公开(公告)号：US20050158305A1

公开(公告)日：2005-07-21

申请号：US10965585

申请日：2004-10-14

申请人： Jonathan Ellis ,  Alan Lewis

发明人： Jonathan Ellis ,  Alan Lewis

IPC分类号： C12N15/02 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07K16/28 ,  C07K16/46 ,  C12P21/08 ,  C07K16/44 ,  C12N5/06

CPC分类号： C07K16/2896 ,  A61K38/00 ,  C07K16/465 ,  C07K2317/24 ,  C07K2319/00

摘要： The present invention relates to a monoclonal antibody, preferably, with specificity for CD38, having CDRs of foreign origin and a recipient framework region having a sequence of human or primate origin, wherein the original amino acid residues in position 29 and/or 78 of the sequence of the recipient framework region of the heavy chain is replaced by a replacement amino acid residue that is the same or similar to that in the corresponding position of the sequence of the corresponding framework region of the heavy chain of the antibody from which the CDRs are derived. Method of preparation of said antibody. Pharmaceutical composition containing said antibody. Use of said antibody for the treatment of cancer and autoimmune diseases.

摘要翻译： 本发明涉及优选具有CD38特异性的单克隆抗体，其具有国外起源的CDR和具有人或灵长类来源序列的受体框架区，其中位于第29位和/或78位的原始氨基酸残基 重链的受体框架区的序列被替换的氨基酸残基取代，所述替换氨基酸残基与抗体重链的相应构架区的序列的相应位置相同或相似，其中CDR是 派生。 所述抗体的制备方法。 含有所述抗体的药物组合物。 使用所述抗体治疗癌症和自身免疫性疾病。

公开(公告)号：US20050014349A1

公开(公告)日：2005-01-20

申请号：US10735695

申请日：2003-12-16

申请人： Glen Carey ,  Ian Jenks ,  Alan Lewis ,  Rene Lujan ,  Hailong Zhou

发明人： Glen Carey ,  Ian Jenks ,  Alan Lewis ,  Rene Lujan ,  Hailong Zhou

IPC分类号： C30B1/00 ,  H01L21/00 ,  H01L21/20 ,  H01L21/36 ,  H01L33/00 ,  H01S5/02 ,  H01S5/183 ,  H01S5/323

CPC分类号： H01S5/18305 ,  H01L21/02395 ,  H01L21/02543 ,  H01L21/02546 ,  H01L33/0079 ,  H01S5/0217 ,  H01S5/0224 ,  H01S5/141 ,  H01S5/323

摘要： A method of fabricating a semiconductor device is described. In this method, a starting substrate of sufficient thickness is selected that has the required defect density levels, which may result in an undesirable doping level. Then a semiconductor layer having a desired doping level is formed on the starting substrate. The resulting semiconductor layer has the required defect density and doping levels for the final product application. After active components, electrical conductors, and any other needed structures are formed on the semiconductor layer, the starting substrate is removed leaving a desired thickness of the semiconductor layer. In a VECSEL application, the active components can be a gain cavity, where the semiconductor layer has the necessary defect density and doping levels to maximize wall plug efficiency (WPE). In one embodiment, the doping of the semiconductor layer is not uniform. For example, a majority of the layer is doped at a low level and the remainder is doped at a much higher level. This can result in improved WPE at particular thicknesses for the higher doped material.

摘要翻译： 描述制造半导体器件的方法。 在该方法中，选择具有所需缺陷密度水平的足够厚度的起始衬底，这可能导致不期望的掺杂水平。 然后在起始衬底上形成具有期望的掺杂水平的半导体层。 所得到的半导体层具有所需的缺陷密度和最终产品应用的掺杂水平。 在有源部件之后，在半导体层上形成电导体和任何其它需要的结构，去除起始衬底，留出半导体层的所需厚度。 在VECSEL应用中，有源部件可以是增益腔，其中半导体层具有必要的缺陷密度和掺杂水平以最大化壁插拔效率（WPE）。 在一个实施例中，半导体层的掺杂不均匀。 例如，该层的大部分以低电平掺杂，其余部分以更高的水平掺杂。 这可以导致用于较高掺杂材料的特定厚度的改进的WPE。

