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公开(公告)号：US11808697B2
公开(公告)日：2023-11-07
申请号：US17877680
申请日：2022-07-29
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Evan Thrush , Steven Swihart , William Strong , Trey Marlowe , Li Lu
IPC: G01N21/31 , G01N21/3577 , G01N21/3563
CPC classification number: G01N21/3103 , G01N21/3563 , G01N21/3577 , G01N2021/3572 , G01N2201/0686
Abstract: Systems for protein quantitation using a Fabry-Perot interferometer. In one arrangement, a quantitation device includes an infrared source, a sample holder, and a Fabry-Perot interferometer positioned to receive infrared radiation from the source passing through a sample on the sample holder. A band pass optical filter sets the working range of the interferometer, and radiation exiting the interferometer falls on a detector that produces a signal indicating the intensity of the received radiation. A controller causes the interferometer to be tuned to a number of different resonance wavelengths and receives the intensity signals, for determination of an absorbance spectrum.
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公开(公告)号：US20230314302A1
公开(公告)日：2023-10-05
申请号：US18195084
申请日：2023-05-09
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kalyan Handique
CPC classification number: G01N15/1484 , B01L3/021 , B01L3/502715 , B01L3/502746 , B01L3/502761 , C12M47/04 , G01N1/20 , G01N1/28 , G01N1/40 , G01N1/405 , B01L2200/0668 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , G01N1/4077 , G01N2015/149 , G01N2035/00158
Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
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公开(公告)号：US20230314301A1
公开(公告)日：2023-10-05
申请号：US18195048
申请日：2023-05-09
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kalyan Handique
CPC classification number: G01N15/1484 , B01L3/021 , B01L3/502715 , B01L3/502746 , B01L3/502761 , C12M47/04 , G01N1/20 , G01N1/28 , G01N1/40 , G01N1/405 , B01L2200/0668 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , G01N1/4077 , G01N2015/149 , G01N2035/00158
Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
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公开(公告)号：US20230313278A1
公开(公告)日：2023-10-05
申请号：US18106189
申请日：2023-02-06
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ronald LEBOFSKY
IPC: C12Q1/6834 , C12Q1/6855
CPC classification number: C12Q1/6834 , C12Q1/6855 , C12Q2565/1015 , C12Q2563/137
Abstract: Methods and compositions for attaching cell-specific barcodes without formation of partitions is provided.
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公开(公告)号：US11768198B2
公开(公告)日：2023-09-26
申请号：US16795467
申请日：2020-02-19
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Michael L. Samuels , Jeffrey Charles Olson , Andrew Watson , Keith Brown , Darren R. Link
IPC: G01N33/53 , G01N33/532 , C40B50/08 , C12Q1/6874 , G01N33/543 , G01N33/58 , C12Q1/6804 , C12Q1/6806 , C12N15/10
CPC classification number: G01N33/53 , C12N15/1075 , C12Q1/6804 , C12Q1/6806 , C12Q1/6874 , C40B50/08 , G01N33/532 , G01N33/5436 , G01N33/58 , C12Q2521/10 , C12Q2563/179 , C12Q2565/30 , G01N2458/10
Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
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Patent Agency Ranking
公开(公告)号：US20230280337A1
公开(公告)日：2023-09-07
申请号：US18305650
申请日：2023-04-24
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Michael L. Samuels , Darren Roy Link
IPC: G01N33/543 , C40B40/04 , C40B70/00 , G01N33/532 , C40B40/00 , C12Q1/6874
CPC classification number: G01N33/54366 , C40B40/04 , C40B70/00 , G01N33/532 , C40B40/00 , C12Q1/6874 , B01F33/3011
Abstract: The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte.
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公开(公告)号：US20230264171A1
公开(公告)日：2023-08-24
申请号：US18307991
申请日：2023-04-27
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： CHRISTOPHER BELISLE , HONG CHEN , YUEPING XU , JIALI LIAO , XUEMEI HE
IPC: B01J20/26 , B01D15/36 , B01J20/32 , C07K16/06 , B01J20/289
CPC classification number: B01J20/262 , B01D15/363 , B01J20/3285 , B01J20/3227 , B01J20/3208 , B01J20/3219 , C07K16/065 , B01J20/289 , B01J20/3248 , B01J20/3253 , B01D15/3847
Abstract: Chromatography resins having mixed mode ligands and methods of using such resins are provided.
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38.发明授权公开(公告)号：US11731108B2
公开(公告)日：2023-08-22
申请号：US17696917
申请日：2022-03-17
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Christopher Belisle , Jiali Liao , Edwin Lozano
IPC: B01J20/28 , B01D15/38 , B01J20/30 , C07K1/16 , B01J20/285 , B01J20/289
CPC classification number: B01J20/285 , B01D15/3809 , B01D15/3847 , B01J20/289 , B01J20/28085 , B01J20/3042 , C07K1/165 , B01J2220/52
Abstract: The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-dioxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
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公开(公告)号：US11690169B2
公开(公告)日：2023-06-27
申请号：US17841931
申请日：2022-06-16
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Amir Sadri , Neven Nikolic , Gabriel Culinco , Thanh-Vi Tran , Nenad Kircanski
CPC classification number: H05K1/0272 , H05K7/20145 , H05K7/20163 , H05K7/20209 , H05K2201/064 , H05K2201/066
Abstract: A thermal management system that include an electronic circuit boards having at least two circuit boards with a space in between and further includes one or more air tubes or conduits. The electronic circuit board and air tubes are configured for drawing air into the space to facilitate cooling of the electronic circuit board concurrent with cooling of a heat sink of a heat pump connected with the electronic circuit board. The system can further include a partition to isolate airflow from the heat sink from airflow through the electronics circuit board, and can further include one or more interface components for maintaining isolation and control of air flow, improving air intake and/or supporting auxiliary components.
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40.发明公开公开(公告)号：US20230182127A1
公开(公告)日：2023-06-15
申请号：US18076667
申请日：2022-12-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Vishal Sharma , Ronald Lebofsky , Man Cheng , Adam McCoy , Kalyan Handique , Eric Pomaranski
CPC classification number: B01L3/502 , C12N13/00 , B01L2200/026 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/047 , B01L2300/0893
Abstract: Inventions covered include methods, systems, and compositions for sample processing, involving morphology-adjustable (e.g., tunable on-demand) functionalized particles. In some embodiments, a method can include distributing a set of functionalized particles, in a first morphological state, across a set of partitions; transitioning the set of functionalized particles, at the set of partitions, from the first morphological state to a second morphological state; transitioning the set of functionalized particles, at the set of partitions, from the second morphological state to a third morphological state, and inducing interactions between the set of functionalized particles and a set of targets, within the set of partitions and according to a set of operations with a set of process fluids.
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