公开(公告)号：US08763454B2

公开(公告)日：2014-07-01

申请号：US13075703

申请日：2011-03-30

Applicant: Johann Camenisch ,  Werner Hinn ,  Lars Kamm ,  Simon Kuenzi

Inventor： Johann Camenisch ,  Werner Hinn ,  Lars Kamm ,  Simon Kuenzi

IPC: G01F23/26

CPC classification number: G01F23/266 ,  G01F23/268

Abstract: The invention relates to apparatuses (100) for the capacitive determination of the fill level in the individual containers (5.1, 5.2) of a group (10) of regularly disposed containers of the same dimensions, wherein the apparatus (100) comprises a transmitter electrode (201.1) and a receiver electrode (201.2, 201.3) as well as a circuit for carrying out a capacitive measurement. The measuring circuit comprises a transmitting circuit (57) and a receiving circuit (58) and the apparatus (100) comprises a horizontal base plate (200) having a plurality of electrodes (201.1, 201.2, 201.3) which protrude in one direction in relation to a horizontal plane defined by the base plate (200) and which are uniformly mutually spaced apart such that a plurality of working zones of the same dimensions are formed. A plurality of connections (202) are provided through which some of the electrodes (201.1) are connectable to the transmitting circuit (57) and controllable by said circuit and some of the electrodes (201.2, 201.3) are connectable to the receiving circuit (58) and can be read out by said circuit. In the area of each working zone in the horizontal plane at least respectively two electrodes (201.1, 201.2, 201.3) are opposite one another. By means of the connections (202) respectively one of these two electrodes (201.1) will be used as transmitter and the other of the two electrodes (201.2, 201.3) will be used as receiver.

Abstract translation: 本发明涉及用于对具有相同尺寸的规则排列的容器组（10）的各个容器（5.1,5.2）中的填充水平进行电容确定的装置（100），其中装置（100）包括发射器电极 （201.1）和接收器电极（201.2,201.3）以及用于进行电容测量的电路。 测量电路包括发射电路（57）和接收电路（58），该装置（100）包括一个具有多个电极（201.1,201.2,201.3）的水平基板， 到由基板（200）限定的水平面，并且彼此均匀地间隔开，使得形成相同尺寸的多个工作区。 提供多个连接（202），一些电极（201.1）通过该连接可连接到发射电路（57）并且可由所述电路控制，并且一些电极（201.2,201.3）可连接到接收电路（58） ），并且可以由所述电路读出。 在每个工作区域的水平面中至少分别有两个电极（201.1,201.2,201.3）彼此相对。 通过连接（202），这两个电极（201.1）中的一个将被用作发射器，并且两个电极（201.2,201.3）中的另一个将被用作接收器。

公开(公告)号：US08508846B2

公开(公告)日：2013-08-13

申请号：US13012476

申请日：2011-01-24

Applicant: Frank Fischer ,  Harald Gebetsroither ,  Andreas Gfrorer

Inventor： Frank Fischer ,  Harald Gebetsroither ,  Andreas Gfrorer

IPC: G02B21/26

CPC classification number: G01N35/00029 ,  G01N15/1475 ,  G01N21/6458 ,  G02B21/0076 ,  G02B21/26 ,  G02B21/34 ,  Y10T436/112499

Abstract: A slide transfer mechanism for a laser scanner device for imaging and measuring fluorescent samples is located in a sample plane on sample slides. The device includes a first optical system for providing laser beams and at least one detector for detecting an emission beam bundle coming from the sample, and a second optical system for forwarding the emission beam bundle to the at least one detector. The slide transfer mechanism has a motorized transport device for transferring a sample slide to the sample table and back. The storage unit of the laser scanner device includes a positioning plate for mounting a sample part magazine that has an open insertion side for storing sample slides in specific depositories. At a corner opposite to the insertion side, the sample part magazine includes a check opening for monitoring the presence or absence of a sample slide in a specific depository.

