公开(公告)号：US20150197733A9

公开(公告)日：2015-07-16

申请号：US14343694

申请日：2012-09-10

Applicant: Yongzhang Luo ,  Peng Liu ,  Xinan Lu ,  Yang Chen ,  Yan Fu ,  Guodong Chang ,  Daifu Zhou

Inventor： Yongzhang Luo ,  Peng Liu ,  Xinan Lu ,  Yang Chen ,  Yan Fu ,  Guodong Chang ,  Daifu Zhou

IPC: C12N9/14 ,  C12Q1/34

CPC classification number: C12N9/14 ,  A61K38/18 ,  A61K47/60 ,  C07K14/475 ,  C12Q1/00

Abstract: The present invention discloses a new anti-tumor medicament comprising a mutant of endostatin. The mutant comprises a mutation in the ATP-binding site of endostatin and has a decreased ATPase activity and an increased anti-angiogenesis activity.

Abstract translation: 本发明公开了一种新的抗肿瘤药物，其包含内皮抑素的突变体。 突变体包含内皮抑素的ATP结合位点中的突变，并且具有降低的ATP酶活性和增加的抗血管生成活性。

公开(公告)号：US08832141B2

公开(公告)日：2014-09-09

申请号：US12683829

申请日：2010-01-07

Applicant: Yan Fu ,  Xiaoyu Gong ,  Ting Zou

Inventor： Yan Fu ,  Xiaoyu Gong ,  Ting Zou

IPC: G06F17/30 ,  H04L12/911 ,  H04L12/54 ,  H04L12/24 ,  H04L29/06 ,  H04L12/923

CPC classification number: H04L41/0893 ,  H04L47/70 ,  H04L47/745 ,  H04L47/762 ,  H04L47/824 ,  H04L47/828 ,  H04L63/20

Abstract: A method, a device and a system for combination of resource admission control are provided. The system includes the policy determination combination device and multiple bearer and transmission devices. The combination device combines functions and interfaces of two or multiple kinds of arbitrary policy determination devices in systems of different standards, and has multiple interfaces to be connected with the bearer and transmission devices, and selects the corresponding interface working protocol according to the type of bearer and transmission device. Multiple bearer and transmission devices are connected with the policy determination combination device by different interfaces. By setting policy determination combination device, the combination of policy determination devices is realized with a few changes to the current network. When there are multiple types of bearer and transmission devices in a management domain, the number of the policy determination devices can be efficiently reduced, and the cost of setting up the network and maintenance can be reduced. Also, it is propitious to collaborate and combine different standards and to improve speed of industrialization.

Abstract translation: 提供了一种用于组合资源准入控制的方法，装置和系统。 该系统包括策略确定组合设备和多个承载和传输设备。 组合设备将不同标准系统中的两种或多种任意策略确定设备的功能和接口相结合，具有与承载和传输设备连接的多个接口，并根据承载类型选择对应的接口工作协议 和传输设备。 多个承载和传输设备通过不同的接口与策略确定组合设备连接。 通过设置策略确定组合设备，通过对当前网络的几个变化来实现策略确定设备的组合。 当在管理域中存在多种类型的承载和传输设备时，可以有效地减少策略确定设备的数量，并且可以降低建立网络和维护的成本。 此外，有利于合作，结合不同标准，提高工业化进程。

公开(公告)号：US08796285B2

公开(公告)日：2014-08-05

申请号：US13377138

申请日：2010-06-03

Applicant: Hailin Zhang ,  Jinlong Qi ,  Diqun Zhang ,  Kewei Wang ,  Fan Zhang ,  Yan Fu ,  Yi Mi ,  Wen Xu ,  Xiaona Du ,  Yibing Wu ,  Qingzhong Jia ,  Shuangge Yang

Inventor： Hailin Zhang ,  Jinlong Qi ,  Diqun Zhang ,  Kewei Wang ,  Fan Zhang ,  Yan Fu ,  Yi Mi ,  Wen Xu ,  Xiaona Du ,  Yibing Wu ,  Qingzhong Jia ,  Shuangge Yang

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00

CPC classification number: C07D487/04

Abstract: The present invention provides new pyrazol-[1,5-a]-pyrimidone derivates and pharmaceutical compositions comprising said compounds and one or more pharmaceutically acceptable carriers or diluents. The uses of the compounds for the manufacture of potassium channel openers, anti-epilepsy medicaments, anti-anxiety medicaments and analgesic medicaments are also provided in the present invention.

