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31.发明申请公开(公告)号：US20060269641A1
公开(公告)日：2006-11-30
申请号：US11433892
申请日：2006-05-12
Applicant: John Atwood , Albert Mossa , Lisa Goven , Fenton Williams , Timothy Woudenberg , Marcel Margulies , Robert Ragusa , Richard Leath , Clive Miles
Inventor： John Atwood , Albert Mossa , Lisa Goven , Fenton Williams , Timothy Woudenberg , Marcel Margulies , Robert Ragusa , Richard Leath , Clive Miles
IPC: B01L9/00
CPC classification number: B01L3/50851 , B01L3/50853 , B01L7/00 , B01L7/52 , B01L2200/147 , B01L2300/042 , B01L2300/046 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , G05D23/1917 , Y10S435/809
Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.
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公开(公告)号：US20060183151A1
公开(公告)日：2006-08-17
申请号：US11400611
申请日：2006-04-07
Applicant: Timothy Woudenberg , Michael Albin , Reid Kowallis , Yefim Raysberg , Robert Ragusa , Emily Winn-Deen
Inventor： Timothy Woudenberg , Michael Albin , Reid Kowallis , Yefim Raysberg , Robert Ragusa , Emily Winn-Deen
IPC: C12Q1/68
CPC classification number: C12Q1/6816 , B01J2219/00317 , B01J2219/00599 , B01J2219/00722 , B01L3/5027 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L2200/027 , B01L2200/0642 , B01L2300/0816 , B01L2300/0864 , B01L2300/1827 , B01L2400/049 , C12Q1/08 , C40B40/06 , C40B50/08 , C40B60/14 , G01N21/6452 , G01N2035/00148 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , C12Q2565/631
Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.
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公开(公告)号：US20050158781A1
公开(公告)日：2005-07-21
申请号：US11029968
申请日：2005-01-05
Applicant: Timothy Woudenberg , Michael Albin , Reid Kowallis , Yefim Raysberg , Robert Raqusa , Emily Winn-Deen
Inventor： Timothy Woudenberg , Michael Albin , Reid Kowallis , Yefim Raysberg , Robert Raqusa , Emily Winn-Deen
CPC classification number: C12Q1/6816 , B01J2219/00317 , B01J2219/00599 , B01J2219/00722 , B01L3/5027 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L2200/027 , B01L2200/0642 , B01L2300/0816 , B01L2300/0864 , B01L2300/1827 , B01L2400/049 , C12Q1/08 , C40B40/06 , C40B50/08 , C40B60/14 , G01N21/6452 , G01N2035/00148 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , C12Q2565/631
Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.
Abstract translation: 本发明涉及一种用于同时测试样品中多种所选分析物中一种或多种的存在，不存在和/或量的方法和装置。 本发明在一个方面包括用于检测或定量液体样品中的多种不同分析物的装置。 每个室可以包括有效地与可能存在于样品中的选定分析物反应的分析物特异性试剂和用于检测信号的检测装置。 还公开了利用该装置的方法。
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公开(公告)号：US20050084957A1
公开(公告)日：2005-04-21
申请号：US10929961
申请日：2004-08-30
Applicant: John Atwood , Susan Stone , Judith Atwood , Albert Mossa , Lisa Goven , Fenton Williams , Timothy Woudenberg , Marcel Margulies , Robert Ragusa , Richard Leath , Clive Miles
Inventor： John Atwood , Susan Stone , Judith Atwood , Albert Mossa , Lisa Goven , Fenton Williams , Timothy Woudenberg , Marcel Margulies , Robert Ragusa , Richard Leath , Clive Miles
CPC classification number: B01L3/50851 , B01L3/50853 , B01L7/00 , B01L7/52 , B01L2200/147 , B01L2300/042 , B01L2300/046 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , G05D23/1917 , Y10S435/809
Abstract: A sample tube including a cylindrical part and a conical part is described. The cylindrical part can include, a first wall portion having a first wall portion thickness, a second wall portion having a second wall portion thickness, and a shoulder including a planar first surface and a conically beveled second surface disposed between the first wall portion and the second wall portion. The first wall portion can be disposed closer to the planar first surface than the conically beveled second surface. The conical part can be shaped as a frustrum of a cone having a conical part wall thickness. The frustrum can include a wider-end and a narrower-end. The wider-end of the frustrum can be in contact with the second wall portion of the cylindrical part. At least one of the first wall portion thickness and the second wall portion thickness can be greater than the conical part wall thickness.
