公开(公告)号：US20110172587A1

公开(公告)日：2011-07-14

申请号：US13012426

申请日：2011-01-24

申请人： John T. Santini, JR. ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello ,  Norman F. Sheppard, JR. ,  Stephen J. Herman

发明人： John T. Santini, JR. ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello ,  Norman F. Sheppard, JR. ,  Stephen J. Herman

IPC分类号： A61F9/00

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61K9/0009 ,  A61K9/0048 ,  A61K9/0097 ,  H01L24/96 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01011 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/0102 ,  H01L2924/01027 ,  H01L2924/01033 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/12043 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/19041 ,  H01L2924/19043 ,  H01L2924/00

摘要： Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.

摘要翻译： 提供了将药物输送到眼睛的方法和系统。 该方法和系统可以包括将包括两个或更多个离散储器的装置植入眼中，每个储存器包含药物; 以及将聚焦光引导到所述植入装置以打开所述储存器中的第一个，从而允许所述药物从所述第一储存器扩散到所述患者的眼睛。

公开(公告)号：US07872396B2

公开(公告)日：2011-01-18

申请号：US11881830

申请日：2007-07-26

申请人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

发明人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

IPC分类号： H01L41/08

CPC分类号： F03G7/005 ,  H01M2/16 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/587 ,  H01M6/30 ,  H01M2004/021 ,  H01M2010/4292

摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.

摘要翻译： 本发明提供涉及电化学致动的系统，装置和相关方法。 在一些情况下，将电压或电流施加到本发明的系统或装置可能产生容积或尺寸变化，这可能产生机械作业。 例如，系统的至少一部分可以被构造和布置成从第一取向向第二取向移位。 诸如这些的系统可用于各种应用，例如泵（例如输注泵）和药物输送装置。

公开(公告)号：US20100152704A1

公开(公告)日：2010-06-17

申请号：US12709551

申请日：2010-02-22

申请人： Heejin Lee ,  Karen Daniel ,  Hong Linh Ho Duc ,  Michael J. Cima ,  Mario Castillo ,  Steven Froelich ,  Jordan Dimitrakov ,  Grace Y. Kim

发明人： Heejin Lee ,  Karen Daniel ,  Hong Linh Ho Duc ,  Michael J. Cima ,  Mario Castillo ,  Steven Froelich ,  Jordan Dimitrakov ,  Grace Y. Kim

IPC分类号： A61M25/00 ,  A61K31/167 ,  A61K33/04 ,  A61K31/737 ,  A61K31/24 ,  A61K31/407

CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61L29/06 ,  A61L29/16 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/45 ,  A61L2300/63 ,  A61M2202/06 ,  A61M2205/0216 ,  A61M2210/1085 ,  C08L83/04

摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.

摘要翻译： 用于膀胱内给药和局部药物输送的植入装置。 该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。 该装置构造成用于微创地插入诸如膀胱的体腔中。 中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在 体腔。 身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

公开(公告)号：US07300668B2

公开(公告)日：2007-11-27

申请号：US10284039

申请日：2002-10-29

申请人： Wendy E. Pryce Lewis ,  Charles William Rowe ,  Michael J. Cima ,  Peter A. Materna

发明人： Wendy E. Pryce Lewis ,  Charles William Rowe ,  Michael J. Cima ,  Peter A. Materna

IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/24

CPC分类号： A61K9/2893 ,  A61J3/10 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2095 ,  B33Y70/00 ,  B33Y80/00

摘要： The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosage forms of the present invention can include spatial variation of API concentration in the dosage form and can include nested regions. Dosage forms according to the present invention may be manufactured by any appropriate method for obtaining the internal structure as disclosed herein for producing zero-order release profiles and increasing or decreasing release profiles. The invention further includes methods of manufacturing such dosage forms, such as by three-dimensional printing, possibly also including compression of the dosage form after three-dimensional printing. The invention further includes methods of designing such dosage forms. Release profiles from non-uniform distributions of API concentration may be predicted based on simple experiments with uniform-concentration dosage forms.

