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公开(公告)号：US5695998A
公开(公告)日：1997-12-09
申请号：US386452
申请日：1995-02-10
申请人： Stephen F. Badylak , George Boder , Sherry Voytik , Robert J. Demeter , John Critser , Chi Liu
发明人： Stephen F. Badylak , George Boder , Sherry Voytik , Robert J. Demeter , John Critser , Chi Liu
CPC分类号： C12N5/0655 , C12M23/34 , C12M25/02 , C12N5/0068 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , Y10S623/915
摘要： A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing eukaryotic cells are described. Submucosal tissue used in accordance with the present invention supports the proliferation and differentiation of eukaryotic cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.
摘要翻译： 描述了包含温血脊椎动物的粘膜下组织的细胞培养生长底物和培养真核细胞的方法。 根据本发明使用的粘膜下组织当所述细胞在有利于细胞增殖的条件下与粘膜下组织接触时，支持真核细胞的增殖和分化。
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公开(公告)号：US5573784A
公开(公告)日：1996-11-12
申请号：US423411
申请日：1995-04-18
申请人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
发明人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
CPC分类号： A61L27/3645 , A61B17/1146 , A61F2/02 , A61F2/08 , A61L27/3629 , A61L27/365 , A61L27/3662 , A61L27/3695 , Y10S623/915
摘要： Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
摘要翻译： 可以使用由分层的肠组织段形成的组织移植来完成患病或损伤的内源性结缔组织的手术修复。 组织移植物包括从中膜肌层和至少中膜粘膜的腔部分离的肠粘膜粘膜下层。 移植物可通过拉伸进行调理，并形成为具有高拉伸强度的多层组合物，并且在其附着于现有生理结构的点处具有抗撕裂性。
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公开(公告)号：US09814744B2
公开(公告)日：2017-11-14
申请号：US13515661
申请日：2010-12-20
IPC分类号： A01N63/00 , A01N65/00 , A01N1/00 , A01N1/02 , A61K35/35 , A61L26/00 , A61L27/38 , A61L27/60 , C07K14/78 , C12N5/00 , C12N5/0775
CPC分类号： A61K35/35 , A61L26/0057 , A61L26/0076 , A61L27/3804 , A61L27/60 , C07K14/78 , C12N5/0068 , C12N5/0667 , C12N2533/90
摘要： Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell growth scaffold.
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公开(公告)号：US09277999B2
公开(公告)日：2016-03-08
申请号：US12714195
申请日：2010-02-26
CPC分类号： A61F2/3099 , A61F2/30756 , A61F2/30942 , A61F2002/30062 , A61F2002/30069 , A61F2002/30113 , A61F2002/30125 , A61F2002/30574 , A61F2002/30576 , A61F2002/30581 , A61F2002/30588 , A61F2002/30754 , A61F2002/30766 , A61F2002/3092 , A61F2210/0004 , A61F2230/0006 , A61F2230/0008 , A61L27/14 , A61L27/3633 , A61L27/48 , A61L27/58 , A61L2430/06 , C08L89/00
摘要： Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
摘要翻译： 本文提供了组合物和医疗装置，特别是能够修复和替代软骨型半月板的可生物降解的支架。 本文还提供了使用支架治疗退行性组织病症的方法。 在某些实施方案中，这种支架可以促进颞下颌关节（TMJ）半月板的组织再生。
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公开(公告)号：US08647677B2
公开(公告)日：2014-02-11
申请号：US12503774
申请日：2009-07-15
CPC分类号： G01N33/56922 , C12N1/20 , C12N5/0068 , C12N2533/92 , G01N33/5091 , Y10S435/851
摘要： A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing fastidious organisms is described. Submucosal tissue used in accordance with the present invention supports the proliferation of cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.
摘要翻译： 描述了包含温血脊椎动物的粘膜下组织的细胞培养生长底物和培养有害生物的方法。 当在有利于细胞增殖的条件下，当所述细胞与粘膜下组织接触时，根据本发明使用的粘膜下组织支持细胞的增殖。
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公开(公告)号：US20130253663A1
公开(公告)日：2013-09-26
申请号：US13814783
申请日：2011-08-17
申请人： Nicholas J. Amoroso , Stephen F. Badylak , Yi Hong , Alexander Huber , Keisuke Takanari , William R. Wagner
发明人： Nicholas J. Amoroso , Stephen F. Badylak , Yi Hong , Alexander Huber , Keisuke Takanari , William R. Wagner
IPC分类号： A61L27/58
CPC分类号： A61L27/18 , A61L27/3633 , A61L27/48 , A61L27/58 , A61L2400/18 , A61L2430/34 , C08L67/04 , C08L75/00
摘要： A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs. Methods of making and using the biohybrid scaffold are provided.
