公开(公告)号：US09738937B1

公开(公告)日：2017-08-22

申请号：US15476848

申请日：2017-03-31

申请人： Cellmax, Ltd.

发明人： Huangpin B. Hsieh ,  XiaoMing Wang

IPC分类号： G06K9/00 ,  C12Q1/68 ,  G01N15/14 ,  G01N33/574 ,  G02B21/00 ,  G01N33/50

CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  G01N1/31 ,  G01N15/1468 ,  G01N15/1475 ,  G01N33/5094 ,  G01N33/57484 ,  G01N33/582 ,  G01N2015/1472 ,  G01N2333/4742 ,  G01N2333/70589

摘要： A method for identifying and enumerating candidate target cells within a biological fluid specimen is described. The method includes obtaining a biological fluid specimen, preparing the biological fluid specimen by staining cell features in the biological fluid specimen, capturing a digital image having a plurality of color channels of the biological fluid specimen, and applying image analysis to the digital image. A computer program product for identifying candidate target cells within a biological fluid specimen is also described. The computer program comprises instructions to cause a processor to carry out the image analysis.

公开(公告)号：US20170219568A1

公开(公告)日：2017-08-03

申请号：US15124171

申请日：2015-03-06

申请人： CellTool GmbH

发明人： Raimund Schütze ,  Karin Schütze

IPC分类号： G01N33/50 ,  G01N33/15 ,  G01N21/65 ,  G01N33/49

CPC分类号： G01N33/5091 ,  G01N21/65 ,  G01N33/15 ,  G01N33/49 ,  G01N33/5094 ,  G01N33/80 ,  G01N2201/12 ,  G01N2333/195

摘要： A method and device for quality controlling a blood-based product. In order to control the quality of a blood-based product which comprises an erythrocyte concentrate, a thrombocyte concentrate, a granulocyte concentrate, a leukocyte concentrate, whole blood and/or blood plasma, a Raman spectrum is recorded. By means of evaluating the Raman spectrum, it is determined whether the blood-based product can be used for a transfusion.

公开(公告)号：US20170209864A1

公开(公告)日：2017-07-27

申请号：US15329753

申请日：2015-08-03

申请人： GPB SCIENTIFIC, LLC ,  THE TRUSTEES OF PRINCETON UNIVERSITY ,  UNIVERSITY OF MARYLAND, BALTIMORE

发明人： Michael GRISHAM ,  Curt I. CIVIN ,  James C. STURM ,  Robert H. AUSTIN ,  Joseph D'SILVA ,  Yu CHEN

IPC分类号： B01L3/00 ,  G01N33/50 ,  G01N33/483

CPC分类号： G01N33/5094 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2300/0883 ,  B01L2400/086 ,  G01N33/4833

摘要： Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.

公开(公告)号：US09709556B2

公开(公告)日：2017-07-18

申请号：US14225512

申请日：2014-03-26

申请人： Analiza, Inc.

发明人： Pavel Idelevich ,  Arnon Chait ,  Alan Bauer

IPC分类号： G01N33/50 ,  G01N33/574

CPC分类号： G01N33/5094 ,  G01N33/5005 ,  G01N33/5091 ,  G01N33/57492 ,  G01N2333/70514 ,  G01N2333/70517

摘要： The present invention generally relates to devices and methods for determining and/or isolating cells. One aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases.

公开(公告)号：US09702806B2

公开(公告)日：2017-07-11

申请号：US14775448

申请日：2014-03-18

申请人： IRIS INTERNATIONAL, INC.

发明人： Bart J. Wanders ,  Gregory A. Farrell ,  Thomas H. Adams ,  Warren Groner ,  Xiaodong Zhao ,  Brett Jordan ,  Jack Cremins ,  Carol Quon

IPC分类号： G01N33/48 ,  G01N15/14 ,  G01N33/50 ,  G01N33/80 ,  G01N1/30 ,  G01N21/53 ,  G01N33/49 ,  G01N15/00 ,  G01N15/10 ,  G01N21/05

CPC分类号： G01N15/1404 ,  G01N1/30 ,  G01N15/1434 ,  G01N15/1463 ,  G01N15/1468 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/53 ,  G01N33/49 ,  G01N33/4915 ,  G01N33/5091 ,  G01N33/5094 ,  G01N33/80 ,  G01N2015/0065 ,  G01N2015/1037 ,  G01N2015/1411 ,  G01N2015/1413 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/058

摘要： Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.

公开(公告)号：US09664690B1

公开(公告)日：2017-05-30

申请号：US14471168

申请日：2014-08-28

申请人： The National Institute for Biotechnology in the Negev Ltd.

发明人： Alon Monsonego ,  Idan Harpaz

IPC分类号： G01N33/68 ,  G01N33/50 ,  G01N33/74

CPC分类号： G01N33/6863 ,  G01N33/5091 ,  G01N33/5094 ,  G01N33/6866 ,  G01N33/6869 ,  G01N33/6872 ,  G01N33/743 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/30 ,  G01N2800/7004

摘要： A diagnostic kit for evaluating stress hormones, and methods of use and manufacture thereof.

