公开(公告)号：US20170290950A1

公开(公告)日：2017-10-12

申请号：US15517297

申请日：2015-10-07

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： William D. WAGNER ,  Victoria Shuangbai JIANG

IPC: A61L26/00 ,  C08J3/24 ,  C08G63/91 ,  C08G63/16

CPC classification number: A61L26/0019 ,  A61K9/70 ,  A61K31/765 ,  A61K47/34 ,  A61L26/0057 ,  A61L26/0085 ,  A61L26/009 ,  C08G63/16 ,  C08G63/916 ,  C08J3/24 ,  C08J2367/02 ,  C08L67/04

Abstract: Wound repair materials and methods of using the same to inhibit excess fibrosis are disclosed.

公开(公告)号：US09757225B2

公开(公告)日：2017-09-12

申请号：US15298382

申请日：2016-10-20

Applicant: Wake Forest University Health Sciences

Inventor： James Yoo ,  Joel D. Stitzel, Jr. ,  Anthony Atala ,  George Christ

IPC: A61F2/08 ,  A61L27/38 ,  C12M3/00 ,  C12M1/42 ,  C12N5/077 ,  A61L27/36

CPC classification number: A61F2/08 ,  A61F2002/0894 ,  A61L27/3604 ,  A61L27/367 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3826 ,  A61L27/3895 ,  A61L2430/30 ,  A61L2430/34 ,  C12M21/08 ,  C12M35/04 ,  C12N5/0658 ,  C12N2527/00 ,  C12N2539/00

Abstract: A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c) optionally but preferably maintaining the support in a substantially static position during a second time period; and then (d) repeating steps (b) and (c) for a number of times sufficient to enhance the functionality of the tissue formed on the support and/or produce organized skeletal muscle tissue on the solid support from the precursor muscle cells.

公开(公告)号：US20170239332A1

公开(公告)日：2017-08-24

申请号：US15371966

申请日：2016-12-07

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Joseph Charles BURNS ,  John D. JACKSON

IPC: A61K38/17 ,  C12N5/071 ,  A61K45/06 ,  A61K48/00 ,  C12N7/00

CPC classification number: A61K38/1761 ,  A61K38/1709 ,  A61K45/06 ,  A61K48/00 ,  A61K48/005 ,  C12N5/062 ,  C12N5/0627 ,  C12N5/0696 ,  C12N7/00 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2506/09 ,  C12N2510/00 ,  C12N2710/10032 ,  C12N2710/10043 ,  C12N2710/10071

Abstract: The invention provides compositions and methods for treating or preventing hearing loss in a subject. The method comprises administering to the subject in need thereof, at least Myc or an agent that increases the expression of Myc in an inner ear organ, or associated neural structures, of the subject so as to treat or prevent the hearing loss.

公开(公告)号：US20170203004A1

公开(公告)日：2017-07-20

申请号：US15515049

申请日：2015-10-01

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Sean V. MURPHY ,  Aleksander SKARDAL ,  Anthony ATALA

IPC: A61L27/36 ,  A61L27/52 ,  A61K38/39 ,  A61L27/60 ,  A61K38/36 ,  A61K38/17 ,  A61L27/54 ,  A61L27/26 ,  A61K35/50 ,  A61K31/726

CPC classification number: A61L27/3604 ,  A61K31/726 ,  A61K35/50 ,  A61K38/177 ,  A61K38/36 ,  A61K38/39 ,  A61L26/0057 ,  A61L26/008 ,  A61L27/20 ,  A61L27/222 ,  A61L27/227 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3641 ,  A61L27/3683 ,  A61L27/52 ,  A61L27/54 ,  A61L27/60 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2430/34

Abstract: The present invention includes compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane powder. The compositions of the present invention comprise amniotic membrane powder and a scaffold. The methods of the present invention comprises applying a composition of the present invention to a subject to induce wound healing and tissue regeneration.

公开(公告)号：US09707256B2

公开(公告)日：2017-07-18

申请号：US14102953

申请日：2013-12-11

Applicant: Wake Forest University Health Sciences

Inventor： Shay Soker ,  J. Koudy Williams ,  Patrick Laber ,  Margaret Greven ,  Keith A. Walter

IPC: A61K35/28 ,  A61K35/30 ,  A61L27/54 ,  A61K35/44 ,  A61F2/14 ,  A61K9/00 ,  A61L27/36 ,  A61L27/38 ,  A61K35/12

CPC classification number: A61K35/44 ,  A61F2/142 ,  A61K9/0051 ,  A61K35/12 ,  A61L27/3604 ,  A61L27/3808 ,  A61L2430/16

Abstract: Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells seeded thereon. Methods of treating a patient in need of corneal endothelial transplant are also provided, including implanting the scaffold as described herein onto a cornea of the patient (e.g., by deep keratectomy).

