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公开(公告)号：US5403415A
公开(公告)日：1995-04-04
申请号：US154222
申请日：1993-11-17
申请人： Carol Schembri
发明人： Carol Schembri
CPC分类号： B29C65/08 , B29C66/73921 , B29C66/80 , B29C66/71 , B29C66/9513
摘要： A method and a device for modifying the energy-applying surface of an ultrasonic welding horn to join two complex thermoplastic parts by applying a thin film to the surface of the horn is disclosed. The thin film is applied to insure that a proper weld occurs along a complex and intricate pattern of energy directors located between the parts.
摘要翻译： 公开了一种用于通过将薄膜施加到喇叭表面来改变超声焊接喇叭的能量施加表面以连接两个复合热塑性部件的方法和装置。 应用薄膜来确保位于两个部件之间的复杂且复杂的能量导向器的适当焊接发生。
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12.发明申请Devices and Methods for Controlling Bubble Formation in Microfluidic Devices 审中-公开用于控制微流控装置中气泡形成的装置和方法公开(公告)号：US20070280856A1
公开(公告)日：2007-12-06
申请号：US11422057
申请日：2006-06-02
申请人： Umberto Ulmanella , Eric S. Nordman , Maengseok Song , Joon Mo Yang , Julie C. Lee , Nigel P. Beard , Min Yue , Carol Schembri , David Liu
发明人： Umberto Ulmanella , Eric S. Nordman , Maengseok Song , Joon Mo Yang , Julie C. Lee , Nigel P. Beard , Min Yue , Carol Schembri , David Liu
IPC分类号： B01L3/02
CPC分类号： B01L3/502746 , B01L3/502723 , B01L3/502784 , B01L2200/0642 , B01L2200/0673 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B01L2400/086
摘要： A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers. At least some of the sample chambers may include a dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.
摘要翻译： 微流体装置可以包括样品分配网络，其包括多个样品室，其被配置为装载用于生物样品的生物样品的生物样品，而在样品室中，生物样品具有在加载期间在样品室内移动的弯液面。 样品分配网络还可以包括多个入口通道，每个入口通道与生物样品流动连通并配置成将生物样品流动到相应的样品室，以及多个出口通道，每个出口通道流动连通并且被配置为 从相应的样品室流动生物样品。 至少一些样品室可以包括物理修改，其被配置为控制弯液面的运动，以便控制至少一些样品室内的气泡形成。 至少一些样品室可以包括位于与至少一些样品室流动连通的入口通道附近的至少一些样品室内的干燥试剂。
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公开(公告)号：US20060141507A1
公开(公告)日：2006-06-29
申请号：US11287808
申请日：2005-11-28
申请人： Mel Kronick , Bernett Saunders , Matthew Marton , John Hinchcliffe , Dianne Rees , Carol Schembri
发明人： Mel Kronick , Bernett Saunders , Matthew Marton , John Hinchcliffe , Dianne Rees , Carol Schembri
CPC分类号： B01L9/52 , B01J2219/00531 , B01J2219/00547 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01L3/508 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , G02B21/34 , Y10T436/25 , Y10T436/2575
摘要： Methods and devices are disclosed for microarray analysis. In one embodiment a method is disclosed for processing a non-standard size slide having an array of chemical compounds attached to a surface of the slide. A sample is exposed to the surface of the non-standard size slide wherein components in the sample bind to the chemical compounds on the surface of the slide. The sample and the slide are incubated under conditions for carrying out the binding reactions, and the surface of the non-standard size slide is examined for the results of the binding reactions. Prior to the exposing step or the incubating step or the examining step, the non-standard size slide is placed into a slide holder comprising a slide-holding section a slide-holding section adapted to dispose the non-standard size slide to a processing instrument in a manner similar to that for a standard size slide. The non-standard size slide may also include an identifier such as a bar code.
