公开(公告)号：US10342898B2

公开(公告)日：2019-07-09

申请号：US15375442

申请日：2016-12-12

申请人： Surmodics, Inc.

发明人： David E. Babcock ,  Joram Slager ,  Robert W. Hergenrother

IPC分类号： B05D7/02 ,  B05D5/08 ,  B05D1/18 ,  A61L29/14 ,  A61L29/08 ,  B05D3/00 ,  B05D3/06 ,  B05D7/00

摘要： Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.

公开(公告)号：US10124088B2

公开(公告)日：2018-11-13

申请号：US14860128

申请日：2015-09-21

申请人： SurModics, Inc.

发明人： Ralph A. Chappa ,  Nathan A. Lockwood ,  Joseph Schmidt McGonigle

IPC分类号： A61L29/14 ,  A61L29/08 ,  A61L29/04 ,  C08J3/20 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14

摘要： Embodiments of the invention include medical device elements formed from polymers with lubricious properties. In an embodiment, a method of forming a medical device element is included. The method can include mixing a first polymeric component and a second polymeric component to form a polymer mixture. The method can further include forming the polymer mixture into the medical device element. The method can also include treating the polymer mixture with at least one of an acid or a base. In an embodiment, a medical device is included. The medical device can include a lubricious element, the lubricious element comprising a mixture of a first polymeric component and a second polymeric component. The second polymeric component can include a polymer that is treated with at least one of an acid or a base after formation of the element. Other embodiments are also included herein.

公开(公告)号：US09795720B2

公开(公告)日：2017-10-24

申请号：US15211833

申请日：2016-07-15

申请人： Surmodics, Inc.

发明人： Ralph A. Chappa ,  Kimberly K. M. Lindsoe

IPC分类号： A61K47/32 ,  A61K31/56 ,  A61L31/16 ,  A61K6/00 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14

CPC分类号： A61L31/16 ,  A61K6/0017 ,  A61K31/56 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/06

摘要： Aspects herein relate to coatings with crystallized active agent(s) and related methods. A method for coating a medical device herein includes selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device.

公开(公告)号：US09757497B2

公开(公告)日：2017-09-12

申请号：US13469844

申请日：2012-05-11

申请人： Joram Slager

发明人： Joram Slager

IPC分类号： A61L29/14 ,  A61L29/08 ,  A61L29/16 ,  A61L29/12 ,  A61K9/14 ,  A61K9/70

CPC分类号： A61L29/14 ,  A61K9/145 ,  A61K9/70 ,  A61L29/085 ,  A61L29/126 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/63 ,  A61L2300/802 ,  F04C2270/0421

摘要： Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.

公开(公告)号：US09737639B2

公开(公告)日：2017-08-22

申请号：US15165650

申请日：2016-05-26

申请人： SurModics, Inc.

发明人： David E. Babcock

IPC分类号： A61L29/08 ,  A61L29/14 ,  A61L27/34 ,  A61L31/10

CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L29/14 ,  A61L31/10 ,  A61L2400/10 ,  A61L2420/06 ,  A61L2420/08 ,  C08L39/06

摘要： Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; anda first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.

公开(公告)号：US20170224876A1

公开(公告)日：2017-08-10

申请号：US15502345

申请日：2015-08-06

申请人： SURMODICS, INC.

发明人： David E. Babcock ,  Sean Lundquist ,  Gary Opperman ,  Adriyn Torguson ,  Tim Jentz

IPC分类号： A61L29/08 ,  A61L29/16 ,  G01N33/543 ,  A61L29/06

CPC分类号： A61L29/085 ,  A61K31/7024 ,  A61L27/34 ,  A61L29/06 ,  A61L29/16 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08 ,  G01N33/54393

摘要： Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological mo lecule.

公开(公告)号：US09487663B2

公开(公告)日：2016-11-08

申请号：US14541768

申请日：2014-11-14

申请人： SurModics, Inc.

