公开(公告)号：US20170146711A1

公开(公告)日：2017-05-25

申请号：US15168395

申请日：2016-05-31

Applicant: AGENCY FOR DEFENSE DEVELOPMENT

Inventor： Yeon-Chul HA ,  Jae-Hwan LEE ,  Young-Su JEONG ,  Sun-Kyung CHOI ,  Young-Jin KOH

IPC: G02B5/28 ,  C23C14/10 ,  C23C14/46 ,  C23C14/08 ,  G01J3/02 ,  G01J3/44

CPC classification number: G02B5/283 ,  C23C14/081 ,  C23C14/10 ,  C23C14/46 ,  G01J3/0205 ,  G01J3/0227 ,  G01J3/44 ,  G01J3/4412 ,  G02B5/285

Abstract: A Raman edge filter and a method of manufacturing the same, wherein in order to obtain a Raman spectrum for compound analysis in a Raman spectrometer using a deep-ultraviolet ray (UV) laser, the Raman edge filter functions to eliminate a deep-UV laser wavelength, which is a light source, and to transmit Raman scattered light.

公开(公告)号：US09638638B2

公开(公告)日：2017-05-02

申请号：US14890109

申请日：2014-05-09

Applicant: Ludwig-Maximilians-Universität München

Inventor： Robert Alexander Huber ,  Thomas Klein ,  Wolfgang Wieser ,  Sebastian Karpf ,  Matthias Eibl

IPC: G01J3/44 ,  G01N21/65 ,  H01S3/067 ,  H01S3/10 ,  H01S3/23 ,  H01S3/30 ,  H01S3/0941 ,  H01S3/16 ,  H01S3/00 ,  H01S3/094

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01J3/4412 ,  G01N2021/655 ,  G01N2201/06113 ,  G01N2201/0683 ,  G01N2201/0697 ,  H01S3/0064 ,  H01S3/0078 ,  H01S3/06758 ,  H01S3/094069 ,  H01S3/09415 ,  H01S3/10015 ,  H01S3/1618 ,  H01S3/2391 ,  H01S3/302

Abstract: Disclosed herein is a system (10) for measuring light induced transmission or reflection changes, in particular due to stimulated Raman emission. The system comprises a first light source (12) for generating a first light signal having a first wavelength, a second light source (14) for generating a second light signal having a second wavelength, an optical assembly (16) for superposing said first and second light signals at a sample location (18), and a detection means (24) for detecting a transmitted or reflected light signal, in particular a stimulated Raman signal caused by a Raman-active medium when located at said sample location. Here in at least one of the first and second light sources (12, 14) is one or both of actively controllable to emit a time controlled light pattern or operated substantially in CW mode and provided with an extra cavity modulation means (64) for generating a time controlled light pattern. The detection means (24) is capable of recording said transmitted or reflected light signal, in particular stimulated Raman signal, as a function of time.

公开(公告)号：US09612108B2

公开(公告)日：2017-04-04

申请号：US14657209

申请日：2015-03-13

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Toru Mikami

IPC: G01B11/16 ,  G01B11/02 ,  G01J3/44 ,  G01J3/02 ,  G01N21/95 ,  G01N21/956 ,  G01J3/28

CPC classification number: G01B11/02 ,  G01J3/0264 ,  G01J3/4412 ,  G01J2003/284 ,  G01N21/9501 ,  G01N21/95607 ,  G01N2021/95615

Abstract: In accordance with an embodiment, a measurement apparatus includes a library creation unit, a spectral profile acquiring unit, and a measurement unit. The library creation unit creates a library in which a layer stack model is matched to a theoretical profile regarding a pattern of stacked layers. The spectral profile acquiring unit acquires an actual measured profile by applying light to a measurement target pattern obtained when the pattern is actually created. The measurement unit measures the sectional shape of the measurement target pattern by performing fitting of the theoretical profile to the actual measured profile. The layer stack model is created by calculating a feature value that reflects the intensity of reflected light from an interface for each of the layers, determining a priority order of analysis from the feature value, and sequentially performing fitting of the theoretical profile to the measured profile in the determined priority order.

公开(公告)号：US09498122B2

公开(公告)日：2016-11-22

申请号：US14308678

申请日：2014-06-18

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  David Muller ,  Amit Paranjape

IPC: A61B3/107 ,  A61B3/14 ,  A61B3/113 ,  A61B3/10 ,  A61B5/00

CPC classification number: A61B3/107 ,  A61B3/10 ,  A61B3/1025 ,  A61B3/113 ,  A61B3/14 ,  A61B5/0075 ,  G01J3/0213 ,  G01J3/0237 ,  G01J3/2823 ,  G01J3/4412

Abstract: A system for determining biomechanical properties of corneal tissue includes a light source configured to provide an incident light and a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of corneal tissue. The incident light is reflected by the corneal tissue as scattered light. The system also includes a filter or attenuating device configured to block or attenuate the Rayleigh peak frequency of the scattered light, a spectrometer configured to receive the scattered light and process frequency characteristics of the received scattered light to determine a Brillouin frequency shift in response to the Rayleigh peak frequency being blocked or attenuated by the filter or attenuating device, and a processor configured to generate a three-dimensional profile of the corneal tissue according to the determined Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the corneal tissue.

