公开(公告)号：US09217739B2

公开(公告)日：2015-12-22

申请号：US14123249

申请日：2012-06-03

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: G01N21/00 ,  G01N33/483 ,  G01N1/06 ,  G01N1/28 ,  A61B10/00 ,  A61B19/00 ,  A61B10/02 ,  G06F19/00

CPC classification number: G01N33/4833 ,  A61B10/00 ,  A61B10/02 ,  A61B2034/107 ,  G01N1/06 ,  G01N1/286 ,  G16H40/63

Abstract: A probe device for use in a tissue inspection system is presented. The probe device comprises a probe body and a control unit at least partially incorporated in the probe body. The probe body carries at least a tissue characterization unit operable for providing sensing data indicative of at least one tissue property at measurement locations in the tissue portion being held by the probe. The control unit comprises: a processor utility for receiving and processing the sensing data and generating measured data indicative of a spatial profile of said at least one tissue property distribution within the tissue portion, and comprises at least one of the following: an imaging utility for receiving said measured data and generating and displaying an image indicative thereof thereby enabling a user to select a region of said tissue portion for further analysis; and a pattern generator module configured for receiving and analyzing said measured data and determining a pattern indicative of an arrangement of regions in said tissue portion, thereby enabling selection of at least one of the regions for further analysis.

Abstract translation: 提出了一种用于组织检测系统的探针装置。 探针装置包括探针体和至少部分地结合在探针体内的控制单元。 探针体携带至少一个组织表征单元，其可操作用于提供感测数据，该感测数据指示由探针保持的组织部分中的测量位置处的至少一个组织属性。 所述控制单元包括：处理器实用程序，用于接收和处理所述感测数据并产生指示所述组织部分内的所述至少一个组织属性分布的空间分布的测量数据，并且包括以下中的至少一个：用于 接收所述测量数据并产生和显示指示其的图像，从而使用户能够选择所述组织部分的区域用于进一步分析; 以及图案生成器模块，被配置为接收和分析所述测量数据并且确定指示所述组织部分中的区域布置的图案，由此能够选择所述区域中的至少一个用于进一步分析。

公开(公告)号：US09008756B2

公开(公告)日：2015-04-14

申请号：US12964511

申请日：2010-12-09

Applicant: Gil Cohen ,  Dan Hashimshony

Inventor： Gil Cohen ,  Dan Hashimshony

IPC: A61B5/00 ,  A61B19/00

CPC classification number: A61B19/5244 ,  A61B34/20 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/3908

Abstract: A mapping system (200) including: (a) at least one external marker (210,212,214,216) adapted for positioning outside a target (520) to define a target context; (b) at least one target marker (230) adapted for positioning with the target; (c) a data acquisition tool (221) configured to provide position coordinates for at least one data point (220) at the target (520); and (d) a registration module (300) adapted to output position coordinates of said at least one data point relative to at least a portion of the target context.

Abstract translation: 一种映射系统（200），包括：（a）适于定位在目标外部（520）以限定目标上下文的至少一个外部标记（210,212,214,216） （b）至少一个适于与靶标定位的靶标记物（230）; （c）数据采集工具（221），被配置为提供所述目标（520）处的至少一个数据点（220）的位置坐标; 和（d）适于相对于所述目标上下文的至少一部分输出所述至少一个数据点的位置坐标的注册模块（300）。

公开(公告)号：US08721565B2

公开(公告)日：2014-05-13

申请号：US11196732

申请日：2005-08-04

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/00

CPC classification number: A61B5/4381 ,  A61B5/6834

Abstract: A device for tissue characterization, comprises a structure; a first mechanism, associated with the structure, configured for exerting a first force on a tissue, for fixing the tissue to the structure, so as to substantially immobilize the tissue; and a second mechanism, associated with the structure, configured for pressing a sensor against an external surface of the immobilized tissue, thereby exerting a second force on the immobilized tissue, wherein at least a component of the first force is in opposition to at least a component of the second force, forcing the immobilized tissue against the sensor, and forcing the sensor against the immobilized tissue, bringing about an effective contact between the sensor and the immobilized tissue.

