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公开(公告)号：US06703467B1
公开(公告)日：2004-03-09
申请号：US09720990
申请日：2001-01-03
申请人： Paul E Milne , Keith M Blackwood , Alan W Hall , John W Goodby
发明人： Paul E Milne , Keith M Blackwood , Alan W Hall , John W Goodby
IPC分类号： C08F2054
CPC分类号： C09J4/00 , C07C69/007 , C07C211/11 , C07C211/21 , C07C211/63 , C07C215/40 , C07C233/05 , C07C233/09 , C07C233/11 , C07C233/56 , C07C233/65 , C07C235/06 , C07C235/34 , C07C237/06 , C07C271/14 , C07C311/11 , C07F7/1804 , C08F238/00 , C08F222/26 , C08F216/02 , C08F226/02
摘要： An adhesive or sealant composition comprising a compound of formula (I) provided that at least one of (a) R1 and R6 or (b) R2 and R3 or (c) R4 and R5 includes an electron withdrawing group; and where necessary, a polymerization initiator. Novel compounds of formula (I) are also described and claimed. Adhesive compositions can be used to bond for example glass and metal surfaces. Certain biocompatible adhesives for medical applications are included.
摘要翻译： 包含式（I）化合物的粘合剂或密封剂组合物，条件是（a）R 1和R 6或（b）R 2和R 3或（c） 4>和R 5包括吸电子基团; 并且如果需要，可以使用聚合引发剂。 新的式（I）化合物也被描述和要求保护。 粘合剂组合物可用于结合例如玻璃和金属表面。 包括用于医疗应用的某些生物相容性粘合剂。
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12.发明授权Anticancer (IV) complexes for oral administration and a method of making the same 失效用于口服给药的抗癌（IV）复合物及其制备方法
公开(公告)号：US5998648A
公开(公告)日：1999-12-07
申请号：US134697
申请日：1998-08-14
申请人： Youn Soo Sohn , Sung Sil Lee , Young-A Lee , Kwan Mook Kim , Chong Ock Lee
发明人： Youn Soo Sohn , Sung Sil Lee , Young-A Lee , Kwan Mook Kim , Chong Ock Lee
IPC分类号： A61K31/28 , A61P35/00 , C07C53/122 , C07C53/124 , C07C53/126 , C07C209/00 , C07C211/09 , C07C211/10 , C07C211/11 , C07C211/18 , C07C211/36 , C07D309/04 , C07F13/00 , C07F15/00
CPC分类号： C07C53/122 , C07C211/10 , C07C211/11 , C07C211/18 , C07C211/36 , C07C53/124 , C07D309/04 , C07F15/0093
摘要： Platinum (IV) complexes for oral administration represented by the structural formula ##STR1## where A--A is a symmetrical diamine that can chelate to platinum and is selected from the group consisting of ethylene diamine, t(.+-.)-1,2-diaminocyclohexane, 2,2-dimethyl-1,3-propanediamine, cyclohexane-1,1-dimethaneamine and tetrahydro-4H-pyran-4,4-dimethaneamine; and R is propionyl, butyryl or valeryl. These complexes are useful in the treatment of cancer.
摘要翻译： 用于口服给药的铂（IV）络合物，其结构式为AA，其为螯合铂的对称二胺，并且选自乙二胺，t（+/-） - 1,2-二氨基环己烷， 2-二甲基-1,3-丙二胺，环己烷-1,1-二甲胺和四氢-4H-吡喃-4,4-二甲胺; R是丙酰基，丁酰基或戊酰基。 这些复合物可用于治疗癌症。
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13.发明授权Use of diamines to disinfect and clean contact lenses and preserve ophthalmic compositions 失效使用二胺消毒和清洁隐形眼镜并保护眼用组合物
公开(公告)号：US5900213A
公开(公告)日：1999-05-04
申请号：US047584
申请日：1998-03-25
IPC分类号： A01N33/04 , A01N33/08 , A61L12/14 , C07C211/09 , C07C211/10 , C07C211/11 , C07C211/21 , C07C211/25 , C07C215/14 , A61L2/16
CPC分类号： C07C211/25 , A01N33/04 , A01N33/08 , A61L12/14 , C07C211/09 , C07C211/10 , C07C211/11 , C07C211/21 , C07C215/14 , Y10S514/839 , Y10S514/84
摘要： N,N-dialkyl and N'-alkylethylene diamines of the formula: ##STR1## wherein R, R.sup.1 and R.sup.2 are as described in the specification. The compounds are useful in disinfecting and cleaning contact lenses and preserving ophthalmic products.
摘要翻译： N，N-二烷基和N'-烷基乙炔二胺，其中R，R 1和R 2如说明书中所述。 该化合物可用于消毒和清洁隐形眼镜并保护眼用产品。
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公开(公告)号：US5149457A
公开(公告)日：1992-09-22
申请号：US374740
申请日：1989-06-30
申请人： W. Novis Smith
发明人： W. Novis Smith
IPC分类号： C07C209/66 , C07C211/00 , C07C211/06 , C07C211/07 , C07C211/10 , C07C211/11
CPC分类号： C07C211/07 , C07C209/66 , C07C211/06 , C07C211/10 , C07C211/11
摘要： A method for preparing lithium amides in a monocyclic aromatic solvent and the reagent compositions formed thereby.