Abstract translation: 本发明提供新的吡唑并[1,5-a] - 嘧啶酮衍生物和包含所述化合物和一种或多种药学上可接受的载体或稀释剂的药物组合物。 本发明还提供了化合物用于制造钾通道开放剂，抗癫痫药物，抗焦虑药物和镇痛药物的用途。

公开(公告)号：US08629568B2

公开(公告)日：2014-01-14

申请号：US12847802

申请日：2010-07-30

Applicant: Yan-Fu Lin ,  Jing-Cheng Lin ,  Wen-Chih Chiou ,  Shin-Puu Jeng ,  Chen-Hua Yu

Inventor： Yan-Fu Lin ,  Jing-Cheng Lin ,  Wen-Chih Chiou ,  Shin-Puu Jeng ,  Chen-Hua Yu

IPC: H01L23/544 ,  H01L21/76

CPC classification number: H01L21/563 ,  H01L23/49838 ,  H01L23/544 ,  H01L24/11 ,  H01L24/81 ,  H01L2223/54413 ,  H01L2223/5442 ,  H01L2223/54426 ,  H01L2223/54473 ,  H01L2223/5448 ,  H01L2223/54486 ,  H01L2224/1132 ,  H01L2224/11334 ,  H01L2224/1145 ,  H01L2224/11462 ,  H01L2224/11849 ,  H01L2224/131 ,  H01L2224/13111 ,  H01L2224/13124 ,  H01L2224/13139 ,  H01L2224/13144 ,  H01L2224/13147 ,  H01L2224/13155 ,  H01L2224/73204 ,  H01L2224/8113 ,  H01L2224/81132 ,  H01L2224/81191 ,  H01L2224/81815 ,  H01L2924/0001 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/0105 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/351 ,  H01L2924/00014 ,  H01L2224/13099 ,  H01L2924/00

Abstract: A system and method for determining underfill expansion is provided. An embodiment comprises forming cover marks along a top surface of a substrate, attaching a semiconductor substrate to the top surface of the substrate, placing an underfill material between the semiconductor substrate and the substrate, and then using the cover marks to determine the expansion of the underfill over the top surface of the substrate. Additionally, cover marks may also be formed along a top surface of the semiconductor substrate, and the cover marks on both the substrate and the semiconductor substrate may be used together as alignment marks during the alignment of the substrate and the semiconductor substrate.

Abstract translation: 提供了一种用于确定底部填充膨胀的系统和方法。 一个实施例包括沿着衬底的顶表面形成覆盖标记，将半导体衬底附接到衬底的顶表面，将底部填充材料放置在半导体衬底和衬底之间，然后使用覆盖标记来确定 底部填充在基材的顶表面上。 此外，也可以沿着半导体衬底的顶表面形成覆盖标记，并且衬底和半导体衬底上的覆盖标记可以在衬底和半导体衬底的对准期间一起用作对准标记。

公开(公告)号：US08605093B2

公开(公告)日：2013-12-10

申请号：US12849647

申请日：2010-08-03

Applicant: Yan Fu ,  Xiaofeng Zhu ,  Jin Yang ,  Zhenggang Yuan

Inventor： Yan Fu ,  Xiaofeng Zhu ,  Jin Yang ,  Zhenggang Yuan

IPC: G06T11/20

CPC classification number: G06K9/00201 ,  G06K9/4638 ,  G06T17/10 ,  G06T2210/56

Abstract: A method, system, apparatus, article of manufacture, and computer readable storage medium provide the ability to reconstruct a pipe from point cloud data. Point cloud data is obtained. Primitive geometric shapes are detected in the point cloud data. A pipeline is determined by determining predecessor and successor primitive geometric shapes for each of the shapes. Diameters, coplanarity, and angles between the shapes are corrected. The shapes are connected and output.