Abstract translation: 用于成像和测量荧光样品的激光扫描仪装置的滑块传送机构位于样品载片上的样品平面中。 该装置包括用于提供激光束的第一光学系统和用于检测来自样品的发射束束的至少一个检测器，以及用于将发射束束转发到至少一个检测器的第二光学系统。 滑块传送机构具有用于将样品载玻片传送到样品台和背部的电动输送装置。 激光扫描器装置的存储单元包括用于安装具有开放插入侧的样品零件盒的定位板，用于将样品载玻片存储在特定的储存器中。 在与插入侧相对的拐角处，样品零件盒包括一个检查开口，用于监测特定托盘中样品载玻片的存在与否。

公开(公告)号：US20130126358A1

公开(公告)日：2013-05-23

申请号：US13737360

申请日：2013-01-09

Applicant: TECAN TRADING AG

Inventor： Travis Lee ,  Michael Benjamin Franklin ,  Kailiang Wang

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502792 ,  B01L3/5029 ,  B01L3/523 ,  B01L3/527 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2200/141 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0683

Abstract: A liquid droplet manipulation system has a substrate with at least one electrode array and a central control unit for controlling selection of individual electrodes of the electrode array and for providing the electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. A working film is placed on top of the electrodes for manipulating samples in liquid droplets with the electrode array. At least one selected individual electrode of the electrode array is configured to be penetrated by light of an optical detection system for the optical inspection or analysis of samples in liquid droplets that are located on the working film. Also disclosed is working film that is to be placed on the electrode array and a cartridge that includes such a working film for manipulating samples in liquid droplets.

Abstract translation: 液滴操作系统具有具有至少一个电极阵列的基板和用于控制电极阵列的各个电极的选择的中央控制单元，并且用于通过电润湿来为电极提供用于操纵液滴的各个电压脉冲。 将工作薄膜放置在电极顶部，用电极阵列操纵液滴中的样品。 电极阵列的至少一个所选择的单独电极被配置为被光学检测系统的光穿透，用于光学检查或分析位于工作膜上的液滴中的样品。 还公开了将放置在电极阵列上的工作膜和包括用于操纵液滴中的样品的这种工作膜的盒。

公开(公告)号：USD682440S1

公开(公告)日：2013-05-14

申请号：US29406585

申请日：2011-11-16

Applicant: Stefan Degn

Designer： Stefan Degn

公开(公告)号：US08287806B2

公开(公告)日：2012-10-16

申请号：US12354322

申请日：2009-01-15

Applicant: Torleif Ove Bjornson ,  Robert Liebhard ,  Adi Zuppiger ,  Dirk Heerklotz

Inventor： Torleif Ove Bjornson ,  Robert Liebhard ,  Adi Zuppiger ,  Dirk Heerklotz

IPC: B01L3/02

CPC classification number: G01N35/1009 ,  G01F23/185 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: A pipetting apparatus has a fluidic space to which a pressure transducer with a pressure sensor is attached with a gas filled space. The fluidic space is defined by a pipette tip, a first tubing that connects the pipette tip to a pump, and an active part of the pump. The pipetting apparatus further has an impulse generating mechanism that is in operative contact with a column of system liquid inside the fluidic space. The impulse generating mechanism induces a vertical movement in the system liquid column, which results in a pressure variation in the gas filled space that is pneumatically connected with the fluidic space. This pressure variation, as recorded with the pressure transducer and as processed by a first data processing unit during utilization of this pipetting apparatus, is taken as an indicator for the detection of penetration or of quitting of a surface of a liquid, with an orifice of the pipette tip, of which liquid an amount is to be aspirated and dispensed. This pressure variation is also taken as an indicator for the detection of the presence or the absence of gas bubbles in the system liquid contained in the fluidic space of this pipetting apparatus.

