公开(公告)号：US10426383B2

公开(公告)日：2019-10-01

申请号：US13779584

申请日：2013-02-27

Applicant: Medtronic MiniMed, Inc.

Inventor： Ting Huang ,  Ashwin K. Rao ,  Rajiv Shah ,  Qingling Yang

IPC: A61B5/145 ,  A61B5/1477

Abstract: The invention disclosed herein includes amperometric glucose sensors having electrodes formed from processes that electrodeposit platinum black in a manner that produces relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

公开(公告)号：US20170290535A1

公开(公告)日：2017-10-12

申请号：US15478126

申请日：2017-04-03

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ashwin K. Rao ,  David C. Antonio ,  Eric Allan Larson ,  Jose J. Ruelas ,  Sukhjeet S. Ranauta ,  Chia-Hung Chiu ,  Rebecca K. Gottlieb ,  Peter Schultz

IPC: A61B5/145 ,  A61M5/172 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/14503 ,  A61B5/6833 ,  A61B5/742 ,  A61B5/746 ,  A61B2562/166 ,  A61M5/1723

Abstract: A simple sensing device includes a case with one or more indicators to indicate levels of an analyte such as glucose. The sensing device for self-monitoring an analyte includes a single, flexible case adapted to adhere to a skin of a patient. It also includes a printed circuit board assembly inside the case. It further includes a first sensor extending from the flexible case and electrically coupled to the printed circuit board, and one or more indicators in the flexible case, where the indicator(s) are adapted to indicate whether a level of an analyte is within a normal range.

公开(公告)号：US20240158827A1

公开(公告)日：2024-05-16

申请号：US18480790

申请日：2023-10-04

Applicant: Medtronic MiniMed, Inc.

Inventor： Qingling Yang ,  Ashwin K. Rao ,  Hanieh Ghadimi

IPC: C12Q1/00

CPC classification number: C12Q1/006 ,  C12Q1/004

Abstract: Embodiments of the invention provide amperometric analyte sensors having elements selected to optimize enzymatic activities associated with such sensors including polymers functionalized with enzymatic mediators as well as methods for making and using such sensors. While embodiments of the invention can be used in a variety of contexts, typical embodiments of the invention include glucose or ketone sensors used in the management of diabetes.

公开(公告)号：US20240065585A1

公开(公告)日：2024-02-29

申请号：US18366299

申请日：2023-08-07

Applicant: Medtronic MiniMed, Inc.

Inventor： Quyen B. Ong ,  Michal Galik ,  Hanieh Ghadimi ,  Carlos E. Maldonado ,  Ashwin K. Rao ,  Robert C. Mucic

IPC: A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/14546 ,  A61B5/14532 ,  A61B5/1486 ,  A61B2562/125

Abstract: The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.

公开(公告)号：US20230123613A1

公开(公告)日：2023-04-20

申请号：US17501292

申请日：2021-10-14

Applicant: Medtronic MiniMed, Inc.

Inventor： Ashwin K. Rao ,  Quyen B. Ong ,  Michael E. Miller ,  Sarnath Chattaraj ,  Guangping Zhang ,  Poonam Gulati ,  Ariel Reider ,  Mohsen Askarinya ,  Michael N. Missaghi ,  Chi-En Lin ,  Xin Heng ,  Inthirai Somasuntharam ,  Melissa Tsang ,  Carlos E. Maldonado ,  Akhil Srinivasan

IPC: G01N27/327 ,  C12N9/04 ,  C12Q1/00 ,  G01N33/49

Abstract: The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.

公开(公告)号：US20220387723A1

公开(公告)日：2022-12-08

申请号：US17342449

申请日：2021-06-08

Applicant: Medtronic MiniMed, Inc.

Inventor： Ellis Garai ,  Ashwin K. Rao

IPC: A61M5/315

Abstract: A medicine delivery and tracking system includes a medicine injection pen and a delivery port. The pen includes a needle through which medicine is dispensed and an electronic unit configured to at least one of log dispensing of medicine from the pen, control dispensing of medicine from the pen, or communicate regarding dispensing of medicine from the pen. Alternatively, the electronic unit may be part of a separate computing device. The delivery port is configured for attachment to a user and to receive the needle of the pen such that medicine dispensed from the pen is dispensed into the delivery port and through the delivery port to the user. The delivery port includes a detector mechanism configured to detect a presence of the pen and, in response thereto, to communicate a signal to the electronic unit for use in the at least one of logging, controlling, or communicating.

公开(公告)号：US20220240823A1

公开(公告)日：2022-08-04

申请号：US17162885

申请日：2021-01-29

Applicant: Medtronic MiniMed, Inc.

Inventor： Ashwin K. Rao ,  Qingling Yang ,  Ellis Garai ,  Daniel E. Pesantez

IPC: A61B5/1486 ,  A61B5/145

Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as interference rejection membranes, and associated architectures, as well as methods for making and using such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US09265455B2

公开(公告)日：2016-02-23

申请号：US13675813

申请日：2012-11-13

Applicant: Medtronic MiniMed, Inc.

Inventor： Rebecca K. Gottlieb ,  Chia-Hung Chiu ,  Ashwin K. Rao

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/055 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/1486 ,  G01N27/327 ,  G01N27/416

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/055 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/742 ,  A61B2560/0204 ,  A61B2560/0223 ,  G01N27/3274 ,  G01N27/4163

Abstract: A method is provided for initializing an analyte sensor, such as a glucose sensor. Where a sensor has been disconnected and reconnected, a disconnection time is determined and a sensor initialization protocol is selected based upon the disconnection time. The sensor initialization protocol may include applying a first series of voltage pulses to the sensor. A method for detecting hydration of a sensor is also provided.

Abstract translation: 提供了用于初始化诸如葡萄糖传感器的分析物传感器的方法。 在传感器断开连接并重新连接的情况下，确定断开时间，并根据断开时间选择传感器初始化协议。 传感器初始化协议可以包括将第一系列电压脉冲施加到传感器。 还提供了用于检测传感器的水合的方法。

公开(公告)号：US20250152058A1

公开(公告)日：2025-05-15

申请号：US19019985

申请日：2025-01-14

Applicant: Medtronic MiniMed, Inc.

Inventor： Ellis Garai ,  Jenn-Hann L. Wang ,  Ashwin K. Rao

IPC: A61B5/1486 ,  A61B5/145 ,  A61K31/573

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

公开(公告)号：US12201421B2

公开(公告)日：2025-01-21

申请号：US17497441

申请日：2021-10-08

Applicant: Medtronic MiniMed, Inc.

Inventor： Ellis Garai ,  Jenn-Hann L. Wang ,  Ashwin K. Rao

IPC: A61B5/1486 ,  A61B5/145 ,  A61K31/573

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.