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    Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis
    32.
    发明授权
    Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis 有权

    公开(公告)号：US11817302B2

    公开(公告)日：2023-11-14

    申请号：US18046986

    申请日：2022-10-17

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Don W. Arnold ,  Thomas R. Covey ,  Chang Liu

    IPC: H01J49/04 ,  G01N1/40 ,  H01J49/16 ,  G01N30/00

    CPC classification number: H01J49/0495 ,  G01N1/405 ,  H01J49/0404 ,  H01J49/165 ,  G01N2030/009

    Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).

    Fourier transform mass spectrometer based on use of a fringing field to convert radial oscillations of excited ions to axial oscillations
    33.
    发明授权
    Fourier transform mass spectrometer based on use of a fringing field to convert radial oscillations of excited ions to axial oscillations 有权

    公开(公告)号：US11810771B2

    公开(公告)日：2023-11-07

    申请号：US16482476

    申请日：2018-01-29

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： James Hager

    IPC: H01J49/00 ,  H01J49/06 ,  H01J49/42

    CPC classification number: H01J49/0031 ,  H01J49/063 ,  H01J49/067 ,  H01J49/427

    Abstract: In one aspect, a mass analyzer is disclosed, which comprises a quadrupole having an input end for receiving ions and an output end through which ions can exit the quadrupole, said quadrupole having a plurality of rods to at least some of which an RF voltage can be applied for generating a quadrupolar field for causing radial confinement of the ions as they propagate through the quadrupole and further generating fringing fields in proximity of said output end. The mass analyzer further includes at least a voltage source for applying a voltage pulse to at least one of said rods so as to excite radial oscillations of at least a portion of the ions passing through the quadrupole at secular frequencies thereof, where the radially-excited ions interact with the fringing fields as they exit the quadrupole such that their radial oscillations are converted into axial oscillations.

    Systems and Methods for Separating Compounds of Similar Mass by Differential Mobility Spectrometry
    37.
    发明公开
    Systems and Methods for Separating Compounds of Similar Mass by Differential Mobility Spectrometry 审中-公开

    公开(公告)号：US20230288372A1

    公开(公告)日：2023-09-14

    申请号：US18019546

    申请日：2021-02-03

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Leigh BEDFORD ,  Bradley SCHNEIDER

    IPC: G01N27/624 ,  G01N27/623

    CPC classification number: G01N27/624 ,  G01N27/623

    Abstract: A method and apparatus are provided for separating and distinguishing between isotopic or isobaric opioid and/or benzodiazepine species within a sample. The method comprises introducing ions of the sample to an inlet of a differential mobility spectrometer (DMS), introducing a transport gas to carry the ions through the DMS, supplying an acetate modifier to the transport gas to modify the differential mobility of the ions, transporting the ions through the DMS in the presences of the acetate modifier and selectively transporting each of the species by selectively applying a corresponding compensation voltage for that species to allow that species to transport through and exit from the DMS.

    Electron Activation Dissociation Reaction Device with Ion Isolation Functionality in Mass Spectrometry
    39.
    发明公开
    Electron Activation Dissociation Reaction Device with Ion Isolation Functionality in Mass Spectrometry 审中-公开

    公开(公告)号：US20230260775A1

    公开(公告)日：2023-08-17

    申请号：US18016173

    申请日：2021-07-12

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Takashi BABA ,  Grant GODBEHERE

    IPC: H01J49/42 ,  H01J49/40

    CPC classification number: H01J49/422 ,  H01J49/427 ,  H01J49/421 ,  H01J49/40

    Abstract: In one aspect, a method of performing mass spectrometry is disclosed, which comprises ionizing a sample to generate a plurality of precursor ions, passing the precursor ions through a mass filter to select at least one subset of the ions, introducing the selected ions into a branched radiofrequency (RF) ion trap and subjecting at least a portion of said selected precursor ions to fragmentation within the ion trap so as to generate a first plurality of fragment ions. The method can further include isolating at least a portion of the first plurality of fragment ions in at least one branch of the branched RF ion trap, removing unwanted fragment ions, releasing the remaining ions from said at least one branch and subjecting at least a portion thereof to fragmentation so as to generate a second plurality of fragment ions. Any combination of collision induced dissociation (CID) and electron activation dissociation (EAD) can be employed for fragmenting the ions.

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