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    Bioengineered tissue substitutes
    31.
    发明授权
    Bioengineered tissue substitutes 失效
    生物工程组织替代品

    公开(公告)号：US07622299B2

    公开(公告)日：2009-11-24

    申请号：US10374755

    申请日：2003-02-24

    申请人： Joan E. Sanders ,  Thomas Neumann

    发明人： Joan E. Sanders ,  Thomas Neumann

    IPC分类号： C12N5/06

    CPC分类号： C12N5/0691 ,  A61K35/12 ,  A61L27/18 ,  A61L27/34 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3852 ,  A61L27/3873 ,  A61L27/3882 ,  A61L27/3886 ,  A61L27/3895 ,  C12N5/0068 ,  C12N5/0658 ,  C12N2533/40 ,  C12N2533/54 ,  C08L67/04 ,  C08L89/00

    摘要： In one aspect, the invention provides methods for forming a target tissue substitute. The methods of the invention comprise the following steps: (a) providing a scaffold comprising one or more layers of one or more arrays of microfibers, wherein one or more of the arrays of microfibers is designed to mimic the configuration of one or more structural elements in a target tissue; and (b) culturing cells on the scaffold to form a target tissue substitute. In another aspect, the invention provides implantable medical devices. The implantable medical devices of the invention comprise a scaffold comprising one or more layers of one or more arrays of microfibers, wherein one or more of the arrays of microfibers is arranged to mimic the configuration of one or more structural elements in a target tissue. Typically, cells are cultured on the scaffold to form a target tissue substitute.

    摘要翻译： 一方面，本发明提供了形成靶组织替代物的方法。 本发明的方法包括以下步骤：（a）提供包含一层或多层一层或多层微纤维阵列的支架，其中一个或多个微纤维阵列被设计为模拟一个或多个结构元件的构型 在目标组织中; 和（b）在支架上培养细胞以形成靶组织替代物。 在另一方面，本发明提供了可植入医疗装置。 本发明的可植入医疗装置包括支架，其包括一层或多层一层或多层微纤维阵列，其中微纤维阵列中的一个或多个排列成模拟靶组织中一种或多种结构元件的构型。 通常，将细胞培养在支架上以形成靶组织替代物。

    Method for creating perfusable microvessel systems
    32.
    发明授权
    Method for creating perfusable microvessel systems 有权
    创建可灌注微血管系统的方法

    公开(公告)号：US07622298B2

    公开(公告)日：2009-11-24

    申请号：US11388920

    申请日：2006-03-24

    申请人： Thomas Neumann

    发明人： Thomas Neumann

    IPC分类号： C12N5/06

    CPC分类号： C12N5/0691 ,  C12M21/08 ,  C12M23/06 ,  C12M23/16 ,  C12M23/20 ,  C12M29/10 ,  C12N2533/50

    摘要： Microvessel networks are produced in vitro from tissue-engineered parent vessels sprouting into a supporting matrix, as for example gels, of extracellular matrix proteins. The microvessel systems are integrated into devices that allow for controlled perfusion with fluids. The vessels may include cells from one cell type, for example, endothelial cells, or from combinations of two or more cell types.

    摘要翻译： 微血管网络在体外从组织工程化的母体血管发育成支持基质，例如凝胶，细胞外基质蛋白。 微血管系统集成到允许用流体控制灌注的装置中。 血管可以包括来自一种细胞类型的细胞，例如内皮细胞，或两种或多种细胞类型的组合。

    Master-slave processor for dual mode mobile telephone
    33.
    发明授权
    Master-slave processor for dual mode mobile telephone 有权
    双模移动电话主从处理器

    公开(公告)号：US07292557B2

    公开(公告)日：2007-11-06

    申请号：US10096233

    申请日：2002-03-08

    申请人： Thomas Neumann ,  Bodo Zeug

    发明人： Thomas Neumann ,  Bodo Zeug

    IPC分类号： H04B7/212

    CPC分类号： H04W88/06 ,  H04M1/72519

    摘要： A wireless telephone includes first and second baseband processors. The first baseband processor (GSM) functions as system master, and the second processor (TDMA) functions as system slave. The first baseband processor interfaces to system controls, such as power supply, man-machine interface (MMI), and the like.

