中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

100 records (took 0.049 seconds)

    UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM
    22.
    发明申请
    UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 有权
    通用样品制备系统及其在综合分析系统中的应用

    公开(公告)号：US20140170645A1

    公开(公告)日：2014-06-19

    申请号：US13967957

    申请日：2013-08-15

    Applicant: IntegenX Inc.

    Inventor： Stevan B. Jovanovich ,  William D. Nielsen ,  David S. Cohen ,  Michael Recknor ,  Mattias Vangbo ,  Ezra Van Gelder ,  Lars Majlof ,  Omar El-Sissi

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  G01J3/4406 ,  G01N1/31 ,  G01N1/405 ,  G01N21/64 ,  G01N27/44721 ,  G01N27/44791 ,  G01N27/745 ,  G01N35/00029 ,  G01N2035/00148 ,  G01N2035/00247 ,  G01N2201/06113 ,  G01N2201/062 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

    Abstract translation: 本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。 例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。 该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。 在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。 在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。 墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。 该系统适合不超过10英尺3的外壳。 并且可以是封闭的，便携式的和/或电池供电的系统。 该系统可用于在不到4小时内从原始样品进行分析。

    Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis
    23.
    发明申请
    Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis 审中-公开
    电泳中多色，异相检测的方法和装置

    公开(公告)号：US20140065628A1

    公开(公告)日：2014-03-06

    申请号：US13966252

    申请日：2013-08-13

    Applicant: IntegenX Inc.

    Inventor： Ezra Van Gelder ,  Stephen J. Williams

    IPC: G01N27/447

    CPC classification number: G01N27/44721 ,  G01N27/44726 ,  G01N27/44791

    Abstract: The disclosure provides methods and devices for separating and detecting nucleic acid fragments labeled with a plurality of spectrally resolvable dyes using a single light source or multiple light sources. Use of a greater number of light sources increases the number of spectrally resolvable dyes that can be interrogated. Labeling fragments with a greater number of spectrally resolvable dyes permits more overlapping of fragments with differentiation of the fragments, and thus separation can be conducted on a smaller range of fragment sizes/lengths. To improve the detection sensitivity of a detection system employing multiple light sources, light emitted by the light sources can be spatially separated from one another and/or the intensity of each of the light sources can be modulated. Each of the one or more light sources can be, e.g., a laser or a light-emitting diode. The methods and devices of the disclosure are useful for performing genetic analysis, e.g., analysis of a plurality of STR markers utilized in a forensic database (e.g., CODIS) to identify humans.

    Abstract translation: 本公开提供了用于使用单个光源或多个光源分离和检测用多个可光谱可分辨染料标记的核酸片段的方法和装置。 使用更多数量的光源可增加可询问的光谱可分辨染料的数量。 具有更多数量的光谱可分辨染料的标记片段允许具有片段分化的片段更多的重叠，因此可以在更小的片段大小/长度范围上进行分离。 为了提高使用多个光源的检测系统的检测灵敏度，光源发射的光可以在空间上彼此分离和/或可以调制每个光源的强度。 一个或多个光源中的每一个可以是例如激光器或发光二极管。 本公开的方法和装置可用于进行遗传分析，例如分析在法医数据库（例如，CODIS）中使用的多个STR标记以鉴定人。

    Composite Plastic Articles
    30.
    发明申请
    Composite Plastic Articles 有权
    复合塑料制品

    公开(公告)号：US20110126911A1

    公开(公告)日：2011-06-02

    申请号：US12949623

    申请日：2010-11-18

    Applicant: Boris Kobrin ,  Iuliu I. Blaga ,  William Nielsen ,  Shize D. Qi ,  Ezra Van Gelder

    Inventor： Boris Kobrin ,  Iuliu I. Blaga ,  William Nielsen ,  Shize D. Qi ,  Ezra Van Gelder

    IPC: F17D1/00 ,  B32B9/04 ,  B32B37/14 ,  B29C47/00 ,  B32B38/06 ,  B32B38/10 ,  F15C1/04 ,  F16K31/48

    CPC classification number: F16K99/0001 ,  B01F11/0071 ,  B01F13/0059 ,  B32B7/02 ,  B32B9/04 ,  B33Y80/00 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/0318 ,  Y10T137/2213 ,  Y10T137/86453 ,  Y10T137/87249 ,  Y10T156/1039 ,  Y10T428/31504

    Abstract: This invention provides composite plastic articles and methods of making them. The articles can be fluidic or microfluidic devices having fluidic conduits and, optionally, pneumatic conduits that regulate flow in the fluidic conduits. The articles comprise a first substrate coated with a layer of a material that comprises, or onto which have been introduced, reactive groups. For example, the substrate can be a plastic coated with an oxide or a siloxane onto which hydroxyl groups have been introduced. These articles are covalently bonded with other articles comprising reactive groups on their surfaces, for example, polysiloxanes treated to have silanol groups. Certain articles have specified locations on their surfaces that are not bonded to the other piece. For example, the coating can be removed from these locations before bonding. Such locations can be useful as functional elements of various devices, such as valve seats in valves of microfluidic devices.

    Abstract translation: 本发明提供复合塑料制品及其制造方法。 制品可以是具有流体导管的流体或微流体装置，以及可选地调节流体管道中的流动的气动导管。 制品包括涂覆有材料层的第一基材，其包含或已经引入反应性基团的材料层。 例如，基底可以是涂覆有已经引入羟基的氧化物或硅氧烷的塑料。 这些制品与其表面上包含反应性基团的其它制品共价键合，例如被处理为具有硅烷醇基团的聚硅氧烷。 某些物品在其表面上指定了未粘结到另一件的位置。 例如，可以在粘合之前从这些位置去除涂层。 这样的位置可以用作各种装置的功能元件，例如微流体装置的阀中的阀座。

Patent Agency Ranking