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    DEVICE FOR PROJECTING IMAGES ON THE RETINA
    61.
    发明申请
    DEVICE FOR PROJECTING IMAGES ON THE RETINA 有权

    公开(公告)号：US20210031051A1

    公开(公告)日：2021-02-04

    申请号：US16947537

    申请日：2020-08-05

    Applicant: ACUCELA INC.

    Inventor： Ryo KUBOTA ,  Karim HAROUD ,  Beat WYSS ,  Hans BERNARD ,  Jean-Noël FEHR ,  Patrizia WEBER ,  Moritz HAEBERLI ,  Amitava GUPTA

    IPC: A61N5/06 ,  G02B27/30 ,  G02B27/01

    Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

    Methods and compositions for treating ophthalmic conditions with retinyl derivatives
    68.
    发明授权
    Methods and compositions for treating ophthalmic conditions with retinyl derivatives 有权
    用视黄醇衍生物治疗眼科疾病的方法和组合物

    公开(公告)号：US08314152B2

    公开(公告)日：2012-11-20

    申请号：US11150641

    申请日：2005-06-10

    Applicant: Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

    Inventor： Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

    IPC: A01N33/18 ,  A01N33/24 ,  A61K31/12

    CPC classification number: A61K31/167 ,  A61K31/16 ,  A61K31/215 ,  G01N2800/164

    Abstract: Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.

    Abstract translation: 引起可逆性夜盲症的化合物可用于治疗与视觉循环过程中积累的废物过量生产相关的眼科疾病。 我们描述使用这些化合物及其衍生物治疗例如黄斑变性和营养不良的方法和组合，或减轻与这种眼科疾病相关的症状。 这些化合物及其衍生物可以用作单一药物治疗或与其它药物或疗法组合使用。

    Extended Primary Retinal Cell Culture and Stress Models, and Methods of Use
    69.
    发明申请
    Extended Primary Retinal Cell Culture and Stress Models, and Methods of Use 审中-公开
    扩展的主要视网膜细胞培养和应激模型和使用方法

    公开(公告)号：US20080003634A1

    公开(公告)日：2008-01-03

    申请号：US11758480

    申请日：2007-06-05

    Applicant: Ryo Kubota

    Inventor： Ryo Kubota

    IPC: C12N5/06 ,  C12Q1/02

    CPC classification number: C12N5/062 ,  C12N2503/02 ,  G01N33/5005 ,  G01N33/5014

    Abstract: A cell culture system related to extended in vitro culture of mature retinal cells and methods for preparing the cell culture system are provided. Also provided is a retinal cell culture stress model related to extended in vitro culture of mature retinal cells in the presence of a stressor and methods for using the cell culture stress model. The invention provides a cell culture system comprising a long-term culture of mature retinal cells, without requiring addition of other types of non-retinal cells such as purified glia, or cells isolated from ciliary bodies within the eye, and the addition of a stressor such as light, A2E, cigarette smoke condensate, glutamate, or hydrostatic pressure. Methods for identifying bioactive agents that alter viability, neurodegeneration, or survival of retinal cells using the retinal cell culture stress system are also provided.

    Abstract translation: 提供了与成熟视网膜细胞的延长体外培养相关的细胞培养系统和用于制备细胞培养系统的方法。 还提供了一种视网膜细胞培养应激模型，其涉及在应激源存在下成熟视网膜细胞的延长体外培养和使用细胞培养应激模型的方法。 本发明提供一种包含成熟视网膜细胞的长期培养物的细胞培养系统，而不需要添加其它类型的非视网膜细胞，例如纯化的神经胶质细胞，或从眼睛内的睫状体分离的细胞，以及加入应激源 如光，A2E，香烟烟雾凝结物，谷氨酸或静水压力。 还提供了用于鉴定使用视网膜细胞培养应激系统改变视网膜细胞的存活力，神经变性或存活的生物活性剂的方法。

    Compositions and methods for diagnosing and treating retinal diseases
    70.
    发明申请
    Compositions and methods for diagnosing and treating retinal diseases 审中-公开
    用于诊断和治疗视网膜疾病的组合物和方法

    公开(公告)号：US20060252107A1

    公开(公告)日：2006-11-09

    申请号：US11361027

    申请日：2006-02-22

    Applicant: Ryo Kubota ,  Krzysztof Palczewski ,  Anna Gall

    Inventor： Ryo Kubota ,  Krzysztof Palczewski ,  Anna Gall

    IPC: G01N33/53 ,  C07K16/18 ,  C07K14/47 ,  C07D213/55 ,  C07D213/20 ,  C12N5/06

    CPC classification number: A61K39/0007 ,  A61K2039/6031 ,  C07D213/20 ,  C07D213/38 ,  C07D213/50 ,  C07D213/56 ,  C07K16/44

    Abstract: The present invention relates generally to the preparation and use of retinoid N-retinylidene-N-retinyl-ethanolamine (A2E) conjugated to a carrier polypeptide and to the preparation and use of antibodies that bind specifically to A2E. The invention relates to the use of A2E conjugates as immunogens or vaccines and to the use of A2E specific antibodies for treatment of ophthalmic diseases. Provided herein are methods for enhancing retinal neuronal cell survival, including photoreceptor cell survival, using antibodies that specifically bind to A2E or by inducing an immune response using an A2E immunoconjugate. Enhancing survival of photoreceptor cells or decreasing accumulation of A2E in the eye using the A2E immunoconjugates or A2E specific antibodies is useful for treatment of ophthalmic diseases such as macular degeneration.

    Abstract translation: 本发明一般涉及与载体多肽缀合的类视黄醇N-亚视黄基-N-视黄醇 - 乙醇胺（A2E）的制备和用途，以及制备和使用与A2E特异性结合的抗体。 本发明涉及使用A2E缀合物作为免疫原或疫苗，以及使用A2E特异性抗体治疗眼科疾病。 本文提供了使用特异性结合A2E的抗体或通过使用A2E免疫缀合物诱导免疫应答来增强视网膜神经元细胞存活的方法，包括感光细胞存活。 使用A2E免疫缀合物或A2E特异性抗体提高感光细胞的存活或减少A2E在眼中的积累，可用于治疗眼部疾病如黄斑变性。

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