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    Methods and Materials for Producing 7-Carbon Chemicals via a C9 Route
    31.
    发明申请
    Methods and Materials for Producing 7-Carbon Chemicals via a C9 Route 审中-公开
    通过C9路线生产7碳化合物的方法和材料

    公开(公告)号：US20160145657A1

    公开(公告)日：2016-05-26

    申请号：US14947570

    申请日：2015-11-20

    申请人： INVISTA North America S.á.r.l.

    发明人： Adriana Leonora Botes ,  Alex Van Eck Conradie ,  Ramdane Haddouche

    IPC分类号： C12P7/64 ,  C12N9/02 ,  C12N9/18 ,  C07C59/01 ,  C07C47/12 ,  C07C55/16 ,  C07C47/19 ,  C07C225/06 ,  C07C233/31 ,  C12N9/10 ,  C07C229/08

    摘要： This document describes biochemical pathways for producing 7-hydroxyheptanoic acid using a polypeptide having monooxygenase activity to form a 8-hydroxynonanoate intermediate, which can be converted to 7-hydroxyheptanoate using a polypeptide having monooxygenase activity, a polypeptide having secondary alcohol dehydrogenase activity, and a polypeptide having esterase activity. 7-hydroxyheptanoic acid can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7 heptanediol. This document also describes recombinant hosts producing 7-hydroxyheptanoic acid as well as pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine and 1,7 heptanediol.

    摘要翻译： 本文件描述了使用具有单加氧酶活性的多肽形成8-羟基壬酸酯中间体以产生7-羟基庚酸的生物化学途径，其可以使用具有单加氧酶活性的多肽，具有仲醇脱氢酶活性的多肽转化为7-羟基庚酸酯， 具有酯酶活性的多肽。 7-羟基庚酸可以酶促转化成庚二酸，7-氨基庚酸，七亚甲基二胺或1,7庚二醇。 该文献还描述了产生7-羟基庚酸以及庚二酸，7-氨基庚酸，七亚甲基二胺和1,7庚二醇的重组宿主。

    Process for obtaining valine derivatives useful for obtaining a pharmaceutically active compound
    32.
    发明授权
    Process for obtaining valine derivatives useful for obtaining a pharmaceutically active compound 失效
    用于获得可用于获得药学活性化合物的缬氨酸衍生物的方法

    公开(公告)号：US07964749B2

    公开(公告)日：2011-06-21

    申请号：US12090729

    申请日：2006-10-19

    申请人： Pere Dalmases Barjoan ,  Joan Huguet Clotet

    发明人： Pere Dalmases Barjoan ,  Joan Huguet Clotet

    IPC分类号： C07C233/31 ,  C07C305/24

    CPC分类号： C07D257/04

    摘要： The invention provides a method for obtaining the intermediate (II), useful for manufacturing Valsartan and a drug directed to a treatment of arterial hypertension or heart failure. The process comprises a) Imination of the aldehyde group of a compound (VII) by L-Valine (IV) salts with organic or inorganic bases and a polar solvent or water, where X means halogen or an —OSO2R group, where R is CF3, tolyl, methyl or F; to give an imine-type compound (VIII), where B+ is the protonated form of an organic base or an alkaline cation; b) Reduction of the imine group of the compound (VIII) followed by acidification, to give the compound (VI); and c) N-Acylation of the compound (VI) with valeryl chloride to give the compound (II). Steps a) and b) can be performed in a “one pot” reaction.

    摘要翻译： 本发明提供了获得中间体（II）的方法，其可用于制造缬沙坦和用于治疗动脉高血压或心力衰竭的药物。 该方法包括a）用有机或无机碱和极性溶剂或水将L-缬氨酸（Ⅳ）盐与化合物（Ⅶ）的醛基进行偶联，其中X表示卤素或-OSO 2 R基团，其中R为CF 3 ，甲苯基，甲基或F; 得到亚胺型化合物（VIII），其中B +是有机碱或碱性阳离子的质子化形式; b）还原化合物（Ⅷ）的亚胺基，然后酸化，得到化合物（Ⅵ）; 和c）将化合物（VI）与戊酰氯进行N-酰化反应，得到化合物（II）。 步骤a）和b）可以在“一锅”反应中进行。