摘要翻译： 本发明包括控制释放剂型和设计和制造剂型以获得特定释放特征的方法，例如零级释放曲线，升级释放曲线或减少释放曲线。 本发明的剂型可以包括剂型中API浓度的空间变化，并且可以包括嵌套区域。 根据本发明的剂型可以通过用于获得本文公开的用于产生零级释放曲线和增加或减少释放曲线的内部结构的任何适当方法来制造。 本发明还包括制造这种剂型的方法，例如通过三维印刷，可能还包括在三维印刷后压制剂型。 本发明还包括设计这种剂型的方法。 可以基于使用均匀浓度剂型的简单实验来预测API浓度不均匀分布的释放曲线。

公开(公告)号：US06977723B2

公开(公告)日：2005-12-20

申请号：US10235922

申请日：2002-09-06

申请人： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas Levinson ,  Alasdair Y. Johnson ,  Örn Almarsson ,  Christopher McNulty

发明人： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas Levinson ,  Alasdair Y. Johnson ,  Örn Almarsson ,  Christopher McNulty

IPC分类号： B01J19/00 ,  B01L3/14 ,  B01L7/00 ,  C12M1/34 ,  C12Q1/68 ,  C30B7/00 ,  C40B60/14 ,  C40B70/00 ,  G01J3/28 ,  G01J3/44 ,  G01N21/25 ,  G01N21/35 ,  G01N21/65 ,  G01N33/48 ,  G01N33/50 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G06F19/00

CPC分类号： G01N35/028 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/0031 ,  B01J2219/00335 ,  B01J2219/00344 ,  B01J2219/00495 ,  B01J2219/00547 ,  B01J2219/00587 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00756 ,  B01L3/5082 ,  B01L7/52 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1805 ,  C30B7/00 ,  C30B29/58 ,  C40B60/14 ,  C40B70/00 ,  G01J3/28 ,  G01N21/253 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/65 ,  G01N35/0099 ,  G01N2021/651 ,  G01N2035/041 ,  G01N2035/042 ,  G01N2035/0425

摘要： Systems and methods are described that allow the high-throughput preparation, processing, and study of arrays of samples, each of which comprises at least one compound. Particular embodiments of the invention allow a large number of experiments to be performed in parallel on samples that comprised of one or more compounds on the milligram or microgram quantities of compounds. Other embodiments of the invention encompass methods and devices for the rapid screening of the results of such experiments, as well as methods and devices for rapidly determining whether or not similarities exist among groups of samples in an array. Particular embodiments of the invention encompass methods and devices for the high-throughput preparation of different forms of compounds (e.g., different crystalline forms), for the discovery of new forms of old compounds, and for the discovery of new methods of producing such forms. Embodiments of the invention also allow for the high-throughput determination of how specific compounds or forms of compounds behave when exposed to other chemicals or environmental conditions.

公开(公告)号：US06945638B2

公开(公告)日：2005-09-20

申请号：US10284425

申请日：2002-10-29

申请人： Patrick Teung ,  Michael J. Cima ,  Timothy J. Pryor ,  Peter A. Materna

发明人： Patrick Teung ,  Michael J. Cima ,  Timothy J. Pryor ,  Peter A. Materna

IPC分类号： B01L3/02 ,  B41J2/02 ,  B41J2/05 ,  B41J29/377 ,  G05D23/19 ,  B41J2/07

CPC分类号： B01L3/0268 ,  B01L3/0265 ,  B01L2200/147 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0439 ,  B01L2400/0487 ,  B01L2400/0633 ,  B33Y40/00 ,  B41J2/02 ,  B41J2/04528 ,  B41J2/04563 ,  B41J29/377 ,  B41J2002/022 ,  G05D23/1919

摘要： A device for controlling or altering the temperature of a liquid at the point of dispensing. A temperature-altering device is thermally coupled to a dispensing device to compensate for heat dissipated into the liquid as it passes through the dispensing device during dispensing. The dispensing device may be for example, a miniature solenoid valve (microvalve), a piezoelectric printhead, or the like. According to aspects of the invention, a temperature-altering device provides or reduces heat at the point of dispensing in order to alter, control or maintain a constant temperature of the dispensed liquid. As a result, improvement is obtained in the consistency of the fluid regime of the dispensed droplet stream. The temperature-altering device may be a thermoelectric device capable of moving heat either from or to the dispensing structure, or may be a heater. This device may be used beneficially even when the dispensing is performed near room temperature and the liquid does not require heating to maintain its liquid state.

