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公开(公告)号：US20180017584A1
公开(公告)日：2018-01-18
申请号：US15648104
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc.
Inventor： Daniel Levner , Christopher David Hinojosa , Noeman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20180017583A1
公开(公告)日：2018-01-18
申请号：US15648029
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20180017582A1
公开(公告)日：2018-01-18
申请号：US15648000
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, INC.
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20180015455A1
公开(公告)日：2018-01-18
申请号：US15648049
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US12298320B2
公开(公告)日：2025-05-13
申请号：US17538518
申请日：2021-11-30
Applicant: EMULATE, Inc.
Inventor： Josiah Sliz , Daniel Levner , Brian Zuckerman , Norman Wen , Jonathan Rubins , Tanvi Shroff , Christopher David Hinojosa , Grace Ahn , Victor Antontsev , Jefferson Puerta , David Conegliano , S. Jordan Kerns
Abstract: The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.
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Patent Agency Ranking
公开(公告)号：US12098352B2
公开(公告)日：2024-09-24
申请号：US16983850
申请日：2020-08-03
Applicant: EMULATE, INC.
Inventor： Janna Nawroth , Riccardo Barrile , David Conegliano , Remi Villenave , Carolina Lucchesi , Justin Nguyen , Antonio Varone , Catherine Karalis , Geraldine Hamilton
CPC classification number: C12M23/16 , B01L3/5027 , C12N5/0688 , C12N5/0696 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/155 , C12N2501/41 , C12N2502/1323 , C12N2502/27 , C12N2503/04 , C12N2506/02 , C12N2513/00 , G01N2800/12
Abstract: An in vitro microfluidic “organ-on-chip” device is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a stem cell-based Lung-on-Chip is described. This in vitro microfluidic system can be used for modeling differentiation of cells on-chip into lung cells, e.g., a lung (Lung-On-Chip), bronchial (Airway-On-Chip; small-Airway-On-Chip), alveolar sac (Alveolar-On-Chip), etc., for use in modeling disease states of derived tissue, i.e. as healthy, pre-disease and diseased tissues. Additionally, stem cells under differentiation protocols for deriving (producing) differentiated lung cells off-chips may be seeded onto microfluidic devices at any desired point during the in vitro differentiation pathway for further differentiation on-chip or placed on-chip before, during or after terminal differentiation.
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公开(公告)号：US11150255B2
公开(公告)日：2021-10-19
申请号：US15648182
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
IPC: G01N33/00 , G01N33/86 , B01L3/00 , C12M3/06 , C12M1/00 , C12M1/42 , C12M1/34 , G01N33/543 , G01N33/80
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20210115406A1
公开(公告)日：2021-04-22
申请号：US17088828
申请日：2020-11-04
Applicant: EMULATE, INC.
Inventor： S. Jordan Kerns , Catherine Karalis , Janna Nawroth , Remi Villenave , Jenifer Obrigewitch , Doris Roth , Michael Salmon , Athanasia Apostolou , David Conegliano
Abstract: The present invention relates to a combination of microbes, cell culture systems and microfluidic fluidic systems for use in providing a human Intestine On-Chip with optimal intestinal motility. More specifically, in some embodiments, a microfluidic chip containing intestinal epithelial cells co-cultured with intestinal endothelial cells in the presence of bacteria, such as probiotic bacteria, may find use in providing an Intestine-On-Chip for testing intestinal motility function. In some embodiments, an Intestine On-Chip may be used for identifying (testing) therapeutic compounds continuing probiotic microbes or compounds for inducing intestinal motility for use in treating gastrointestinal disorders or diseases related to intestinal function.
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公开(公告)号：US10852311B2
公开(公告)日：2020-12-01
申请号：US15648029
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US10228381B2
公开(公告)日：2019-03-12
申请号：US15648085
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
IPC: B01L3/00 , G01N33/50 , G01N33/569 , C12M1/00 , C12M3/00 , G01N33/86 , C12M3/06 , C12M1/42 , C12M1/34 , G01N33/543 , G01N35/08
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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