公开(公告)号：US5164616A

公开(公告)日：1992-11-17

申请号：US459096

申请日：1989-12-29

申请人： Alan Lewis ,  Richard H. Bruce ,  William F. Gunning

发明人： Alan Lewis ,  Richard H. Bruce ,  William F. Gunning

IPC分类号： G11C27/02

CPC分类号： G11C27/024

摘要： An integrated sample and hold circuit includes a capacitor that is charged through a channel, such as a first input transistor's channel. Feedback circuitry connected to the first transistor's channel leads maintains approximately zero voltage difference between the channel leads to prevent leakage current when the first transitor is turned off. Isolation circuitry, such as a second input transistor, isolates the first transistor from the input voltage while a voltage level is being stored, and the gates of both input transistors can be connected to receive the same store signal. The feedback circuitry can include a follower transistor with its gate connected to the first transistor's output lead and a first channel lead connected to the first transistor's input lead and to load circuitry that maintains current flow through the follower transistor. To ensure that it does not pass current to or from the capacitive element, the follower transistor can be an MOS device or other insulated gate transistor. The follower transistor's other channel lead can be connected to a bias voltage that, together with the current flow, keeps the follower transistor's gate and first channel lead at the stored voltage level. The load circuitry can include a transistor identical to the follower transistor, with one of its channel leads connected to the follower transistor's first channel lead and with its other channel lead and its gate lead connected to a bias voltage that maintains sufficient current flow through the follower transistor. The substrate can be an insulating material such as glass, quartz, sapphire, silicon dioxide, or silicon nitride, and the circuitry can be thin film structures, amorphous silicon, polysilicon, or single crystal devices, so that the only significant leakage path to and from the capacitive element is through the first input transistor's channel.

公开(公告)号：US08775107B2

公开(公告)日：2014-07-08

申请号：US13526192

申请日：2012-06-18

申请人： Alok Govil ,  Kostadin Djordjev ,  Alan Lewis ,  Wilhelmus Johannes Robertus Van Lier

发明人： Alok Govil ,  Kostadin Djordjev ,  Alan Lewis ,  Wilhelmus Johannes Robertus Van Lier

IPC分类号： G06F19/00 ,  B81C99/00 ,  G09G3/00 ,  G09G3/34 ,  G09G5/00

CPC分类号： B81C99/0045 ,  B81B2201/042 ,  G01R19/0046 ,  G02B26/001 ,  G09G3/006 ,  G09G3/346 ,  G09G5/003 ,  G09G2310/061 ,  G09G2320/0693

摘要： Methods and devices to measure voltage margins of electromechanical devices are disclosed. The voltage margins are determined based on responses to test voltages which cause the devices to change states. State changes of the devices are detected by monitoring integrated current or charge used to drive the devices with the test voltages.

摘要翻译： 公开了用于测量机电装置的电压裕度的方法和装置。 电压裕度是基于对导致器件改变状态的测试电压的响应来确定的。 通过监测用于用测试电压驱动设备的集成电流或电荷来检测器件的状态变化。

公开(公告)号：US08451298B2

公开(公告)日：2013-05-28

申请号：US12121706

申请日：2008-05-15

申请人： Louis D. Silverstein ,  Alan Lewis ,  Jennifer L. Gille

发明人： Louis D. Silverstein ,  Alan Lewis ,  Jennifer L. Gille

IPC分类号： G09G5/10

CPC分类号： G09G5/10 ,  G09G3/2055 ,  G09G3/2081 ,  G09G3/3466

摘要： Displays, and methods of displaying images with the displays, which have quantized display characteristics for each of the pixels are disclosed. The displays and methods relate to both spatially and temporally dithering images so that the effective resolution of the display is higher than the result of the native spatial and intensity resolutions of the display, defined by pixel size, pitch, and number of quantization levels of each of the pixels.

