公开(公告)号：US09512105B2

公开(公告)日：2016-12-06

申请号：US14364003

申请日：2012-12-10

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Frank I. Carroll ,  James B. Thomas ,  Hernan A. Navarro ,  S. Wayne Mascarella ,  Scott P. Runyon ,  Chunyang Jin ,  Chad M. Kormos

IPC: C07D241/04 ,  C07D401/12 ,  C07D295/13

CPC classification number: C07D401/12 ,  C07D241/04 ,  C07D295/13

Abstract: Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.

公开(公告)号：US09437796B2

公开(公告)日：2016-09-06

申请号：US13725156

申请日：2012-12-21

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Rama Venkatasubramanian ,  Bruce Allen Cook ,  Evgenii M. Levin ,  Joel Lee Harringa

IPC: H01L35/14 ,  H01L35/16 ,  C22C1/02 ,  C22C28/00 ,  H01F1/40

CPC classification number: H01L35/16 ,  C22C1/02 ,  C22C28/00 ,  H01F1/401

Abstract: A thermoelectric material and a thermoelectric converter using this material. The thermoelectric material has a first component including a semiconductor material and a second component including a rare earth material included in the first component to thereby increase a figure of merit of a composite of the semiconductor material and the rare earth material relative to a figure of merit of the semiconductor material. The thermoelectric converter has a p-type thermoelectric material and a n-type thermoelectric material. At least one of the p-type thermoelectric material and the n-type thermoelectric material includes a rare earth material in at least one of the p-type thermoelectric material or the n-type thermoelectric material.

Abstract translation: 使用这种材料的热电材料和热电转换器。 热电材料具有包括半导体材料的第一部件和包括在第一部件中的稀土材料的第二部件，从而相对于品质因数增加半导体材料和稀土材料的复合材料的品质因数 的半导体材料。 热电转换器具有p型热电材料和n型热电材料。 p型热电材料和n型热电材料中的至少一种在p型热电材料或n型热电材料中的至少一种中包括稀土材料。

公开(公告)号：US20160243480A1

公开(公告)日：2016-08-25

申请号：US14975978

申请日：2015-12-21

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Howard Jerome WALLS ,  Randall J. NEWSOME ,  Anthony Clint CLAYTON ,  Robert W. YAGA ,  David Samuel ENSOR

IPC: B01D46/00 ,  B01D46/54 ,  A62B18/08 ,  A62B18/04 ,  A62B18/02 ,  A62B23/02 ,  B01D46/10 ,  D01D5/00

CPC classification number: B01D46/0001 ,  A62B18/02 ,  A62B18/04 ,  A62B18/084 ,  A62B23/025 ,  B01D46/103 ,  B01D46/546 ,  D01D5/0076 ,  D10B2509/00

Abstract: A filtration device including a contoured support having 1) an interior surface, 2) an outside peripheral surface spaced farther from a center of the contoured support than the interior surface, and 3) a rim enclosed and sealed to a perimeter of the contoured support. The filtration device includes macroscopic openings in the contoured support extending from the interior surface to the outside peripheral surface, and a plurality of nanofibers having diameters less than 1 micron. The nanofibers are disposed on the outside peripheral surface of the contoured support, and cover the macroscopic openings to form a filtration medium on the contoured support.

Abstract translation: 一种过滤装置，包括具有1）内表面的轮廓支撑件，2）与内表面相比间隔开比轮廓支撑件的中心更远的外周表面，以及3）封闭并密封到轮廓支撑件的周边的边缘。 过滤装置包括从内表面延伸到外周表面的轮廓支撑件中的宏观开口，以及直径小于1微米的多个纳米纤维。 纳米纤维布置在成型支撑体的外周表面上，并且覆盖宏观开口以在轮廓支撑件上形成过滤介质。

公开(公告)号：US20160042826A1

公开(公告)日：2016-02-11

申请号：US14819585

申请日：2015-08-06

Applicant: Research Triangle Institute

Inventor： Nicholas Guy Baldasaro

IPC: G21G1/06

CPC classification number: G21G1/06

Abstract: An apparatus for use with a neutron source for producing reaction-product nuclei from reactant nuclei includes a plurality of reactant nuclei and a plurality of moderating nuclei. The reactant nuclei and the moderating nuclei are configured to increase the probability of neutron capture by reactant nuclei to achieve enhanced ratios of neutron capture by reactant nuclei to neutron source neutron production. Moderating nuclei and neutron reflection are used to minimize neutron leakage. Temperature control, including cryogenic temperature control, may be used to enhance the rate or probability of reactant nuclei neutron capture. The reactant nuclei may include molybdenum-98 and reaction-product nuclei may include technetium-99m.

