公开(公告)号：US09215985B2

公开(公告)日：2015-12-22

申请号：US14111248

申请日：2012-04-10

Applicant: Malte Gross ,  Pascal Kopperschmidt ,  Andreas Maierhofer ,  Alfred Gagel

Inventor： Malte Gross ,  Pascal Kopperschmidt ,  Andreas Maierhofer ,  Alfred Gagel

IPC: G01N21/00 ,  A61B5/00 ,  A61M1/36 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/64 ,  G01N21/65

CPC classification number: A61B5/0082 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/14557 ,  A61M1/367 ,  G01N21/6486 ,  G01N21/65

Abstract: A method of monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration and/or peritoneal dialysis, that includes the steps of irradiating a sample of a dialysis liquid used in the treatment with irradiation light of at least a first irradiation wavelength, detecting light emitted by the irradiated sample in at least a first detection wavelength, the detection wavelength being different from the first irradiation wavelength, and determining the presence and/or concentration of at least one analyte in the sample on the basis of the detected light.

Abstract translation: 一种监测患者治疗的方法，优选用于监测血液透析，血液透析滤过和/或腹膜透析，其包括以下步骤：用至少第一照射波长的照射光照射用于治疗的透析液样品，检测 由至少第一检测波长的被照射样品发射的光，检测波长不同于第一照射波长，并且基于检测到的光来确定样品中至少一种分析物的存在和/或浓度。

公开(公告)号：US08747663B2

公开(公告)日：2014-06-10

申请号：US11128088

申请日：2005-05-11

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: B01D21/24 ,  B01D24/38

CPC classification number: A61M1/342 ,  A61B5/02141 ,  A61B5/7225 ,  A61B5/7257 ,  A61M1/1601 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3465 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3658 ,  A61M2205/3355 ,  A61M2205/702 ,  A61M2230/30

Abstract: The invention relates to a process for monitoring the supply of substitution fluid upstream or downstream of a dialyser or filter arranged in an extracorporeal blood stream. One embodiment provides, for the detection of predilution or postdilution, for measuring the pressure in the blood stream downstream of the dialyser or filter, predilution or postdilution being recognized on the basis of the change in pressure following the shutting off and/or starting up of the substituate pump provided for conveying the substitution fluid. Another embodiment provides for recognizing predilution or postdilution on the basis of the comparison of the oscillating pressure signal attributable to the substituate pump to a characteristic reference signal. The characteristic reference signal to which the pressure signal of the substituate pump is compared is preferably the oscillating pressure signal of a blood pump arranged in the blood stream for conveying the blood upstream of the dialyser or filter. In addition, the invention relates to an extracorporeal blood treatment device with a facility for detecting predilution or postdilution, which device operates according to the processes detailed above.

Abstract translation: 本发明涉及一种用于监测布置在体外血流中的透析器或过滤器上游或下游的置换液的供给的方法。 一个实施方案提供了用于检测预稀释或后稀释用于测量透析器或过滤器下游的血流中的压力，根据在关闭和/或启动后的压力变化来识别预稀释或后稀释 提供用于输送替代流体的替代泵。 另一个实施例提供了基于归因于替代泵的振荡压力信号与特征参考信号的比较来识别预稀释或后稀释。 比较替代泵的压力信号的特征参考信号优选是布置在用于输送透析器或过滤器上游的血液的血液中的血液泵的振荡压力信号。 此外，本发明涉及具有检测预稀释或后稀释的设备的体外血液处理装置，该装置根据上述方法进行操作。

公开(公告)号：US08439857B2

公开(公告)日：2013-05-14

申请号：US13130116

申请日：2009-11-14

Applicant: Pascal Kopperschmidt ,  Malte Gross ,  Reiner Spickermann

Inventor： Pascal Kopperschmidt ,  Malte Gross ,  Reiner Spickermann

IPC: A61M37/00 ,  A61B5/02

CPC classification number: A61B5/02042 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/18 ,  A61M2205/3331

Abstract: A method and a device for recognition of paravasal bleeding upon a supplying of blood to a vascular access via a line and/or upon the removal of blood from a vascular access via a line is provided. A device for extracorporeal blood treatment comprising a device for recognition of paravasal bleeding is also provided. The method and the device are based on the change of arterial pressure in the arterial branch or the venous pressure in the venous branch of the extra-corporeal circuit being registered during the extracorporeal blood treatment. One aspect of the method and the device is that pressure changes that come from a pressure level exhibiting a large difference from a reference value are more strongly considered than those that come from a pressure level that exhibits only a minor difference from the reference value.