    Process for producing benzylamine derivative
    37.
    发明授权
    Process for producing benzylamine derivative 有权
    生产苄胺衍生物的方法

    公开(公告)号：US07326813B2

    公开(公告)日：2008-02-05

    申请号：US10540749

    申请日：2003-12-26

    申请人： Akinori Ito ,  Hideaki Ohashi ,  Kagetomo Magaribuchi

    发明人： Akinori Ito ,  Hideaki Ohashi ,  Kagetomo Magaribuchi

    IPC分类号： C07C209/62 ,  C07C211/29 ,  C07C231/12 ,  C07C233/31 ,  C07C269/04

    CPC分类号： C07C231/12 ,  C07C209/62 ,  C07C211/29 ,  C07C233/31 ,  C07C269/04 ,  C07C271/18

    摘要： Disclosed is a process for producing a benzylamine derivative represented by the general formula (3): wherein X1, R1 and R2 are as defined below, which comprises reacting a benzyl derivative represented by the general formula (1): wherein X1 represents a halogen atom and R1 represents an acyl group, with a haloacyl compound represented by the general formula (2): R2—X2  (2) wherein X2 represents a halogen atom and R2 represents an acyl group, in the presence of Lewis acid. According to this method, a benzylamine derivative as an intermediate, which is useful for the preparation of a carbamate-based agricultural or horticultural bactericide, can be preferably prepared.

    摘要翻译： 公开了一种由通式（3）表示的苄胺衍生物的制备方法：其中X 1，R 1和R 2均为 其包括使由通式（1）表示的苄基衍生物：其中X 1表示卤素原子，R 1表示酰基，与卤代酰基 由通式（2）表示的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”→> R 2> 2 （2）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中X 2表示卤原子，R 2' 在路易斯酸存在下代表酰基。 根据该方法，可以优选制备可用于制备氨基甲酸酯类农业或园艺杀菌剂的作为中间体的苄胺衍生物。

    Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell
    38.
    发明授权
    Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell 失效
    用于将药剂或遗传物质递送到细胞中的多功能载体

    公开(公告)号：US07314956B2

    公开(公告)日：2008-01-01

    申请号：US10137355

    申请日：2002-05-03

    申请人： Frank Q. Li ,  Yong Liang Chu ,  Shuren Zhu ,  Jian-Tai Qiu ,  Wan-Ching Lai

    发明人： Frank Q. Li ,  Yong Liang Chu ,  Shuren Zhu ,  Jian-Tai Qiu ,  Wan-Ching Lai

    IPC分类号： C07C233/02 ,  C07C233/04 ,  C07C233/05 ,  C07C233/07 ,  C07C233/17 ,  C07C233/31 ,  A61K31/16

    CPC分类号： B82Y5/00 ,  A61K47/6949 ,  A61K48/00 ,  C12N15/87

    摘要： The present invention provides a drug delivery vehicle that can improve the pharmacokinetics of pharmacological agents. The invention relates to a multifunctional carrier capable of delivering a carried material such as a pharmacological agent or genetic material to a recipient. The multifunctional carrier includes a multifunctional core and a plurality of adduct molecules bonded thereto. The molecular carrier has surface functional groups which can be associated with a carried material. The carried material can be associated with the molecular carrier through covalent interactions or ionic interactions. The polyvalent core can be ethylene-diamine tetraacetic acid (EDTA) or succinic acid. The invention also relates to methods for producing and using such molecules.

    摘要翻译： 本发明提供能够改善药理学药剂的药代动力学的药物输送载体。 本发明涉及一种能够将诸如药物学或遗传物质的载体材料递送到接受者的多功能载体。 多功能载体包括多功能核心和与其键合的多个加合物分子。 分子载体具有可与载体材料相关的表面官能团。 携带的材料可以通过共价相互作用或离子相互作用与分子载体结合。 多价核可以是乙二胺四乙酸（EDTA）或琥珀酸。 本发明还涉及生产和使用这些分子的方法。