摘要翻译： 公开了用于微阵列分析的方法和装置。 在一个实施方案中，公开了一种用于处理具有附着到载玻片的表面的化学化合物阵列的非标尺寸载玻片的方法。 将样品暴露于非标准尺寸载玻片的表面，其中样品中的组分与载玻片表面上的化合物结合。 将样品和载玻片在进行结合反应的条件下孵育，并检查非标准尺寸载玻片的表面的结合反应结果。 在暴露步骤或孵化步骤或检查步骤之前，将非标准尺寸的载玻片放置在载玻片保持器中，滑动保持器包括滑动保持部分，该滑动保持部分适于将非标准尺寸滑块配置到处理器械 以类似于标准尺寸幻灯片的方式。 非标准尺寸的幻灯片还可以包括诸如条形码的标识符。
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公开(公告)号：US20050214854A1
公开(公告)日：2005-09-29
申请号：US11136227
申请日：2005-05-23
申请人： SueAnn Dahm , Arthur Schleifer , Carol Schembri , Douglas Amorese
发明人： SueAnn Dahm , Arthur Schleifer , Carol Schembri , Douglas Amorese
CPC分类号： B01L3/502 , B01L3/5025 , B01L7/00 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/0803 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , Y10T436/2575
摘要： A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
摘要翻译： 用多个生物聚合物阵列测试多个流体样品的方法。 将盖组装到承载在第一侧上的连续基底，多个阵列，每个阵列具有连接到基底的多个生物聚合区域，使得盖和基底一起形成多个腔室，每个腔室包含生物聚合物阵列，并且每个腔室可通过 自己的港口 多个流体样品通过各自的端口引入相应的室中，使得流体样品与相应的阵列接触。 观察到阵列的绑定模式。 还提供了一种在这些方法中有用的装置和试剂盒。
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公开(公告)号：US20050084867A1
公开(公告)日：2005-04-21
申请号：US10687397
申请日：2003-10-15
申请人： Michael Caren , Richard Pittaro , Carol Schembri
发明人： Michael Caren , Richard Pittaro , Carol Schembri
CPC分类号： G01N35/00029 , B01J2219/00326 , B01J2219/0052 , B01J2219/00657 , B01J2219/00702 , C40B60/14 , G01N2035/00049 , G01N2035/00158
摘要： Apparatus and methods are disclosed relating to linear arrays. An embodiment of an apparatus comprises a rotatable support for one or more linear arrays, a mechanism for rotating the support, and a device for examining the linear arrays for the results of chemical reactions. Each of the linear arrays comprises a plurality of features for conducting the chemical reactions. Optionally, the apparatus may comprise a heater for heating the linear arrays. Optionally, the apparatus may comprise a fluid dispensing device for dispensing processing fluids such as, for example, wash solutions.
摘要翻译： 公开了与线性阵列相关的装置和方法。 装置的实施例包括用于一个或多个线性阵列的可旋转支撑件，用于旋转支撑件的机构，以及用于检查用于化学反应结果的线性阵列的装置。 每个线性阵列包括用于进行化学反应的多个特征。 可选地，该装置可以包括用于加热线性阵列的加热器。 可选地，该装置可以包括用于分配处理流体例如洗涤溶液的流体分配装置。
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16.发明申请公开(公告)号：US20070280857A1
公开(公告)日：2007-12-06
申请号：US11422058
申请日：2006-06-02
申请人： Maengseok Song , Joon Mo Yang , Julie C. Lee , Nigel P. Beard , Yuh-Min Chiang , Roy H. Tan , Carol Schembri
发明人： Maengseok Song , Joon Mo Yang , Julie C. Lee , Nigel P. Beard , Yuh-Min Chiang , Roy H. Tan , Carol Schembri
IPC分类号： B01L3/02
CPC分类号： B01L3/502723 , B01L3/502746 , B01L3/502784 , B01L2200/0642 , B01L2200/0673 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B01L2400/086 , C12Q1/6806 , Y10T436/2575
摘要： A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers. At least some of the sample chambers may include a dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.