Abstract translation: 描述了包括圆柱形部分和圆锥形部分的样品管。 圆柱形部分可以包括具有第一壁部分厚度的第一壁部分，具有第二壁部分厚度的第二壁部分和包括平面第一表面和设置在第一壁部分和第二壁部分之间的锥形斜面第二表面的肩部 第二壁部。 第一壁部分可以比锥形倾斜的第二表面更靠近平面的第一表面设置。 锥形部分可以形成为具有圆锥形部分壁厚度的圆锥体。 风险可以包括更广泛的和更窄的一端。 膛孔的较宽端可与圆柱形部分的第二壁部分接触。 第一壁部分厚度和第二壁部分厚度中的至少一个可以大于锥形部分壁厚度。
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公开(公告)号：US20050019803A1
公开(公告)日：2005-01-27
申请号：US10866640
申请日：2004-06-12
Applicant: Timothy Liu , Timothy Woudenberg , Jer-Kang Chen
Inventor： Timothy Liu , Timothy Woudenberg , Jer-Kang Chen
CPC classification number: B01J19/0046 , B01J2219/00527 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , C40B40/06
Abstract: Disclosed herein is an array patterned on an electrode and a method for fabricating the same. The array comprises a probe covalently attached to the electrode through a coupling group, an attachment group, and an aryl group.
Abstract translation: 本文公开了在电极上图案化的阵列及其制造方法。 阵列包括通过偶联基团，连接基团和芳基共价连接到电极上的探针。
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Patent Agency Ranking
公开(公告)号：US08637247B2
公开(公告)日：2014-01-28
申请号：US13590794
申请日：2012-08-21
Applicant: Muhammad Sharaf , Timothy Woudenberg , Khairuzzaman Bashar Mullah
Inventor： Muhammad Sharaf , Timothy Woudenberg , Khairuzzaman Bashar Mullah
IPC: C12Q1/68
CPC classification number: C12Q1/6825 , C12Q1/6816 , C12Q1/6823 , C12Q1/6827 , C12Q1/6832 , C12Q1/6876 , G01N27/44726 , G01N27/44791 , C12Q2565/631
Abstract: The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. The modified coded molecule is detected by isolating the modified coded molecules from the unmodified coded molecules prior to analysis through the nanopore or by detecting a change in the signal pattern of the coded molecule when analyzed through the nanopore.
Abstract translation: 本公开内容涉及通过使用编码分子鉴定靶核酸的方法及其通过纳米孔易位的分析。 通常，经编码的分子经受目标多核苷酸依赖性修饰。 通过在通过纳米孔分析之前将经修饰的编码分子与未修饰的编码分子分离，或者当通过纳米孔分析时，通过检测编码分子的信号图谱的变化来检测修饰的编码分子。
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公开(公告)号：US20120261007A1
公开(公告)日：2012-10-18
申请号：US13295028
申请日：2011-11-11
Applicant: Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
Inventor： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
IPC: F16K31/12
CPC classification number: G01N1/28 , B01L3/502738 , B01L7/52 , B01L2200/16 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , C12Q1/686 , G01N21/05 , G01N21/6452 , G01N2021/0346 , Y10T137/7793 , Y10T436/2575
Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.