    摘要翻译： 无线电话包括第一和第二基带处理器。 第一基带处理器（GSM）用作系统主机，第二处理器（TDMA）用作系统从机。 第一个基带处理器与系统控制接口，如电源，人机界面（MMI）等。

    System and method for rate adaptation in a wireless communication system
    35.
    发明授权
    System and method for rate adaptation in a wireless communication system 失效

    公开(公告)号：US07103129B2

    公开(公告)日：2006-09-05

    申请号：US10095670

    申请日：2002-03-08

    申请人： Thomas Neumann ,  Claudio Koehl

    发明人： Thomas Neumann ,  Claudio Koehl

    IPC分类号： H04L25/00

    CPC分类号： H04M1/725

    摘要： A wireless telephone includes first and second baseband processors. The first baseband processor functions as system master, and the second processor functions as system slave. The first baseband processor interfaces to system controls, such as power supply, man-machine interface (MMI), and the like. The master processor implements a first pair of buffers in the downlink direction and a second pair in an uplink direction. The buffers in the pairs are swapped periodically, based on an internal counter running on the master processor. The timing of the master processor is continuously adjusted to that of the slaved co-processor, by counting a number of samples received from the microphone respectively fed to the earpiece between the beginning of consecutive frames. The timing of the master processor is then adjusted accordingly. The output of the counter may be lowpass filtered to separate jitter from frequency deviation.

    Method of preparing N-phosphonomethyl glycine
    36.
    发明授权
    Method of preparing N-phosphonomethyl glycine 失效
    制备N-膦酰基甲基甘氨酸的方法

    公开(公告)号：US06121485A

    公开(公告)日：2000-09-19

    申请号：US194953

    申请日：1998-12-07

    申请人： Thomas Neumann ,  Frank Fleischer ,  Jurgen Graefe ,  Benedikt Hammer

    发明人： Thomas Neumann ,  Frank Fleischer ,  Jurgen Graefe ,  Benedikt Hammer

    IPC分类号： C07F9/38

    CPC分类号： C07F9/3813

    摘要： To prepare N-phosphonomethyl glycine,a) aminomethylphosphonic acid or one of its salts in water, if necessary or desirable with the addition of lyes, is reacted with an alkali carbonate and/or alkali hydrogencarbonate or with carbon dioxide and a lye,b) the resulting alkali salt of N-phosphonomethylcarbamic acid is subsequently hydroxymethylated with formaldehyde,c) the salts, resulting from b), of N-hydroxymethyl-N-phosphonomethyl-carbamic acid, if necessary or desirable with addition of a lye, are reacted with hydrocyanic acid and/or a cyanide andd) the N-carboxy-N-phosphonomethylglyconitrile salts thus obtained are treated with acids and converted by means of hydrolysis and decarboxylation into N-phosphonomethyl glycine.In this way, it is possible to obtain excellent yields of high-purity N-phosphonomethyl glycine.

    摘要翻译： PCT No.PCT / EP97 / 03955 371 1998年12月7日第 102（e）日期1998年12月7日PCT 1997年7月22日PCT公布。 第WO98 / 03517号公报 日期1998年1月29日为了制备N-膦酰基甘氨酸，a）氨基甲基膦酸或其盐中的一种盐，如果需要或需要加入碱液，则与碱金属碳酸盐和/或碱金属碳酸盐或二氧化碳反应， 碱液，b）得到的N-膦酰基甲基氨基甲酸的碱金属盐随后用甲醛羟甲基化，c）由N-羟甲基-N-膦酰基甲基 - 氨基甲酸产生的盐，如果需要或需要，加入 碱液与氢氰酸和/或氰化物反应，d）由此得到的N-羧基-N-膦酰基甲基甘腈盐用酸处理并通过水解和脱羧转化为N-膦酰基甲基甘氨酸。 以这种方式，可以获得高纯度N-膦酰基甲基甘氨酸的良好产率。

    Apparatus for separating off light materials from sand and gravel
    37.
    发明授权
    Apparatus for separating off light materials from sand and gravel 失效
    用于从沙子和砾石中分离轻质材料的装置

