公开(公告)号：US20170197907A1

公开(公告)日：2017-07-13

申请号：US15313365

申请日：2015-05-29

Applicant: E I DU PONT DE NEMOURS AND COMPANY

Inventor： Stephen Ernest Jacobson ,  Donald J. Dumas ,  Rupert Spence ,  Sarah May Crawford ,  Venkateswara Rao Surisetty

IPC: C07C201/12 ,  C07C253/14 ,  C07C231/02

CPC classification number: C07C201/12 ,  C07C231/02 ,  C07C253/14 ,  C07C205/57

Abstract: A method for preparing 3-methyl-2-nitrobenzoic acid is disclosed wherein 1,3-dimethyl-2-nitrobenzene is combined with an oxidation catalyst in the presence of an oxygen source and an initiator, provided that less than 99% of the 1,3-dimethyl-2-nitrobenzene is oxidized.A method for preparing compounds of Formula 7 and Formula 11 is also disclosed wherein the method is characterized by using 3-methyl-2-nitrobenzoic acid as prepared by the method disclosed above. wherein R1 is C1-C7 alkyl, C3-C6 cycloalkyl or C4-C7 alkylcycloalkyl

公开(公告)号：US20170160636A1

公开(公告)日：2017-06-08

申请号：US15323043

申请日：2015-07-14

Applicant: TOKYO OHKA KOGYO CO., LTD.

Inventor： Yoshinori TADOKORO ,  Dai SHIOTA

IPC: G03F7/031 ,  C07C249/10 ,  C07C201/12 ,  G02B5/22 ,  C07D333/22 ,  G03F7/00 ,  G02F1/1335 ,  C07C251/66 ,  C07C45/46

CPC classification number: G03F7/031 ,  C07C45/46 ,  C07C201/12 ,  C07C249/10 ,  C07C251/40 ,  C07C251/66 ,  C07C255/40 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/18 ,  C07D333/22 ,  C08F2/48 ,  G02B5/20 ,  G02B5/223 ,  G02F1/1333 ,  G02F1/1335 ,  G02F1/133514 ,  G03F7/0007

Abstract: The purpose of the present invention is to provide a photosensitive composition having excellent sensitivity, an insulating film formed using said photosensitive composition, a color filter formed using said photosensitive composition, a display device provided with said insulating film or said color filter, and a compound suitable for incorporation as a photopolymerization initiator into said photosensitive composition. This photosensitive composition includes (A) a photopolymerizable compound and (B) a photopolymerization initiator, wherein the photopolymerization initiator (B) contains a compound represented by formula (1). In formula (1), R1 is a hydrogen atom, a nitro group, or a monovalent organic group; R2 and R3 are each an optionally substituted linear alkyl group, an optionally substituted cyclic organic group, or a hydrogen atom, and R2 and R3 may be bonded to one another to form a ring; R4 is a monovalent organic group; R5 is a hydrogen atom, an optionally substituted C1-11 alkyl group, or an optionally substituted aryl group; n is an integer from 0 to 4; and m is 0 or 1.

公开(公告)号：US09663475B2

公开(公告)日：2017-05-30

申请号：US14768252

申请日：2014-01-20

Applicant: Merck Patent GmbH

Inventor： Markus Klein ,  Christos Tsaklakidis

IPC: A61K31/517 ,  C07D239/84 ,  C07D403/06 ,  C07D413/06 ,  A61K31/5377 ,  A61K31/538 ,  C07C201/12 ,  C07C209/22 ,  C07C209/36 ,  C07C213/02 ,  C07C331/28 ,  C07D239/95

CPC classification number: C07D239/84 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/538 ,  C07C201/12 ,  C07C209/22 ,  C07C209/36 ,  C07C213/02 ,  C07C331/28 ,  C07D239/95 ,  C07D403/06 ,  C07D413/06

Abstract: The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.