Abstract translation: 移液装置具有流体空间，具有压力传感器的压力传感器与气体填充空间相连。 流体空间由移液管尖端，将移液管尖端连接到泵的第一管和泵的有效部分限定。 移液装置还具有脉冲发生机构，其与流体空间内的系统液体柱可操作地接触。 脉冲产生机构在系统液柱中引起垂直运动，这导致与流体空间气动连接的气体填充空间中的压力变化。 该压力变化记录在压力传感器中并且在利用该移液装置期间由第一数据处理单元处理，被作为用于检测液体的表面的渗透或退出的指示器，其中孔口 移液管尖端，其中液体的量将被吸入和分配。 该压力变化也被用作检测包含在该移液装置的流体空间中的系统液体中是否存在气泡的指标。

公开(公告)号：US20110239757A1

公开(公告)日：2011-10-06

申请号：US13075703

申请日：2011-03-30

Applicant: Johann Camenisch ,  Werner Hinn ,  Lars Kamm ,  Simon Kuenzi

Inventor： Johann Camenisch ,  Werner Hinn ,  Lars Kamm ,  Simon Kuenzi

IPC: G01F23/26

CPC classification number: G01F23/266 ,  G01F23/268

Abstract: The invention relates to apparatuses (100) for the capacitive determination of the fill level in the individual containers (5.1, 5.2) of a group (10) of regularly disposed containers of the same dimensions, wherein the apparatus (100) comprises a transmitter electrode (201.1) and a receiver electrode (201.2, 201.3) as well as a circuit for carrying out a capacitive measurement. The measuring circuit comprises a transmitting circuit (57) and a receiving circuit (58) and the apparatus (100) comprises a horizontal base plate (200) having a plurality of electrodes (201.1, 201.2, 201.3) which protrude in one direction in relation to a horizontal plane defined by the base plate (200) and which are uniformly mutually spaced apart such that a plurality of working zones of the same dimensions are formed. A plurality of connections (202) are provided through which some of the electrodes (201.1) are connectable to the transmitting circuit (57) and controllable by said circuit and some of the electrodes (201.2, 201.3) are connectable to the receiving circuit (58) and can be read out by said circuit. In the area of each working zone in the horizontal plane at least respectively two electrodes (201.1, 201.2, 201.3) are opposite one another. By means of the connections (202) respectively one of these two electrodes (201.1) will be used as transmitter and the other of the two electrodes (201.2, 201.3) will be used as receiver.

Abstract translation: 本发明涉及用于对具有相同尺寸的规则排列的容器组（10）的各个容器（5.1,5.2）中的填充水平进行电容确定的装置（100），其中装置（100）包括发射器电极 （201.1）和接收器电极（201.2,201.3）以及用于进行电容测量的电路。 测量电路包括发射电路（57）和接收电路（58），该装置（100）包括一个具有多个电极（201.1,201.2,201.3）的水平基板， 到由基板（200）限定的水平面，并且彼此均匀地间隔开，使得形成相同尺寸的多个工作区。 提供多个连接（202），一些电极（201.1）通过该连接可连接到发射电路（57）并且可由所述电路控制，并且一些电极（201.2,201.3）可连接到接收电路（58） ），并且可以由所述电路读出。 在每个工作区域的水平面中至少分别有两个电极（201.1,201.2,201.3）彼此相对。 通过连接（202），这两个电极（201.1）中的一个将被用作发射器，并且两个电极（201.2,201.3）中的另一个将被用作接收器。

公开(公告)号：US07988934B2

公开(公告)日：2011-08-02

申请号：US11739163

申请日：2007-04-24

Applicant: Johannes Balmer

Inventor： Johannes Balmer

IPC: B01L3/02

CPC classification number: G01N35/1011 ,  G01N35/0099 ,  G01N2035/1051 ,  Y10T74/18248

Abstract: Relates to a carrier (1) for positioning objects (5), which are oriented in the Z direction of a coordinate system, in relation to laboratory articles. Z rods (12) comprise a Z guide (43), on a cage (10) carrying the individual drive wheel (17), on which the Z rod (12) is guided in the Z direction. Each drive wheel (17) comprises a section (41), which is tailored to the cross-section of the profiled rod (18) of the Z drive of the carrier (1), individually driven by a motor, on which the drive wheel (17) is seated so it is not rotatable and is displaceable by sliding in the Y direction. The carrier (1) is characterized in that the attack faces (40) of the profiled rods (18) for driving a drive wheel are larger than the attack faces of a profiled rod having a square cross-section but having equally large radius.