Abstract translation: 用于确定角膜组织的生物力学性质的系统包括被配置为提供入射光的光源和被配置为扫描穿过角膜组织的多个横截面的入射光的共焦显微镜系统。 入射光被角膜组织反射为散射光。 该系统还包括被配置为阻挡或衰减散射光的瑞利峰值频率的滤波器或衰减装置，被配置为接收散射光的光谱仪和接收的散射光的处理频率特性，以响应于所述散射光的布里渊频移来确定布里渊频移 瑞利峰值频率被滤波器或衰减装置阻挡或衰减，以及处理器，被配置为根据确定的布里渊频移产生角膜组织的三维轮廓。 三维轮廓提供角膜组织的一种或多种生物力学性质的指标。

公开(公告)号：US09395247B2

公开(公告)日：2016-07-19

申请号：US14767828

申请日：2014-02-13

Applicant: OULUN YLIOPISTO ,  TEKNOLOGIAN TUTKIMUSKESKUS VTT

Inventor： Juha Kostamovaara ,  Jussi Tenhunen

IPC: G01J3/44 ,  G01J3/28 ,  G01N21/65

CPC classification number: G01J3/4412 ,  G01J3/2803 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/65

Abstract: An apparatus comprises a semiconductor single-photon avalanche detector, and a counter. The detector performs detections of photons of optical radiation caused by an optical excitation pulse to the object. The counter measures timing of each detection made in the detector with respect to the excitation pulse causing the detected photons, and performs at least one of the following: forming a number of Raman detections, forming a number of fluorescence detections. Forming the number of the Raman detections is performed by eliminating an estimate of a number of fluorescence photons in the measurement. Forming the number of the fluorescence detections is performed by eliminating an estimate of a number of Raman photons in the measurement. The estimates are formed in a predetermined manner from the number and timing of the detections.

Abstract translation: 一种装置包括半导体单光子雪崩检测器和计数器。 检测器执行由对该物体的光激发脉冲引起的光辐射的光子的检测。 该计数器测量检测器中相对于引起检测到的光子的激发脉冲进行的每次检测的定时，并执行以下至少之一：形成多个拉曼检测，形成多个荧光检测。 通过消除测量中的荧光光子数量的估计来进行形成拉曼检测的数量。 通过消除测量中的拉曼光子数量的估计来进行荧光检测的数量。 从检测的次数和定时以预定的方式形成估计。

公开(公告)号：US20160177366A1

公开(公告)日：2016-06-23

申请号：US14910459

申请日：2014-08-07

Applicant: SERAPH BIOSCIENCES, LLC ,  WAYNE STATE UNIVERSITY

Inventor： Gregory William Auner ,  Charles Shanley ,  Michelle Brusatori ,  Tara Twomey ,  David Sant

IPC: C12Q1/04 ,  G01J3/44 ,  C12Q1/14

CPC classification number: C12Q1/04 ,  A61B5/0075 ,  A61B5/445 ,  A61B5/6815 ,  A61B5/6819 ,  A61B5/682 ,  A61B5/6846 ,  C12Q1/14 ,  G01J3/0208 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/44 ,  G01J3/4406 ,  G01J3/4412 ,  G01N21/65 ,  G01N2201/0221 ,  G01N2333/11 ,  G01N2333/31 ,  G01N2333/34

Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.

Abstract translation: 基于拉曼光谱的系统和检查和询问方法提供了用于快速和成本有效地筛选各种基于蛋白质的化合物如细菌，病毒，药物和组织异常的方法。 手持式分光镜包括用于产生拉曼移位采样信号的激光和光学系列，用于信号调节和目标检测的信号处理和识别算法，其中包括超高分辨率微滤器和成像检测器阵列的组合，以提供特定分析 在与目标病原体相关的离散光谱带内的目标光谱峰。

公开(公告)号：US20160123812A1

公开(公告)日：2016-05-05

申请号：US14891475

申请日：2014-05-21

Applicant: CANON KABUSHIKI KAISHA

Inventor： Masafumi Kyogaku

IPC: G01J3/44 ,  G01J3/06 ,  G02B21/00

CPC classification number: G01J3/4412 ,  G01J3/06 ,  G01N21/3151 ,  G01N21/65 ,  G01N2021/653 ,  G02B21/002

Abstract: A spectral microscopy device includes a spectral detecting unit including a light source capable of controlling an output wavelength, a microscope section having an observation area illuminated with light output from the light source, and a signal detector that detects light from the observation area as spectral data; a moving unit configured to move the observation area; and a controller that performs a control operation to allow the spectral detecting unit and the moving unit to move in response to each other. The spectral microscopy device is controlled so that switching between different measurement conditions based on the number of measurement points is performed at an observation area movement time in which the observation area is moved by the moving unit and measurement is performed and at a an observation area movement stoppage time in which the observation area is fixed and measurement is performed, and spectral data is detected.

