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公开(公告)号：US6048498A
公开(公告)日：2000-04-11
申请号：US190428
申请日：1998-11-12
申请人： Colin B. Kennedy
发明人： Colin B. Kennedy
IPC分类号： B01L3/00 , B01L9/00 , G01N27/447
CPC分类号： B01L3/502715 , B01L9/527 , G01N27/44791 , B01L2200/025 , B01L2200/087 , B01L2300/0816 , B01L2400/0415
摘要： Microfluidic apparatus which include a planar device and polymeric holder assembly are provided. The polymeric holder assembly includes a cavity disposed through the holder, providing optical access to the top and bottom of the planar device when the device is mounted in the polymeric holder. The planar device includes microscale channels disposed within the device.
摘要翻译： 提供了包括平面装置和聚合物保持器组件的微流体装置。 聚合物保持器组件包括通过保持器设置的空腔，当该装置安装在聚合物保持器中时，提供对平面装置的顶部和底部的光学接近。 平面装置包括设置在装置内的微细通道。
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22.发明授权公开(公告)号：US06498353B2
公开(公告)日：2002-12-24
申请号：US10038525
申请日：2001-10-24
申请人： Robert Nagle , Colin B. Kennedy
发明人： Robert Nagle , Colin B. Kennedy
IPC分类号： G01N1506
CPC分类号： B01L3/5027 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , G01N21/0303
摘要： The present invention provides microfluidic devices and systems that utilize optical detection systems, and where one or more light altering optical elements are integrated into the body structure of the microfluidic device. The resulting devices perform at least a portion of the optical manipulations used in the optical detection method employed.
摘要翻译： 本发明提供了利用光学检测系统的微流体装置和系统，并且其中一个或多个光改变光学元件被集成到微流体装置的主体结构中。 所得到的装置执行在所采用的光学检测方法中使用的光学操作的至少一部分。
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公开(公告)号：US08496875B2
公开(公告)日：2013-07-30
申请号：US11133943
申请日：2005-05-20
IPC分类号： G01N21/00
CPC分类号： G01N35/00584 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2300/0819 , G01N21/05 , G01N21/11 , G01N21/13 , G01N35/04 , G01N35/1095 , G01N2021/0346 , G01N2021/058
摘要： The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.
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公开(公告)号：US20120080315A1
公开(公告)日：2012-04-05
申请号：US13290843
申请日：2011-11-07
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44791 , B01L3/5027 , B01L2200/0636 , B01L2200/0689 , B01L2300/021 , B01L2300/0645 , B01L2300/0861 , B01L2400/0421 , G01N27/44717
摘要： The invention provides fluidic devices having incorporated electrodes, systems for using such devices, and methods for manufacturing such devices. The invention also provides fluidic devices configured to absorb joule heating within the device.
摘要翻译： 本发明提供了具有并入电极的流体装置，用于使用这种装置的系统以及用于制造这种装置的方法。 本发明还提供了被配置为吸收装置内的焦耳加热的流体装置。
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公开(公告)号：US06881312B2
公开(公告)日：2005-04-19
申请号：US10319045
申请日：2002-12-13
申请人： Anne R. Kopf-Sill , Andrea W. Chow , Peter C. Jann , Morten J. Jensen , Michael Spaid , Colin B. Kennedy , Michael J. Kennedy
发明人： Anne R. Kopf-Sill , Andrea W. Chow , Peter C. Jann , Morten J. Jensen , Michael Spaid , Colin B. Kennedy , Michael J. Kennedy
IPC分类号： B01L3/00 , B01L7/00 , B01L9/00 , G01N21/05 , G01N21/64 , G01N27/447 , G01N35/00 , G01N37/00 , G01N27/26
CPC分类号： G01N21/6452 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00628 , B01J2219/0063 , B01J2219/00659 , B01J2219/00707 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/54 , B01L9/527 , B01L2200/023 , B01L2200/027 , B01L2200/028 , B01L2200/147 , B01L2300/0654 , B01L2300/0816 , B01L2300/0829 , B01L2300/0867 , B01L2300/1822 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44782 , G01N35/0099 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421
摘要： Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided. Increased throughput and improved emissions detection is provided by the present invention by simultaneously illuminating multiple parallel microchannels at a non-normal incidence using an excitation beam including multiple excitation frequencies, and simultaneously detecting emissions from the substances in the microchannels in a direction normal to the substrate using a detection module with multiple detectors.