公开(公告)号：US20170144961A1

公开(公告)日：2017-05-25

申请号：US15300010

申请日：2015-04-08

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Teruki TAKAHASHI ,  Kazuya UEKI ,  Yuta NAGASHIMA

IPC: C07C201/12 ,  C07C205/11 ,  C07C209/68

CPC classification number: C07C201/12 ,  C07C205/11 ,  C07C209/68 ,  C07C211/29

Abstract: A compound represented by formula (1): can be produced by: a step wherein a compound represented by formula (2): is reacted with a compound represented by formula (3): thereby obtaining a compound represented by formula (4): a step wherein a compound represented by formula (4) is reacted with hypohalogenous acid or a salt thereof, thereby obtaining a compound represented by formula (5): and a step wherein a compound represented by formula (5) is reduced.

公开(公告)号：US09637462B2

公开(公告)日：2017-05-02

申请号：US15034751

申请日：2014-11-05

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED

Inventor： Gennady Nisnevich ,  Kseniya Kulbitski ,  Mark Gandelman ,  Alexander Artaryan

IPC: C07D263/26 ,  C07D275/06 ,  C07D233/82 ,  C07C41/22 ,  C07D233/74 ,  C07D263/22 ,  C07D209/48 ,  C07C17/093 ,  C07C29/64 ,  C07C41/05 ,  C07C67/05 ,  C07C201/12 ,  C07D211/38 ,  C07C17/10 ,  C07C17/12 ,  C07C17/14 ,  C07C17/363 ,  C07B39/00 ,  C07D207/46

CPC classification number: C07D263/26 ,  C07B39/00 ,  C07C17/093 ,  C07C17/10 ,  C07C17/12 ,  C07C17/14 ,  C07C17/363 ,  C07C29/64 ,  C07C41/05 ,  C07C41/22 ,  C07C67/05 ,  C07C201/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/42 ,  C07D207/46 ,  C07D209/48 ,  C07D211/38 ,  C07D233/74 ,  C07D233/82 ,  C07D263/22 ,  C07D275/06 ,  C07C43/225 ,  C07C35/48 ,  C07C43/192 ,  C07C33/46 ,  C07C43/174 ,  C07C69/63 ,  C07C22/04 ,  C07C25/02 ,  C07C205/12 ,  C07C25/13 ,  C07C205/11 ,  C07C23/10 ,  C07C23/28 ,  C07C23/08 ,  C07C23/14 ,  C07C23/16 ,  C07C19/07

Abstract: The present invention provides new stable crystalline N-iodoamides-1-iodo-3,5,5-trimethylhydantoin (1-ITMH) and 3-iodo-4,4-dimethyl-2-oxazolidinone (IDMO). The present invention further provides a process for the preparation of organic iodides using N-iodoamides of this invention and recovery of the amide co-products from waste water.

公开(公告)号：US09586883B2

公开(公告)日：2017-03-07

申请号：US14255049

申请日：2014-04-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Zachary K. Wickens ,  Bill Morandi ,  Robert H. Grubbs ,  Kacper Skakuj ,  Sarah M. Bronner

IPC: C07C45/34 ,  C07C249/04 ,  C07C253/00 ,  C07C201/12 ,  C07C205/44 ,  C07C209/60 ,  C07C213/00 ,  C07C227/08 ,  C07C51/373 ,  C07C59/235 ,  C07C211/48 ,  C07C217/48 ,  C07D301/22

CPC classification number: C07C45/34 ,  C07C51/373 ,  C07C201/12 ,  C07C205/44 ,  C07C209/60 ,  C07C213/00 ,  C07C227/08 ,  C07C249/04 ,  C07C253/00 ,  C07D301/22 ,  C07C59/235 ,  C07C211/48 ,  C07C217/48 ,  C07C229/18 ,  C07C47/02 ,  C07C47/11 ,  C07C47/14 ,  C07C47/19 ,  C07C47/198 ,  C07C47/277

Abstract: This disclosure is directed to methods of preparing organic aldehydes, each method comprising contacting a terminal olefin with an oxidizing mixture comprising: (a) a dichloro-palladium complex; (b) a copper complex; (c) a source of nitrite; under aerobic reaction conditions sufficient to convert at least a portion of the terminal olefin to an aldehyde.