摘要翻译： 用于在分配点控制或改变液体的温度的装置。 温度改变装置热耦合到分配装置以补偿在分配期间通过分配装置时散失到液体中的热量。 分配装置可以是例如微型电磁阀（微型阀），压电打印头等。 根据本发明的方面，改变温度的装置在分配点处提供或减少热量，以便改变，控制或维持所分配液体的恒定温度。 结果，在分配的液滴流的流体状态的一致性方面获得了改进。 温度改变装置可以是能够从分配结构移动热量的热电装置，也可以是加热器。 即使当在室温附近进行分配并且液体不需要加热以保持其液体状态时，该装置也可以有利地使用。

公开(公告)号：US06530958B1

公开(公告)日：2003-03-11

申请号：US08463203

申请日：1995-06-05

申请人： Linda G. Cima ,  Michael J. Cima

发明人： Linda G. Cima ,  Michael J. Cima

IPC分类号： A61F228

CPC分类号： A61F2/022 ,  A61F2/105 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2002/0086 ,  A61F2002/009 ,  A61F2002/30011 ,  A61F2002/30032 ,  A61F2002/30034 ,  A61F2002/30062 ,  A61F2002/3028 ,  A61F2002/30677 ,  A61F2002/3093 ,  A61F2002/30932 ,  A61F2002/30962 ,  A61F2210/0004 ,  A61F2230/0063 ,  A61F2240/001 ,  A61F2250/0023 ,  A61F2250/003 ,  A61F2250/0031 ,  A61F2250/0067 ,  A61K9/0024 ,  A61K9/0097 ,  A61K9/1647 ,  A61K9/1694 ,  A61L27/34 ,  A61L27/38 ,  A61L27/40 ,  A61L27/56 ,  A61L27/60 ,  B29C64/165 ,  B29K2995/0064 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  Y10S623/901 ,  Y10T428/249953 ,  Y10T428/249954 ,  Y10T428/249961 ,  Y10T428/249978 ,  Y10T428/249986 ,  Y10T428/249994 ,  Y10T428/249999

摘要： Solid free-form (SSF) techniques for making medical devices for implantation and growth of cells from polymers or polymer/inorganic composites using computer aided design are described. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The devices can incorporate inorganic particles to improve the strength of the walls forming the pores within the matrix and to provide a source of mineral for the regenerating tissue. The devices can contain tissue adhesion peptides, or can be coated with materials which reduce tissue adhesion. The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.

摘要翻译： 描述了使用计算机辅助设计来制备用于从聚合物或聚合物/无机复合材料植入和生长细胞的医疗装置的固体自由形式（SSF）技术。 SFF方法的实例包括立体光刻（SLA），选择性激光烧结（SLS），弹道粒子制造（BPM），熔融沉积建模（FDM）和三维印刷（3DP）。 该装置可以掺入无机颗粒以提高在基质内形成孔的壁的强度，并为再生组织提供矿物来源。 该装置可以包含组织粘附肽，或者可以用减少组织粘附的材料涂覆。 可以通过控制打印参数来操纵装置的宏观结构和孔隙度。 最重要的是，可以使用计算机辅助设计（CAD）为个别患者设计和量身定制这些功能，以优化治疗。

公开(公告)号：US06527762B1

公开(公告)日：2003-03-04

申请号：US09638109

申请日：2000-08-11

申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott Albert Uhland

发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott Albert Uhland

IPC分类号： A61K911

CPC分类号： B01L3/50853 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2300/0819 ,  B01L2400/0677

摘要： Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules are released from the reservoir upon heating or cooling the device or a portion thereof sufficient to rupture the reservoir cap. In a preferred embodiment, the device includes a resistor integrated into the reservoir or mounted near the reservoir, which upon application of an electric current through the resistor, causes at least one of the contents of the reservoir to thermally expand, vaporize, phase change, or undergo a thermally driven reaction, such that the reservoir cap ruptures due to mechanical stress. In another preferred embodiment, application of an electric current to a resistor located on or near the reservoir cap causes the cap to expand, contract, or undergo a phase change that results in the rupture of the reservoir cap. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.

