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公开(公告)号：US12090170B2
公开(公告)日：2024-09-17
申请号：US17042032
申请日：2019-04-04
CPC分类号： A61K35/17 , A61K38/1793
摘要： Methods are provided for treating a subject for glioblastoma, including e.g., an EGFRvIII negative glioblastoma. The methods of the present disclosure involve administering to a subject a molecular circuit that includes a binding triggered transcriptional switch (BTTS) that binds to a priming antigen expressed by the subjects glioblastoma multiforme (GBM) that, when bound to the priming antigen, induces one or more encoded therapeutics specific for one or more antigens expressed by the GBM. Nucleic acids containing sequences encoding all or portions of such circuits are also provided, as well as cells, expression cassettes and vectors that contain such nucleic acids. Also provided are kits for practicing the described methods.
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公开(公告)号：US20240304399A1
公开(公告)日：2024-09-12
申请号：US18489907
申请日：2023-10-19
CPC分类号： H01G11/60 , H01G11/26 , H01G11/28 , H01G11/30 , H01G11/68 , H01G11/70 , H01G11/86 , Y02E60/13
摘要： The present disclosure provides supercapacitors that may avoid the shortcomings of current energy storage technology. Provided herein are supercapacitor devices, and methods of fabrication thereof comprising the manufacture or synthesis of an active material on a current collector and/or the manufacture of supercapacitor electrodes to form planar and stacked arrays of supercapacitor electrodes and devices. Prototype supercapacitors disclosed herein may exhibit improved performance compared to commercial supercapacitors. Additionally, the present disclosure provides a simple, yet versatile technique for the fabrication of supercapacitors through masking and etching.
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公开(公告)号：US20240303544A1
公开(公告)日：2024-09-12
申请号：US18551483
申请日：2022-03-29
IPC分类号： G06N20/00
CPC分类号： G06N20/00
摘要： A process is provided for using a graph database (e.g., SPOKE) to generate training vectors (SPOKEsigs) and train a machine learning model to classify biological entities. A cohort's input data records (EHRs) are compared to graph database nodes to identify overlapping concepts. Entry nodes (SEPs) associated with these overlapping concepts are used to generate propagated entry vectors (PSEVs) that encode the importance of each database node for a particular cohort, which helps train the model with only relevant information. Further, the propagated entry vectors for a given entity with a known classification can be aggregated to create training vectors. The training vectors are used as inputs to train a machine learning model. Biological entities with an unknown classification can be classified with a trained machine learning model. Entity signature vectors are generated for entities without a classification and input into the trained machine learning model to obtain a classification.
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公开(公告)号：US20240297199A1
公开(公告)日：2024-09-05
申请号：US18613895
申请日：2024-03-22
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC
发明人： Francois Leonard , Maurice Garcia-Sciveres , Mi-Young Im , Yuan Mei , Andrew Nonaka , Aikaterini Papadopoulou , Archana Raja , Grigory Tikhomirov
IPC分类号： H01L27/146 , H01L31/02 , H01L31/0352 , H01L31/18
CPC分类号： H01L27/14652 , H01L27/14683 , H01L31/02005 , H01L31/035227 , H01L31/18 , H01L31/035218
摘要： A pixelated electronic sensor is disclosed for imaging from infra-red to ultraviolet wavelengths, composed of a CMOS integrated circuit plus layers of nano-materials monolithically integrated via low temperature post-processing. Co-design, simulation, and integration methods for the device are described. Each pixel has color-resolved single photon sensitivity without dark counts and without inefficiency. The device operates at temperatures above 70° Kelvin. Current state of the art imagers that can color-resolve single photons are of bolometric or filter type. Bolometric devices must operate at temperature below 1° Kelvin and are limited to few pixels. Devices that use filters are inefficient as all the photons rejected by a filter are wasted. Single photon imagers that operate at non-cryogenic temperature (like Silicon Photomultipliers) have large dark counts typically measured in MHz/cm2. Imaging applications include astronomical telescopes, exoplanet imaging, distant galaxy imaging, microscopic imaging, medical devices, and hyperspectral imaging.
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公开(公告)号：US20240293578A1
公开(公告)日：2024-09-05
申请号：US18658077
申请日：2024-05-08
发明人： Stephanie Cherqui
CPC分类号： A61K48/005 , A61K35/14 , A61K35/28 , C12N9/22 , C12N15/111 , C12N15/85 , C12N2310/20 , C12N2800/80
摘要： Provided herein are methods for treating a disease or disorder associated with mitochondrial dysfunction through ex vivo introduction of a nucleic acid molecule into hematopoietic stem and progenitor cells (HSPCs) followed by transplantation of the HSPCs into a subject in need of treatment. The nucleic acid molecule may include a functional human frataxin (hFXN) or may include a gene editing system that when transfected into the cells removes a trinucleotide extension mutation of endogenous hFXN.
