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31.发明授权MEN1, the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof 失效MEN1，与多发性内分泌肿瘤1型有关的基因，menin多肽及其用途公开(公告)号：US07358347B1
公开(公告)日：2008-04-15
申请号：US09380337
申请日：1998-03-04
申请人： Settara Chandrasekharappa , Siradanahalli Guru , Pachiappan Manickam , Francis S. Collins , Michael R. Emmert-Buck , Larisa V. Debelenko , Irina A. Lubensky , Lance A. Liotta , Sunita K. Agarwal , Allen M. Spiegel , A. Lee Burns , Stephen J. Marx , Zhengping Zhuang
发明人： Settara Chandrasekharappa , Siradanahalli Guru , Pachiappan Manickam , Francis S. Collins , Michael R. Emmert-Buck , Larisa V. Debelenko , Irina A. Lubensky , Lance A. Liotta , Sunita K. Agarwal , Allen M. Spiegel , A. Lee Burns , Stephen J. Marx , Zhengping Zhuang
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.
摘要翻译： 本发明涉及一种与多发性内分泌肿瘤1型相关的新型肿瘤抑制基因的发现。该基因被命名为MEN1，该基因产物是menin。 在具有1型多发性内分泌肿瘤1型的个体中已经鉴定了相应基因中不存在该蛋白质和相关突变。鉴定该多重内分泌肿瘤1型的该标志物具有诊断用途以及基因治疗。
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公开(公告)号：US06951761B2
公开(公告)日：2005-10-04
申请号：US10233193
申请日：2002-08-30
IPC分类号： A01N1/02 , B01J19/00 , B01L3/00 , C12Q1/68 , C40B30/04 , G01N1/42 , G01N33/68 , G01N1/36 , C12Q1/00 , G01N1/00 , G01N1/30
CPC分类号： C40B30/04 , A01N1/02 , A01N1/0263 , B01J19/0046 , B01J2219/00531 , B01J2219/00659 , B01J2219/00673 , B01J2219/0072 , B01J2219/0074 , B01J2219/00743 , B01L3/50851 , B01L2300/0829 , C12Q1/6841 , G01N1/42 , G01N33/6845 , Y10S435/81 , Y10T436/10 , Y10T436/25
摘要： This disclosure relates to CryoArrays, which permit the analysis of samples (such as protein, nucleic acid, virus, or cell samples) in arrays that are prepared at low temperatures. Because CryoArrays are constructed as a block of substantially columnar samples, the block can be sliced to provide a plurality of identical or substantially identical individual arrays. The individual arrays can be used for parallel analysis of the same array feature set, for instance with different probes or under different conditions. Also provided are methods of making CryoArrays, devices for making CryoArrays, and kits.
摘要翻译： 本公开涉及CryoArrays，其允许在低温下制备的阵列中分析样品（例如蛋白质，核酸，病毒或细胞样品）。 由于CryoArrays被构造为基本上柱状样本的块，所以可以将块切片以提供多个相同或基本相同的单独阵列。 各个阵列可以用于同一阵列特征集的并行分析，例如使用不同的探针或在不同的条件下。 还提供了制作CryoArrays，制作CryoArrays的设备和工具包的方法。
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公开(公告)号：US5843657A
公开(公告)日：1998-12-01
申请号：US544388
申请日：1995-10-10
IPC分类号： G01N33/48 , C12M1/26 , C12M1/34 , G01N1/02 , G01N1/04 , G01N1/08 , G01N1/28 , G01N1/31 , G01N15/14 , G01N33/483 , G01N33/50 , G01N35/00 , G02B21/32 , A01N1/02 , A01N1/00 , A01N3/00
CPC分类号： G02B21/32 , C12M33/02 , G01N1/2813 , G01N1/286 , G01N33/50 , G01N1/04 , G01N1/08 , G01N1/2806 , G01N1/31 , G01N15/1468 , G01N2001/028 , G01N2001/2833 , G01N2001/284 , G01N2035/00237 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
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公开(公告)号：US5705514A
公开(公告)日：1998-01-06
申请号：US455825
申请日：1995-05-31
IPC分类号： A61K31/12 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4192 , A61P35/00 , C07D233/90 , C07D249/04
CPC分类号： A61K31/4164 , A61K31/12 , A61K31/41 , A61K31/415 , A61K31/4192 , C07D233/90 , C07D249/04
摘要： A method of inhibiting the invasion and metastasis of malignant solid tumors in mammals, said method comprising administering to said mammal an anti-proliferative, anti-invasive and anti-metastasis effective amount of a compound selected from the group of formulas consisting of: ##STR1## wherein: p is an integer of from 0 to 4; Ar.sup.1 is a moiety selected from the group consisting of --Ar.sup.2 --X--Ar.sup.3, phenyl, trioxaadamantyl, anthracenyl, anthraquinonyl, naphthyl, phenanthryl, and substituted versions thereof; Ar.sup.2 and Ar.sup.3 are each aromatic moieties independently selected from the group consisting of phenyl, naphthyl, and substituted versions thereof; X is a linking moiety selected from the group consisting of O, S, SO.sub.2 2, CO, CHCN, straight chain alkyl, alkoxy, and alkoxyalkyl; and Z is a nitrogen-containing heterocyclic moiety selected from the group consisting of imidazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl and substituted versions thereof, said heterocyclic moieties being attached to the --(CH.sub.2).sub.p -- portion of the molecule at the N1 position of the heterocycle.
