阻挡所述通道。 还描述了通过该方法涂覆的支架。

公开(公告)号：US5843743A

公开(公告)日：1998-12-01

申请号：US467815

申请日：1995-06-06

申请人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill ,  Syed F. A. Hossainy

发明人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill ,  Syed F. A. Hossainy

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K38/42 ,  A61K38/44 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52 ,  A61L29/08 ,  A61L31/10 ,  A61L31/14 ,  C08B37/08 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/08 ,  C08F290/10 ,  C08F291/00 ,  C09D153/00 ,  C12N5/00 ,  C12N5/071 ,  C12N5/077 ,  C12N11/04 ,  A61K9/48 ,  B05D7/00 ,  C12N11/00 ,  C12N11/02

CPC分类号： C12N11/04 ,  A61K38/42 ,  A61K38/44 ,  A61K47/48315 ,  A61K47/48784 ,  A61K47/48876 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5073 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  B82Y5/00 ,  C08B37/003 ,  C08B37/0072 ,  C08B37/0084 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/062 ,  C08F290/08 ,  C08F290/10 ,  C08F291/00 ,  C09D153/00 ,  C12N5/0012 ,  C12N5/0677 ,  A61K2035/128 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74 ,  Y10S514/801 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/815 ,  Y10S530/817 ,  Y10T428/2987 ,  Y10T428/2989

摘要： Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.

公开(公告)号：US5801033A

公开(公告)日：1998-09-01

申请号：US480678

申请日：1995-06-07

申请人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Syed F. A. Hossainy

发明人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Syed F. A. Hossainy

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K38/42 ,  A61K38/44 ,  A61K47/48 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52 ,  A61L29/08 ,  A61L31/10 ,  A61L31/14 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F291/00 ,  C09D153/00 ,  C12N5/00 ,  C12N5/071 ,  C12N11/04 ,  C12N11/02

CPC分类号： A61L27/36 ,  A61K38/42 ,  A61K38/44 ,  A61K47/48315 ,  A61K47/48869 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5031 ,  A61K9/5073 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/062 ,  C08F291/00 ,  C09D153/00 ,  C12N11/04 ,  C12N5/0012 ,  C12N5/0677 ,  A61K2035/128 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74

摘要： This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a "glue" to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material which is already encapsulated.

公开(公告)号：US5573934A

公开(公告)日：1996-11-12

申请号：US24657

申请日：1993-03-01

申请人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill-West ,  Syed F. A. Hossainy

发明人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill-West ,  Syed F. A. Hossainy

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K38/42 ,  A61K38/44 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52 ,  A61L29/08 ,  A61L31/10 ,  A61L31/14 ,  C08B37/08 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/08 ,  C08F290/10 ,  C08F291/00 ,  C09D153/00 ,  C12N5/00 ,  C12N5/071 ,  C12N5/077 ,  C12N11/04 ,  C12N11/02 ,  C12N5/06 ,  C12N11/08 ,  C08J7/04 ,  C08J7/16 ,  A61K47/32

CPC分类号： C12N11/04 ,  A61K38/42 ,  A61K38/44 ,  A61K47/48315 ,  A61K47/48784 ,  A61K47/48876 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5073 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  B82Y5/00 ,  C08B37/003 ,  C08B37/0072 ,  C08B37/0084 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/062 ,  C08F290/08 ,  C08F290/10 ,  C08F291/00 ,  C09D153/00 ,  C12N5/0012 ,  C12N5/0677 ,  A61K2035/128 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74 ,  Y10S514/801 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/815 ,  Y10S530/817 ,  Y10T428/2987 ,  Y10T428/2989

摘要： Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.