公开(公告)号：US09642863B2

公开(公告)日：2017-05-09

申请号：US13988245

申请日：2011-11-17

申请人： Hillary D. White

发明人： Hillary D. White

IPC分类号： A61K31/568 ,  A61K31/5685

CPC分类号： A61K31/5685 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/568 ,  A61K45/06 ,  G01N33/5094 ,  G01N33/6896 ,  G01N33/743 ,  G01N2333/4737 ,  G01N2800/2842 ,  G01N2800/52 ,  G01N2800/7095

摘要： Methods are provided for reducing chronic inflammatory pain, increasing the levels of endogenous opioid peptides, as well as increasing the pain threshold of a subject having symptoms of androgen deficiency, comprising transdermally administering a composition comprising a bioactive androgen on a daily basis. In addition, the invention also relates to increasing the levels of endogenous opioid peptides in a human subject by administering an androgen composition to the subject. The invention also encompasses administration of a composition consisting essentially of an androgen for the treatment of chronic inflammatory pain, and for increasing the pain-threshold in a subject.

公开(公告)号：US09600878B2

公开(公告)日：2017-03-21

申请号：US14711794

申请日：2015-05-14

申请人： IXENSOR INC.

发明人： Tungmeng Tsai ,  Chieh Hsiao Chen ,  Yenyu Chen

IPC分类号： G01N21/78 ,  G06T7/00 ,  G01N33/50 ,  G01N21/84 ,  G01N33/66 ,  G06K9/46 ,  G06K9/62 ,  G06T7/90

CPC分类号： G06T7/0012 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/5094 ,  G01N33/66 ,  G06K9/4652 ,  G06K9/4661 ,  G06K9/6215 ,  G06T7/90 ,  Y10T436/144444

摘要： A method is provided for a computing device with an imaging device to read a specimen test strip. The method includes capturing an image of the specimen test strip, wherein the image includes a reaction area, a color calibration area, and a temperature calibration area on the specimen test strip, determining a color of the reaction area based on one or more colors of the color calibration area, and determining a value of a characteristic of an analyte by correlating the color of the reaction area to the value and then adjusting the value based on the color of the temperature calibration area, or adjusting the color of the reaction area based on the color of the temperature calibration area and then correlating the color of the reaction area to the value.

公开(公告)号：US09588126B2

公开(公告)日：2017-03-07

申请号：US14584606

申请日：2014-12-29

申请人： SISCAPA Assay Technologies, Inc.

发明人： N. Leigh Anderson

IPC分类号： G01N33/68 ,  G01N27/62 ,  H01J49/00 ,  G01N33/50 ,  G01N33/80 ,  G01N33/96

CPC分类号： G01N33/6848 ,  G01N27/62 ,  G01N33/5094 ,  G01N33/80 ,  G01N33/96 ,  H01J49/0036

摘要： Methods are provided for estimating the relative amounts of identifiable compartments, such as different types of cells or cell components, within a biological sample. The methods use mass spectrometric analysis in quantitate compartment-specific molecules and thereby allow calculation of the amount of each compartment that is present in a biological sample. The methods can, for example, provide a measurement of hematocrit from a dried blood sample.

摘要翻译： 提供了用于估计生物样品中可识别隔室（例如不同类型的细胞或细胞组分）的相对量的方法。 该方法在定量室特异性分子中使用质谱分析，从而允许计算存在于生物样品中的每个隔室的量。 所述方法可以例如提供来自干血样品的血细胞比容的测量。

公开(公告)号：US20170010282A1

公开(公告)日：2017-01-12

申请号：US15217251

申请日：2016-07-22

申请人： GALPHARMA CO., LTD.

发明人： Mitsuomi HIRASHIMA ,  Toshiro NIKI ,  Tomohiro ARIKAWA ,  Souichi OOMIZU ,  Takeshi KADOWAKI

IPC分类号： G01N33/68 ,  A61K38/17 ,  C12N5/0783 ,  G01N33/569 ,  C12N5/0784 ,  C12N5/0786 ,  G01N33/50 ,  C07K14/47 ,  C12N5/0781

CPC分类号： G01N33/6893 ,  A61K35/17 ,  A61K38/1732 ,  A61K49/0004 ,  C07K14/4726 ,  C12N5/0635 ,  C12N5/0636 ,  C12N5/0637 ,  C12N5/0639 ,  C12N5/0645 ,  C12N5/0646 ,  C12N2501/59 ,  G01N33/5094 ,  G01N33/56972 ,  G01N33/68 ,  G01N2333/42 ,  G01N2333/4724 ,  G01N2333/705

摘要： The object of the present invention is to provide a cell that can exhibit physiological activity based on galectin-9, a method for producing the cell, and use of the cell. In order to achieve the above object, the cell of the present invention contains galectin-9, and the galectin-9 is expressed on a cell surface.

摘要翻译： 本发明的目的是提供一种可以显示基于半乳凝素-9的生理活性的细胞，细胞的制造方法和细胞的使用。 为了实现上述目的，本发明的细胞含有半乳凝素-9，半乳凝素-9在细胞表面表达。