Abstract translation: 方法，系统，装置，制品和计算机可读存储介质提供从点云数据重建管道的能力。 得到点云数据。 在点云数据中检测到原始几何形状。 通过确定每个形状的前导和后继原始几何形状来确定管道。 校正直径，共平面和形状之间的角度。 形状连接并输出。

公开(公告)号：US08603973B2

公开(公告)日：2013-12-10

申请号：US12529981

申请日：2008-09-24

Applicant: Yan Fu ,  Zailin Yu

Inventor： Yan Fu ,  Zailin Yu

IPC: A61K38/00 ,  A61K38/22 ,  A61K38/38 ,  C12P21/06

CPC classification number: A61K8/64 ,  A61K8/99 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/107 ,  A61K36/064 ,  A61K38/1808 ,  A61K38/1816 ,  A61K38/1858 ,  A61K38/193 ,  A61K38/20 ,  A61K38/217 ,  A61K38/30 ,  A61K38/38 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  C07K14/475 ,  C07K2319/00 ,  A61K2300/00

Abstract: The present invention provides a recombinant fusion protein which stimulates the rejuvenation and reactivation of skin and epidermal cells for improving skin appearance, smoothing wrinkles and freckles, and whitening skin. Particularly, the present invention provides various types of products for improving skin, which contain recombinant fusion protein of human serum albumin (HSA) with cytokine peptides (EGF, FGF, KGF, HGH, HGF, PDGF, GCSF, interferon, IL-11 or IGF) by genetic engineering technology. The fusion protein can be used independently or in a combination or combination with yeast fermentation products, or with varied emulsifiers, thickeners, moisturizer, preservatives, yeasts and ferments.

Abstract translation: 本发明提供了一种重组融合蛋白，其能刺激皮肤和表皮细胞的复原和再激活，以改善皮肤外观，使皱纹和雀斑平滑，以及美白皮肤。 特别地，本发明提供各种类型的用于改善皮肤的产品，其含有人血清白蛋白（HSA）与细胞因子肽（EGF，FGF，KGF，HGH，HGF，PDGF，GCSF，干扰素，IL-11或 IGF）通过基因工程技术。 融合蛋白可以独立使用或与酵母发酵产物组合使用，或与各种乳化剂，增稠剂，保湿剂，防腐剂，酵母和发酵剂组合使用。

公开(公告)号：US20130218472A1

公开(公告)日：2013-08-22

申请号：US13399158

申请日：2012-02-17

Applicant: Yan Fu ,  Jin Yang

Inventor： Yan Fu ,  Jin Yang

IPC: G06F19/00

CPC classification number: G06T7/11 ,  G01S7/4802 ,  G01S17/89 ,  G06K9/00637 ,  G06T7/187 ,  G06T2207/10028 ,  G06T2207/20016

Abstract: A method, apparatus, system, and article of manufacture provide object descriptors for objects in point cloud data for an urban environment by segmenting the point cloud data. Point cloud data for an urban environment is obtained using a ground-based laser scanner. Terrain points are filtered out from the point cloud data using ground filtering. The point cloud data is then segmented into two or more blocks. Objects that lie on neighboring adjacent blocks are combined. Object descriptors for the combined objects are then provided (e.g., to the user or a program used by the user).

Abstract translation: 一种方法，装置，系统和制品通过分割点云数据为城市环境的点云数据中的对象提供对象描述符。 使用地面激光扫描仪获得城市环境的点云数据。 地形点使用地面滤波从点云数据中滤除。 然后将点云数据分割成两个或更多个块。 位于相邻相邻块上的对象组合。 然后提供组合对象的对象描述符（例如，给用户或用户使用的程序）。

公开(公告)号：US20130060885A1

公开(公告)日：2013-03-07

申请号：US13224905

申请日：2011-09-02

Applicant: Yan Fu

Inventor： Yan Fu

IPC: G06F15/16

CPC classification number: G06F16/9574

Abstract: An approach is provided for providing client-side caching of content using one or more web cookies. A data caching module determines a request from a device for specifying content data directed to at least one web server, at least one storage destination, or a combination thereof. The data caching module processes the content data for storage in one or more web cookies, then causes transmission of the content data via the one or more web cookies to the at least one web server, the at least one storage destination, or a combination thereof based on the request.

Abstract translation: 提供了一种方法来提供使用一个或多个web cookie的客户端缓存内容。 数据缓存模块确定来自设备的用于指定指向至少一个web服务器，至少一个存储目的地或其组合的内容数据的请求。 数据缓存模块处理用于存储在一个或多个web cookie中的内容数据，然后通过一个或多个web cookie将内容数据传输到至少一个Web服务器，至少一个存储目的地或其组合 根据要求。

公开(公告)号：US20120064078A1

公开(公告)日：2012-03-15

申请号：US12880265

申请日：2010-09-13

Applicant: Yongzhang LUO ,  Xiaomin SONG ,  Xiaofeng WANG ,  Wei ZHUO ,  Guodong CHANG ,  Yan FU