摘要翻译： 提供Microchip输送装置，其控制释放分子的速率和时间，其中所述装置包括底物，所述基质中含有所述分子的至少一个储存器和位于所述分子上的所述储存器上的储存器盖，其中所述分子 在加热或冷却装置或其一部分足以破坏储存器盖时从储存器释放。 在优选实施例中，该装置包括集成在储存器中或安装在储存器附近的电阻器，当施加电流通过电阻器时，储存器的至少一个内容物热膨胀，蒸发，相变， 或经历热驱动反应，使得储存器盖由于机械应力而破裂。 在另一个优选实施例中，将电流施加到位于储存器盖上或附近的电阻器使得盖膨胀，收缩或经历相变，导致储存器盖的破裂。 储层可以含有多种药物或其他可变剂量的分子。 单个微芯片的每个储存器可以包含不同的分子和/或不同的量和浓度，其可以独立释放。

公开(公告)号：US06491666B1

公开(公告)日：2002-12-10

申请号：US09715493

申请日：2000-11-17

申请人： John T. Santini, Jr. ,  Charles E. Hutchinson ,  Scott A. Uhland ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello

发明人： John T. Santini, Jr. ,  Charles E. Hutchinson ,  Scott A. Uhland ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello

IPC分类号： A61M500

CPC分类号： A61K9/0097 ,  A23L2/52 ,  A61F2/91 ,  A61F2250/0035 ,  A61F2250/0068 ,  A61K9/0009 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61M5/1407 ,  A61M15/0031 ,  A61M15/0045 ,  A61M15/005 ,  A61M15/008 ,  A61M15/0083 ,  A61M15/009 ,  A61M2205/8225

摘要： Apparati and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparati include microchip devices which have reservoirs containing the molecules for release. The apparati and methods provide for active or passive controlled release of the molecules. Preferred embodiments include systems for intravenous administration of drugs, wherein drug molecules are released from the microchip devices into a carrier fluid ex vivo, such as a saline solution, forming a drug/saline solution mixture which is then delivered to a patient intravenously.

摘要翻译： 提供了通过载体流体将分子递送到部位的方法和方法。 该装置包括具有含有释放分子的储存器的微芯片装置。 该设备和方法提供分子的主动或被动控制释放。 优选的实施方案包括用于静脉内施用药物的系统，其中药物分子从微芯片装置释放到离体的载体液体中，例如盐水溶液，形成药物/盐溶液混合物，然后静脉内递送给患者。

公开(公告)号：US5231074A

公开(公告)日：1993-07-27

申请号：US510115

申请日：1990-04-17

申请人： Michael J. Cima ,  Paul McIntyre

发明人： Michael J. Cima ,  Paul McIntyre

IPC分类号： H01L39/24

CPC分类号： H01L39/2451 ,  Y10S505/734

摘要： Highly-textured superconductor oxide thin films are prepared on substrates, including lattice matched, non-lattice matThe Government has rights in this invention pursuant to contract Number MDA972-88-K0006 awarded by the U.S. Defense Advance Research Project Agency.

摘要翻译： 通过金属有机沉积（MOD）在衬底上制备高纹理超导体氧化物薄膜，包括晶格匹配的，非晶格匹配的惰性和非惰性材料。 选择前体溶液组成以及加工温度和气氛以控制瞬态液相的存在。 以高度纹理化的形态和完全致密均匀的微观结构为特征的超导体氧化物膜在77°K时能够保持超过104A / cm 2的临界电流密度，当在非晶格匹配衬底上制备时，其临界电流密度超过106A / cm2，当在晶格匹配的基底上制备时。