公开(公告)号：US20230295360A1

公开(公告)日：2023-09-21

申请号：US18017854

申请日：2021-07-23

Applicant: Ankon Medical Technologies (Shanghai) Co., LTD.

Inventor： Shupeng ZHANG ,  Xiaodong Duan

IPC: C08F220/48 ,  C08J5/18 ,  C08K5/46 ,  C08K5/23 ,  G01N33/84 ,  G01N31/22

CPC classification number: C08F220/48 ,  C08J5/18 ,  C08K5/23 ,  C08K5/46 ,  G01N31/221 ,  G01N33/84 ,  C08J2333/20

Abstract: The present invention provides a method for preparing a polyion thin film (in particular a polyion thin film with different surface morphologies) and the polyion thin film prepared by the method. The method comprises: providing a substrate, and coating a first lubricant on a surface of the substrate or on a surface of a tinfoil covered on the surface of the substrate; covering a film-forming liquid of the polyion thin film on the surface of the substrate with the first lubricant, and after coating uniformly, covering a cover plate coated with a second lubricant on the film-forming liquid; performing a polymerization reaction of ionic liquid monomers in the film-forming liquid to form a polyion thin film; and separating the polyion thin film and cleaning it to obtain the polyion thin film. The polyion thin films with different surface morphology can be prepared. The present invention further provides a detection kit.

公开(公告)号：US11761948B2

公开(公告)日：2023-09-19

申请号：US14778234

申请日：2014-03-14

Applicant: Northwestern University

Inventor： William E Funk ,  Thomas McDade

IPC: A61B5/15 ,  G01N33/49 ,  A61B5/145 ,  G01N33/84 ,  A61B5/151

CPC classification number: G01N33/49 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/15142 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150755 ,  G01N33/84 ,  A61B2562/0295 ,  A61B2562/242

Abstract: The present invention provides methods, compositions, kits, and devices for detecting heavy metals in dried blood (e.g., dried blood spots). For example, the present invention provides: 1) dried blood spot paper that is detectably free of heavy metals and methods of preparing such paper using organic acid; 2) dried blood extraction solutions optimized for heavy metal detection (e.g., extraction solutions containing acetic acid and/or gold); 3) methods for estimating venous blood volume from dried blood mass; and 4) kits and kit components optimized for heavy metal detection in dried blood (e.g., kits with paper detectably free of heavy metals, heavy metal free skin wipes, metal free collection case, etc.).

公开(公告)号：US11759478B2

公开(公告)日：2023-09-19

申请号：US17198645

申请日：2021-03-11

Applicant: NANOBACTERIE

Inventor： Edouard Alphandery ,  Mickael Durand-Dubief

IPC: A61K33/26 ,  A61K41/00 ,  C01G49/08 ,  A61K8/02 ,  A61K8/19 ,  A61K8/25 ,  A61K8/26 ,  A61K8/365 ,  A61K8/49 ,  A61K8/55 ,  A61K8/73 ,  A61K8/85 ,  A61K8/99 ,  A61K9/51 ,  A61K35/74 ,  A61K49/18 ,  A61L31/02 ,  A61L31/08 ,  A61L31/10 ,  A61Q19/00 ,  G01N33/84

CPC classification number: A61K33/26 ,  A61K8/0245 ,  A61K8/19 ,  A61K8/25 ,  A61K8/26 ,  A61K8/365 ,  A61K8/4953 ,  A61K8/55 ,  A61K8/553 ,  A61K8/73 ,  A61K8/736 ,  A61K8/85 ,  A61K8/99 ,  A61K9/5115 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5153 ,  A61K9/5161 ,  A61K9/5176 ,  A61K35/74 ,  A61K41/0052 ,  A61K49/183 ,  A61K49/1827 ,  A61K49/1836 ,  A61K49/1839 ,  A61K49/1842 ,  A61K49/1857 ,  A61K49/1863 ,  A61L31/028 ,  A61L31/08 ,  A61L31/086 ,  A61L31/088 ,  A61L31/10 ,  A61Q19/00 ,  C01G49/08 ,  G01N33/84 ,  A61K2800/10 ,  A61K2800/413 ,  A61K2800/62 ,  A61K2800/621 ,  A61K2800/622 ,  A61K2800/624 ,  A61K2800/651 ,  A61L2300/102 ,  C01P2004/50 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2004/80 ,  C01P2006/42 ,  G01N2333/195

Abstract: A non-pyrogenic preparation containing nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications. The nanoparticles are constituted by a crystallized mineral central part including predominantly an iron oxide, as well as a surrounding coating without material from the magnetotactic bacteria.

公开(公告)号：US20230277584A1

公开(公告)日：2023-09-07

申请号：US17959909

申请日：2022-10-04

Applicant: Neurocentria, Inc.

Inventor： Guosong Liu ,  Hang Zhou

IPC: A61K33/06 ,  G01N33/50 ,  A61K31/191 ,  G01N33/84

CPC classification number: A61K33/06 ,  G01N33/5058 ,  A61K31/191 ,  G01N33/84 ,  G01N2800/52 ,  G01N2800/2814

Abstract: Methods for modifying neuronal functional activity and/or treating a neurological disorder by using agents that raise neuronal intracellular concentration of magnesium are disclosed. Also provided herein are methods of determining the amenability of an individual to treatment for a neurological disorder, by measuring changes in intracellular magnesium concentration.

