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    Array cytometry
    21.
    发明授权
    Array cytometry 失效
    阵列细胞计数

    公开(公告)号：US06958245B2

    公开(公告)日：2005-10-25

    申请号：US09995894

    申请日：2001-11-28

    Applicant: Michael Seul ,  Alice X. Li

    Inventor： Michael Seul ,  Alice X. Li

    IPC: B01J19/00 ,  B01L3/00 ,  C07B61/00 ,  C12Q1/68 ,  G01N15/14 ,  G01N33/543 ,  G02B3/00 ,  G21K1/00 ,  H05H3/04 ,  G01N33/546

    CPC classification number: G02B3/0056 ,  B01J19/0046 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0454 ,  C12Q1/6825 ,  C12Q1/6837 ,  C40B40/00 ,  G01N15/1463 ,  G01N33/54313 ,  G01N2015/149 ,  G02B3/0012 ,  H05H3/04 ,  Y10T436/25125 ,  C12Q2565/501 ,  C12Q2563/155 ,  C12Q2565/607

    Abstract: A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled elektrokinetic assembly of particles near surfaces relies on the combination of three functional elements, the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. This invention is also for a method and apparatus to direct the lateral motion and induce the assembly into planar arrays of cells on semiconductor surfaces in response to temporally and spatially varying electric fields and to projected patterns of illumination.

    Abstract translation: 一种用于在诸如氧化硅的绝缘电极和电解质溶液之间的界面处操作胶体颗粒和生物分子的方法和装置。 表面附近颗粒的光控电动组装取决于三个功能元素的组合，即AC电场引起的平面聚集体的组装; 电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。 本发明提供一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。 本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。 此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装光学部件的步骤。 本发明还涉及一种方法和装置，以响应于时间和空间上变化的电场以及投射的照明模式，引导横向运动并将组件引导到半导体表面上的平面阵列阵列。

    Providing Real-time Interaction Between Users and Providers of Genetically Characterized Blood Products
    26.
    发明申请
    Providing Real-time Interaction Between Users and Providers of Genetically Characterized Blood Products 审中-公开
    提供用户与遗传表征血液制品供应商之间的实时互动

    公开(公告)号：US20140257858A1

    公开(公告)日：2014-09-11

    申请号：US14281190

    申请日：2014-05-19

    Applicant: Bioarray Solutions, Ltd.

    Inventor： Michael Seul ,  Robert Danehy

    IPC: G06F19/00

    CPC classification number: G16H40/20 ,  G06F19/3481 ,  G06Q10/10 ,  G06Q50/22 ,  G06Q50/24 ,  G16B20/00 ,  G16B40/00 ,  G16B50/00 ,  G16H10/60 ,  Y02A90/22 ,  Y02A90/26

    Abstract: Disclosed is a registry system, including member institutions, in which transfusion donors and recipients are registered following genotyping, which would typically take place in a member institution, or a member institution would have access to the genotyping information, if performed outside. The registry database can be accessed and searched by members seeking samples of particular type(s). Systems are disclosed for maintaining economic viability of genotyping in connection with transfusions, by maximizing the number of units placed with the minimal number of candidate donors typed. Genotyping of potential donors, and product supply, is matched to forecasted demand. Genotyping can also be limited to the more clinically relevant markers. The registry system can also be Integrated with one format of assay which generates an image for analysis, whereby the imaged results can be analyzed and redacted by experts in a central location, and then transmitted back to the patient or their representative.

    Abstract translation: 披露了一个注册系统，包括成员机构，其中输血捐赠者和接受者在基因分型之后注册，通常在成员机构中进行注册，或者成员机构如果在外部执行，则可以访问基因分型信息。 可以通过搜索特定类型的样本的成员访问和搜索注册表数据库。 公开了系统，用于通过最大限度地利用输入的候选捐赠者的数量最大化来维持与输血相关的基因分型的经济可行性。 潜在捐赠者的基因分型和产品供应与预测需求相匹配。 基因分型也可以限于更临床相关的标记物。 注册表系统也可以集成一种形式的测定法，其生成用于分析的图像，由此，成像结果可以由中心位置的专家分析和编辑，然后传送回患者或其代表。

    Optimization of gene expression analysis using immobilized capture probes
    27.
    发明授权
    Optimization of gene expression analysis using immobilized capture probes 有权
    使用固定化捕获探针优化基因表达分析

    公开(公告)号：US08795960B2

    公开(公告)日：2014-08-05

    申请号：US12480215

    申请日：2009-06-08

    Applicant: Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    Inventor： Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    IPC: C12Q1/68 ,  C12P19/34 ,  C12M1/34 ,  C12M3/00 ,  C07H21/04

    CPC classification number: C12Q1/6832 ,  B01J2219/00459 ,  B01J2219/00576 ,  B01J2219/00608 ,  B01J2219/00648 ,  B01J2219/00722 ,  C12Q1/6809 ,  C12Q1/6834 ,  C12Q1/6837 ,  C12Q2537/143 ,  C12Q2565/501 ,  C12Q2565/507 ,  C12Q2533/101 ,  C12Q2565/514 ,  C12Q2565/519

    Abstract: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized (“grafted”) probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3′ terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.

    Abstract translation: 公开了样品中寡核苷酸多重分析的方法，包括：探针和靶标“工程”的方法，以及通过多种因素与探针 - 靶亲和常数K的调节相关的信号分析方法，包括 目标链和固定（“接枝”）探针层的弹性性质; 以及与以下方法相关的测定方法：调整测定信号强度，包括动态范围压缩和片上信号放大; 杂交介导和延长介导检测的组合用于定量测定显示高度序列相似性的消息丰度，包括例如同时确定相对表达水平，以及鉴定特异性类别，未翻译 位于mRNA的3'末端附近的富含子序列; 以及仅需要单一颜色标签的减法差分基因表达分析的新方法。

    Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
    28.
    发明授权
    Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation 有权
    通过寡核苷酸连接或延伸产生官能化微粒文库

    公开(公告)号：US08486629B2

    公开(公告)日：2013-07-16

    申请号：US11411510

    申请日：2006-04-26

    Applicant: Sukanta Banerjee ,  Jiacheng Yang ,  Michael Seul

    Inventor： Sukanta Banerjee ,  Jiacheng Yang ,  Michael Seul

    IPC: C12Q1/68 ,  C40B50/00

    CPC classification number: B01J19/0046 ,  B01J2219/005 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00648 ,  B01J2219/00722 ,  B01J2219/00725 ,  C12N15/1093 ,  C40B20/04 ,  C40B50/14

    Abstract: Disclosed are methods of for constructing a bead-displayed library of oligonucleotide probes (or sequence-modified capture moieties such as protein-nucleic acid conjugates) by ligation of a capture probe, having an analyte-specific sequence, to an anchor probe that is attached, at its 5′-end, (or possibly at the 3′ end) to an encoded carrier such as a color-coded microparticle (“bead”). Such a library can also be constructed by elongation of an anchor probe, using a second probe as the elongation template, wherein the second probe has an anchor-specific subsequence and an analyte-specific subsequence.

    Abstract translation: 公开了通过将具有分析物特异性序列的捕获探针连接到所连接的锚定探针上来构建寡核苷酸探针（或序列修饰的捕获部分，例如蛋白质 - 核酸缀合物）的珠显示文库的方法 （或可能在3'端）的编码载体，例如着色微粒（“珠粒”）。 也可以使用第二探针作为延伸模板，通过锚定探针的伸长来构建这种文库，其中第二探针具有锚特异性亚序列和分析物特异性亚序列。

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