摘要翻译： 一种抑制哺乳动物恶性实体瘤侵袭和转移的方法，所述方法包括对所述哺乳动物施用抗增殖，抗侵袭和抗转移的有效量的选自下组的化合物：Z（ CH 2）pAr 1（I）和
（II）其中：p是0至4的整数; Ar1是选自-Ar2-X-Ar3，苯基，三氧杂金刚烷基，蒽基，蒽醌基，萘基，菲基及其取代形式的部分; Ar 2和Ar 3各自独立地选自苯基，萘基及其取代形式的芳族部分; X是选自O，S，SO22，CO，CHCN，直链烷基，烷氧基和烷氧基烷基的连接部分; 并且Z是选自咪唑基，1,2,3-三唑基，1,2,4-三唑基及其取代形式的含氮杂环部分，所述杂环部分连接到 - （CH 2）p - 分子在杂环的N1位的部分。 -
公开(公告)号：US5602156A
公开(公告)日：1997-02-11
申请号：US209089
申请日：1994-03-10
申请人： Elise C. Kohn , Lance A. Liotta
发明人： Elise C. Kohn , Lance A. Liotta
IPC分类号： A61K31/41 , A61K31/415
CPC分类号： A61K31/415 , A61K31/41
摘要： Calcium homeostasis is an important regulator of MMP-2 transcription, activation and activity. Disclosed herein are compounds which inhibit the expression of matrix metalloproteinases in cells. Pharmaceutical application of these compounds to inhibit the expression of MMPs offers a new approach to cancer treatment as well as treatment for nerve healing, degenerative cartilagenous diseases, decubitus ulcers, arthritis, Alzheimer's disease, wound healing, proliferative retinopathy, proliferative renal diseases, corneal ulcers and fertility problems.
摘要翻译： 钙稳态是MMP-2转录，激活和活性的重要调节因子。 本文公开了抑制细胞中基质金属蛋白酶表达的化合物。 这些化合物抑制MMP表达的药物应用提供了一种新的治疗方法，以及治疗神经愈合，退行性软骨疾病，褥疮性溃疡，关节炎，阿尔茨海默氏病，伤口愈合，增殖性视网膜病变，增殖性肾病，角膜溃疡 和生育问题。
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36.发明授权Antibody composition for the detection of malignant cells with metastatic cell activity 失效用于检测具有转移性细胞活性的恶性细胞的抗体组合物
公开(公告)号：US4808528A
公开(公告)日：1989-02-28
申请号：US67598
申请日：1987-06-26
申请人： Karl Tryggvason , Lance A. Liotta
发明人： Karl Tryggvason , Lance A. Liotta
IPC分类号： C07K16/30 , C07K16/40 , C12N9/64 , C12Q1/37 , G01N33/574 , G01N33/577
CPC分类号： C12N9/6491 , C07K16/30 , C07K16/40 , C12Q1/37 , G01N33/574 , G01N2333/96486 , Y10S436/813 , Y10S530/828
摘要： Basement membrane collagen degrading enzymes are provided which are useful for the detection of malignant cells with metastatic activity. Means for detecting such cells are also provided.
摘要翻译： 提供了可用于检测具有转移活性的恶性细胞的基底膜胶原降解酶。 还提供了用于检测这种电池的装置。
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37.发明授权
公开(公告)号：US3989591A
公开(公告)日：1976-11-02
申请号：US502843
申请日：1974-09-03
申请人： Lance A. Liotta
发明人： Lance A. Liotta
CPC分类号： G01N35/00029 , C12Q1/24 , G01N2001/2833 , G01N2035/00099 , G01N2035/1025 , Y10S435/808
摘要： The specification and drawings disclose methods and apparatus for separating and/or isolating bacteria and tissue cells for testing or rapid automatic scanning. The invention uses an expansible membrane on which the tissue cell or bacteria sample is placed and thereafter expanded to cause the sample to be separated. Apparatus is disclosed for facilitating stretching of the membrane and automatically scanning it.