摘要翻译： 公开了显示和显示具有每个像素的量化显示特性的显示图像的方法。 显示器和方法涉及空间和时间抖动图像，使得显示器的有效分辨率高于由像素尺寸，间距和每个像素的量化级数定义的显示器的原始空间和强度分辨率的结果 的像素。

公开(公告)号：US07991646B2

公开(公告)日：2011-08-02

申请号：US12262012

申请日：2008-10-30

申请人： Alan Lewis ,  Ken Sun

发明人： Alan Lewis ,  Ken Sun

IPC分类号： G06Q30/00

CPC分类号： G06Q30/0641 ,  G06Q30/0601 ,  G06Q30/0603

摘要： Embodiments of computer-implemented systems and methods for marketplace listings using a camera enabled mobile device are described. One example embodiment comprises receiving a request via a camera enabled mobile device to list one or more sale items, receiving images having the one or more sale items, the images being taken by the camera enabled mobile device, receiving data associated with the one or more sale items, and based on the data, listing the one or more sale items on a marketplace.

摘要翻译： 描述了使用启用相机的移动设备的计算机实现的系统和用于市场列表的方法的实施例。 一个示例性实施例包括经由启用相机的移动设备接收请求以列出一个或多个销售项目，接收具有一个或多个销售项目的图像，由相机启用的移动设备拍摄的图像，接收与该一个或多个销售项目相关联的数据 销售物品，并根据数据，在市场上列出一个或多个销售物品。

公开(公告)号：US20110145106A1

公开(公告)日：2011-06-16

申请号：US13033504

申请日：2011-02-23

申请人： Helen M. Gould ,  Edward O'Neil Garcia ,  Ryan Melcher ,  Diego Lagunas ,  Alvaro Bolivar ,  Jennifer T. Anderson ,  Karenina Susilo ,  Ryan Spoon ,  Alan Lewis

发明人： Helen M. Gould ,  Edward O'Neil Garcia ,  Ryan Melcher ,  Diego Lagunas ,  Alvaro Bolivar ,  Jennifer T. Anderson ,  Karenina Susilo ,  Ryan Spoon ,  Alan Lewis

IPC分类号： G06Q30/00 ,  G06F3/00

CPC分类号： G06Q30/0613 ,  G06F3/04812 ,  G06F3/04842 ,  G06Q10/10 ,  G06Q20/12 ,  G06Q20/29 ,  G06Q30/06 ,  G06Q30/0601 ,  G06Q30/0641 ,  H04L51/04 ,  H04L67/02 ,  H04L67/20 ,  H04L67/22

摘要： Examples of a method and system for collaborative and private sessions are provided. A cursor movement request may be received from at least two users of a plurality of users of a collaborative session during a time period. The cursor may move on a common interface according to the cursor movement request from a first user selected from the at least two users that has satisfied a movement criterion. A completion criterion and a private session parameter may be designated for a private session. A number of user interactions may be processed from a participant of the private session. The private shopping session may be terminated for the participant when the completion criterion is satisfied.

摘要翻译： 提供了用于协作和私人会话的方法和系统的示例。 在一段时间内可以从协作会话的多个用户的至少两个用户接收光标移动请求。 光标可以根据来自已满足移动标准的至少两个用户中选择的第一用户的光标移动请求在公共接口上移动。 可以为私人会话指定完成标准和私人会话参数。 可以从私人会话的参与者处理许多用户交互。 当满足完成标准时，可以为参与者终止私人购物会话。

公开(公告)号：US20110055195A1

公开(公告)日：2011-03-03

申请号：US12940715

申请日：2010-11-05

申请人： Alec Reitter ,  Barb Chang ,  Ken Sun ,  Raghav Gupta ,  Alvaro Bolivar ,  Alan Lewis

发明人： Alec Reitter ,  Barb Chang ,  Ken Sun ,  Raghav Gupta ,  Alvaro Bolivar ,  Alan Lewis

IPC分类号： G06F17/30

CPC分类号： G06Q30/00 ,  G06F17/2745 ,  G06F17/30864

摘要： A computer-implemented system and method for keyword extraction and contextual advertisement generation are disclosed. The system in an example embodiment includes a keyword extraction service to receive from a consumer application a request for activation of a keyword extraction service via an application programming interface, the request including an identity of a content source, the request further including an identification of a particular extraction process to be used by the keyword extraction service on the identified content source; determine if the keyword extraction service has already processed the identified content source and retained extracted keywords in a data store; extract keywords from the identified content source using the particular extraction process identified in the request; and make the extracted keywords accessible to the consumer application.

