公开(公告)号：US11654235B2

公开(公告)日：2023-05-23

申请号：US16569401

申请日：2019-09-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Akhil Srinivasan ,  Peter Ajemba ,  Steven C. Jacks ,  Robert C. Mucic ,  Tyler R. Wong ,  Melissa Tsang ,  Chi-En Lin ,  Mohsen Askarinya ,  David Probst

IPC: A61B5/1495 ,  A61B5/145 ,  A61M5/172 ,  A61M5/142 ,  A61B5/00 ,  G16H20/17

CPC classification number: A61M5/1723 ,  A61B5/1495 ,  A61B5/14532 ,  A61M5/14244 ,  A61B5/145 ,  A61B5/4839 ,  A61B2560/0223 ,  A61B2560/0228 ,  A61B2560/0238 ,  A61M2005/14208 ,  G16H20/17

Abstract: Medical devices and related systems and methods are provided. A method of calibrating an instance of a sensing element involves obtaining fabrication process measurement data from a substrate having the instance of the sensing element fabricated thereon, obtaining a calibration model associated with the sensing element, determining calibration data associated with the instance of the sensing element for converting the electrical signals into a calibrated measurement parameter based on the fabrication process measurement data using the calibration model, and storing the calibration data in a data storage element associated with the instance of the sensing element.

公开(公告)号：US11583213B2

公开(公告)日：2023-02-21

申请号：US15892162

申请日：2018-02-08

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Akhil Srinivasan ,  Barry P. Pham ,  Robert C. Mucic ,  Tyler R. Wong

IPC: A61B5/1486 ,  A61B5/145 ,  G01N33/66 ,  A61B5/00 ,  A61B5/1468

Abstract: A single flex double-sided electrode useful in a continuous glucose monitoring sensor. In one example, a counter electrode is placed on the back-side of the flex and a work electrode is placed on the top-side of the sensor flex. The electrode is fabricated on physical vapor deposited metal deposited on a base substrate. Adhesion of the electrode to the base substrate is carefully controlled so that the electrode can be processed on the substrate and subsequently removed from the substrate after processing.

公开(公告)号：US20190094169A1

公开(公告)日：2019-03-28

申请号：US16200337

申请日：2018-11-26

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Qingling Yang ,  Robert C. Mucic ,  Jenn-Hann Larry Wang

IPC: G01N27/327 ,  C12Q1/00

Abstract: The invention pertains to analyte sensors designed to include layered compositions that provide these sensors with enhanced functional and/or material properties including, for example, resistance to damage caused by ethylene oxide during sterilization processes. Embodiments of the invention include polyvinyl alcohol N-methyl-4(4′-formylstyryl)pyridinium (SbQ) polymer materials and methods for employing such materials during the ethylene oxide sterilization of glucose sensors.

公开(公告)号：US20240065585A1

公开(公告)日：2024-02-29

申请号：US18366299

申请日：2023-08-07

Applicant: Medtronic MiniMed, Inc.

Inventor： Quyen B. Ong ,  Michal Galik ,  Hanieh Ghadimi ,  Carlos E. Maldonado ,  Ashwin K. Rao ,  Robert C. Mucic

IPC: A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/14546 ,  A61B5/14532 ,  A61B5/1486 ,  A61B2562/125

Abstract: The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.

公开(公告)号：US20200337642A1

公开(公告)日：2020-10-29

申请号：US16392527

申请日：2019-04-23

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ellis Garai ,  David Choy ,  David C. Antonio ,  Robert C. Mucic

IPC: A61B5/00 ,  H05K1/02 ,  H05K1/11 ,  H05K1/18 ,  H05K3/34 ,  H05K3/36 ,  H05K1/14 ,  H01Q9/04 ,  H05K7/14 ,  H05K5/02 ,  A61B5/145

Abstract: A physiological characteristic sensor assembly includes a flexible top housing including a needle port having a central opening, and a flexible lower housing defining a sensor bore through the lower housing, the sensor bore coaxial with the central opening of the needle port. The physiological characteristic sensor assembly also includes an electrical subsystem disposed between the top housing and the lower housing. The electrical subsystem includes a flexible printed circuit board having a sensor contact pad, a physiological characteristic sensor and an electrically conductive adhesive patch. The physiological characteristic sensor has a distal end that extends through the needle port and a proximal end that includes at least one electrical contact. The conductive adhesive patch electrically and physically couples the at least one electrical contact of the physiological characteristic sensor to the sensor contact pad of the flexible printed circuit board.