Abstract translation: 用于从反应物核产生反应产物核的中子源的装置包括多个反应物核和多个调节核。 反应物核和调节核被配置为增加反应物核的中子捕获的可能性，以实现反应物核到中子源中子产生的中子俘获的增强比例。 使用中等核和中子反射来最小化中子泄漏。 包括低温温度控制在内的温度控制可用于提高反应物核子中子捕获的速率或概率。 反应物核可以包括钼-98，反应产物核可以包括锝-99m。

公开(公告)号：US09257335B2

公开(公告)日：2016-02-09

申请号：US14426302

申请日：2013-09-04

Applicant: Research Triangle Institute

Inventor： Erik Vick ,  Garry Brian Cunningham ,  Dorota Temple

IPC: H01L21/768 ,  H01L23/48 ,  H01L23/00

CPC classification number: H01L21/76898 ,  H01L23/481 ,  H01L23/49827 ,  H01L24/03 ,  H01L24/05 ,  H01L24/06 ,  H01L24/16 ,  H01L24/94 ,  H01L25/0657 ,  H01L2224/0311 ,  H01L2224/0345 ,  H01L2224/03462 ,  H01L2224/036 ,  H01L2224/039 ,  H01L2224/0401 ,  H01L2224/05025 ,  H01L2224/05096 ,  H01L2224/05555 ,  H01L2224/05557 ,  H01L2224/05569 ,  H01L2224/0557 ,  H01L2224/05572 ,  H01L2224/056 ,  H01L2224/05624 ,  H01L2224/05639 ,  H01L2224/05644 ,  H01L2224/05647 ,  H01L2224/05655 ,  H01L2224/05666 ,  H01L2224/05676 ,  H01L2224/05684 ,  H01L2224/05687 ,  H01L2224/06181 ,  H01L2224/13025 ,  H01L2224/16146 ,  H01L2224/16235 ,  H01L2224/94 ,  H01L2225/06513 ,  H01L2225/06541 ,  H01L2924/12042 ,  H01L2924/1461 ,  H01L2924/00014 ,  H01L2924/0476 ,  H01L2924/01074 ,  H01L2924/04941 ,  H01L2224/0239 ,  H01L2924/01029 ,  H01L2924/01013 ,  H01L2924/01022 ,  H01L2924/01028 ,  H01L2924/01079 ,  H01L2924/01047 ,  H01L2924/01044 ,  H01L2224/03 ,  H01L2924/00

Abstract: An electronic device includes a substrate including a front side, a back side, a thickness between the front side and back side, one or more front-side vias extending from the front side into a part of the thickness, and an interconnect via extending from the back side toward the front side; a contact pad on the front side and including one or more protrusions extending through corresponding front-side vias and into the interconnect via; and an interconnect extending through the interconnect via and into contact with the protrusion(s).

Abstract translation: 一种电子设备包括：基板，包括正面，背面，前侧和后侧之间的厚度，从前侧延伸到厚度的一部分的一个或多个正面通孔;以及互连件， 背面朝前方; 接触垫，其包括一个或多个延伸穿过相应的前侧通孔并进入所述互连通孔中的突起; 以及通过互连件延伸并与突起接触的互连。

公开(公告)号：US09187480B2

公开(公告)日：2015-11-17

申请号：US14378479

申请日：2013-02-15

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Rangan Maitra ,  Alan Bradley Fulp ,  Yanan Zhang ,  Herbert H. Seltzman

IPC: C07D401/04 ,  C07D473/32 ,  C07D473/34

CPC classification number: C07D473/34

Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.

Abstract translation: 本发明提供了能够根据下式用作大麻素受体拮抗剂的化合物：这些化合物可用于治疗涉及大麻素受体系统的病症，例如肥胖，肝脏疾病，糖尿病，疼痛和炎症。

公开(公告)号：US09150582B2

公开(公告)日：2015-10-06

申请号：US14363079

申请日：2012-12-06

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Scott Runyon ,  Yanan Zhang ,  Carla Hassler ,  Brian Gilmour

IPC: C07D491/04 ,  A61K31/4355 ,  C07D491/048 ,  C07D491/10 ,  C07D491/107

CPC classification number: C07D491/048 ,  C07D491/04 ,  C07D491/10 ,  C07D491/107

Abstract: Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.

