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87 条记录 (耗时 0.031 秒)

    Valves with Hydraulic Actuation System
    11.
    发明申请
    Valves with Hydraulic Actuation System 审中-公开
    带液压驱动系统的阀门

    公开(公告)号：US20120181460A1

    公开(公告)日：2012-07-19

    申请号：US13349832

    申请日：2012-01-13

    申请人： David Eberhart ,  Ezra Van Gelder

    发明人： David Eberhart ,  Ezra Van Gelder

    IPC分类号： F16K31/00

    CPC分类号： F16K99/0015 ,  F16K99/0026 ,  F16K99/0059

    摘要： This invention provides a device comprising at least one diaphragm valve actuated by a hydraulic actuation system. The device comprises a fluidics layer, an actuation layer and an elastic layer sandwiched between the fluidics layer and the actuation layer. The diaphragm valve comprises: a valve inlet and valve outlet comprised in the fluidics layer; a valve seat; a diaphragm comprised in the elastic layer; and an actuator. The diaphragm is actuatable to move into contact or out of contact with the valve seat, thereby closing or opening the diaphragm valve. The actuator comprises: a hydraulic conduit; a translator; and an incompressible fluid contained within the hydraulic conduit, wherein the incompressible fluid communicates with the translator and with the diaphragm. Translation of the translator transmits pressure through the incompressible fluid to actuate the diaphragm. The invention also provides systems including elements to operate the device and methods of using the device.

    摘要翻译： 本发明提供了一种包括由液压致动系统致动的至少一个隔膜阀的装置。 该装置包括流体层，致动层和夹在流体层和致动层之间的弹性层。 隔膜阀包括：流体层中包括的阀入口和阀出口; 阀座; 包括在弹性层中的隔膜; 和致动器。 隔膜可致动以与阀座接触或脱离接触，从而关闭或打开隔膜阀。 致动器包括：液压管道; 翻译员 以及包含在液压管道内的不可压缩流体，其中不可压缩流体与平移器和隔膜连通。 翻译器的翻译通过不可压缩流体传递压力以致动隔膜。 本发明还提供了包括用于操作设备的元件和使用该设备的方法的系统。

    Serial electrophoresis
    13.
    发明授权
    Serial electrophoresis 有权

    公开(公告)号：US11592421B2

    公开(公告)日：2023-02-28

    申请号：US16616339

    申请日：2018-05-22

    申请人： Integenx Inc.

    发明人： Mattias Vangbo ,  David King ,  Arnaldo Barican

    IPC分类号： G01N27/447 ,  C12Q1/6806 ,  C12Q1/686

    摘要： Disclosed are methods for performing capillary electrophoresis on two or more nucleic acid samples. The methods employ a forward voltage to move a first sample forward from an inlet to an interrogation region in the capillary, then a backward voltage to move the first sample backward, and then a forward voltage again to move the first sample and a second sample forward. Systems and apparatuses for performing capillary electrophoresis are also provided.

    Command Center
    14.
    发明申请
    Command Center 有权

    公开(公告)号：US20210021670A1

    公开(公告)日：2021-01-21

    申请号：US17039647

    申请日：2020-09-30

    申请人： IntegenX Inc.

    发明人： Robert A. Schueren ,  David King ,  Chungsoo Charles Park ,  Arnaldo Barican ,  Charles David Troup

    IPC分类号： H04L29/08 ,  G01N27/447 ,  G16B40/00 ,  G16B50/40 ,  G06F3/01

    摘要： A command center includes at least one network communications interface configured for two-way communications with a plurality of sites remote from the command center and at least one display screen and user interface. Each of the plurality of sites includes at least one forensic field test device configured to identify individuals using DNA samples from the individuals. The display screen and user interface are configured to depict aspects of forensic field test devices of the plurality of sites, wherein the aspects include a site identifier for each of the forensic field test devices and one or more additional aspects.

