公开(公告)号：US20210137698A1

公开(公告)日：2021-05-13

申请号：US16730000

申请日：2019-12-30

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE ,  NATIONAL TAIWAN UNIVERSITY HOSPITAL

Inventor： Fang-Jie JANG ,  Pei-I TSAI ,  De-Yau LIN ,  An-Li CHEN ,  Fon-Yih TSUANG ,  Chih-Chieh HUANG ,  Hsin-Hsin SHEN

IPC: A61F2/44

Abstract: The disclosure relates to a vertebral body implant including a flexible main body and at least one pedicle screw joint. The flexible main body is an integrally formed single piece having at least one joint-accommodating hole and at least one opening connected to the at least one joint-accommodating hole. The pedicle screw joint is an integrally formed single piece movably accommodated in the at least one joint-accommodating hole.

公开(公告)号：US20200178966A1

公开(公告)日：2020-06-11

申请号：US16225714

申请日：2018-12-19

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Wan-Shiun LOU ,  Yuen-Yung LOH ,  Yung-Lung LIU ,  Wei-Lin YU ,  Yen-Ling WANG ,  Hsin-Hsin SHEN ,  Chia-Hao CHANG

IPC: A61B17/11 ,  A61B17/04 ,  A61B17/122

Abstract: A fixing device for suturing of blood vessels is provided, which includes a connecting rod, a first clamping member, a second clamping member, a first extension tube and a second extension tube. One end of the first clamping member is disposed on the connecting rod, and the other end of the first clamping member has a first clamping head. One end of the second clamping member is disposed on the connecting rod, and the other end of the second clamping member has a second clamping head. The first extension tube is disposed on an inner side of the first clamping head. The second extension tube is disposed on an inner side of the second clamping head and opposite to the first extension tube, wherein a relative position of the first extension tube and the second extension tube is adjustable.

公开(公告)号：US20190201061A1

公开(公告)日：2019-07-04

申请号：US15856774

申请日：2017-12-28

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE ,  National Taiwan University Hospital

Inventor： Pei-I TSAI ,  Hsin-Hsin SHEN ,  Kuo-Yi YANG ,  Shih-Ping LIN ,  Jui-Sheng SUN ,  Chih-Yu CHEN ,  Yu-Tsung CHIU ,  Chun-Ti CHEN ,  De-Yau LIN ,  An-Li CHEN

IPC: A61B17/72 ,  A61B17/74

CPC classification number: A61B17/7266 ,  A61B17/746 ,  A61B17/8805

Abstract: An expandable orthopedic implant includes a casing pipe, a shaft, a first expandable element and a first link lever. The casing pipe has a first opening, a second opening and an axis passing through the first and second opening. The casing pipe sheathes one end of the shaft, and the other end of the shaft has a top portion disposed out of the first opening. The first expandable element has a first terminal pivoted on the casing pipe and a second terminal. The first link lever has a proximal end pivoted to the top portion and a distal end pivoted to the second terminal. When the top portion is driven moving away from the first opening along an extending direction of the axis, the first link-lever can be pushed by the shaft to enact the second terminal moving away from the axis along a direction perpendicular to the axis.

公开(公告)号：US20170044516A1

公开(公告)日：2017-02-16

申请号：US14984938

申请日：2015-12-30

Applicant: Industrial Technology Research Institute

Inventor： Pei-Yi Tsai ,  Chih-Hung CHEN ,  Yi-Hung LIN ,  Chih-Chieh HUANG ,  Hsin-Hsin SHEN ,  Liang-Yin KE ,  Chu-Huang CHEN

IPC: C12N11/12 ,  A61M1/34 ,  C12M1/00

CPC classification number: C12N11/12 ,  A61M1/3486 ,  A61M2202/08 ,  C12M45/09 ,  C12N11/10 ,  C12N11/14

Abstract: The present disclosure provides a biochemistry reactive material, including a substrate and an enzyme composition immobilized on the substrate. The enzyme composition is selected from a group consisting of a first enzyme, a second enzyme, and a combination thereof. The first enzyme is used for eliminating a glycan residue of an electronegative low-density lipoprotein (electronegative LDL). The second enzyme is used for eliminating ceramide carried by an electronegative low-density lipoprotein. The biochemistry reactive material is capable of eliminating electronegative low-density lipoprotein.