摘要翻译： 微流体装置可以包括样品分配网络，其包括多个样品室，其被配置为装载用于生物样品的生物样品的生物样品，而在样品室中，生物样品具有在加载期间在样品室内移动的弯液面。 样品分配网络还可以包括多个入口通道，每个入口通道与生物样品流动连通并配置成将生物样品流动到相应的样品室，以及多个出口通道，每个出口通道流动连通并且被配置为 从相应的样品室流动生物样品。 至少一些样品室可以包括物理修改，其被配置为控制弯液面的运动，以便控制至少一些样品室内的气泡形成。 至少一些样品室可以包括位于与至少一些样品室流动连通的入口通道附近的至少一些样品室内的干燥试剂。
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公开(公告)号：US20060281193A1
公开(公告)日：2006-12-14
申请号：US11148623
申请日：2005-06-09
申请人： John Petrilla , Carol Schembri , Peter Robrish
发明人： John Petrilla , Carol Schembri , Peter Robrish
IPC分类号： C12M1/34 , G01N33/558
CPC分类号： G01N33/558
摘要： A test zone is read. Conjugate material is exposed to a sample. The conjugate material, when conjugated with at least one analyte in the sample, forms either electrically detectable conjugated material or magnetically detectable conjugated material. Conjugated material in the sample is captured in a test zone. A test is performed on the conjugated material captured in the test zone in order to detect analyte in the sample. The test is an electrical measurement, or a magnetic measurement.
摘要翻译： 读取测试区。 共轭材料暴露于样品。 当共轭材料与样品中的至少一种分析物共轭时，形成电可检测的共轭材料或磁性可检测的共轭材料。 样品中的共轭材料被捕获在测试区域中。 对在测试区中捕获的共轭材料进行测试，以便检测样品中的分析物。 测试是电测量或磁测量。
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公开(公告)号：US20060223194A1
公开(公告)日：2006-10-05
申请号：US11097035
申请日：2005-04-01
IPC分类号： G01N33/558
CPC分类号： G01N33/6842
摘要： The invention provides methods of analyzing a sample. In general, the methods involve: a) depositing sub-fractions of a multi-dimensionally fractionated sample into wells of a multi-well substrate; b) contacting each of the deposited sub-fractions with an array to produce a set of sub-fraction-contacted arrays; and c) interrogating the sub-fraction-contacted arrays to identify a sub-fraction containing a post-translationally modified analyte. Also provided are systems and kits for performing the subject methods.
摘要翻译： 本发明提供了分析样品的方法。 通常，所述方法包括：a）将多维分级样品的次级级分沉积到多孔底物的孔中; b）将每个沉积的子级分与阵列接触以产生一组次级部分接触的阵列; 和c）询问子级分接触的阵列以鉴定含有翻译后修饰的分析物的亚级分。 还提供了用于执行主题方法的系统和套件。
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公开(公告)号：US20050186598A1
公开(公告)日：2005-08-25
申请号：US11030391
申请日：2005-01-05
申请人： Carol Schembri , Kimberly Tam
发明人： Carol Schembri , Kimberly Tam
CPC分类号： B01L9/52 , B01L2300/0819 , B01L2300/0822 , Y10T436/112499
摘要： A method of reading an array of moieties such as polynucleotides (for example, DNA) on at least a portion of a surface of a transparent slide which is opposite a first portion on the opposing surface, which array has been previously exposed to a sample. The method may include mounting the slide on a slide holder and retaining the slide thereon in a mounted position in which the holder does not contact the previously exposed array. The holder is then inserted into an array reader and the array read. A holder and slides which can be used in the method are also provided.
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公开(公告)号：US20050116986A1
公开(公告)日：2005-06-02
申请号：US10952234
申请日：2004-09-27
申请人： Michael Caren , Carol Schembri
发明人： Michael Caren , Carol Schembri
CPC分类号： B41J2/1707 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , B41J2/16552 , C40B40/06 , C40B60/14
摘要： A method is described for removing residue from a fluid deposited on the interior surface of an inkjet printhead after the printhead has contained or dispensed the fluid at least once. The method makes use of a reverse flushing technique optionally used in combination with sonication. A cleaning station for flushing an inkjet printhead with a wash fluid, rinse fluid, and/or inert gas is provided as well.
摘要翻译： 描述了一种用于在打印头已经包含或分配流体至少一次之后从沉积在喷墨打印头的内表面上的流体去除残留物的方法。 该方法利用可选地与超声波结合使用的反冲洗技术。 还提供了用于冲洗具有洗涤流体，冲洗流体和/或惰性气体的喷墨打印头的清洁站。
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