Abstract translation: 提供了一种方法和装置，用于在通过管线向血管通路供血时和/或通过管线从血管通路中取出血液来供应血液，以识别旁路出血。 还提供了一种用于体外血液处理的装置，其包括用于识别paravasal出血的装置。 该方法和装置基于在体外血液处理期间记录的动脉分支中的动脉压的变化或在体外循环的静脉分支中的静脉压。 该方法和装置的一个方面是，从与参考值相比仅显示较小差异的压力水平的压力水平的压力变化更强烈地考虑来自与参考值的差异较大的压力水平的压力变化。

公开(公告)号：US20130056418A1

公开(公告)日：2013-03-07

申请号：US13599028

申请日：2012-08-30

Applicant: Pascal KOPPERSCHMIDT ,  Alfred GAGEL

Inventor： Pascal KOPPERSCHMIDT ,  Alfred GAGEL

IPC: A61M1/16

CPC classification number: A61M1/16 ,  A61M1/1605 ,  A61M1/1615 ,  A61M1/36 ,  A61M1/3609 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3368 ,  A61M2205/50

Abstract: Method and apparatus for controlling the dialysate flow in a dialysis device. A change of the value of a control factor, caused by a variation of a property of the dialysate or of the blood or by a change of the dialysate flow, is determined in order to control the dialysate flow. The control factor is a measure for the exchange of substances via the dialyzer and thus the effectiveness of the dialyzer. If the change of the value of the control factor exceeds a limit, the dialysate flow is increased. On the other hand, the dialysate flow is reduced if the change of the value of the control factor falls short of the limit range.

Abstract translation: 用于控制透析装置中透析液流动的方法和装置。 为了控制透析液流动，确定由透析液或血液的性质的变化或透析液流的变化引起的控制因素的变化。 控制因子是通过透析器交换物质的方法，因此是透析器的有效性。 如果控制因素的值的变化超过限制，则增加透析液流量。 另一方面，如果控制因素的值的变化低于极限范围，则透析液流量减少。

公开(公告)号：US20120318739A1

公开(公告)日：2012-12-20

申请号：US13512133

申请日：2010-11-16

Applicant: Pascal Kopperschmidt ,  Alfred Gagel

Inventor： Pascal Kopperschmidt ,  Alfred Gagel

IPC: A61M1/16 ,  B01D61/32

CPC classification number: A61M1/342 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1603 ,  A61M1/1613 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3635 ,  A61M2205/3334 ,  B01D61/243 ,  B01D61/28 ,  B01D61/32 ,  B01D2311/14 ,  B01D2311/16

Abstract: The present invention relates to a method for regulating supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. Moreover, the present invention relates to an extracorporeal blood treatment apparatus having a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete.

Abstract translation: 本发明涉及一种用体外血液处理装置调节供体取代物的方法，所述体外血液处理装置包括由半透膜分隔成血液室的透析器和透析液室以及用于供给取代基的装置。 此外，本发明涉及具有用于调节供体的装置的体外血液处理装置。 对体外血液治疗中取代基的供应调节作为透析器流变负荷的函数。 为了调节体外血液处理中取代基的供应，透析器的流变学载量由透析器上的跨膜压力和透析器的流动阻力确定，并且根据负载增加或降低取代率。 因此，不再需要选择透析器参数或血液参数，并且预稀释和稀释后的区别也被淘汰。

公开(公告)号：US20100168640A1

公开(公告)日：2010-07-01

申请号：US12086593

申请日：2007-03-06

Applicant: Pascal Kopperschmidt ,  Joachim Noack

Inventor： Pascal Kopperschmidt ,  Joachim Noack

IPC: A61M1/16

CPC classification number: A61M1/3643 ,  A61M1/1682 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/365 ,  A61M1/3652

Abstract: The invention relates to a method and a hemodialysis machine for at least partial emptying of an extracorporeal blood circulation after the blood of a patient in the extracorporeal blood circulation has been returned to the patient with the help of an infusion liquid which displaces the blood and after the patient has been separated from the extracorporeal blood circulation. The object of the invention is to empty at least the blood chamber of a hemodialyzer (1) that is subdivided by a semipermeable membrane (2) into a blood chamber (3) and a dialysis fluid chamber (4) without additionally connecting the arterial blood line (5) and the venous blood line (7) of the extracorporeal blood circulation to one another. To do so, the arterial blood line (5) is actively or passively aerated at a first point (50) and/or the venous blood line (7) is actively or passively aerated at a second point (40) and the liquid is emptied through the semipermeable membrane (2) into the dialysis fluid chamber (4) and a dialysis fluid discharge line (21) leaving this chamber. The inventive method can take place here through a control program that runs automatically in the control unit (30) of a hemodialysis machine without requiring special operating steps by the operating person after activation of the program.