Abstract translation: 本公开提供了生物化学反应性材料，其包括固定在基材上的底物和酶组合物。 酶组合物选自第一酶，第二酶及其组合。 第一种酶用于消除电负性低密度脂蛋白（电负性LDL）的聚糖残基。 第二种酶用于消除由负电性低密度脂蛋白携带的神经酰胺。 生物化学反应性材料能够消除电负性低密度脂蛋白。

公开(公告)号：US20140220085A1

公开(公告)日：2014-08-07

申请号：US14251472

申请日：2014-04-11

Applicant: Industrial Technology Research Institute

Inventor： Pei-Yi TSAI ,  Yi-Hung WEN ,  Zhi-Jie HUANG ,  Pei-Shan LI ,  Hsin-Hsin SHEN ,  Yi-Hung LIN ,  Chih-Hung CHEN

IPC: A61L27/54 ,  A61L27/10 ,  C12N5/00 ,  A61L27/12

CPC classification number: A61L27/10 ,  A61L27/12 ,  A61L27/28 ,  A61L27/54 ,  A61L2300/624 ,  A61L2400/12 ,  C12N5/0068

Abstract: In an embodiment of the disclosure, a biomedical material is provided. The biomedical material includes a biocompatible material having a surface and a carrier distributed over the surface of the biocompatible material, wherein both of the biocompatible material and the carrier have no charges, one of them has charges or both of them have charges with different electricity. The biomedical material is utilized for dentistry, orthopedics, wound healing or medical beauty and applied in the repair and regeneration of various soft and hard tissues.

Abstract translation: 在本公开的一个实施方案中，提供生物医学材料。 生物医学材料包括具有分布在生物相容性材料的表面上的表面和载体的生物相容性材料，其中生物相容性材料和载体都不具有电荷，其中之一具有电荷，或者两者都具有不同电荷的电荷。 生物医学材料用于牙科，骨科，伤口愈合或医疗美容，并用于各种软组织和硬组织的修复和再生。

公开(公告)号：US20250129316A1

公开(公告)日：2025-04-24

申请号：US18542398

申请日：2023-12-15

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Chao-Hong HSU ,  Teng-Yen WANG ,  Yang-Cheng LIN ,  Hsin-Yi HSU ,  Yu-Bing LIOU ,  Chang-Chou LI ,  Chih-Hung HUANG ,  Tung-Ying LIN ,  Li-Hsin LIN ,  Yuchi WANG ,  Hsin-Hsin SHEN

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/12

Abstract: This disclosure relates to a biological tissue forming method includes the following steps: providing a biological tissue forming package with a base, a membrane, a sliding assembly and a sealing film that seals a chamber of the base used for receiving the membrane and the sliding assembly with one of the base and the sealing film being light-transmitting; passing a biological tissue fluid through the sealing film and the sliding assembly so as to be dispensed on the membrane; moving the sliding assembly away from a covering position used for covering the membrane via at least one passive magnetic element so as to expose the biological tissue fluid on the membrane; and emitting the biological tissue fluid exposed on the membrane by a curing light transmitting through the one of the base and the sealing film so as to cure the biological tissue fluid into a biological tissue.