发明人： Aleksey V. Kurdyumov ,  Dale G. Swan

IPC分类号： C07F9/145 ,  C09D7/12 ,  A61L17/14 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C07F7/10 ,  C07F7/18 ,  C07F9/12 ,  C07F9/40 ,  C08F2/48 ,  C07F9/06 ,  C08K5/51 ,  C08K5/5419 ,  C08K5/544

CPC分类号： C09D7/63 ,  A61L17/145 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2400/18 ,  A61L2420/02 ,  C07F7/10 ,  C07F7/1804 ,  C07F7/184 ,  C07F9/06 ,  C07F9/12 ,  C07F9/145 ,  C07F9/4025 ,  C07F9/4084 ,  C08F2/48 ,  C08K5/51 ,  C08K5/5419 ,  C08K5/544 ,  C09D7/1233

摘要： Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.

摘要翻译： 本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。 可降解交联剂包括至少一个光反应基团和连接基团之间的共价键，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。 还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。

公开(公告)号：US09416221B2

公开(公告)日：2016-08-16

申请号：US13221464

申请日：2011-08-30

申请人： Howard Bowman ,  Don Lucast ,  Philip Morris

发明人： Howard Bowman ,  Don Lucast ,  Philip Morris

IPC分类号： C09J7/02 ,  A61L15/58 ,  C09J7/04 ,  A61F13/02 ,  B32B7/12 ,  B32B1/02 ,  C08G63/08 ,  A61L15/26 ,  A61L24/04 ,  C09J7/00 ,  C09J167/04 ,  C08L67/04

CPC分类号： C08G63/08 ,  A61L15/26 ,  A61L15/58 ,  A61L24/046 ,  C08L67/04 ,  C09J7/00 ,  C09J7/255 ,  C09J7/38 ,  C09J167/04 ,  C09J2467/00 ,  C09J2467/006 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/1476 ,  Y10T428/21 ,  Y10T428/24777 ,  Y10T428/24942 ,  Y10T428/249921 ,  Y10T428/2839 ,  Y10T428/2865 ,  Y10T428/31681 ,  Y10T428/31786 ,  Y10T428/31855 ,  Y10T442/172

摘要： Disclosed herein are terpolymers and blends prepared from polyester terpolymers that can function as pressure-sensitive adhesives. The disclosed articles can comprise the terpolymer and terpolymer blends coated to a conformable backing member. The terpolymer and terpolymer blends can further comprise a bioactive agent.

摘要翻译： 本文公开了由可用作压敏粘合剂的聚酯三元共聚物制备的三元共聚物和共混物。 所公开的制品可以包括涂覆到适形背衬构件的三元共聚物和三元共聚物共混物。 三元共聚物和三元共聚物共混物可进一步包含生物活性剂。

公开(公告)号：US09410044B2

公开(公告)日：2016-08-09

申请号：US13886031

申请日：2013-05-02

申请人： SurModics, Inc.

发明人： Aleksey V. Kurdyumov

IPC分类号： C07F5/02 ,  C09D5/00 ,  C08J7/12 ,  C08J7/18 ,  C07F5/00

CPC分类号： C09D5/00 ,  C07F5/003 ,  C07F5/02 ,  C07F5/022 ,  C07F5/025 ,  C08J7/123 ,  C08J7/18

摘要： Embodiments of the invention include linking agents including borate, borazine, or boronate groups and coatings and devices that incorporate such linking agents, along with related methods. Other embodiments are also included herein.

摘要翻译： 本发明的实施方案包括连接剂，包括硼酸盐，环硼氮烷或硼酸酯基团，以及包含这种连接剂的涂料和装置以及相关方法。 本文还包括其它实施例。

公开(公告)号：US20150165094A1

公开(公告)日：2015-06-18

申请号：US14613777

申请日：2015-02-04

申请人： Surmodics, Inc.

发明人： James Howard Arps ,  Andrew G. Bach

IPC分类号： A61L29/04 ,  A61M25/10 ,  A61K31/337

CPC分类号： A61M25/1002 ,  A61K31/337 ,  A61L29/041 ,  A61L29/085 ,  A61L29/145 ,  A61L29/148 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/622 ,  A61M25/104 ,  A61M2025/1004 ,  A61M2025/105 ,  C08L3/02

摘要： The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.