Inventor： Yongzhang LUO ,  Xiaomin SONG ,  Xiaofeng WANG ,  Wei ZHUO ,  Guodong CHANG ,  Yan FU

IPC: A61K39/395 ,  G01N33/68 ,  A61P35/02 ,  C12N5/09 ,  A61P35/00 ,  A61P35/04 ,  C07K14/47 ,  G01N33/566

CPC classification number: C07K16/30 ,  A61K39/39558 ,  A61K2039/505 ,  C07K14/4702 ,  C07K16/18 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/73 ,  G01N33/57415 ,  G01N33/57438 ,  G01N33/6893 ,  G01N2440/14 ,  Y10T436/25

Abstract: The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence or metastasis of cancer by detecting plasma Hsp90α having the amino acid sequence of SEQ ID No.1 as a tumor marker. In addition, the present invention also relates to a method for the treatment of cancer and metastasis.

Abstract translation: 本发明涉及癌症的诊断和治疗，具体涉及通过检测具有SEQ ID No.1的氨基酸序列的血浆Hsp90α作为肿瘤标志物来诊断癌症的存在或转移的方法。 此外，本发明还涉及治疗癌症和转移的方法。

公开(公告)号：US20110304042A1

公开(公告)日：2011-12-15

申请号：US12846260

申请日：2010-07-29

Applicant: Jing-Cheng Lin ,  Ya-Hsi Hwung ,  Hsin-Yu Chen ,  Po-Hao Tsai ,  Yan-Fu Lin ,  Cheng-Lin Huang ,  Fang Wen Tsai ,  Wen-Chih Chiou

Inventor： Jing-Cheng Lin ,  Ya-Hsi Hwung ,  Hsin-Yu Chen ,  Po-Hao Tsai ,  Yan-Fu Lin ,  Cheng-Lin Huang ,  Fang Wen Tsai ,  Wen-Chih Chiou

IPC: H01L23/498 ,  H01L21/768

CPC classification number: H01L24/11 ,  H01L23/488 ,  H01L24/13 ,  H01L24/16 ,  H01L24/73 ,  H01L24/81 ,  H01L24/92 ,  H01L24/94 ,  H01L25/0657 ,  H01L2224/0401 ,  H01L2224/05099 ,  H01L2224/05571 ,  H01L2224/05599 ,  H01L2224/10126 ,  H01L2224/10145 ,  H01L2224/1182 ,  H01L2224/11823 ,  H01L2224/1191 ,  H01L2224/13017 ,  H01L2224/13022 ,  H01L2224/13083 ,  H01L2224/13111 ,  H01L2224/13113 ,  H01L2224/13118 ,  H01L2224/13139 ,  H01L2224/13144 ,  H01L2224/13147 ,  H01L2224/13155 ,  H01L2224/13157 ,  H01L2224/13164 ,  H01L2224/13564 ,  H01L2224/13565 ,  H01L2224/1357 ,  H01L2224/13578 ,  H01L2224/13583 ,  H01L2224/13644 ,  H01L2224/13655 ,  H01L2224/13664 ,  H01L2224/1369 ,  H01L2224/16058 ,  H01L2224/16148 ,  H01L2224/32145 ,  H01L2224/32225 ,  H01L2224/73204 ,  H01L2224/81193 ,  H01L2224/81801 ,  H01L2224/81815 ,  H01L2224/92125 ,  H01L2224/94 ,  H01L2224/97 ,  H01L2225/06513 ,  H01L2225/06541 ,  H01L2924/00011 ,  H01L2924/0002 ,  H01L2924/01029 ,  H01L2924/01322 ,  H01L2924/01327 ,  H01L2924/014 ,  H01L2924/10253 ,  H01L2924/14 ,  H01L2924/37001 ,  H01L2924/00 ,  H01L2224/81 ,  H01L2224/16225 ,  H01L2924/00012 ,  H01L2224/16145 ,  H01L2924/00014 ,  H01L2924/01047 ,  H01L2224/05552 ,  H01L2224/81805

Abstract: A work piece includes a copper bump having a top surface and sidewalls. A protection layer is formed on the sidewalls, and not on the top surface, of the copper bump. The protection layer includes a compound of copper and a polymer, and is a dielectric layer.

Abstract translation: 工件包括具有顶表面和侧壁的铜凸块。 在铜凸块的侧壁而不是顶表面上形成保护层。 保护层包括铜和聚合物的化合物，并且是介电层。