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公开(公告)号:US10131626B2
公开(公告)日:2018-11-20
申请号:US15480420
申请日:2017-04-06
发明人: Alain Wagner , Oleksandr Koniev
IPC分类号: C07K16/00 , C07C255/34 , C07K1/13 , C07C255/37 , C07C255/42 , C07C255/44 , C07C255/41 , C07C255/35 , C07C309/42 , C07D249/06 , C07C331/28 , C07C335/22 , C07C271/16 , C07C275/42 , C07C271/28 , C07F7/08 , C07C271/22 , C07D495/04 , C07F9/54 , C07D207/452 , C07D207/46 , C07D337/04 , C07D409/12 , C07D405/12 , C07D265/38 , C07D403/12 , C07C323/42 , C07D311/82 , C07C323/60 , C07K16/32 , C12N9/36
摘要: The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.
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公开(公告)号:US20180271851A1
公开(公告)日:2018-09-27
申请号:US15853174
申请日:2017-12-22
发明人: Patrick Henry Maxwell , Christopher William Pugh , Peter John Ratcliffe , Christopher Joseph Schofield
IPC分类号: A61K31/455 , A61K31/44 , A61K31/137 , A61K31/14 , A61K31/165 , A61K31/166 , A61K31/185 , A61K31/192 , G01N33/573 , C12Q1/34 , C12Q1/26 , C12N9/02 , C07K16/40 , C07K14/47 , C07D213/82 , C07D213/81 , C07D213/80 , C07C327/32 , C07C323/60 , C07C235/80 , A61K31/4412 , A61K31/327 , A61K31/265 , A61K31/24 , A61K31/235 , A61K31/225 , A61K31/223 , A61K31/221 , A61K31/21 , A61K31/198 , A61K31/197 , A61K31/195 , A61K31/194 , A61K39/395 , A61K38/00
CPC分类号: A61K31/455 , A01K2217/05 , A61K31/137 , A61K31/14 , A61K31/165 , A61K31/166 , A61K31/185 , A61K31/192 , A61K31/194 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/21 , A61K31/221 , A61K31/223 , A61K31/225 , A61K31/235 , A61K31/24 , A61K31/265 , A61K31/327 , A61K31/44 , A61K31/4412 , A61K38/00 , A61K39/3955 , C07C235/80 , C07C323/60 , C07C327/32 , C07D213/80 , C07D213/81 , C07D213/82 , C07K14/4702 , C07K16/40 , C07K2317/30 , C12N9/0071 , C12Q1/26 , C12Q1/34 , G01N33/573 , G01N2333/90245 , G01N2500/04 , G01N2500/20
摘要: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
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公开(公告)号:US20180265460A1
公开(公告)日:2018-09-20
申请号:US15913940
申请日:2018-03-07
发明人: Hsien-Yeh Chen , Zhen-Yu Guan , Chih-Yu Wu
IPC分类号: C07C319/22 , C07C45/30 , C07C17/16 , C07C29/14 , C07C209/08 , C07C45/45 , C09D165/04 , C07C323/60 , C07C211/31 , C07C22/04 , C07C33/34 , C07C47/546
CPC分类号: C07C319/22 , C07C17/16 , C07C22/04 , C07C29/14 , C07C45/30 , C07C45/45 , C07C209/08 , C07C2603/92 , C08G2261/1426 , C08G2261/1432 , C08G2261/145 , C08G2261/3424 , C09D165/04 , C07C323/60 , C07C211/31 , C07C33/34 , C07C47/546
摘要: The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3′-dithiodipropionic acid (DPDPA) and N-ethyl-N′-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.