Abstract translation: 一种用于组织表征的装置，包括结构; 与所述结构相关联的第一机构，被配置为在组织上施加第一力，用于将所述组织固定到所述结构上，以便基本上固定所述组织; 以及与所述结构相关联的第二机构，其被配置为将传感器压靠在所述固定化组织的外表面上，从而对所述固定化组织施加第二力，其中所述第一力的至少一部分与至少一个 使固定的组织抵抗传感器，并迫使传感器抵靠固定的组织，从而在传感器和固定的组织之间产生有效的接触。

公开(公告)号：US08319502B2

公开(公告)日：2012-11-27

申请号：US12147090

申请日：2008-06-26

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: G01R35/00

CPC classification number: G01R27/32 ,  G01R35/007

Abstract: A measurement device is presented being configured to be connectable to an analyzer unit (including a network analyzer). The measurement device includes a measuring unit and a calibration and control unit connected to and integral with the measuring unit. The calibration and control unit is configured to enable connection of the measuring unit to the analyzer unit. The calibration and control unit includes a number of terminals of known RF reflection coefficients respectively and includes a memory utility carrying recorded data indicative of said RF reflection coefficients and recorded data indicative of RF transfer coefficients of the calibration and control unit. This configuration enables calculation of the RF response of the measuring unit while remaining integral with the calibration and control unit.

Abstract translation: 呈现被配置为可连接到分析器单元（包括网络分析器）的测量装置。 测量装置包括测量单元和连接到测量单元并与其成一体的校准和控制单元。 校准和控制单元被配置为使得测量单元能够连接到分析器单元。 校准和控制单元分别包括多个已知射频反射系数的终端，并且包括一个存储器实用工具，其承载表示所述RF反射系数的记录数据和表示校准和控制单元的RF传输系数的记录数据。 该配置使得能够计算测量单元的RF响应，同时与校准和控制单元保持一体。

公开(公告)号：US20120238867A1

公开(公告)日：2012-09-20

申请号：US13485412

申请日：2012-05-31

Applicant: Dan HASHIMSHONY

Inventor： Dan HASHIMSHONY

IPC: A61B5/00 ,  A61B5/053 ,  A61B6/00

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.

Abstract translation: 一种用于通过使检查组织对包含与选择性地与靶细胞结合的生物载体结合的物理元素的小颗粒的造影剂来检查组织是否存在靶细胞特别是癌细胞的方法，装置和探针。 能量脉冲被施加到被检查的组织。 检测由所施加的能量脉冲产生的被检查组织的阻抗和/或光学特性的变化并用于确定所检查组织中靶细胞的存在。 在所描述的优选实施例中，所施加的能量脉冲包括激光脉冲，并且与生物载体共轭的物理元件是具有在存在光时显着降低的阻抗的光敏半导体。 用于检测靶细胞的相同探针也可用于破坏如此靶向的细胞。

公开(公告)号：US20120126828A1

公开(公告)日：2012-05-24

申请号：US13387492

申请日：2010-08-03

Applicant: Gil Cohen ,  Dan Hashimshony ,  Iddo Geltner ,  Harel Golombek

Inventor： Gil Cohen ,  Dan Hashimshony ,  Iddo Geltner ,  Harel Golombek

IPC: G01R27/04

CPC classification number: A61B5/053 ,  A61B5/05 ,  A61B2560/04 ,  A61B2562/0209 ,  A61B2562/046 ,  A61B2562/227

Abstract: A sensor unit for use in measurements on a subject is presented. The sensor unit includes a near field electromagnetic sensor and a flexible signal transmission structure, which are integral with one another by means of at least one common continuous surface. The flexible signal transmission structure is constructed from a first layer including signal connection lines associated with sensor cells near field electromagnetic sensor and a second electrically conductive layer electrically coupled to the electrically conductive material of the sensor.

Abstract translation: 介绍了一种用于测量对象的传感器单元。 传感器单元包括通过至少一个公共连续表面彼此成一体的近场电磁传感器和柔性信号传输结构。 柔性信号传输结构由包括与传感器单元近场电磁传感器相关联的信号连接线的第一层和与传感器的导电材料电耦合的第二导电层构成。

公开(公告)号：US20120123296A1

公开(公告)日：2012-05-17

申请号：US13387504

申请日：2010-08-03

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: A61B10/00

CPC classification number: A61B10/0266 ,  A61B5/05 ,  A61B5/0538 ,  A61B10/0275 ,  A61B10/06 ,  A61B2505/05 ,  A61B2562/227

Abstract: A surgical tool for use in a tissue removal procedure from a subject is described. The surgical tool has proximal and distal regions and at least one sensor for sensing one or more predetermined conditions located at a distal region of the surgical tool. And a substantially flat signal transmission structure electrically connected with the at least one sensor and extending between the location at the distal region and the proximal region. The signal transmission structure is configured for providing impedance controlled signal transmission between the at least one sensor and the proximal region.