Abstract translation: 提供神经肽S受体拮抗剂，其在功能测定中与神经肽S受体结合; 提供了这些拮抗剂用于治疗通过阻断神经肽S受体而改善的病症或疾病状态的方法，包括药物滥用和药物滥用复发; 并且用于神经肽S受体拮抗剂在制备用于治疗疾病状态和治疗神经肽S受体结合敏感的疾病状态的治疗剂的前药中的用途。

公开(公告)号：US20150265561A1

公开(公告)日：2015-09-24

申请号：US14711355

申请日：2015-05-13

Applicant: Temple University - Of The Commonwealth System of Higher Education ,  Duke University ,  Research Triangle Institute

Inventor： Mary E. Abood ,  Pingwei Zhao ,  Lawrence S. Barak ,  Herbert H. Seltzman

IPC: A61K31/194

CPC classification number: A61K31/194 ,  A61K31/191

Abstract: Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation.

Abstract translation: 提供具有对G蛋白偶联受体35（GPR35）具有激动作用的化合物。 该化合物可用于提供抗感受伤害，在中风或局部缺血的情况下提供神经保护作用或治疗胃炎。

公开(公告)号：US08906908B2

公开(公告)日：2014-12-09

申请号：US13680710

申请日：2012-11-19

Applicant: Research Triangle Institute ,  Dignity Health ,  Virginia Commonwealth University

Inventor： F. Ivy Carroll ,  Bruce E. Blough ,  Hernan A. Navarro ,  S. Wayne Mascarella ,  Ana Zamfira Muresan ,  M. Imad Damaj ,  Ronald J. Lukas

IPC: C07D265/32 ,  A61K31/5375

CPC classification number: C07D265/32 ,  A61K31/5375

Abstract: The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.

Abstract translation: 本发明提供能够抑制一种或多种单胺再摄取和/或在烟碱型乙酰胆碱受体上作为拮抗剂的羟基安非他丁类似物。 所述化合物可以选择性地结合一种或多种单胺转运蛋白，包括用于多巴胺，去甲肾上腺素和5-羟色胺的单胺转运蛋白和/或可以选择性地结合一种或多种烟碱型乙酰胆碱受体亚型。 这些化合物可用于治疗对单胺水平的修饰和/或烟碱乙酰胆碱受体的拮抗作用有反应的病症，包括药物依赖性，抑郁症和肥胖症。

公开(公告)号：US20140335496A1

公开(公告)日：2014-11-13

申请号：US14362419

申请日：2012-12-04

Applicant: Research Triangle Institute ,  The University of North Carolina at Chapel Hill

Inventor： Sonia Grego ,  Kristin Hedgepath Gilchrist ,  Scott H. Randell

IPC: G09B23/30

CPC classification number: G09B23/306 ,  C12M21/08 ,  C12M23/16 ,  C12M25/02 ,  C12M25/14 ,  C12M35/08 ,  G01N33/5088

Abstract: A multicellular fluidic enhanced airway model system of the conducting airways as a tool for the evaluation of biological threats and medical countermeasures is provided. The airway model system can include a first chamber having an inlet and an outlet and containing epithelial cells; a second chamber having an inlet and an outlet and containing an extracellular matrix, wherein the second chamber is separated from the first chamber by a porous membrane; and a third chamber having an inlet and an outlet, wherein the third chamber is separated from the second chamber by a porous membrane, and wherein the airway tissue model system is configured to provide a separate fluidic pathway through each of said first, second, and third chambers. A method of analyzing tissue response to an agent via an airway tissue model system is also provided.

Abstract translation: 提供了导航气道的多细胞流体强化气道模型系统作为评估生物威胁和医疗对策的工具。 气道模型系统可以包括具有入口和出口并包含上皮细胞的第一腔室; 具有入口和出口并且包含细胞外基质的第二腔室，其中所述第二腔室通过多孔膜与所述第一腔室分离; 以及具有入口和出口的第三腔室，其中所述第三腔室通过多孔膜与所述第二腔室分离，并且其中所述气道组织模型系统构造成提供通过所述第一，第二和第 第三室。 还提供了一种通过气道组织模型系统分析对试剂的组织反应的方法。