Abstract translation: 本发明涉及一种方法和血液透析机，用于在体外血液循环中的患者的血液已经借助置换血液的输注液体返回给患者之后至少部分排空体外血液循环，并且之后 病人已经与体外血液循环分离。 本发明的目的是至少将由半透膜（2）细分的血液透析器（1）的血液室排空到血液室（3）和透析液室（4）中，而不需要额外连接动脉血 线（5）和体外血液循环的静脉血液线（7）。 为此，动脉血液管线（5）在第一点（50）处被主动地或被动地通气，和/或静脉血液管线（7）在第二点（40）被主动地或被动地充气并且液体被排空 通过半透膜（2）进入透析液室（4）和离开该室的透析液排出管（21）。 本发明的方法可以通过在血液透析机的控制单元（30）中自动运行的控制程序进行，而不需要操作者在程序激活之后的特殊操作步骤。

公开(公告)号：US20090152179A1

公开(公告)日：2009-06-18

申请号：US12085680

申请日：2006-07-14

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: B01D35/14 ,  B01D35/143

Abstract: This invention relates to a method for clearing a wetted hydrophobic filter, in which in a first step the air permeability of the hydrophobic filter is monitored and in which in a second step the hydrophobic filter is cleared by means of a connected air pump, if it is detected that the hydrophobic filter is clogged. Furthermore, the invention relates to an apparatus for performing this method.

Abstract translation: 本发明涉及一种清洗湿润疏水性过滤器的方法，其中在第一步骤中监测疏水性过滤器的透气性，并且在第二步骤中，通过连接的空气泵将疏水性过滤器清除，如果 检测到疏水性过滤器堵塞。 此外，本发明涉及一种用于执行该方法的装置。

公开(公告)号：US20090053083A1

公开(公告)日：2009-02-26

申请号：US12282544

申请日：2007-03-01

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: F04B43/12

CPC classification number: A61M1/16 ,  F04B43/0081 ,  F04B43/12 ,  F04B51/00 ,  F04B2201/1203 ,  F04B2207/70

Abstract: The invention relates to a method and to a device for operating an electric peristaltic hose pump, in particular a hose pump for transporting fluids in medical-technical devices, in particular extracorporeal blood treatment devices. In order to monitor the regular operation of a hose pump, the power consumption of the pump or a physical variable in correlation with the power consumption, in particular the pump flow, is monitored. The pump flow includes a periodically non-altering direct component which is superimposed on a periodically altering alternating component. In order to monitor the regular operation of the hose pump, the alternating component of the power consumption in relation to the direct component of the power consumption is monitored as whether it increases and/or decreases during blood treatment.

Abstract translation: 本发明涉及一种用于操作电动蠕动软管泵的方法和装置，特别是用于在医疗技术装置中输送流体的软管泵，特别是体外血液处理装置。 为了监测软管泵的常规操作，监测泵的功率消耗或与功率消耗特别是泵流量相关的物理变量。 泵流包括周期性地不改变的直接分量，其被叠加在周期性变化的交替分量上。 为了监视软管泵的常规操作，监测与功耗的直接分量相关的功率消耗的交替分量，以及在血液处理期间是否增加和/或减少。

公开(公告)号：US10744466B2

公开(公告)日：2020-08-18

申请号：US12085680

申请日：2006-07-14

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: B01D35/14 ,  B01D35/143 ,  B01D65/10 ,  A61M1/36 ,  B01D65/02

Abstract: A method for clearing a wetted hydrophobic filter includes a first step in which the air permeability of the hydrophobic filter is monitored, and a second step in which the hydrophobic filter is cleared by means of a connected air pump, if it is detected that the hydrophobic filter is clogged. An apparatus for performing this method includes a pressure sensor and an air pump connected to an air separation chamber via a conduit, and a control and monitoring unit configured to actuate the air pump in order to clear the hydrophobic filter.

公开(公告)号：US09005153B2

公开(公告)日：2015-04-14

申请号：US13059249

申请日：2009-08-14

Applicant: Pascal Kopperschmidt ,  Reiner Spickermann

Inventor： Pascal Kopperschmidt ,  Reiner Spickermann

IPC: A61M37/00 ,  F04B43/12 ,  A61M1/16 ,  F04B43/00 ,  A61M1/10

CPC classification number: F04B43/12 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3607 ,  A61M2205/3331 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/702 ,  F04B43/0081 ,  F04B2201/1203

Abstract: The invention further relates to an apparatus and method for monitoring a peristaltic hose pump, in particular a peristaltic hose pump of an extracorporeal blood treatment device. The power consumed by the pump and/or the pressure in the tubing segment upstream or downstream of the pump is/are measured during operation of the pump and test signals I1(t), I2(t) which are associated with the individual displacement members are determined. The power or pressure signals associated with the individual displacement members significantly differ from each other during abnormal operation of the hose pump, but no significant differences can be recognized during normal operation of the pump.

Abstract translation: 本发明还涉及一种用于监测蠕动软管泵，特别是体外血液处理装置的蠕动软管泵的装置和方法。 在泵的运行期间测量泵所消耗的功率和/或泵上游或下游的管段中的压力，并且与各个位移构件相关联的测试信号I1（t），I2（t） 确定。 与各个位移构件相关联的动力或压力信号在软管泵的异常操作期间彼此显着不同，但是在泵的正常操作期间不能识别出明显的差异。