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公开(公告)号：US09872911B2
公开(公告)日：2018-01-23
申请号：US14364028
申请日：2012-12-15
发明人： Arturo Jose Vegas , Kathryn Ann Whitehead , Daniel Griffith Anderson , Robert S. Langer , Joseph R. Dorkin
IPC分类号： A61K47/34 , A61K9/127 , A61K31/713 , A61K9/51 , C08G73/00 , C08L79/00 , A61K33/00 , A61K38/16 , A61K39/00 , C08G12/06 , C08G12/34 , C12N15/113
CPC分类号： A61K47/34 , A61K9/1271 , A61K9/5146 , A61K31/713 , A61K33/00 , A61K38/16 , A61K39/00 , C08G12/06 , C08G12/34 , C08G73/00 , C08L79/00 , C12N15/113
摘要： α-Aminoamidine polymers and methods of preparing a-aminoamidine polymers by reacting by reacting one or more amines with one or more isocyanides and one or more aldehydes are described. Methods of preparing a-aminoamidine polymers from commercially available starting materials are also provided, wherein the starting materials are racemic or stereochemically pure. a-Aminoamidine polymers or salt forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems and for other purposes as well such as, for example, coatings, additives, excipients, plastics, and materials, etc. Given the amino moiety of these α-aminoamidine polymers, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive α-aminoamidine polymers and polynucleotides can be prepared. The inventive α-aminoamidine polymers may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
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公开(公告)号：US09724447B2
公开(公告)日：2017-08-08
申请号：US14286743
申请日：2014-05-23
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The Children's Medical Center Corporation
发明人： Jeffrey M. Karp , Pedro del Nido , Nora Lang , Robert S. Langer , Maria Jose M. N. Pereira , Yuhan Lee
IPC分类号： A61L24/00 , A61L24/04 , C08G63/91 , A61L15/58 , C08G63/47 , A61L15/26 , A61L15/42 , C08F222/10
CPC分类号： A61L24/046 , A61L15/26 , A61L15/42 , A61L15/58 , A61L24/001 , A61L2400/18 , C08F2222/1073 , C08G63/47 , C08G63/914 , C08L67/04
摘要： Pre-polymers for use as tissue sealants and adhesives, and methods of making and using thereof are provided. The pre-polymers have flow characteristics such that they can be applied through a syringe or catheter but are sufficiently viscous to remain in place at the site of application and not run off the tissue. The pre-polymers are also sufficiently hydrophobic to resist washout by bodily fluids. The pre-polymers are stable in bodily fluids; that is the pre-polymer does not spontaneously crosslink in bodily fluids absent the presence of an intentionally applied stimulus to initiate crosslinking. Upon crosslinking, the adhesive exhibits significant adhesive strength in the presence of blood and other bodily fluids. The adhesive is sufficiently elastic that it is able to resist movement of the underlying tissue. The adhesive can provide a hemostatic seal. The adhesive is biodegradable and biocompatible, causing minimal inflammatory response.
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公开(公告)号：US20170216216A1
公开(公告)日：2017-08-03
申请号：US15484892
申请日：2017-04-11
发明人： Ana Jaklenec , Xian Xu , Lowell L. Wood, JR. , Philip A. Eckhoff , William Gates , Boris Nikolic , Robert S. Langer
IPC分类号： A61K9/50 , A61K31/714 , A61K33/30 , A61K31/295 , A61K33/26 , A61K31/23 , A61K31/519 , A61K31/593 , A61K33/18 , A61K31/375 , A61K45/06 , A23L27/00 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A61K9/48
CPC分类号： A61K9/5026 , A23L27/72 , A23L27/74 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A23V2002/00 , A61K9/4866 , A61K9/501 , A61K9/5073 , A61K31/07 , A61K31/23 , A61K31/295 , A61K31/375 , A61K31/519 , A61K31/593 , A61K31/714 , A61K33/18 , A61K33/26 , A61K33/30 , A61K45/06 , A61K47/26 , A61K47/36
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
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公开(公告)号：US09682169B2
公开(公告)日：2017-06-20
申请号：US14975039
申请日：2015-12-18
IPC分类号： A61K31/00 , A61L27/26 , A61L27/52 , C08J3/24 , C08J3/075 , A61K31/7052 , A61L27/38 , A61L27/50
CPC分类号： A61L27/26 , A61K31/00 , A61K31/7052 , A61L27/38 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08J3/075 , C08J3/246 , C08J2305/08 , C08J2371/02 , C08L71/02
摘要： The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrogels or compositions thereof are injected into the superficial lamina propria or phonatory epithelium to restore the phonatory mucosa of the vocal cords, thereby restoring a patient's voice. In particular, it has been discovered that hydrogels with an elastic shear modulus of approximately 25 Pa are useful in restoring the pliability of the phonatory mucosa. The invention also provides methods of preparing and using the inventive hydrogels.