摘要翻译： 在单环芳族溶剂中制备酰胺的方法和由此形成的试剂组合物。
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公开(公告)号：US3270059A
公开(公告)日：1966-08-30
申请号：US25890563
申请日：1963-02-15
申请人： BASF AG
发明人： SIEGFRIED WINDERL , ERICH HAARER , HUBERT CORR , PAUL HORNBERGER
IPC分类号： B01J23/38 , B01J23/70 , C07C209/16 , C07C211/10 , C07C211/11 , C07C211/12
CPC分类号： C07C209/16 , B01J23/38 , B01J23/70 , C07C211/10 , C07C211/11 , C07C211/12
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公开(公告)号：US20240245778A1
公开(公告)日：2024-07-25
申请号：US18594194
申请日：2024-03-04
发明人： Martin MAIER , Muthusamy JAYARAMAN , Akin AKINC , Shigeo MATSUDA , Pachamuthu KANDASAMY , Kallanthottathil G. RAJEEV , Muthiah MANOHARAN , Jayaprakash K. NAIR , Thomas A. BAILLIE
IPC分类号： A61K47/18 , A61K9/127 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/713 , C07C31/125 , C07C211/09 , C07C211/10 , C07C211/11 , C07C217/08 , C07C229/12 , C07C235/06 , C07C251/38 , C07C323/12 , C07C323/58 , C07C327/22 , C07C327/28 , C07C327/32 , C07D207/32 , C07D233/54 , C07D295/08 , C07D295/12 , C07D295/14 , C07D317/30 , C07F5/02
CPC分类号： A61K47/18 , A61K9/1272 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/713 , C07C31/125 , C07C211/09 , C07C211/10 , C07C211/11 , C07C217/08 , C07C229/12 , C07C235/06 , C07C251/38 , C07C323/12 , C07C323/58 , C07C327/22 , C07C327/28 , C07C327/32 , C07D207/32 , C07D233/54 , C07D295/08 , C07D295/12 , C07D295/14 , C07D317/30 , C07F5/022
摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
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公开(公告)号：US20180305311A1
公开(公告)日：2018-10-25
申请号：US15962498
申请日：2018-04-25
IPC分类号： C07D207/333 , C07C215/40 , A61K38/26 , C07D295/027 , A61K31/4985 , C07C215/10 , C07C217/60 , C07C211/51 , C07D233/58 , A61K31/4015 , C07C211/11 , C07C215/12 , C07C211/30 , C07C229/26 , A61K31/40 , A61K31/155 , C07C211/27 , A61K31/64 , A61K31/505 , C07C211/35 , A61K45/06 , C07C279/14
CPC分类号： C07D207/333 , A61K31/155 , A61K31/40 , A61K31/4015 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K45/06 , A61K2300/00 , C07C211/11 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/51 , C07C215/10 , C07C215/12 , C07C215/40 , C07C217/60 , C07C229/26 , C07C279/14 , C07C2601/14 , C07D233/58 , C07D295/027
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of these novel salts and use thereof.
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公开(公告)号：US09957230B2
公开(公告)日：2018-05-01
申请号：US15594795
申请日：2017-05-15
IPC分类号： C07D207/333 , C07D233/58 , A61K31/155 , C07C279/14 , C07C229/26 , C07C217/60 , C07C215/40 , C07C215/12 , C07C215/10 , C07C211/51 , C07C211/35 , C07C211/30 , C07C211/27 , C07C211/11 , A61K45/06 , A61K38/26 , A61K31/64 , A61K31/505 , A61K31/4985 , A61K31/4015 , A61K31/40 , C07D295/027
CPC分类号： C07D207/333 , A61K31/155 , A61K31/40 , A61K31/4015 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K45/06 , A61K2300/00 , C07C211/11 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/51 , C07C215/10 , C07C215/12 , C07C215/40 , C07C217/60 , C07C229/26 , C07C279/14 , C07C2601/14 , C07D233/58 , C07D295/027
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (1a) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of: these novel salts and use thereof.
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19.发明申请公开(公告)号：US20160324781A1
公开(公告)日：2016-11-10
申请号：US15219602
申请日：2016-07-26
申请人： AXOLABS GMBH
发明人： Rainer CONSTIEN , Anke GEICK , Philipp HADWIGER , Torsten HANEKE , Ludger ICKENSTEIN , Carla Alexandra HERNANDEZ PRATA , Andrea SCHUSTER , Timo WEIDE
IPC分类号： A61K9/14 , C07D241/04 , A61K31/713 , C07D295/13
CPC分类号： A61K9/145 , A61K9/1271 , A61K31/575 , A61K31/70 , A61K31/7088 , A61K31/713 , A61K38/02 , A61K39/00 , A61K47/18 , A61K47/22 , B82Y5/00 , C07C211/11 , C07C211/13 , C07C211/14 , C07C211/22 , C07C217/08 , C07C217/28 , C07C217/42 , C07D241/04 , C07D295/13 , C07D295/30
摘要： The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.
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公开(公告)号：US09433681B2
公开(公告)日：2016-09-06
申请号：US14178538
申请日：2014-02-12
申请人： AXOLABS GMBH
发明人： Rainer Constien , Anke Geick , Philipp Hadwiger , Torsten Haneke , Ludger Markus Ickenstein , Carla Alexandra Hernandez Prata , Andrea Schuster , Timo Weide
IPC分类号： C07C211/22 , C07D295/30 , C07D241/04 , A61K31/713 , A61K31/7088 , C07C211/11 , C07C211/13 , A61K47/18 , A61K31/575 , A61K31/70 , B82Y5/00 , C07C217/42 , C07C211/14 , C07C217/08 , C07C217/28 , A61K9/127 , A61K9/14 , A61K38/02 , A61K47/22 , A61K39/00
CPC分类号： A61K9/145 , A61K9/1271 , A61K31/575 , A61K31/70 , A61K31/7088 , A61K31/713 , A61K38/02 , A61K39/00 , A61K47/18 , A61K47/22 , B82Y5/00 , C07C211/11 , C07C211/13 , C07C211/14 , C07C211/22 , C07C217/08 , C07C217/28 , C07C217/42 , C07D241/04 , C07D295/13 , C07D295/30
摘要： The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.
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