Abstract translation: 关于与实验室物品相关的用于定位在坐标系的Z方向上的物体（5）的载体（1）。 Z杆（12）包括在承载单个驱动轮（17）的保持架（10）上的Z引导件（43），Z杆（Z）在Z方向上被引导到该引导件上。 每个驱动轮（17）包括一个部分（41），该部分根据载体（1）的Z驱动的成型杆（18）的横截面进行调整，分别由马达驱动，驱动轮 （17）就位，因此它不能旋转，并且可以通过在Y方向上滑动来移动。 载体（1）的特征在于用于驱动驱动轮的成型杆（18）的攻击面（40）大于具有正方形横截面但具有相等大半径的成型杆的攻击面。

公开(公告)号：US07618812B2

公开(公告)日：2009-11-17

申请号：US11191327

申请日：2005-07-28

Applicant: Wolfgang Streit ,  Gyoergy Wenczel ,  Anton Mathes ,  Waltraud Lamprecht

Inventor： Wolfgang Streit ,  Gyoergy Wenczel ,  Anton Mathes ,  Waltraud Lamprecht

IPC: C12M1/34

CPC classification number: B01L3/502715 ,  B01F5/10 ,  B01F11/0071 ,  B01F13/0059 ,  B01F15/00123 ,  B01F15/00318 ,  B01F15/00396 ,  B01F15/0244 ,  B01F2015/00084 ,  B01F2215/0037 ,  B01F2215/0073 ,  B01J2219/00353 ,  B01J2219/00396 ,  B01J2219/00477 ,  B01J2219/00479 ,  B01J2219/00533 ,  B01J2219/00659 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/50855 ,  B01L9/06 ,  B01L2200/0689 ,  B01L2300/0636 ,  B01L2300/0822 ,  B01L2300/0877 ,  B01L2400/0481 ,  C40B60/14

Abstract: A device provides a hybridization chamber for hybridizing nucleic acid samples, proteins or tissue sections on a slide, and is an essentially rectangular body movable opposite the slide. The device includes a surface, lines for supplying and/or removing media, a specimen supply line and an agitating device. The agitation device includes at least one membrane which separates a pressure chamer to be fillable with a pressure fluid via one of the lines, from at least one agitation chamber connected via an agitation line to the hybridization chamber. The lines are continuously open so the media therein can permanently flow unhindered. Four such devices can be combined into a process unit for providing a hybridization chamber. Such unit is pivotable around an axis and has a holder with four seats, which is lockable in relation to a baseplate, one device being insertable into each one of the seats.

Abstract translation: 一种装置提供用于将载体上的核酸样品，蛋白质或组织切片杂交的杂交室，并且是与载片相对移动的基本上矩形的主体。 该装置包括表面，用于供应和/或移除介质的管线，试样供应管线和搅拌装置。 所述搅拌装置包括至少一个膜，其通过所述管线将至少一个通过搅动管线连接的搅拌室与压力流体分离成压缩倒角，所述至少一个搅拌室通过所述杂交室。 线路是连续打开的，因此其中的介质可以永久地不受阻碍地流动。 四个这样的装置可以组合成用于提供杂交室的处理单元。 这种单元可围绕轴线枢转并且具有具有四个座的保持器，该座具可相对于底板锁定，一个装置可插入每个座中。

公开(公告)号：US07473897B2

公开(公告)日：2009-01-06

申请号：US10487160

申请日：2002-03-12

Applicant: Hansjoerg Braendle ,  Erich Nadler ,  Matthias Graeter ,  Daniel Bischof

Inventor： Hansjoerg Braendle ,  Erich Nadler ,  Matthias Graeter ,  Daniel Bischof