    公开(公告)号：US6036028A

    公开(公告)日：2000-03-14

    申请号：US68216

    申请日：1998-06-12

    申请人： Andreas Jungmann ,  Walter Strangalies ,  Thomas Neumann

    发明人： Andreas Jungmann ,  Walter Strangalies ,  Thomas Neumann

    IPC分类号： B03B5/00 ,  B03B5/62 ,  B03B11/00 ,  B04C5/12 ,  B03B5/60 ,  B03B7/00

    CPC分类号： B03B11/00 ,  B03B5/00 ,  B03B5/62

    摘要： An apparatus for separating out light materials from mineral raw materials is provided. The apparatus includes a charging device that has a charging tube provided with an eccentrically arranged inlet for tangential introduction of raw material. The apparatus also has an inner chamber for separating out coarse sand received from the charging tube, and an outer chamber that serves for sorting out fine sand pursuant to the fluidized bed process. The outer chamber communicates with an overflow chute of the charging tube via an inclined overflow surface. An impingement body is centrally disposed in the inner chamber while leaving free an outer annular gap. The charging tube opens out centrally above the impingement body. A perforated basket, for adjusting flow resistance, is disposed so as to be displaceable in the axis of the charging tube and bridges a space between the impingement body and the end of the charging tube. The overflow chute of the charging tube is provided at that end thereof remote from the impingement body. As a function of a separation particle size setting of the charging device, which is adjusted by displacement of the perforated basket, the overflow chute communicates either with the outer chamber or with a light material overflow associated therewith.

    摘要翻译： PCT No.PCT / DE96 / 02081 Sec。 371日期：1998年6月12日 102（e）1998年6月12日PCT PCT 1996年10月29日PCT公布。 公开号WO97 / 16253 日期1997年5月9日提供了一种用于从矿物原料中分离出轻质材料的设备。 该装置包括充电装置，其具有设置有用于切向引入原材料的偏心布置的入口的充电管。 该设备还具有用于分离从充电管接收的粗砂的内室和用于根据流化床工艺分选细砂的外室。 外部室通过倾斜的溢流表面与充电管的溢流槽连通。 冲击体中心设置在内腔中，同时留下外部环形间隙。 充电管在冲击体的上方中心开口。 布置用于调节流动阻力的穿孔篮，以便能够在充电管的轴线上移动，并且将冲击体和充电管的端部之间的空间桥接。 充电管的溢流槽设置在其远离冲击体的一端。 作为通过多孔筐的位移来调节的充电装置的分离粒度设定的函数，溢流槽与外部室或与其相关联的轻质材料溢出连通。

    Functional imaging of cells with optical projection tomography
    38.
    发明授权
    Functional imaging of cells with optical projection tomography 有权
    光学投影断层扫描的细胞功能成像

    公开(公告)号：US08947510B2

    公开(公告)日：2015-02-03

    申请号：US12999515

    申请日：2009-06-08

    申请人： Michael G. Meyer ,  J. Richard Rahn ,  Anna V. Tourovskaia ,  Julia Oi Yan Yu ,  Christy A Lancaster ,  Thomas Neumann ,  Mark E. Fauver

    发明人： Michael G. Meyer ,  J. Richard Rahn ,  Anna V. Tourovskaia ,  Julia Oi Yan Yu ,  Christy A Lancaster ,  Thomas Neumann ,  Mark E. Fauver

    IPC分类号： H04N13/02 ,  G06T11/00 ,  G01N15/14

    CPC分类号： G06T11/006 ,  G01N15/1434 ,  G01N15/1475 ,  G01N21/49 ,  G01N21/6458 ,  G01N2015/1445

    摘要： A method for 3D imaging of a biologic object (1) in an optical tomography system where a subcellular structure of a biological object (1) is labeled by introducing at least one nanoparticle-biomarker. The labeled biological object (1) is moved relatively to a microscope objective (62) to present varying angles of view and the labeled biological object (1) is illuminated with radiation having wavelengths between 150 nm and 900 nm. Radiation transmitted through the labeled biological object (1) and the microscope objective (62) within at least one wavelength bands is sensed with a color camera, or with a set of at least four monochrome cameras. A plurality of cross-sectional images of the biological object (1) from the sensed radiation is formed and reconstructed to make a 3D image of the labeled biological object (1).

    摘要翻译： 一种用于在其中通过引入至少一种纳米颗粒 - 生物标志物标记生物体（1）的亚细胞结构的光学层析成像系统中的生物物体（1）的3D成像的方法。 标记的生物体（1）相对于显微镜物镜（62）移动以呈现不同的视角，并且用波长在150nm和900nm之间的辐射照射标记的生物物体（1）。 用彩色照相机或一组至少四个单色照相机检测在至少一个波长带内通过标记的生物物体（1）和显微镜物镜（62）发射的辐射。 形成并重构来自感测辐射的生物体（1）的多个横截面图像，以便制成标记的生物体（1）的3D图像。