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公开(公告)号：US06488895B1
公开(公告)日：2002-12-03
申请号：US09568557
申请日：2000-05-09
申请人： Colin B. Kennedy
发明人： Colin B. Kennedy
IPC分类号： B01L302
CPC分类号： B01L3/502715 , B01J2219/0081 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0689 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0487
摘要： Multiplexed microfluidic devices include a plurality of modular microfluidic elements, all of which are attached to a common frame or substrate, which itself includes one or more common input elements that are connected to corresponding input elements within several or each of the microfluidic modules for use in common control and/or common detection operations for each of the modules.
摘要翻译： 复数微流体装置包括多个模块化微流体元件，所有这些都是连接到共同的框架或基底上，其本身包括一个或多个公共输入元件，其连接到几个或每个微流体模块内的相应的输入元件，用于 用于每个模块的公共控制和/或常见检测操作。
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公开(公告)号：US5876675A
公开(公告)日：1999-03-02
申请号：US906441
申请日：1997-08-05
申请人： Colin B. Kennedy
发明人： Colin B. Kennedy
IPC分类号： B01L3/00 , B01L9/00 , G01N27/447
CPC分类号： B01L3/502715 , B01L9/527 , G01N27/44791 , B01L2200/025 , B01L2200/087 , B01L2300/0816 , B01L2400/0415
摘要： Microfluidic devices and systems, and particularly, microfluidic devices that are easier to handle by the operator, without damaging, contaminating or otherwise fouling, as a result of manual contact with the device. These microfluidic devices and systems include manual handling structures, to allow handling of the small scale devices with minimal potential for fouling as a result of manual contact with the device.
摘要翻译： 微流体装置和系统，特别是由于与装置的手动接触而易于操作的微流体装置，而不会损坏，污染或以其他方式结垢。 这些微流体装置和系统包括手动处理结构，以允许以与装置的手动接触的结果最小的结垢潜力处理小规模装置。
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公开(公告)号：US20110139274A1
公开(公告)日：2011-06-16
申请号：US13030379
申请日：2011-02-18
CPC分类号： G01N27/44743 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2300/0816 , B01L2300/0887 , B01L2300/1894 , B01L2400/0421 , B01L2400/0481 , G01N27/44717 , G01N27/44791 , G01N30/84 , G01N33/5438 , Y10T29/49826 , Y10T137/8158 , Y10T137/8376
摘要： The invention provides fluidic devices having incorporated electrodes, systems for using such devices, and methods for manufacturing such devices. The invention also provides fluidic devices configured to absorb joule heating within the device.
摘要翻译： 本发明提供了具有并入电极的流体装置，用于使用这种装置的系统以及用于制造这种装置的方法。 本发明还提供了被配置为吸收装置内的焦耳加热的流体装置。
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公开(公告)号：US07727371B2
公开(公告)日：2010-06-01
申请号：US11245878
申请日：2005-10-07
申请人： Colin B. Kennedy , Evelio Perez
发明人： Colin B. Kennedy , Evelio Perez
IPC分类号： G01N27/26
CPC分类号： B01L9/527 , B01L3/5027 , B01L2200/025 , B01L2300/043 , B01L2300/0645 , B01L2400/0415
摘要： An electrode alignment apparatus may be used with a microfluidic device for accurate and repeatable alignment of electrode pins with reservoirs on the microfluidic device. The apparatus includes a base unit and an electrode block assembly that are moveable with respect to each other from an open position to a closed position. The electrode block assembly includes an interface array that is coupled to an interface array platform such that the interface array is moveable with respect to the interface array platform in three dimensions.
摘要翻译： 电极对准装置可以与微流体装置一起使用，用于精确和可重复地将电极针与微流体装置上的储存器对准。 该装置包括可从打开位置到关闭位置相对于彼此移动的基座单元和电极块组件。 电极块组件包括耦合到接口阵列平台的接口阵列，使得接口阵列在三维方面可相对于接口阵列平台移动。
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公开(公告)号：US06986837B2
公开(公告)日：2006-01-17
申请号：US10215885
申请日：2002-08-09
IPC分类号： G01N27/453
CPC分类号： G01N27/44721 , B01L3/5027 , B01L9/527 , B01L2200/027 , B01L2200/148 , B01L2400/0415 , G01N27/44791
摘要： A microfluidic controller and detector system and method for performing screening assays are disclosed. The microfluidic controller and detector system comprises a fluidic chip that includes at least two intersecting channels and a detection zone, a fluid direction system comprising an electrical interface configured for electrical contact with the at least two intersecting channels, an optics block having an objective lens disposed adjacent the detection zone, and a control system coupled to the optics block and adapted to receive and analyze data from the optics block. The electrical interface generally includes electrodes configured for electrical contact with the intersecting channels and coupled to electrode channels for supplying electrical input to the electrodes. A reference channel is optionally provided to calibrate the electrode channels.
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