Abstract translation: 本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。 提供了减少使用微流体装置期间的混合时间的方法。 微流控装置和相关的制造方法具有提高的制造成品率。 提供改进的装置和相关系统用于向微流体装置提供受控的压力。 提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。 微流控装置和相关方法提供了改进的样品与试剂混合比控制。 微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。 提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。 提供了用于改进微流体装置的荧光成像的方法和系统。
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公开(公告)号：US20100261158A1
公开(公告)日：2010-10-14
申请号：US11423403
申请日：2006-06-09
Applicant: Eric S. Nordman , Mark F. Oldham , Timothy Woudenberg
Inventor： Eric S. Nordman , Mark F. Oldham , Timothy Woudenberg
CPC classification number: C12Q1/6874 , C12Q1/6869 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N21/6486 , G01N2021/6441 , C12Q2563/107
Abstract: The present disclosure provides apparatus, systems and method for detecting separately and substantially simultaneously light emissions from a plurality of localized light-emitting analytes. A system according to exemplary embodiments of the present disclosure comprises a sample holder having structures formed thereon for spatially separating and constraining a plurality of light-emitting analytes each having a single nucleic acid molecule or a single nucleic acid polymerizing enzyme, a light source configured to illuminate the sample holder, an optical assembly configured to collect and detect separately and substantially simultaneously light emissions associated with the plurality of light emitting analytes. The system may further include a computer system configured to analyze the light emissions to determine the structures or properties of a target nucleic acid molecule associated with each analyte.
Abstract translation: 本公开提供了用于单独和基本同时地检测来自多个局部发光分析物的光发射的装置，系统和方法。 根据本公开的示例性实施例的系统包括具有形成在其上的结构的样本保持器，用于空间分离和约束各自具有单个核酸分子或单个核酸聚合酶的多个发光分析物，光源被配置为 照亮样品架，光学组件被配置成分别收集和检测与多个发光分析物相关联的基本上同时的发光。 该系统还可以包括被配置为分析光发射以确定与每个分析物相关联的靶核酸分子的结构或性质的计算机系统。
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公开(公告)号：US20100230613A1
公开(公告)日：2010-09-16
申请号：US12688462
申请日：2010-01-15
Applicant: Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
Inventor： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
IPC: G01J1/58
CPC classification number: G01N1/28 , B01L3/502738 , B01L7/52 , B01L2200/16 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , C12Q1/686 , G01N21/05 , G01N21/6452 , G01N2021/0346 , Y10T137/7793 , Y10T436/2575
Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.
Abstract translation: 本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。 提供了减少使用微流体装置期间的混合时间的方法。 微流控装置和相关的制造方法具有提高的制造产率。 提供改进的装置和相关系统用于向微流体装置提供受控的压力。 提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。 微流控装置和相关方法提供了改进的样品与试剂混合比控制。 微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。 提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。 提供了用于改进微流体装置的荧光成像的方法和系统。
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40.发明申请Thermal Cycler for Automatic Performance of the Polymerase Chain Reaction with Close Temperature Control 审中-公开热循环仪用于自动性能的聚合酶链反应与温度控制公开(公告)号：US20100112683A2
公开(公告)日：2010-05-06
申请号：US11999179
申请日：2007-12-04
Applicant: John Atwood , Albert Mossa , Lisa Goven , Fenton Williams , Timothy Woudenberg , Marcel Margulies , Robert Ragusa , Richard Leath , Clive Miles
Inventor： John Atwood , Albert Mossa , Lisa Goven , Fenton Williams , Timothy Woudenberg , Marcel Margulies , Robert Ragusa , Richard Leath , Clive Miles
IPC: C12M1/00
CPC classification number: B01L3/50851 , B01L3/50853 , B01L7/00 , B01L7/52 , B01L2200/147 , B01L2300/042 , B01L2300/046 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , G05D23/1917 , Y10S435/809
Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.
Abstract translation: 提供了用于自动执行聚合酶链式反应的热循环仪。 热循环仪包括提供对反应的温度控制的加热器控制。
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