    Valved cartridge and system
    15.
    发明授权
    Valved cartridge and system 有权

    公开(公告)号：US10767225B2

    公开(公告)日：2020-09-08

    申请号：US16264389

    申请日：2019-01-31

    申请人： IntegenX, Inc.

    发明人： Philip Justus Wunderle ,  Chungsoo Charles Park ,  David King ,  Dennis Lehto

    IPC分类号： C12Q1/6874 ,  C12Q1/686 ,  B01L3/00 ,  F16K99/00 ,  B01L7/00 ,  B01F13/00 ,  B01F13/02

    摘要： This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.

    UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM
    17.
    发明申请
    UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 有权
    通用样品制备系统及其在综合分析系统中的应用

    公开(公告)号：US20140170645A1

    公开(公告)日：2014-06-19

    申请号：US13967957

    申请日：2013-08-15

    申请人： IntegenX Inc.

    发明人： Stevan B. Jovanovich ,  William D. Nielsen ,  David S. Cohen ,  Michael Recknor ,  Mattias Vangbo ,  Ezra Van Gelder ,  Lars Majlof ,  Omar El-Sissi

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6806 ,  G01J3/4406 ,  G01N1/31 ,  G01N1/405 ,  G01N21/64 ,  G01N27/44721 ,  G01N27/44791 ,  G01N27/745 ,  G01N35/00029 ,  G01N2035/00148 ,  G01N2035/00247 ,  G01N2201/06113 ,  G01N2201/062 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/25 ,  Y10T436/2575

    摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

    摘要翻译： 本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。 例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。 该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。 在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。 在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。 墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。 该系统适合不超过10英尺3的外壳。 并且可以是封闭的，便携式的和/或电池供电的系统。 该系统可用于在不到4小时内从原始样品进行分析。

    Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis
    18.
    发明申请
    Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis 审中-公开
    电泳中多色，异相检测的方法和装置

    公开(公告)号：US20140065628A1

    公开(公告)日：2014-03-06

    申请号：US13966252

    申请日：2013-08-13

    申请人： IntegenX Inc.

    发明人： Ezra Van Gelder ,  Stephen J. Williams

    IPC分类号： G01N27/447

    CPC分类号： G01N27/44721 ,  G01N27/44726 ,  G01N27/44791

    摘要： The disclosure provides methods and devices for separating and detecting nucleic acid fragments labeled with a plurality of spectrally resolvable dyes using a single light source or multiple light sources. Use of a greater number of light sources increases the number of spectrally resolvable dyes that can be interrogated. Labeling fragments with a greater number of spectrally resolvable dyes permits more overlapping of fragments with differentiation of the fragments, and thus separation can be conducted on a smaller range of fragment sizes/lengths. To improve the detection sensitivity of a detection system employing multiple light sources, light emitted by the light sources can be spatially separated from one another and/or the intensity of each of the light sources can be modulated. Each of the one or more light sources can be, e.g., a laser or a light-emitting diode. The methods and devices of the disclosure are useful for performing genetic analysis, e.g., analysis of a plurality of STR markers utilized in a forensic database (e.g., CODIS) to identify humans.

    摘要翻译： 本公开提供了用于使用单个光源或多个光源分离和检测用多个可光谱可分辨染料标记的核酸片段的方法和装置。 使用更多数量的光源可增加可询问的光谱可分辨染料的数量。 具有更多数量的光谱可分辨染料的标记片段允许具有片段分化的片段更多的重叠，因此可以在更小的片段大小/长度范围上进行分离。 为了提高使用多个光源的检测系统的检测灵敏度，光源发射的光可以在空间上彼此分离和/或可以调制每个光源的强度。 一个或多个光源中的每一个可以是例如激光器或发光二极管。 本公开的方法和装置可用于进行遗传分析，例如分析在法医数据库（例如，CODIS）中使用的多个STR标记以鉴定人。