公开(公告)号：US11709146B2

公开(公告)日：2023-07-25

申请号：US16701682

申请日：2019-12-03

Applicant: Case Western Reserve University

Inventor： Miklos Gratzl ,  Tamas Cseefalvi ,  Christian Zorman ,  John W. Stanton ,  Zhehao Zhang

IPC: G01N27/30 ,  G01N33/573 ,  G01N33/84 ,  G01N33/543 ,  C12Q1/25

CPC classification number: G01N27/302 ,  C12Q1/25 ,  G01N33/5438 ,  G01N33/573 ,  G01N33/84

Abstract: A microfluidic pH-stat with a specially-is designed slide and portable device can be used for point-of-care enzyme diagnostics. The slide includes a microchamber and a substrate for the enzyme being tested. The substrate is homogenized with the sample in the microchamber to form a test volume. The microchamber includes a working microelectrode that injects current to split water in the test volume to generate hydrogen ions and/or hydroxide ions and a micro-pH-electrode to measure a pH of the test volume; the slide also includes a reference microelectrode. The device includes a processor to adjust the injected current based on the pH of the test volume and determine an activity of the enzyme based on an amount the injected current is adjusted.

公开(公告)号：US11708397B2

公开(公告)日：2023-07-25

申请号：US16768153

申请日：2018-12-31

Applicant: HOWARD HUGHES MEDICAL INSTITUTE

Inventor： Eric R Schreiter ,  Luke D. Lavis ,  Claire Deo ,  Hersh Bhargava ,  Ahmed Abdelfattah

IPC: C07K14/47 ,  G01N33/58 ,  G01N33/84 ,  G01N21/77 ,  A61K49/00

CPC classification number: C07K14/4728 ,  A61K49/0004 ,  A61K49/0041 ,  A61K49/0056 ,  G01N21/77 ,  G01N33/582 ,  G01N33/84 ,  C07K2319/20 ,  C07K2319/60 ,  G01N2021/7786 ,  G01N2333/4727

Abstract: A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.

公开(公告)号：US20230204572A1

公开(公告)日：2023-06-29

申请号：US18053501

申请日：2022-11-08

Applicant: The Johns Hopkins University

Inventor： Rachel A. Hegab ,  Brooke M. Luisi ,  Julie E. Gleason

IPC: G01N33/543 ,  G01N33/84 ,  G01N33/544

CPC classification number: G01N33/54386 ,  G01N33/84 ,  G01N33/544 ,  G01N2333/21 ,  G01N2520/00

Abstract: Provided is a whole-cell biosensor system with robust biocontainment for field deployment and a strong visual reporter for readouts in the deployed environment. The engineered biosensors in an encapsulated and deployable system (eBEADS) demonstrate a portable, no power living sensor for detection of environmental pollutants, e.g., 2-phenylphenol (2-PP). The whole-cell biosensor system uses bacteria engineered to detect an analyte and generate a visual colorimetric output upon being contacted with the analyte. Advantageously, the analyte is detectable with the naked eye and the whole-cell biosensor system enables analyte detection without electronics.

公开(公告)号：US20230152334A1

公开(公告)日：2023-05-18

申请号：US17968606

申请日：2022-10-18

Applicant: PHARMAKURE LIMITED

Inventor： Christopher Stanley

IPC: G01N33/68 ,  G01N33/543 ,  G01N33/84

CPC classification number: G01N33/6896 ,  G01N33/54393 ,  G01N33/54333 ,  G01N33/84 ,  G01N2800/2835 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present invention relates to a method of detecting one or more tissue-derived aggregated proteins in a biological sample.

公开(公告)号：US20190216849A1

公开(公告)日：2019-07-18

申请号：US16324681

申请日：2017-08-11

Applicant: Sulfilatec, Inc.

Inventor： Christopher Cummings ,  David Shifrin

IPC: A61K33/14 ,  A61P13/12 ,  A61P9/00 ,  G01N33/84 ,  A61K33/00 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K33/14 ,  A61K9/0019 ,  A61K9/0053 ,  A61K33/00 ,  A61K45/06 ,  A61P9/00 ,  A61P13/12 ,  G01N33/84

Abstract: Embodiments of the invention provide pharmaceutical compositions and methods for preventing and treating disease and promoting the health in subjects at risk of cardiovascular disease and/or kidney disease. Additional embodiments of the present invention provide compositions and methods useful for treating and preventing a cardiovascular disease or a kidney disease.

公开(公告)号：US20190076386A1

公开(公告)日：2019-03-14

申请号：US16128140

申请日：2018-09-11

Applicant: Horizon Therapeutics, LLC

Inventor： Bruce SCHARSCHMIDT ,  Masoud MOKHTARANI

IPC: A61K31/216 ,  A61K9/00 ,  G01N33/84

CPC classification number: A61K31/216 ,  A61K9/0053 ,  A61K9/0095 ,  G01N33/84 ,  G01N2800/52 ,  G01N2800/708

Abstract: Nitrogen scavenging drugs such as glycerol phenylbutyrate can be administered safely to infants and toddlers with urea cycle disorders by adjusting the dosage based on one or more biomarkers selected from the group consisting of urinary-PAGN and plasma PAA:PAGN ratio.