Abstract translation: 光谱显微镜装置包括：光谱检测单元，包括能够控制输出波长的光源;具有由光源输出的光照射的观察区域的显微镜部分;以及检测来自观察区域的光作为光谱数据的信号检测器 ; 移动单元，被配置为移动所述观察区域; 以及控制器，其执行控制操作以允许所述光谱检测单元和所述移动单元彼此响应地移动。 控制光谱显微镜装置，使得在观察区域移动时间中，通过移动单元移动观察区域并进行测量，并且在观察区域移动中执行基于测量点数的不同测量条件之间的切换 观察区域固定并进行测量的停止时间，并检测光谱数据。

公开(公告)号：US20160123806A1

公开(公告)日：2016-05-05

申请号：US14896556

申请日：2014-06-04

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Philip Varghese ,  Manfred Fink

IPC: G01J3/02 ,  G01J3/44

CPC classification number: G01J3/0205 ,  G01J3/0208 ,  G01J3/0264 ,  G01J3/4412 ,  G01J2003/1213

Abstract: Raman scattering, while a powerful and versatile technique, relies of the detection of weak signals. Detecting the signal can be difficult if there is interference, especially if the interference comes from scattered stray light of the laser used to generate the Raman signal. Described here is a frequency modulation technique in combination with heterodyne detection that simultaneously rejects interference from ambient light as well as from scattered stray laser light. This provides a means to detect Raman signal and discriminate against scattered light without using an expensive and bulky spectrometer.

Abstract translation: 拉曼散射虽然功能强大，功能多样，但依赖于弱信号的检测。 如果存在干扰，检测信号可能很困难，特别是如果干扰来自用于产生拉曼信号的激光的散射杂散光。 这里描述的是与外差检测相结合的频率调制技术，其同时抑制来自环境光的干扰以及散射的杂散激光。 这提供了一种检测拉曼信号并且不使用昂贵和庞大的光谱仪来区分散射光的手段。

公开(公告)号：US20160109291A1

公开(公告)日：2016-04-21

申请号：US14971049

申请日：2015-12-16

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masashi ITO ,  Katsumi SHIBAYAMA ,  Takashi KASAHARA ,  Yoshihiro MARUYAMA

IPC: G01J3/02 ,  G01J3/44

CPC classification number: G01J3/0205 ,  G01J3/4412 ,  G01N21/658 ,  Y10T29/49155

Abstract: A method for making a surface enhanced Raman scattering device in accordance with one aspect of the present invention comprises a first step of forming a nanoimprint layer on a main surface of a wafer including a plurality of portions each corresponding to a substrate; a second step of transferring, by using a mold having a pattern corresponding to a fine structural part, the pattern to the nanoimprint layer after the first step, and thereby forming the formed layer including the fine structural part for each portion corresponding to the substrate; a third step of forming a conductor layer on the fine structural part after the second step; and a fourth step of cutting the wafer into each portion corresponding to the substrate after the second step.

Abstract translation: 根据本发明的一个方面的用于制造表面增强拉曼散射装置的方法包括在晶片的主表面上形成纳米压印层的第一步骤，该晶片的主表面包括各自对应于基板的多个部分; 在第一步骤之后，通过使用具有与精细结构部分相对应的图案的模具转移到纳米压印层的第二步骤，从而形成对应于基板的每个部分的包含精细结构部分的成形层; 在第二步骤之后，在精细结构部件上形成导体层的第三步骤; 以及在第二步骤之后将晶片切割成与基板相对应的每个部分的第四步骤。

公开(公告)号：US20160103069A1

公开(公告)日：2016-04-14

申请号：US14374933

申请日：2013-09-02

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva UMAPATHY ,  Sanchita SIL ,  John KIRAN

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/4412 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/129

Abstract: The invention provides a method for obtaining sample specific signatures. The method comprises of irradiating the sample at a predefined location with an electromagnetic radiation of specific wavelength; selectively capturing a certain component of the scattered electromagnetic radiation to obtain a plurality of profiles; and filtering the profiles to obtain a sample specific signature. The invention provides an apparatus for obtaining sample specific signatures.

Abstract translation: 本发明提供了一种获取样本特定签名的方法。 该方法包括在预定位置用特定波长的电磁辐射照射样品; 选择性地捕获散射电磁辐射的某一部分以获得多个轮廓; 并过滤配置文件以获得样本特定签名。 本发明提供一种用于获取样本特定签名的装置。