摘要翻译： 提供了一种生物混合支架，可用于腹壁重建，盆底修复，乳房重建以及其他软组织修复的临床应用。 提供制造和使用生物混合支架的方法。
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公开(公告)号：US08361503B2
公开(公告)日：2013-01-29
申请号：US12040140
申请日：2008-02-29
IPC分类号： A61K9/14 , A61K35/12 , A61K35/37 , A61K35/38 , A61K35/407 , A61K35/22 , A61K35/23 , A61K35/52
CPC分类号： A61L27/3633 , A61K35/12 , A61K38/00 , A61L27/34 , A61L27/3687 , A61L27/38 , A61L27/52 , A61L27/54 , A61L2300/64 , A61L2400/06 , A61L2420/04 , C12P21/06
摘要： Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
摘要翻译： 提供了制备用作细胞生长支架的凝胶化，溶解的细胞外基质（ECM）组合物的方法。 还提供了根据方法制备的组合物以及组合物的用途。 在一个实施方案中，提供了一种装置，例如假体，其包括无机基质，凝胶化的可溶解的ECM被分散在该无机基质中，以促进细胞生长进入ECM，从而将该装置适应和/或附着到患者 。
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公开(公告)号：US20110184439A1
公开(公告)日：2011-07-28
申请号：US12991809
申请日：2009-05-08
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , A61B2017/00867
摘要： Provided herein is a device to occlude a hole in a wall of an organ or tissue. In another embodiment, a device is provided which comprises an extracellular matrix-derived material and an adhesive to occlude a hole in a wall of an organ or tissue. Provided are devices prepared from extracellular matrix-derived cell-growth scaffolding to repair defects in walls of organs or tissues. Also provided are methods for preparing the device as well as for using the device.
摘要翻译： 本文提供了一种用于封闭器官或组织的壁中的孔的装置。 在另一个实施方案中，提供了一种装置，其包括细胞外基质衍生的材料和用于封闭器官或组织的壁中的孔的粘合剂。 提供的是从细胞外基质衍生的细胞生长支架制备的装置来修复器官或组织的壁中的缺陷。 还提供了用于准备装置以及使用装置的方法。
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公开(公告)号：US07820634B2
公开(公告)日：2010-10-26
申请号：US11799724
申请日：2007-05-02
CPC分类号： A61K48/0025 , A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61K35/38 , A61K48/00 , A61L27/3629
摘要： A composition useful for the production of transformed eukaryotic cells is described. The composition comprises submucosal tissue and a nucleic acid sequence. The nucleic acid sequence is typically recombinant DNA including gene(s) encoding for one or more biofunctional proteins. The submucosal tissue component of the present composition comprises the tunica submucosa of vertebrate intestine delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa. Injection or implantation of the composition into a host induces the formation of transformed cells capable of expressing gene(s) encoded by the nucleic acid sequence.
摘要翻译： 描述了可用于生产转化真核细胞的组合物。 组合物包含粘膜下组织和核酸序列。 核酸序列通常是包含编码一种或多种生物功能蛋白质的基因的重组DNA。 本发明组合物的粘膜下组织组分包括从肌层剥离的脊椎动物肠的粘膜下膜和至少中膜粘膜的腔内部分。 将组合物注入或植入宿主中诱导能够表达由核酸序列编码的基因的转化细胞的形成。
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公开(公告)号：US07771717B2
公开(公告)日：2010-08-10
申请号：US11705847
申请日：2007-02-13
IPC分类号： A61L27/00
CPC分类号： A61L27/3808 , A61K35/38 , A61K35/44 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3683 , A61L27/3839 , C12N5/0068 , C12N5/0655 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , A61K2300/00
摘要： An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo.
摘要翻译： 描述了包括温血脊椎动物的粘膜下层和预选的真核细胞组的改进的组织移植物构建体。 可以根据本发明使用改进的组织移植物构建体，以增强体内受损或患病组织的修复。
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