Abstract translation: 描述了用于来自受试者的组织去除程序的外科手术工具。 外科手术工具具有近端和远端区域和至少一个传感器，用于感测位于手术工具的远端区域的一个或多个预定条件。 以及基本上平坦的信号传输结构，其与所述至少一个传感器电连接并且在远端区域和近侧区域之间的位置之间延伸。 信号传输结构被配置用于在至少一个传感器和近端区域之间提供阻抗控制的信号传输。

公开(公告)号：US08147423B2

公开(公告)日：2012-04-03

申请号：US11712529

申请日：2007-03-01

Applicant: Dan Hashimshony ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

IPC: A61B10/00

CPC classification number: A61B5/0059 ,  A61B5/0064 ,  A61B5/05 ,  A61B5/6834

Abstract: A measurement system and method are provided for use in characterizing a tissue. The system comprises a probe adapted for operating in either a scan mode or a measure mode, and a control unit for operating the probe. The probe comprises a sensing module for measuring one or more parameters indicative of one or more states of the tissue; and an attachment module configured and operable to enable selective operation of the probe in either one of the scan mode and the measure modes. The control unit is configured and operative to selectively operate the probe in either one of the scan and measure modes.

Abstract translation: 提供了用于表征组织的测量系统和方法。 该系统包括适于以扫描模式或测量模式操作的探针和用于操作探针的控制单元。 探针包括用于测量指示组织的一个或多个状态的一个或多个参数的感测模块; 以及附件模块，其配置和可操作以使得能够以所述扫描模式和所述测量模式中的任一个选择性地操作所述探针。 控制单元被配置和操作以选择性地在扫描和测量模式中的任何一个中操作探针。

公开(公告)号：US08116845B2

公开(公告)日：2012-02-14

申请号：US11350102

申请日：2006-02-09

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/05 ,  A61B8/14 ,  A61B6/00

CPC classification number: A61B6/032 ,  A61B5/0059 ,  A61B5/015 ,  A61B5/0536 ,  A61B5/055 ,  A61B5/103 ,  A61B5/4312 ,  A61B5/6834 ,  A61B5/6843 ,  A61B5/6844 ,  A61B5/6885 ,  A61B5/6886 ,  A61B6/4417 ,  A61B6/5247 ,  A61B8/13

Abstract: The present invention relates to a device for tissue-characterization, designed for effective sensor-to-tissue contact. The device includes an element, having a rigid surface of a linear cross-section, on which at least one sensor is arranged, and a mechanism for applying a force to a soft tissue, the line of force being at an acute angle with the rigid surface, for stretching or stretching and pushing the soft tissue against the rigid surface, thus achieving effective contact between the tissue and the at least one sensor. In consequence, the accuracy of the sensing is improved. In accordance with another embodiment, a plurality of sensors is employed, arranged along a curved element, for providing three-dimensional information regarding the tissue, for example, by small-scale computerized tomography.

Abstract translation: 本发明涉及一种用于组织表征的设备，用于有效的传感器与组织接触。 该装置包括具有线性横截面的刚性表面的元件，至少一个传感器布置在该元件上，以及用于向软组织施加力的机构，该力与刚性线成锐角 表面，用于拉伸或拉伸并将软组织推靠在刚性表面上，从而实现组织与至少一个传感器之间的有效接触。 因此，传感的精度得到改善。 根据另一个实施例，采用多个传感器，沿弯曲元件布置，用于提供关于组织的三维信息，例如通过小规模计算机断层摄影。

公开(公告)号：US08032211B2

公开(公告)日：2011-10-04

申请号：US11797167

申请日：2007-05-01

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/05

CPC classification number: A61B5/053 ,  A61B5/0538 ,  A61B5/415 ,  A61B5/418 ,  A61B10/0041 ,  A61B17/320016 ,  A61B17/320783 ,  A61B2017/00026

Abstract: The present invention relates to probes, systems, and methods for tissue characterization by its dielectric properties, wherein a physical feature of the probe is designed to define and delimit a tissue volume, at a tissue edge, where characterization takes place. Thus, the probe for tissue-edge characterization comprises: a first inner conductor, which comprises: proximal and distal ends, with respect to a tissue edge, along an x-axis; a first sharp edge, inherently associated with the proximal end; at least one feature, issuing from the first inner conductor, substantially at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a generally predefined tissue volume, at the tissue edge, the tissue volume being generally defined by physical parameters associated with the at least one feature; and a dielectric material, which encloses the conductor, in the y-z planes.