公开(公告)号：US10017510B2

公开(公告)日：2018-07-10

申请号：US15116978

申请日：2015-02-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Christopher J. Kloxin ,  Weixian Xi ,  Tao Gong ,  Sankha Pattanayak

IPC: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C12Q1/68 ,  C12Q1/6876 ,  C12N15/10

CPC classification number: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C12N15/1048 ,  C12N15/1093 ,  C12Q1/68 ,  C12Q1/6876

Abstract: Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol moiety; an optionally protected Michael acceptor moiety; a primary functional side chain and one ore more secondary functional side chains. A clickable sequence controllable monomer, can have the structure: wherein independently Y and Z are atoms having a valence electrons of 3 or more; n is a integer from 0-10; m is a integer from 0-10; x is a integer from 0-10; PFS is a functional group SFSi; SFS2; and SFS3 are independently a combination of hydrogen, hydroxyl, aromatic, amine, carboxyl, and carbonyls, optionally substituted to form hydrophilic, hydrophobic, amphiphilic, or charged (positive or negative or both) side chains; T is an optionally protected thiol; and TCA is an optionally protected thiol-click acceptor. Methods of using such polymers are also disclosed.

公开(公告)号：US20180187232A1

公开(公告)日：2018-07-05

申请号：US15815370

申请日：2017-11-16

Applicant: The Regents of the University of Colorado, a body Corporate ,  AmideBio, LLC

Inventor： Michael H.B. Stowell ,  Jonathan Caruthers ,  Travis Nemkov ,  Brian Hiester ,  Leslie Boux ,  Mikhail Plam

IPC: C12P21/06 ,  G06Q99/00 ,  C07K14/47 ,  C12N15/70 ,  C12N9/90 ,  C07K14/755 ,  C07K14/655 ,  C07K14/65 ,  C07K14/635 ,  C07K14/62 ,  C07K14/61 ,  C07K14/605 ,  C07K14/585 ,  C07K14/56 ,  C07K14/535 ,  C07K14/505 ,  C07K14/005 ,  C07K1/04 ,  C07K1/12

CPC classification number: C12P21/06 ,  C07K1/04 ,  C07K1/12 ,  C07K14/005 ,  C07K14/4703 ,  C07K14/4711 ,  C07K14/505 ,  C07K14/535 ,  C07K14/56 ,  C07K14/585 ,  C07K14/605 ,  C07K14/61 ,  C07K14/62 ,  C07K14/635 ,  C07K14/65 ,  C07K14/655 ,  C07K14/755 ,  C07K2319/01 ,  C07K2319/20 ,  C07K2319/21 ,  C12N9/90 ,  C12N15/70 ,  C12N2740/16122 ,  C12Y503/03001 ,  G06Q99/00

Abstract: The present invention relates to processes for the production of peptides, and the peptides produced accordingly. Peptides produced according to the invention may be produced more efficiently than peptides produced according to prior art processes. The production process of the invention may lead to advantages in yield, purity, and/or price. Methods of marketing peptides are also disclosed.

公开(公告)号：US20180185317A1

公开(公告)日：2018-07-05

申请号：US15856532

申请日：2017-12-28

Applicant: Immodulon Therapeutics Limited ,  The Regents of the University of Colorado, a Body Corporate

Inventor： Laura Rosa Brunet ,  Christopher A. Lowry

IPC: A61K31/201 ,  A61K31/231 ,  A61K9/00 ,  A61P31/00

CPC classification number: A61K31/201 ,  A61K9/0019 ,  A61K31/231 ,  A61P31/00

Abstract: Compounds for use in the treatment of sepsis and/or the prevention or treatment of post-sepsis syndrome.

公开(公告)号：US20180177180A1

公开(公告)日：2018-06-28

申请号：US15580980

申请日：2016-06-08

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Michael P. CHAPMAN ,  Ernest MOORE

IPC: A01N1/02 ,  A61K35/16 ,  A61M1/02

CPC classification number: A01N1/0263 ,  A01N1/0273 ,  A01N1/0284 ,  A61K35/16 ,  A61M1/025 ,  A61M1/0277 ,  A61M1/0281 ,  A61M2205/3368 ,  A61M2205/366

Abstract: Systems for controlled freezing, storing and thawing a biological material in a bag and supporting apparatus. The systems are adapted to receive the biological material therein for freezing, storing, transporting and rapid thawing immediately prior to administration to a patient in need of the biological material.