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公开(公告)号:US20180193476A1
公开(公告)日:2018-07-12
申请号:US15702586
申请日:2017-09-12
发明人: Patrick Dennler , Delphine Bregeon , Laurent Gauthier , François Romagné , Christian Belmant , Eliane Fischer , Roger Schibli
IPC分类号: A61K47/68 , G01N33/68 , C12N9/10 , C12P21/00 , C07K19/00 , C07K16/00 , C07F9/50 , C07D277/06 , C07D257/08 , C07D225/08 , C07C323/60 , C07C323/12 , C07C247/04 , C07C233/62 , C07C229/26 , C07C223/02 , C07C217/08
摘要: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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公开(公告)号:US20180071402A1
公开(公告)日:2018-03-15
申请号:US15654585
申请日:2017-07-19
发明人: Delphine Bregeon , Patrick Dennler , Christian Belmant , Eliane Fischer , Laurent Gauthier , Francois Romagné , Roger Schibli
IPC分类号: G01N33/68 , C12N9/10 , C12P21/00 , C07K19/00 , C07K16/00 , C07F9/50 , C07D277/06 , C07D257/08 , C07D225/08 , C07C323/60 , C07C323/12 , C07C247/04 , C07C233/62 , C07C229/26 , C07C223/02 , C07C217/08
CPC分类号: A61K47/6803 , A61K47/60 , A61K47/68 , A61K47/6807 , A61K47/6813 , A61K47/6817 , A61K47/6865 , A61K47/6871 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07C323/12 , C07C323/60 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/5022 , C07K16/00 , C07K19/00 , C07K2317/40 , C12N9/1044 , C12P21/005 , G01N33/6854
摘要: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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公开(公告)号:US09896422B2
公开(公告)日:2018-02-20
申请号:US15427235
申请日:2017-02-08
申请人: Neumedics
发明人: Iain W. Duncan , Edward A. Kesicki , Carl G. Osborne , William D. Schwieterman , Irina Jacobson
IPC分类号: C07D265/34 , C07D263/52 , A61K31/423 , A61K31/536 , A61K45/06 , C07C323/60 , C07D263/62 , C07D498/10 , A61K31/65 , C07C233/58
CPC分类号: C07D265/34 , A61K31/423 , A61K31/536 , A61K31/65 , A61K45/06 , C07C233/58 , C07C323/60 , C07C2603/46 , C07D263/52 , C07D263/62 , C07D498/10
摘要: The present disclosure is directed to compositions and methods which utilize the tetracycline scaffold, preferably the scaffold of tetracycline or minocycline, and which significantly lack antibiotic activity. The compounds have neuroprotective attributes without interfering with the drugs capacity to pass through the blood brain barrier. These compounds have neuroprotective activity because of their inhibition of neuronal cell cycle progression. The compounds are characterized in part by a fifth ring joining positions 9 and 10.
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公开(公告)号:US20170342046A1
公开(公告)日:2017-11-30
申请号:US15604000
申请日:2017-05-24
发明人: Chi B. Vu
IPC分类号: C07D317/60 , C07C323/60 , C07C323/41 , C07C323/59 , C07D261/18 , C07D213/82
CPC分类号: C07D317/60 , A61P11/00 , C07C323/41 , C07C323/59 , C07C323/60 , C07D213/82 , C07D261/18
摘要: The invention relates to fatty acid cysteine-based conjugates, compositions comprising a fatty acid cysteine-based conjugates, and methods for using such conjugates and compositions to treat disease, such as a disease caused by dysregulation of autophagy or mitochondrial bioenergetics.
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公开(公告)号:US09815783B2
公开(公告)日:2017-11-14
申请号:US15179382
申请日:2016-06-10
申请人: EXSYMOL
IPC分类号: A61K8/46 , C07C323/41 , A61Q17/04 , C07C317/44 , C07C323/60 , A61K8/19 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/41 , A61K8/49 , A61K8/60 , A61K8/73 , A61K8/81 , A61K8/92
CPC分类号: C07C323/41 , A61K8/19 , A61K8/34 , A61K8/342 , A61K8/36 , A61K8/37 , A61K8/41 , A61K8/46 , A61K8/4973 , A61K8/608 , A61K8/73 , A61K8/8111 , A61K8/922 , A61Q17/04 , C07C317/44 , C07C323/60
摘要: The present invention relates to compounds of general formula (I): wherein Y, R1, R2 and R3 are as defined in the specification. The invention also relates to cosmetic or dermocosmetic composition containing such compounds.The compounds according to the invention are useful as photoprotective agents.
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公开(公告)号:US20170304254A1
公开(公告)日:2017-10-26
申请号:US15644993
申请日:2017-07-10
发明人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan R. DeAngelis
IPC分类号: A61K31/277 , C07D333/16 , C07C323/62 , C07C323/20 , A61K31/192 , C07C317/22 , C07C59/70 , C07C59/68 , C07D333/28 , C07C323/60
CPC分类号: A61K31/277 , A61K31/192 , C07C59/68 , C07C59/70 , C07C317/22 , C07C323/20 , C07C323/60 , C07C323/62 , C07D333/16 , C07D333/28
摘要: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
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30.
公开(公告)号:US09765020B2
公开(公告)日:2017-09-19
申请号:US14533131
申请日:2013-05-19
申请人: Mahesh Kandula
发明人: Mahesh Kandula
IPC分类号: C07C279/24 , A61K31/155 , C07C323/25 , C07C323/48 , C07C323/60 , C07D339/04
CPC分类号: C07C279/24 , A61K31/155 , C07C323/25 , C07C323/48 , C07C323/60 , C07D339/04
摘要: The invention relates to the compounds of related compounds, or pharmaceutically acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of mucositis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of mucus diseases related to painful inflammation and ulceration of the digestive tract lining and in the mouth.
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