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55.发明授权Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates 有权用于包封细胞和细胞聚集体的多层水凝胶胶囊公开(公告)号：US09555007B2
公开(公告)日：2017-01-31
申请号：US13831250
申请日：2013-03-14
发明人： Minglin Ma , Daniel G. Anderson , Robert S. Langer , Omid Veiseh , Arturo Jose Vegas , Joshua Charles Doloff , Delai Chen , Christian J. Kastrup
CPC分类号： A61K35/39 , A61K9/0024 , A61K9/5036 , A61K9/5078 , A61K9/5089 , A61K2035/126 , A61K2035/128 , B01J13/046
摘要： Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
摘要翻译： 公开了包封直径大于1mm的哺乳动物细胞和任选的无细胞核的生物相容性水凝胶胶囊，其在植入受试者后具有减少的纤维化过度生长。 还公开了治疗受试者疾病的方法，其涉及向受试者施用治疗有效量的所公开的封闭细胞。
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公开(公告)号：US09539210B2
公开(公告)日：2017-01-10
申请号：US13844382
申请日：2013-03-15
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , The Children's Medical Center Corporation
发明人： Ulrich H. von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
CPC分类号： A61K9/14 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K47/6937 , A61K2039/555 , A61K2039/60 , Y02A50/464 , Y02A50/472
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供了在一些实施方案中能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，其包含至少一种免疫调节剂，并且任选地包含最后一个靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含本发明疫苗纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明疫苗纳米载体及其药物组合物的方法。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种本发明的疫苗纳米载体。
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公开(公告)号：US20170000888A1
公开(公告)日：2017-01-05
申请号：US15174267
申请日：2016-06-06
发明人： Jeffrey M. Karp , Praveen Kumar Vemula , Nathaniel R. Campbell , Abdullah M. Syed , Sufeng Zhang , Omid C. Farokhzad , Robert S. Langer
IPC分类号： A61K47/22 , A61K31/4188 , A61K31/4745 , A61K38/28 , A61K31/573 , A61K31/405 , A61K31/713 , A61K47/26 , A61K31/58
CPC分类号： A61K47/22 , A61K9/0019 , A61K9/06 , A61K9/1075 , A61K31/166 , A61K31/405 , A61K31/4188 , A61K31/4745 , A61K31/573 , A61K31/58 , A61K31/713 , A61K38/28 , A61K47/14 , A61K47/26 , A61K47/28
摘要： Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
摘要翻译： 描述了包含胶凝剂，例如分子量为2500以下的可酶切割凝胶剂的自组装凝胶组合物。 自组装凝胶组合物可以包封一种或多种试剂。 还描述了使用自组装凝胶组合物制备自组装凝胶组合物的方法和药物递送方法。
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公开(公告)号：US20160280827A1
公开(公告)日：2016-09-29
申请号：US15078685
申请日：2016-03-23
发明人： Daniel Griffith Anderson , Eric Andrew Appel , Yizhou Dong , Robert S. Langer , Benjamin C. Tang , Omid Veiseh , Weiheng Wang , Matthew J. Webber , Kun Xue
IPC分类号： C08F230/06 , C08F220/54 , C08F220/60 , A61K47/32
摘要： Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.
摘要翻译： 通过自由基聚合制备并且可以自组装成聚合物凝胶如水凝胶。 还提供了方法或制备聚合物，涉及聚合物和/或聚合物凝胶或其组合物的试剂盒，用作试剂到受试者的材料或递送应用。
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公开(公告)号：US20160206740A1
公开(公告)日：2016-07-21
申请号：US14995842
申请日：2016-01-14
发明人： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
IPC分类号： A61K47/22 , C07D273/00 , C07D295/084 , C12N15/113 , A61K9/127
CPC分类号： A61K47/22 , A61K9/0019 , A61K9/1272 , A61K47/34 , A61K47/543 , A61K47/59 , A61K47/6907 , A61K47/6911 , A61K47/6921 , C07D257/02 , C07D273/00 , C07D273/08 , C07D295/084 , C08G73/10 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/32
摘要： The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
摘要翻译： 本发明提供含有一个或多个式（ⅲ）基团的本发明共轭聚乙烯亚胺（PEI）聚合物和共轭氮杂 - 大环化合物（统称为“共轭脂族”或“脂聚合物”）：其中R3和R4定义如上 这里。 还提供了包含本发明的共轭脂族物的组合物，以及制备和使用方法。
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公开(公告)号：US20160114042A1
公开(公告)日：2016-04-28
申请号：US14987717
申请日：2016-01-04
发明人： Daniel Griffith Anderson , Kathryn Ann Whitehead , Joseph R. Dorkin , Arturo Jose Vegas , Yunlong Zhang , Robert S. Langer
IPC分类号： A61K47/22 , C07D241/04 , C12N15/113 , C07D295/13
CPC分类号： A61K47/22 , A61K9/1272 , A61K9/5123 , A61K31/225 , A61K31/357 , A61K31/40 , A61K31/445 , A61K31/495 , A61K31/4985 , A61K31/573 , A61K31/704 , A61K31/713 , A61K45/06 , A61K47/18 , A61K47/542 , A61K47/543 , A61K47/6925 , C07C225/06 , C07C229/12 , C07C229/14 , C07C229/24 , C07C229/26 , C07C229/28 , C07C229/34 , C07C2601/14 , C07D207/09 , C07D211/14 , C07D211/26 , C07D211/34 , C07D241/04 , C07D295/13 , C07D295/15 , C07D295/16 , C07D319/16 , C07D319/18 , C07D487/04 , C12N15/111 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2320/32 , A61K2300/00
摘要： Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.
摘要翻译： 本文提供的是可以通过将烷基胺偶联加成丙烯酸酯制备的类脂。 在一些实施方案中，提供的类脂质是可生物降解的并且可以用于多种药物递送系统中。 考虑到类固醇的氨基部分，除了其它药剂之外，它们非常适合于递送多核苷酸。 已经制备了含有本发明的类脂和多核苷酸的纳米颗粒，并且已显示其在递送siRNA方面是有效的。
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