公开(公告)号：US10004634B2

公开(公告)日：2018-06-26

申请号：US15180451

申请日：2016-06-13

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Malik Y. Kahook

IPC: A61N1/36 ,  A61N1/372 ,  A61N1/05 ,  A61F9/00 ,  A61N1/378 ,  A61F9/007 ,  A61F7/12 ,  A61H23/02 ,  A61N2/00 ,  A61N5/06 ,  A61N7/00

CPC classification number: A61F9/0017 ,  A61F7/12 ,  A61F9/0026 ,  A61F9/00772 ,  A61H23/02 ,  A61N1/0551 ,  A61N1/36 ,  A61N1/36046 ,  A61N1/36057 ,  A61N1/37205 ,  A61N1/37211 ,  A61N1/37229 ,  A61N1/3787 ,  A61N2/004 ,  A61N5/0603 ,  A61N7/00 ,  A61N2007/0004

Abstract: A device for inducing production of tears may include a body extending from a proximal end to a distal end. The body may be configured for insertion through a puncta of a subject. The device also may include a stimulus delivery mechanism positioned between the proximal end and the distal end and an induction coil operably coupled to the stimulus delivery mechanism. Further, the device may include an external controller wirelessly coupled to the induction coil for inductively transferring energy to the induction coil.

公开(公告)号：US20180161153A1

公开(公告)日：2018-06-14

申请号：US15890914

申请日：2018-02-07

Applicant: ClarVista Medical, Inc. ,  The Regents of the University of Colorado, a body corporate

Inventor： Malik Y. KAHOOK ,  Glenn SUSSMAN ,  Paul McLEAN ,  Andrew SCHIEBER

IPC: A61F2/16

CPC classification number: A61F2/1648 ,  A61F2/16 ,  A61F2/1613 ,  A61F2/1664 ,  A61F2/167 ,  A61F2/1672 ,  A61F2/1678 ,  A61F2002/1681 ,  A61F2002/1689 ,  A61F2002/169 ,  A61F2002/16902 ,  A61F2002/16905 ,  A61F2220/0033 ,  A61F2250/006 ,  A61F2250/0067 ,  A61F2310/0097

Abstract: Modular IOL systems including a base and a lens, wherein the lens includes fixed and actuatable tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively. Drug delivery capabilities and/or sensing capabilities may be incorporated into the base. Injector devices may be used to facilitate placement of the base and the lens sequentially or simultaneously into the eye.

公开(公告)号：US20180148442A1

公开(公告)日：2018-05-31

申请号：US15569186

申请日：2016-04-29

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Xiang Wang ,  Patrick Barbour

IPC: C07D471/04 ,  A61K31/437 ,  A61K45/06 ,  A61P31/04

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K45/06 ,  A61P31/04 ,  C07D471/10 ,  C07D471/18

Abstract: The present invention relates to indoline and indolenine alkaloid compounds. In particular, indoline and indolenine alkaloid compounds of the invention have antibacterial activity and/or are capable of re-sensitizing the susceptibility of methicillin-resistant S. aureus to a β-lactam antibiotic. The present invention also relates to a method for producing and using the same.

公开(公告)号：US20180140493A1

公开(公告)日：2018-05-24

申请号：US15579409

申请日：2016-06-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Robin Shandas ,  Omer Yehezkel Mei-Dan ,  Jacob Segil ,  Jennifer Wagner

IPC: A61G13/00 ,  A61G13/08

CPC classification number: A61G13/0081 ,  A61G13/08 ,  A61G13/101 ,  A61G13/1245

Abstract: Embodiments disclosed herein concern a distraction system for use with a surgical table having a table portion and a base portion. The distraction system includes a pair of arms rotatably connectable to the base portion at a proximal end portion of each arm. A pair of telescopically adjustable support posts extend upwardly from corresponding arms. Each arm rotates about a vertically oriented axis to provide for hip adduction and abduction of a patient's leg. Each support post extends from a linear bearing attacked to the corresponding one of the pair of arms for movement along the arm to facilitate applying traction to a patient's leg. The system can also include a table extension attachable to the table portion and a friction pad mounted on the table extension.

公开(公告)号：US20180133056A1

公开(公告)日：2018-05-17

申请号：US15791204

申请日：2017-10-23

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Malik Y. KAHOOK

IPC: A61F9/007 ,  A61B17/3211

CPC classification number: A61F9/00736 ,  A61B17/3211 ,  A61B2017/320064 ,  A61F9/00781

Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.

公开(公告)号：US20180118801A1

公开(公告)日：2018-05-03

申请号：US15695812

申请日：2017-09-05

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate

Inventor： Thomas DELONG ,  Kathryn HASKINS

IPC: C07K14/62 ,  G01N33/74 ,  G01N33/564 ,  G01N33/50

CPC classification number: C07K14/62 ,  C07K2319/00 ,  G01N33/505 ,  G01N33/564 ,  G01N33/56972 ,  G01N33/74 ,  G01N2333/62 ,  G01N2800/042

Abstract: Disclosed are compositions and methods for detecting, isolating, and/or characterizing a T cell or autoantibody associated with type I diabetes. The composition and methods comprise the use of a hybrid insulin peptide having an N-terminal amino acid sequence taken from the human insulin peptide and a C-terminal amino acid sequence taken from a secretory granule protein that are joined through a peptide bond to form an autoimmune antigen. The detecting, isolating and characterization step further includes performing an immunoassay and/or T cell proliferation assay with the disclosed hybrid insulin peptides, where preferably, the immunoassay is an ELISPOT assay.