公开(公告)号：US20210269765A1

公开(公告)日：2021-09-02

申请号：US17126942

申请日：2020-12-18

Applicant: Industrial Technology Research Institute

Inventor： Chia-Jung LU ,  Jing-En HUANG ,  Liang-Cheng SU ,  Hsin-Hsin SHEN ,  Yuchi WANG ,  Ying-Hsueh CHAO ,  Li-Hsin LIN ,  Hsiu-Hua HUANG

IPC: C12N5/00 ,  A61K35/12 ,  A61K9/00 ,  A61K47/38 ,  A61K47/42

Abstract: A temperature-sensitive cell culture composition is provided. The temperature-sensitive cell culture composition includes a hydrogel, a cellulose, a gelatin and a collagen. Based on 1 part by weight of the collagen, a content of the hydrogel is between 0.03 parts by weight and 60 parts by weight, a content of the cellulose is between 150 parts by weight and 360 parts by weight, and a content of the gelatin is between 21 parts by weight and 12 parts by weight. In addition, a method for using the temperature-sensitive cell culture composition, a method for forming the temperature-sensitive cell culture composition, and a use of the temperature-sensitive cell culture composition are also provided.

公开(公告)号：US20210196626A1

公开(公告)日：2021-07-01

申请号：US16731966

申请日：2019-12-31

Applicant: Industrial Technology Research Institute

Inventor： Yu-Bing LIOU ,  Hsin-Yi HSU ,  Ying-Wen SHEN ,  Yun-Chung TENG ,  Yuchi WANG ,  Hsin-Hsin SHEN

IPC: A61K9/00 ,  A61K47/42 ,  A61K47/32 ,  A61K47/34

Abstract: An ophthalmic drug delivery device and a method for fabricating the same are provided. The ophthalmic drug delivery device includes a shield element and a drug release element. The shield element has a light transmittance more than or equal to 80%. The drug release element is an annular body so that the drug release element surrounds the shield element. The drug release element is neutral and includes a cross-linked neutral collagen, a first hydrophilic biodegradable polymer and a drug. The shield element is acidic and includes a cross-linked acidic collagen and a second hydrophilic biodegradable polymer.

公开(公告)号：US20210085606A1

公开(公告)日：2021-03-25

申请号：US17113785

申请日：2020-12-07

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin SHEN ,  Wen-Shiang CHEN ,  Chueh-Hung WU ,  Ming-Kuan SUN ,  Yu-Chi WANG ,  Sen-Lu CHEN ,  Wei-Lin YU ,  Lih-Tao HSU ,  Shih-Ping LIN

IPC: A61K9/14 ,  A61K9/06 ,  A61K35/16 ,  A61K35/19 ,  A61K38/18 ,  A61K38/38 ,  A61K41/00 ,  A61M37/00 ,  A61K31/704 ,  A61K47/10 ,  A61K47/34 ,  A61L27/00 ,  A61K9/00

Abstract: The disclosure provides a use of hydrogel composition for alleviating degenerative joint and tendon tear. The hydrogel composition includes 100 parts by weight of therapeutic agent and 120-380 parts by weight of biodegradable copolymer, wherein the therapeutic agent comprises platelet-rich plasma (PRP), doxorubicin, transforming growth factor, bovine serum albumin, or a combination thereof. The biodegradable copolymer has a structure of Formula (I) or Formula (II): wherein A is a hydrophilic polyethylene glycol polymer; B is a hydrophobic polyester polymer; BOX is a bifunctional group monomer of 2, 2′-bis(2-oxazoline) used for coupling the blocks A-B or B-A-B; and n is 0 or an integer greater than 0.

公开(公告)号：US20190076234A1

公开(公告)日：2019-03-14

申请号：US16122438

申请日：2018-09-05

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Yu-Bing LIOU ,  Ming-Chia YANG ,  Hsin-Yi HSU ,  Yun-Han LIN ,  Wei-Hong CHANG ,  I-Jong WANG ,  Hsin-Hsin SHEN

IPC: A61F2/14 ,  A61B17/34

Abstract: An implanting device is used for implanting a membrane in a biological tissue. The implanting device includes a sleeve, a membrane storage element, an injection element and a bubble generating element. The membrane storage element is fixed at the sleeve. The injection element is inserted in the sleeve and the membrane storage element, and includes a capturing end and connecting end. The capturing end is for capturing the membrane and has a hole. The bubble generating element is connected to the connecting end, and is for providing a gas that is then outputted via the hole. By the rotation of the injection element, the capturing end extends straight out of the membrane storage element or retracts straight into the membrane storage element.