摘要翻译： 说明书和附图公开了用于分离和/或分离用于测试或快速自动扫描的细菌和组织细胞的方法和装置。 本发明使用其上放置有组织细胞或细菌样品的可膨胀膜，然后膨胀以使样品分离。 公开了用于促进膜的拉伸并自动扫描的装置。
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公开(公告)号：US20120077843A1
公开(公告)日：2012-03-29
申请号：US13258119
申请日：2010-03-29
CPC分类号： G01N33/502 , A61K31/00 , A61K31/138 , A61K31/4706 , A61K35/12 , C12N5/0695 , G01N33/5044 , G01N2800/52
摘要： Described herein are progenitor cancer cells and cell lines isolated from human breast ductal carcinoma in situ (DCIS) lesions and the uses of these cells or cell lines in drug design, drug screening, and monitoring in vivo therapy. The DCIS malignant precursor cells or cell lines are epithelial in origin, are positive for markers of autophagy, show at least one genetic difference from normal cells of said fragment, form 3-D tube-like structures or ball aggregates, or are inhibited in formation of 3-D structures and migration by treatment with chloroquine.
摘要翻译： 本文描述了从人乳腺导管原位癌（DCIS）病变分离的祖细胞癌细胞和细胞系，以及这些细胞或细胞系在药物设计，药物筛选和体内治疗监测中的用途。 DCIS恶性前体细胞或细胞系起源于上皮，对自噬标志物呈阳性，与所述片段的正常细胞呈现至少一个遗传差异，形成3-D管状结构或球聚集体，或形成抑制 的3-D结构和通过用氯喹处理的迁移。
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39.发明申请PHOSPHORYLATED C-ErbB2 AS A SUPERIOR PREDICTIVE THERANOSTIC MARKER FOR THE DIAGNOSIS AND TREATMENT OF CANCER 有权磷酸化C-ErbB2作为诊断和治疗癌症的高级预测性治疗标记公开(公告)号：US20110189173A1
公开(公告)日：2011-08-04
申请号：US13003206
申请日：2009-07-08
IPC分类号： A61K39/395 , C40B30/00 , G01N33/574 , A61K31/517 , C12Q1/48 , A61P35/00
CPC分类号： G01N33/57492 , A61K31/517 , A61K39/39558 , A61K2039/505 , C12Q1/6841 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N1/30 , G01N33/54366 , G01N33/574 , G01N33/57415 , G01N2033/57403 , G01N2333/71 , G01N2800/52
摘要： The present invention provides reliable methods to identify subsets of subjects with a cancer of epithelial origin characterized by a high level of phosphorylated c-erbB2 which does not correlate with the over-expression of total c-erbB2 as measured by IHC or FISH, for selection and inclusion for c-erbB2-direct treatment and therapy. Furthermore, the present invention provides a reliable method to determine whether a subject with a cancer of epithelial origin who has been determined to be c-erbB2 positive by IHC and by FISH should be excluded from c-erbB2-direct treatment because of a non-significant level of phosphorylated c-erbB2 in epithelial tumor tissue.
摘要翻译： 本发明提供了可靠的方法来鉴定具有上皮起源癌症的受试者的亚群，其特征在于高水平的磷酸化c-erbB2，其与通过IHC或FISH测量的总c-erbB2的过表达不相关，用于选择 并包括c-erbB2直接治疗和治疗。 此外，本发明提供了一种可靠的方法，用于确定由IHC和FISH确定为c-erbB2阳性的具有上皮起源癌症的受试者是否应从c-erbB2直接治疗中排除， 磷酸化c-erbB2在上皮肿瘤组织中的显着水平。
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公开(公告)号：US20100317740A1
公开(公告)日：2010-12-16
申请号：US12669833
申请日：2008-07-28
IPC分类号： A61K31/135 , G01N33/53 , A61P35/04
CPC分类号： G01N33/57415 , G01N2800/52
摘要： This invention relates, e.g., to a method for predicting the response of a subject having, or at risk of developing, breast cancer to Tamoxifen therapy. The method comprises measuring the amount of phosphorylation at residues S70 of Bcl-2, Y992 of EGFR, and/or Y527 of Src in a suitable sample from the subject, wherein a statistically significantly elevated level of phosphorylation at one or more of the three residues compared to a baseline value indicates that the subject is likely to be responsive to Tamoxifen therapy.
摘要翻译： 本发明涉及例如用于预测具有或有发展为乳腺癌患有他莫昔芬治疗的风险的受试者的反应的方法。 该方法包括在来自受试者的合适样品中测量在Bcl-2，Y992的EGFR和/或Src的残基S70处的磷酸化量，其中三个残基中的一个或多个的统计学上显着升高的磷酸化水平 与基线值相比表明受试者可能对他莫昔芬治疗有反应。
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