IPC: G01J5/02 ,  G01N21/00 ,  G01F23/00

CPC classification number: G01F23/2927 ,  G01N21/3151 ,  G01N2035/1025

Abstract: A device for conducting a transmission measurement includes a system for generating a light wave consisting of a first and a second wavelength fraction, in addition to an optical channel guiding the light wave to a sample tube with a sample, wherein the light wave permeates the sample tube with a sample. The device also has a motion unit for producing a relative movement of the light wave along the sample tube. A receiver for receiving and separating the first and second wavelength fragments after the light wave has permeated the sample tube with a sample is also provided. A converter converts the first wavelength fraction into a first digital measuring value describing the degree of transmission in the first wavelength and converts the second wavelength fraction into a second digital measuring value describing the degree of transmission in the second wavelength. Quotients are formed from the first digital measuring values and the second digital measuring values by an evaluation system and the first derivative of the quotients is calculated.

Abstract translation: 用于进行透射测量的装置包括用于产生由第一和第二波长部分组成的光波的系统，以及将光波引导到具有样品的样品管的光通道，其中光波渗透样品 管样品。 该装置还具有用于产生沿着样品管的光波的相对运动的运动单元。 还提供了用于在光波已经用样品渗透到样品管之后接收和分离第一和第二波长碎片的接收器。 A转换器将第一波长分数转换成描述第一波长的透射度的第一数字测量值，并将第二波长分数转换成描述第二波长的透射度的第二数字测量值。 通过评估系统从第一数字测量值和第二数字测量值形成词汇，并且计算商的一阶导数。

公开(公告)号：US07077940B2

公开(公告)日：2006-07-18

申请号：US10405688

申请日：2003-04-02

Applicant: Nikolaus Ingenhoven ,  Remo Hoechli ,  Marcel Rutishauser ,  Anton Posch

Inventor： Nikolaus Ingenhoven ,  Remo Hoechli ,  Marcel Rutishauser ,  Anton Posch

IPC: B01D57/02 ,  G01N27/26

CPC classification number: G01N27/44795 ,  G01N27/44773

Abstract: A strip holder (1) is disclosed for accommodating a gel strip (3) for separating molecules using gel electrophoresis. The strip holder (1) disclosed is distinguished by including a baseplate (4), at least one stop (5), which is offset to a lower level in relation to the carrier surface (2), and at least one sealing surface (6), this stop (5) being implemented to be applied to counter surfaces (7) of an electrophoresis chamber, through which offset to a lower level of the stop (5) the installation depth of the strip holder (1) carrying a gel strip (3) into this electrophoresis chamber is determined and the sealing surface (6) ensuring a sealing installation of the strip holder (1) carrying a gel strip (3) into this electrophoresis chamber. Such a chamber (15) for isoelectric focusing of molecules in gel strips (3) is distinguished by including such a strip holder (1), a frame (16), and a cover (20). Another chamber in the form of a cassette (33), for performing an electrophoresis in the second dimension following the isoelectric focusing, includes two plates (34, 35) and at least one seal (36) which separates these plates and is distinguished by including such a strip holder (1), the strip holder being sealingly inserted into a recess (37) in one of these plates (34). The first dimension of a corresponding 2-D gel electrophoresis method is also disclosed.

Abstract translation: 公开了一种用于容纳用于使用凝胶电泳分离分子的凝胶条（3）的条带支架（1）。 公开的条带架（1）通过包括底板（4），至少一个止挡件（5）相对于载体表面（2）偏移到较低的水平面，以及至少一个密封表面（6） ），该止挡件（5）被实施为施加到电泳室的相对表面（7），通过该止动件偏移到止动件（5）的较低水平，带状保持器（1）的安装深度承载凝胶条 （3）进入该电泳室，密封面（6）确保将带有胶带（3）的带状支架（1）的密封安装在该电泳室中。 用于凝胶条（3）中分子的等电聚焦的这种室（15）的特征在于包括这种条带保持器（1），框架（16）和盖（20）。 用于在等电聚焦之后的第二维中执行电泳的盒（33）形式的另一个室包括两个板（34,35）和至少一个分隔这些板的密封件（36），其特征在于包括 这种条带保持器（1），条带保持器被密封地插入到这些板（34）之一中的凹部（37）中。 还公开了相应的2-D凝胶电泳方法的第一维度。