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公开(公告)号：US12080549B2
公开(公告)日：2024-09-03
申请号：US17397640
申请日：2021-08-09
发明人： Iljo Kwak , Kasra Sardashti , Andrew Kummel
IPC分类号： H01L21/02 , B82Y10/00 , H01L21/28 , H01L21/3105 , H01L29/06 , H01L29/16 , H01L29/24 , H01L29/423 , H01L29/49 , H01L29/51 , H01L29/66 , H01L29/775 , H01L29/778 , H01L29/786 , H10B63/00 , H10N50/01 , H10N70/00
CPC分类号： H01L21/0228 , B82Y10/00 , H01L21/02178 , H01L21/02181 , H01L21/022 , H01L21/28194 , H01L21/3105 , H01L29/0673 , H01L29/1606 , H01L29/24 , H01L29/42384 , H01L29/4908 , H01L29/517 , H01L29/66439 , H01L29/66742 , H01L29/775 , H01L29/778 , H01L29/78603 , H01L29/78645 , H01L29/78681 , H01L29/78684 , H01L29/78696 , H10B63/30 , H10N50/01 , H10N70/011 , H01L29/0676
摘要： A semiconductor structure includes a nanofog oxide adhered to an inert 2D or 3D surface or a weakly reactive metal surface, the nanofog oxide consisting essentially of 0.5-2 nm Al2O3 nanoparticles. The nanofog can also consists of sub 1 nm particles. Oxide layers can be formed on the nanofog, for example a bilayer stack of Al2O3—HfO2. Additional examples are from the group consisting of ZrO2, HfZrO2, silicon or other doped HfO2 or ZrO2, ZrTiO2, HfTiO2, La2O3, Y2O3, Ga2O3, GdGaOx, and alloys thereof, including the ferroelectric phases of HfZrO2, silicon or other doped HfO2 or ZrO2. The structure provides the basis for various devices, including MIM capacitors, FET transistors and MOSCAP capacitors.
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公开(公告)号：US12078625B2
公开(公告)日：2024-09-03
申请号：US17605213
申请日：2020-04-15
发明人： R. Michael van Dam , Jia Wang , Alejandra Rios
摘要： A method of performing high-throughput radio thin layer chromatography (radio-TLC) includes spotting a plurality of locations on one or more TLC plates with samples containing a radiochemical or a radiopharmaceutical, each location defining an individual lane on the one or more TLC plates for the respective samples. The one or more TLC plates are developed with a developing solution and dried. The TLC plates are imaged with an imaging device comprising a camera, wherein the image obtained from the camera comprises a field of view that contains regions of interest (ROIs) from the plurality of lanes. The ROIs in the images obtained from the camera may then be analyzed by the user. The ROIs may be used, for example, reaction optimization or for quality control check of the production of radiotracers.
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公开(公告)号：US12076329B2
公开(公告)日：2024-09-03
申请号：US17332865
申请日：2021-05-27
申请人： The Regents of the University of California , Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V. , Cornell University
IPC分类号： A61K31/655 , A61F9/00 , A61K9/00 , A61K31/52 , A61K35/76 , A61K38/16 , A61K47/40 , A61K47/60 , A61K47/65 , A61K47/68 , A61P27/02
CPC分类号： A61K31/655 , A61F9/0008 , A61K9/0048 , A61K31/52 , A61K35/76 , A61K38/16 , A61K47/40 , A61K47/60 , A61K47/65 , A61K47/6849 , A61P27/02
摘要： The present disclosure provides a conjugate comprising an affinity agent, a branched linker, and two or more photoisomerizable regulators. The present disclosure provides compositions comprising the conjugate, as well as devices comprising the compositions. The present disclosure provides methods for enhancing visual function, the methods comprising administering the conjugate to an individual in need thereof.
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公开(公告)号：US12076301B2
公开(公告)日：2024-09-03
申请号：US17407043
申请日：2021-08-19
IPC分类号： A61K31/137 , A61K31/4168 , A61K31/4178 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/527 , A61N1/05 , A61N1/36
CPC分类号： A61K31/137 , A61K31/4168 , A61K31/4178 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/527 , A61N1/0551 , A61N1/36003 , A61N1/36034 , A61N1/36067 , A61N1/36171
摘要： In various embodiments, methods are provided for applying transcutaneous and/or epidural spinal cord stimulation with and without selective pharmaceuticals to restore voluntary control of hand function in tetraplegic subjects.
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50.发明公开公开(公告)号：US20240285531A1
公开(公告)日：2024-08-29
申请号：US18429272
申请日：2024-01-31
发明人： Andre E. Nel , Jeffrey I. Zink , Huan Meng
IPC分类号： A61K9/127 , A61K9/51 , A61K31/337 , A61K31/4709 , A61K31/7068 , A61K31/7105 , A61K31/713 , A61K45/06 , A61K47/02
CPC分类号： A61K9/127 , A61K9/5115 , A61K31/337 , A61K31/4709 , A61K31/7068 , A61K31/7105 , A61K31/713 , A61K45/06 , A61K47/02
摘要： A submicron structure comprising a silica body defining a plurality of pores that are suitable to receive molecules therein, and having a surface, and a phospholipid bilayer coating the surface, wherein said submicron structure has a maximum dimension of less than one micron, and wherein the phospholipid bilayer stably seals the plurality of pores; and wherein the submicron structure is a member of a monodisperse population of submicron structures.
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