公开(公告)号：US20190239778A1

公开(公告)日：2019-08-08

申请号：US15892162

申请日：2018-02-08

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Akhil Srinivasan ,  Barry P. Pham ,  Robert C. Mucic ,  Tyler R. Wong

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/1486 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/14865 ,  A61B2562/0209 ,  A61B2562/125 ,  G01N33/66

Abstract: A single flex double-sided electrode useful in a continuous glucose monitoring sensor. In one example, a counter electrode is placed on the back-side of the flex and a work electrode is placed on the top-side of the sensor flex. The electrode is fabricated on physical vapor deposited metal deposited on a base substrate. Adhesion of the electrode to the base substrate is carefully controlled so that the electrode can be processed on the substrate and subsequently removed from the substrate after processing.

公开(公告)号：US20130331674A1

公开(公告)日：2013-12-12

申请号：US13778630

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah ,  Catherine M. Szyman ,  Michael E. Miller ,  Jenn-Hann Larry Wang ,  Yiwen Li ,  Wayne A. Morgan ,  Paris Chen ,  Robert C. Mucic ,  Genival D. de Barros ,  Carlos A. Callirgos ,  Manjunath Sirigiri ,  Joseph Paul Brinson

IPC: G01R35/00 ,  A61B5/145

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20130328578A1

公开(公告)日：2013-12-12

申请号：US13778473

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Robert C. Mucic ,  Genival D. de Barros ,  Carlos A. Callirgos ,  Manjunath Sirigiri ,  Joseph Paul Brinson

IPC: G01N27/02

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20210077717A1

公开(公告)日：2021-03-18

申请号：US16569401

申请日：2019-09-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Akhil Srinivasan ,  Peter Ajemba ,  Steven C. Jacks ,  Robert C. Mucic ,  Tyler R. Wong ,  Melissa Tsang ,  Chi-En Lin ,  Mohsen Askarinya ,  David Probst

IPC: A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  A61B5/1495

Abstract: Medical devices and related systems and methods are provided. A method of calibrating an instance of a sensing element involves obtaining fabrication process measurement data from a substrate having the instance of the sensing element fabricated thereon, obtaining a calibration model associated with the sensing element, determining calibration data associated with the instance of the sensing element for converting the electrical signals into a calibrated measurement parameter based on the fabrication process measurement data using the calibration model, and storing the calibration data in a data storage element associated with the instance of the sensing element.

公开(公告)号：US20170311858A1

公开(公告)日：2017-11-02

申请号：US15140129

申请日：2016-04-27

Applicant: Medtronic MiniMed, Inc.

Inventor： Qingling Yang ,  Robert C. Mucic

IPC: A61B5/1486 ,  A61B5/145 ,  C12Q1/00

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/14735 ,  A61B2562/125 ,  C12Q1/006 ,  G01N27/3271

Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as interference rejection membranes as well as methods for making and using such sensors. The amperometric analyte sensor apparatus comprises: a base layer; a conductive layer disposed on the base layer and comprising a working electrode; an interference rejection membrane disposed on an electroactive surface of the working electrode, wherein the interference rejection membrane comprises poly(vinyl alcohol) (PVA) polymers crosslinked by an acid crosslinker, wherein the crosslinker is a dicarboxylic acid type monomer or a polymer comprising a carboxylic acid group; and an analyte sensing layer. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.