摘要翻译： 公开了一种用于关键词提取和上下文广告生成的计算机实现的系统和方法。 在包括从消费者应用程序接收的关键词提取服务的应用程序接口激活关键字提取服务的请求的示例实施例中的系统包括内容源的标识，该请求还包括标识 由所述关键字提取服务在所识别的内容源上使用的特定提取过程; 确定关键字提取服务是否已经处理了所识别的内容源，并且将所提取的关键字保留在数据存储中; 使用请求中标识的特定提取过程从标识的内容源中提取关键字; 并使消费者应用程序可以访问提取的关键字。

公开(公告)号：US07837923B2

公开(公告)日：2010-11-23

申请号：US12173973

申请日：2008-07-16

申请人： Ed Bearse ,  Thomas Bohan ,  David Hedley ,  Alan Lewis

发明人： Ed Bearse ,  Thomas Bohan ,  David Hedley ,  Alan Lewis

IPC分类号： B29C67/20 ,  B29C45/14 ,  B29B13/00

CPC分类号： B29C44/569 ,  B29C47/003 ,  B29C47/004 ,  B29C47/0042 ,  B29C47/0054 ,  B29C51/12 ,  B29C51/165 ,  B29C51/427 ,  B29C65/02 ,  B29C65/08 ,  B29C65/10 ,  B29C66/1122 ,  B29C66/433 ,  B29C66/71 ,  B29C66/727 ,  B29C66/7315 ,  B29C66/73151 ,  B29C66/73921 ,  B29C66/8242 ,  B29C66/8322 ,  B29C66/83221 ,  B29C66/91411 ,  B29C66/91645 ,  B29C66/91931 ,  B29C2035/0822 ,  B29C2791/001 ,  B29K2105/04 ,  B29K2995/007 ,  B29K2995/0089 ,  B29L2009/00 ,  B29L2031/7178 ,  B65D19/0018 ,  B65D2519/00034 ,  B65D2519/00069 ,  B65D2519/00273 ,  B65D2519/00288 ,  B65D2519/00318 ,  B65D2519/00338 ,  B65D2519/00562 ,  B65D2519/00835 ,  B29K2023/04 ,  B29K2023/10 ,  B29K2025/04 ,  B29K2069/00 ,  B29K2071/12 ,  B29K2067/00 ,  B29K2025/08 ,  B29K2025/06 ,  B29K2023/12 ,  B29K2023/065 ,  B29K2023/0633 ,  B29K2023/06

摘要： Load-bearing articles are manufactured from shape defining compressible cores and thermoplastic shells. The manufacture of these articles requires specific methods and tools. Articles that can be manufactured using these methods include relatively lightweight pallets with high load-bearing capacity.

摘要翻译： 承载制品由形状可定义可压缩芯和热塑性外壳制成。 这些制品的制造需要具体的方法和工具。 可以使用这些方法制造的制品包括具有高承载能力的相对轻质的托盘。

公开(公告)号：US07684107B2

公开(公告)日：2010-03-23

申请号：US11544978

申请日：2006-10-06

申请人： Gang Xu ,  Alan Lewis ,  Brian Gally ,  Mark Mienko

发明人： Gang Xu ,  Alan Lewis ,  Brian Gally ,  Mark Mienko

IPC分类号： G02B26/00 ,  G02F1/29

摘要： An optical isolation structure is incorporated into a display between the display elements and the transparent substrate for the display elements. The optical isolation structure reflects light rays within the substrate that impact the structure at high angles relative to normal to the structure, thereby permitting the substrate to be used as an integrated light guide for distributing light over the display from a light source on the edge of the substrate. The optical isolation structure may include a single layer having an index of refraction less than the substrate or a plurality of thin-film interference layers.