公开(公告)号：US11925580B2

公开(公告)日：2024-03-12

申请号：US16777648

申请日：2020-01-30

Applicant: Iantrek

Inventor： Tsontcho Ianchulev

IPC: A61F9/007 ,  A61L27/36

CPC classification number: A61F9/00781 ,  A61F9/00763 ,  A61L27/3604 ,  A61L27/3641 ,  A61L2430/16

Abstract: A system for preparation of an implant and ab interno insertion of the implant into an eye including a handle having one or more actuators and an elongated shaft having an outer sheath and an elongate member positioned within a lumen of the tubular outer sheath. The system includes a recess sized for holding a patch of material fixed relative to the handle and a cutting member movable relative to the handle and to the recess. The cutting member cuts the patch of material into an implant as the cutting member moves towards a cutting configuration. The implant, once cut, is axially aligned with the lumen of the tubular outer sheath. The inner elongate member is movable relative to the tubular outer sheath to advance the implant into a deployment position in the lumen of the tubular outer sheath for delivery into the eye. Related devices and methods are provided.

公开(公告)号：US20230404805A1

公开(公告)日：2023-12-21

申请号：US18205320

申请日：2023-06-02

Applicant: Gholam A. Peyman

Inventor： Gholam A. Peyman

IPC: A61F9/008 ,  A61F2/14 ,  A61N5/06 ,  A61L27/36

CPC classification number: A61F9/00812 ,  A61F2/1451 ,  A61F2/148 ,  A61F9/00804 ,  A61N5/062 ,  A61F9/00836 ,  A61F9/00834 ,  A61L27/3604 ,  A61L27/3666 ,  A61F2009/00872 ,  A61N2005/0661 ,  A61L2430/16 ,  A61F2240/004

Abstract: A tissue-augmented corneal inlay surgery technique is disclosed herein. In one embodiment, the surgery method includes the steps of: (i) implanting a corneal inlay into a recipient cornea of an eye of a patient; (ii) applying laser energy to a central portion of the corneal inlay and a portion of stromal tissue of the recipient cornea underneath the corneal inlay so as to modify the refractive power of the eye; (iii) applying a cross-linking solution that includes a photosensitizer to the recipient cornea of the eye of the patient; and (iv) irradiating the corneal inlay and surrounding corneal tissue so as to activate cross-linkers in the corneal inlay and the surrounding corneal tissue. In this embodiment, the central portion of the corneal inlay remains clear for the patient without being obstructed by swollen tissue so that the patient is able to see immediately after the corneal inlay surgery.

公开(公告)号：US20230320841A1

公开(公告)日：2023-10-12

申请号：US18325280

申请日：2023-05-30

Applicant: ALCON, INC.

Inventor： ALI AKINAY ,  XUWEI JIANG ,  JIAN LIU ,  JINGBO LIU

IPC: A61F9/008 ,  A61L27/16 ,  A61L27/50 ,  A61F2/16 ,  A61L27/26

CPC classification number: A61F2/16 ,  A61F9/008 ,  A61L27/16 ,  A61L27/26 ,  A61L27/50 ,  A61F2/1629 ,  A61F2/1632 ,  A61F2002/1686 ,  A61F2002/1689 ,  A61F2002/16901 ,  A61L2430/16

Abstract: The present disclosure provides an intralocular-lens (IOL) or ophthalmic device including an optic and at least one haptic, at least a portion of which is formed from a photoresponsive shape memory polymer network, such as a polydomain azo liquid crystalline polymer network (PD-LCN). The present disclosure further provides systems and methods for adjusting the position of such an IOL or other ophthalmic device using polarized laser radiation.

公开(公告)号：US20230285640A1

公开(公告)日：2023-09-14

申请号：US18100696

申请日：2023-01-24

Applicant: BioTissue Holdings Inc.

Inventor： Scheffer TSENG ,  Ek Kia TAN

IPC: A61L31/00 ,  A61F9/00 ,  A61L31/16 ,  A61L31/14 ,  A61N1/36 ,  A61N1/04

CPC classification number: A61L31/005 ,  A61F9/0017 ,  A61L31/16 ,  A61L31/146 ,  A61N1/36003 ,  A61N1/0452 ,  A61L2300/406 ,  A61L2430/16

Abstract: The invention relates generally to the fields of biology and health sciences. More particularly, the invention relates to compositions and methods for modulating cellular physiology and pathological processing using a combination of compounds that can be found in amniotic membrane tissue and umbilical cord tissue preparations.

公开(公告)号：US11752239B2

公开(公告)日：2023-09-12

申请号：US16816579

申请日：2020-03-12

Applicant: Luke Lu ,  Hsiao Sen Tseng ,  Michelle Lu ,  Emily Lu

Inventor： Luke Lu ,  Hsiao Sen Tseng ,  Michelle Lu ,  Emily Lu

IPC: A61L31/02 ,  A61F9/00 ,  A61F9/007 ,  A61M27/00 ,  A61L31/16 ,  A61L31/14

CPC classification number: A61L31/026 ,  A61F9/0017 ,  A61F9/00781 ,  A61L31/148 ,  A61L31/16 ,  A61M27/002 ,  A61F2250/0067 ,  A61L2430/16

Abstract: A combination bioactive silicate (e.g., bioactive glass) medicine carrier and shunt of one embodiment includes a shunt which is a tubular member made of bioactive silicate or glass being adapted to be bioresorbable and water soluble, or fiber bundle, the shunt including an insertion end at a first end. Gaps in the bioactive silicate or gaps in the glass adapted to be bioresorbable and water soluble are served as at least one storage for storing medicines.