Abstract translation: 本公开涉及制备有机醛的方法，每种方法包括使末端烯烃与氧化混合物接触，所述氧化混合物包含：（a）二氯 - 钯络合物; （b）铜络合物; （c）亚硝酸盐源; 在需氧反应条件下，足以将至少一部分末端烯烃转化为醛。

公开(公告)号：US20170037008A1

公开(公告)日：2017-02-09

申请号：US15101385

申请日：2014-11-06

Applicant: Zhiyong ZHANG ,  BEIJING ZHIBO BIO-MEDICAL TECHNOLOGY CO., LTD

Inventor： Zhiyong Zhang ,  Mengchao Cui ,  Chunping Lin ,  Boli Liu ,  Yuzhi Guo

IPC: C07D213/64 ,  C07C201/12 ,  C07C43/205 ,  C07C319/20 ,  C07C217/86 ,  C07C213/02 ,  C07C323/20 ,  C07C205/37 ,  C07C41/18

CPC classification number: C07D213/64 ,  A61K51/04 ,  A61K51/0406 ,  C07B2200/05 ,  C07C41/18 ,  C07C43/2055 ,  C07C43/225 ,  C07C43/23 ,  C07C201/12 ,  C07C205/37 ,  C07C211/53 ,  C07C213/02 ,  C07C217/86 ,  C07C319/20 ,  C07C323/20 ,  C07D213/65 ,  C07F7/2208

Abstract: Parts of compounds, after being labeled by radionuclide, of the phenyl benzyl ether derivative, are used as Aβ plaque imaging agent. The structural formula of the phenyl benzyl ether derivative is shown by formula (I). The present invention develops a kind of brand new phenyl benzyl ether derivative which has high affinity with Aβ plaques in brains of AD patients. The chemical structure of the phenyl benzyl ether derivative is different from that of compounds disclosed in the prior art and the phenyl benzyl ether derivative belongs to a brand new compound for diagnosing and treating AD. The obtained Aβ plaque imaging agent has the advantages that the in-vivo stability is good, the fat solubility is low, the removal speed for the brain is fast, the problem of removing the radionuclide in vivo does not exist, and the application prospect and the market value are great.

Abstract translation: 本发明涉及苯基苄基醚衍生物及其制备方法和用途，一部分化合物在放射性核素标记后作为Aβ斑块显像剂，苯基苄基醚衍生物用于制备 用于诊断和治疗阿尔茨海默病（AD）的药物。 苯基苄基醚衍生物具有式（I）所示的结构式; 本发明开发了一种对AD患者大脑中的Aβ斑块具有高亲和力的全新苯基苄基醚衍生物，其化学结构与现有技术公开的化合物的化学结构不同，属于 用于诊断和治疗阿尔茨海默病的全新化合物; 得到的Aβ噬菌斑显像剂体内稳定性好，脂质溶解度低，使得脑部消除速度快，体内不含放射性核素的去除问题，具有广阔的应用前景， 市场价值。

公开(公告)号：US09561998B2

公开(公告)日：2017-02-07

申请号：US15107872

申请日：2014-12-15

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Yuya Yoshimoto ,  Tatsuya Toriumi ,  Yuta Nagashima

IPC: C07C205/00 ,  C07C201/12 ,  C07C205/34 ,  C07C213/02

CPC classification number: C07C201/12 ,  C07C205/34 ,  C07C213/02 ,  C07C217/76

Abstract: A nitro compound represented by formula (1) which is a raw material for producing a compound represented by formula (7) can be produced by reacting at least one type selected from the group consisting of a compound represented by formula (2), a compound represented by formula (3), and a compound represented by formula (3′) with a compound represented by formula (4). [In the formula, R1, R2, R3, and R4 are each independently a hydrogen atom, etc., X1 and X2 are each independently a chlorine atom, etc., R6, R7, R8, and R9 are a hydrogen atom, etc., provided that X1, X2, R6, R7, R8, and R9 are not all the same, X3, X4, and X5 are a halogen atom, R10 is a nitro group, etc., R5 is an alkyl group having 1 to 12 carbon atoms, etc., and M is an alkali metal atom.]