公开(公告)号：US09700581B2

公开(公告)日：2017-07-11

申请号：US14427150

申请日：2013-09-10

Applicant: Wake Forest University Health Sciences

Inventor： Yuanyuan Zhang ,  Emmanuel C. Opara

IPC: A61K35/22 ,  A61K38/18 ,  C12N5/0775 ,  C12N5/071 ,  A61K9/00 ,  A61K9/16 ,  A61K35/545

CPC classification number: A61K35/22 ,  A61K9/0019 ,  A61K9/16 ,  A61K35/545 ,  A61K38/18 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/1866 ,  C12N5/0668 ,  C12N5/0684 ,  C12N5/0685 ,  C12N5/069 ,  C12N2501/165 ,  C12N2506/1392 ,  C12N2506/25

Abstract: Provided herein are methods of treating a subject in need of treatment for a urological condition including administering urine stem cells to said subject in a treatment effective amount; and, in conjunction therewith, administering growth factors to said subject in an amount effective to promote differentiation of said stem cells into skeletal muscle cells. Compositions useful for the same are also provided.

公开(公告)号：US09675358B2

公开(公告)日：2017-06-13

申请号：US14391346

申请日：2013-03-15

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： William D. Wagner ,  Nicole Levi ,  Tabitha Rosenbalm ,  Louis C. Argenta ,  Michael J. Morykwas

IPC: A61B17/11 ,  A61L27/18 ,  A61L27/44 ,  A61L27/50 ,  A61F2/00 ,  A61L27/26 ,  A61L27/58 ,  C08G63/12 ,  C08G63/47 ,  H01B1/12 ,  A61B17/00

CPC classification number: A61B17/1128 ,  A61B2017/00004 ,  A61B2017/00831 ,  A61B2017/00991 ,  A61B2017/1132 ,  A61F2/0077 ,  A61L27/18 ,  A61L27/26 ,  A61L27/446 ,  A61L27/50 ,  A61L27/58 ,  A61L2400/12 ,  A61L2430/32 ,  C08G63/12 ,  C08G63/47 ,  H01B1/125 ,  C08L67/00

Abstract: A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.

公开(公告)号：US09663824B2

公开(公告)日：2017-05-30

申请号：US15028323

申请日：2014-10-10

Applicant: Wake Forest University Health Sciences

Inventor： Floyd H. Chilton ,  Timothy D. Howard

IPC: C12Q1/68 ,  A61K31/202 ,  A23L1/30

CPC classification number: C12Q1/6883 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/202 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156

Abstract: Compositions and methods for identifying and treating patients having altered capacity for LC-PUFA production are disclosed.

公开(公告)号：US20170107483A1

公开(公告)日：2017-04-20

申请号：US15294154

申请日：2016-10-14

Applicant: Wake Forest University Health Sciences

Inventor： Samuel Pendergraft ,  Hooman Sadri-Ardekani ,  Anthony Atala ,  Colin Bishop

IPC: C12N5/076 ,  A01N1/02

CPC classification number: A01N1/021 ,  A01N1/0221 ,  C12N5/0697 ,  C12N2506/246 ,  C12N2510/04 ,  C12N2533/90

Abstract: A cell composition composed of spermatogonial stem cells, Sertoli cells, Leydig cells and optionally peritubular cells, is provided, as is a culture composition, artificial testicular construct, hydrogel composition, and device containing the same. A method for using the device as a physiologically relevant in vitro model of human testicular function to screen compounds for pharmacological or toxicological activity is also provided.

公开(公告)号：US20170106050A1

公开(公告)日：2017-04-20

申请号：US15309093

申请日：2015-04-30

Applicant: Wake Forest University Health Sciences

Inventor： James K. Williams

IPC: A61K38/19 ,  A61K38/39 ,  A61K9/00

Abstract: A method of treating a sphincter deficiency disorder (e.g., incontinence; gastrointestinal disorders) is carried out by administering stromal cell-derived factor 1 (SDF-1) to a sphincter or sphincter complex, such as a urethral or gastrointestinal sphincter (e.g., a rectal sphincter) of the subject in a treatment-effective amount.