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公开(公告)号：US09620344B2
公开(公告)日：2017-04-11
申请号：US14900827
申请日：2014-04-21
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Ahmed Mohamed Hamid , Alan Keith Jarmusch , Zheng Ouyang
CPC classification number: H01J49/0445 , C12N13/00 , C12Q1/04 , G01N2560/00 , H01J49/16
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
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12.发明授权公开(公告)号：US09500572B2
公开(公告)日：2016-11-22
申请号：US13784094
申请日：2013-03-04
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/492 , G01N1/10 , G01N1/28 , G01N1/286 , G01N33/48714 , G01N33/48785 , G01N33/491 , G01N2001/2893 , H01J49/0009 , H01J49/0027 , H01J49/16
Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof. In certain embodiments, the invention provides a fluid dispenser that includes a fluid chamber. A portion of an inner wall of the chamber includes an internal standard. The chamber is configured such that fluid introduced to the chamber must interact with the portion of the chamber wall that includes the internal standard prior to flowing through an outlet of the chamber. The dispenser additionally includes a member coupled to the chamber such that it can control movement of fluid within the chamber.
Abstract translation: 本发明一般涉及一种包括内部标准的样品分配器及其使用方法。 在某些实施例中，本发明提供一种包括流体室的流体分配器。 室的内壁的一部分包括内标。 腔室被配置成使得引入腔室的流体必须在流过腔室的出口之前与包括内部标准的腔室壁的部分相互作用。 分配器还包括联接到室的构件，使得其可以控制腔室内的流体的运动。
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公开(公告)号：US08859958B2
公开(公告)日：2014-10-14
申请号：US13727167
申请日：2012-12-26
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/6848 , G01N1/00 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0431 , H01J49/16 , H01J49/168
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
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公开(公告)号：US08816275B2
公开(公告)日：2014-08-26
申请号：US14023531
申请日：2013-09-11
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/6848 , G01N1/00 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0431 , H01J49/16 , H01J49/168
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
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公开(公告)号：US08772710B2
公开(公告)日：2014-07-08
申请号：US14010130
申请日：2013-08-26
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Jason Harper , Nicholas Charipar , Robert Graham Cooks
CPC classification number: H01J37/32009 , H01J27/022 , H01J37/00 , H01J37/32348 , H01J49/02 , H01J49/105 , H01J49/142 , H01J2237/0044 , H05H1/24 , H05H1/2406 , H05H1/30 , H05H2001/2412 , H05H2001/2443 , H05H2240/10 , H05H2240/20 , Y10T436/145555 , Y10T436/147777 , Y10T436/173076 , Y10T436/203332 , Y10T436/24
Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.
Abstract translation: 本发明一般涉及用于解吸和电离样品中至少一种分析物的低温等离子体探针及其使用方法。 在一个实施方案中，本发明一般涉及一种低温等离子体探针，其包括：壳体，其具有放电气体入口端口，探针尖端，两个电极和介电屏障，其中两个电极由电介质屏障隔开， 来自电源的电压的施加产生低温等离子体，其中通过电场和/或放电气体流将低温等离子体推出排出区域。
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Patent Agency Ranking
公开(公告)号：US08686351B2
公开(公告)日：2014-04-01
申请号：US13937913
申请日：2013-07-09
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Robert Graham Cooks , Sandilya Venkata Garimella , Jason David Harper , Nicholas Alan Charipar
IPC: H01J37/301 , H01J49/04 , H01J3/18
CPC classification number: H01J49/0404 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/0459 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/4215
Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
Abstract translation: 本发明一般涉及用于转移离子进行分析的系统和方法。 在某些实施方案中，本发明提供了一种用于分析样品的系统，该样品包括用于将样品分子转化成大气压的区域中的气相离子的电离源，离子分析装置和可操作地耦合到气体的离子传递构件 气体发生装置，其中气体流动产生装置产生将气相离子通过离子传递构件转移到离子分析装置的入口的层流气流。
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公开(公告)号：US20130330714A1
公开(公告)日：2013-12-12
申请号：US13926645
申请日：2013-06-25
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Ahmed Mohamed Hamid , Alan Keith Jarmusch , Zheng Ouyang
IPC: C12Q1/04
CPC classification number: H01J49/0036 , C12Q1/04 , G01N2560/00 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/10 , H01J49/16 , H01J49/26
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
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公开(公告)号：US11531024B2
公开(公告)日：2022-12-20
申请号：US15762597
申请日：2016-09-24
Applicant: Purdue Research Foundation
Inventor： Zane Baird , Robert Graham Cooks , Adam Hollerbach , Zheng Ouyang , Michael Pugia
IPC: G01N33/53
Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.
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19.发明申请公开(公告)号：US20210302288A1
公开(公告)日：2021-09-30
申请号：US17346576
申请日：2021-06-14
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Wenpeng Zhang
Abstract: Systems and methods for analyzing an analyte extracted from a sample using an adsorbent material.
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公开(公告)号：US20210166927A1
公开(公告)日：2021-06-03
申请号：US17153156
申请日：2021-01-20
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Linfan Li , Xiaoyu Zhou
Abstract: The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte. Those ions are transferred through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer in a manner in which the discontinuous sample introduction interface remains open during the transferring. The discontinuous sample introduction interface is closed and the ions are sequentially transferred to a second ion trap of the mass spectrometer where they are sequentially analyzed.
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