Abstract translation: 作为用于制备由式（7）表示的化合物的原料的由式（1）表示的硝基化合物可以通过使选自由式（2）表示的化合物，化合物 （3）表示的化合物和式（3'）表示的化合物与式（4）表示的化合物反应。 [式中，R 1，R 2，R 3和R 4各自独立地为氢原子等，X 1和X 2各自独立地为氯原子等，R 6，R 7，R 8 ，R 9为氢原子等，条件是X 1，X 2，R 6，R 7，R 8和R 9不全部相同，X 3，X 4和X 5为卤素 原子，R 10为硝基等，R 5为碳原子数1〜12的烷基等，M为碱金属原子。

公开(公告)号：US20160339418A1

公开(公告)日：2016-11-24

申请号：US15158238

申请日：2016-05-18

Applicant: Bruce H. Lipshutz ,  Sachin Handa

Inventor： Bruce H. Lipshutz ,  Sachin Handa

IPC: B01J31/24 ,  C07C45/68 ,  C07F9/12 ,  C07D317/46 ,  C07C201/12 ,  C07D317/22 ,  C07D213/64 ,  C07D239/26 ,  C07D213/30 ,  C07D241/18 ,  C07D215/06 ,  C07D471/04 ,  C07D333/60 ,  C07D239/54 ,  C07D211/70 ,  C07D409/04 ,  C07D403/04 ,  C07D401/04 ,  C07D405/14 ,  C07D405/04 ,  B01J31/22 ,  B01J35/00 ,  B01J35/12 ,  C07C41/30

CPC classification number: B01J31/2404 ,  B01J23/8906 ,  B01J31/0202 ,  B01J31/0209 ,  B01J31/068 ,  B01J31/22 ,  B01J35/0013 ,  B01J35/10 ,  B01J35/12 ,  B01J37/16 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2231/4266 ,  B01J2231/64 ,  B01J2531/004 ,  B01J2531/007 ,  B01J2531/824 ,  B01J2531/842 ,  B01J2531/96 ,  B01J2531/985 ,  C07B37/04 ,  C07C37/18 ,  C07C41/30 ,  C07C45/68 ,  C07C201/12 ,  C07C205/12 ,  C07C209/325 ,  C07C209/68 ,  C07C211/45 ,  C07C269/06 ,  C07C269/08 ,  C07C319/20 ,  C07C2603/24 ,  C07D211/70 ,  C07D213/30 ,  C07D213/64 ,  C07D215/06 ,  C07D239/26 ,  C07D239/54 ,  C07D241/18 ,  C07D317/22 ,  C07D317/46 ,  C07D333/60 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D471/04 ,  C07F9/12 ,  C07C271/28 ,  C07C321/28 ,  C07C43/215 ,  C07C43/205 ,  C07C43/2055 ,  C07C47/546 ,  C07C47/575 ,  C07C39/21

Abstract: In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle (NP) catalyst, prepared by a reduction of an iron salt in an organic solvent, wherein the catalyst comprises at least one other metal selected from the group consisting of Pd, Pt, Au, Ni, Co, Cu, Mn, Rh, Jr, Ru and Os or mixtures thereof; c) a ligand; and d) a surfactant; wherein the metal or mixtures thereof is present in less than or equal to 50,000 ppm relative to the iron salt.

Abstract translation: 在一个实施方案中，本申请公开了一种催化剂组合物，其包含：a）反应溶剂或反应介质; b）有机金属纳米颗粒，其包含：i）通过在有机溶剂中还原铁盐制备的纳米颗粒（NP）催化剂，其中所述催化剂包含至少一种选自Pd，Pt，Au，Ni ，Co，Cu，Mn，Rh，Jr，Ru和Os或其混合物; c）配体; 和d）表面活性剂; 其中所述金属或其混合物相对于所述铁盐以小于或等于50,000ppm的量存在。

公开(公告)号：US20160332956A1

公开(公告)日：2016-11-17

申请号：US15112617

申请日：2015-02-16

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Satoru Ujita ,  Takashi Miyamoto

IPC: C07C205/11 ,  B01J23/44 ,  C07C201/12

CPC classification number: C07C205/11 ,  B01J21/18 ,  B01J23/44 ,  C07C201/12

Abstract: Position-1 halogen can be selectively reduced by reacting a compound represented by formula (3): [wherein X represents a chlorine atom, a bromine atom, or an iodine atom] with halogen in the presence of a heterogeneous transition metal catalyst to produce 2-(halogenomethyl)-1-methyl-3-nitrobenzene represented by formula (1): [wherein the symbol is as defined above].