公开(公告)号：US20230226256A1

公开(公告)日：2023-07-20

申请号：US18009495

申请日：2021-06-09

Applicant: Dompe' Farmaceutici S.P.A.

Inventor： Giuseppina ACERRA ,  Nicola DETTA ,  Assunta PANDOLFI ,  Leonardo MASTROPASQUA ,  Mario NUBILE ,  Domitilla MANDATORI

IPC: A61L27/36 ,  A61K38/18 ,  A61L27/54 ,  A61K9/16 ,  A61K9/00

CPC classification number: A61L27/3604 ,  A61K38/185 ,  A61L27/54 ,  A61K9/1647 ,  A61L27/3687 ,  A61K9/1682 ,  A61L27/3641 ,  A61K9/0051 ,  A61L2300/414 ,  A61L2430/16 ,  A61L2430/40

Abstract: Object of the present invention is a drug delivery system comprising a decellularized corneal stroma scaffold having dispersed within and/or bound to its surface microparticles containing at least one pharmaceutically active molecule dispersed in a matrix having a composition consisting for at least 70% of polylactic co-glycolic acid (PLGA).

公开(公告)号：US11701220B2

公开(公告)日：2023-07-18

申请号：US16840660

申请日：2020-04-06

Applicant: ALCON, INC.

Inventor： Ali Akinay ,  Xuwei Jiang ,  Jian Liu ,  Jingbo Liu

IPC: A61F2/16 ,  A61F9/008 ,  A61L27/16 ,  A61L27/26 ,  A61L27/50

CPC classification number: A61F2/16 ,  A61F9/008 ,  A61L27/16 ,  A61L27/26 ,  A61L27/50 ,  A61F2/1629 ,  A61F2/1632 ,  A61F2002/1686 ,  A61F2002/1689 ,  A61F2002/16901 ,  A61L2430/16

Abstract: The present disclosure provides an intraocular lens (IOL) or ophthalmic device including an optic and at least one haptic, at least a portion of which is formed from a photoresponsive shape memory polymer network, such as a polydomain azo liquid crystalline polymer network (PD-LCN). The present disclosure further provides systems and methods for adjusting the position of such an IOL or other ophthalmic device using polarized laser radiation.

公开(公告)号：US11679180B2

公开(公告)日：2023-06-20

申请号：US16467681

申请日：2017-11-13

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Alan D. Marmorstein ,  Raymond Iezzi ,  Jarel K. Gandhi ,  Jose S. Pulido

IPC: A61L27/38 ,  C12N5/079 ,  A61K35/36 ,  A61K35/30 ,  A61K38/36 ,  A61K38/48 ,  A61L27/22 ,  A61L27/52 ,  A61L27/34 ,  A61L27/36

CPC classification number: A61L27/3813 ,  A61K35/30 ,  A61K35/36 ,  A61K38/363 ,  A61K38/484 ,  A61L27/225 ,  A61L27/34 ,  A61L27/3687 ,  A61L27/3808 ,  A61L27/3839 ,  A61L27/52 ,  C12N5/0621 ,  C12Y304/21007 ,  A61L2420/02 ,  A61L2430/16 ,  C12N2501/734 ,  C12N2501/999 ,  C12N2506/45 ,  C12N2533/56 ,  C12N2533/90

Abstract: This document provides methods and materials for performing retinal pigment epithelium transplantation. For example, methods and materials for using fibrin supports for retinal pigment epithelium transplantation are provided.

公开(公告)号：US20180289857A1

公开(公告)日：2018-10-11

申请号：US16003424

申请日：2018-06-08

Applicant: LinkoCare Life Sciences AB

Inventor： Mehrdad Rafat

IPC: A61L27/24 ,  A61L27/52 ,  A61L27/56 ,  A61L27/54 ,  A61L27/36 ,  A61F2/14 ,  A61F2/00 ,  A61F2/10 ,  A61F2/24

CPC classification number: A61L27/24 ,  A61F2/0063 ,  A61F2/105 ,  A61F2/142 ,  A61F2/1451 ,  A61F2/2478 ,  A61L27/3675 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/16

Abstract: A composite collagen hydrogel material for use in tissue engineering, and an implantable ophthalmic device comprising such composite material. The composite material comprises: a first collagen network comprising collagen crosslinked with a first crosslinking agent, and/or a second collagen network comprising collagen crosslinked with a second crosslinking agent, and a three dimensional collagen mesh comprising partially and plastically compressed collagen hydrogel with a compression degree of 50-95%, wherein the three dimensional collagen mesh is embedded in the first collagen network and/or second collagen network, and the first collagen network and/or the second collagen network and the three dimensional collagen mesh are physically and chemically interconnected in the composite collagen hydrogel material.

公开(公告)号：US20180289468A1

公开(公告)日：2018-10-11

申请号：US15756787

申请日：2016-08-30

Applicant: Aslan Ramazanovich Khurai

Inventor： Aslan Ramazanovich Khurai

IPC: A61F2/14 ,  A61F9/007 ,  A61L27/36

CPC classification number: A61F2/142 ,  A61B2017/00969 ,  A61F9/0017 ,  A61F9/007 ,  A61F2230/0008 ,  A61F2230/0013 ,  A61F2230/0019 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61L27/362 ,  A61L27/3641 ,  A61L2430/16

Abstract: The claimed method for performing ophthalmosurgical operations includes forming a recipient bed and implanting an autograft consisting of a portion of the patient's own nail plate, which is shaped to fit the recipient bed, and which is sterilized and then kept in a dry environment prior to implantation. The autograft is similar in chemical composition and physical characteristics to the tissues of the eye, is not accompanied by an immune system rejection reaction, and adapts to the shape of the recipient bed as a result of natural swelling.